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Conserved domains on  [gi|568961636|ref|XP_006511305|]
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ankyrin repeat domain-containing protein 34C isoform X1 [Mus musculus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat (ANK) domain-containing protein is involved in mediating protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  33435370|17176038

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-155 7.55e-25

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 104.65  E-value: 7.55e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961636  34 GAYINESNDKGETALMVACITKHVDqqsiskskMVKYLLDNRADPNIQDKSGKTALIHACiRRAGGEVVSLLLENGADPS 113
Cdd:COG0666  143 GADVNAQDNDGNTPLHLAAANGNLE--------IVKLLLEAGADVNARDNDGETPLHLAA-ENGHLEIVKLLLEAGADVN 213

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 568961636 114 LEDRTGASALVYAINADDKDALKHLLDACKAKGKEVIIITTD 155
Cdd:COG0666  214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTA 255
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-155 7.55e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 104.65  E-value: 7.55e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961636  34 GAYINESNDKGETALMVACITKHVDqqsiskskMVKYLLDNRADPNIQDKSGKTALIHACiRRAGGEVVSLLLENGADPS 113
Cdd:COG0666  143 GADVNAQDNDGNTPLHLAAANGNLE--------IVKLLLEAGADVNARDNDGETPLHLAA-ENGHLEIVKLLLEAGADVN 213

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 568961636 114 LEDRTGASALVYAINADDKDALKHLLDACKAKGKEVIIITTD 155
Cdd:COG0666  214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTA 255
Ank_2 pfam12796
Ankyrin repeats (3 copies);
32-116 1.36e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.29  E-value: 1.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961636   32 EGGAYINESNDKGETALMVACITKHVDqqsiskskMVKYLLDNrADPNIQDKsGKTALIHACIRRAgGEVVSLLLENGAD 111
Cdd:pfam12796  18 ENGADANLQDKNGRTALHLAAKNGHLE--------IVKLLLEH-ADVNLKDN-GRTALHYAARSGH-LEIVKLLLEKGAD 86


                  ....*
gi 568961636  112 PSLED 116
Cdd:pfam12796  87 INVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 34-111 1.94e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 56.60  E-value: 1.94e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568961636  34 GAYINESNDKGETALMVACITKHVDqqsiskskMVKYLLDNRADPNIQDKSGKTALiHACIRRAGGEVVSLLLENGAD 111
Cdd:PHA03100 182 GVPINIKDVYGFTPLHYAVYNNNPE--------FVKYLLDLGANPNLVNKYGDTPL-HIAILNNNKEIFKLLLNNGPS 250
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 43-80 7.53e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 7.53e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568961636    43 KGETALMVACITKHVDqqsiskskMVKYLLDNRADPNI 80
Cdd:smart00248   1 DGRTPLHLAAENGNLE--------VVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
34-155 7.55e-25

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 104.65  E-value: 7.55e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961636  34 GAYINESNDKGETALMVACITKHVDqqsiskskMVKYLLDNRADPNIQDKSGKTALIHACiRRAGGEVVSLLLENGADPS 113
Cdd:COG0666  143 GADVNAQDNDGNTPLHLAAANGNLE--------IVKLLLEAGADVNARDNDGETPLHLAA-ENGHLEIVKLLLEAGADVN 213

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 568961636 114 LEDRTGASALVYAINADDKDALKHLLDACKAKGKEVIIITTD 155
Cdd:COG0666  214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTA 255
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
15-141 1.85e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 94.64  E-value: 1.85e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961636  15 LLKAVWLGRLRLTRLLLEGGAYINESNDKGETALMVACITKHVDqqsiskskMVKYLLDNRADPNIQDKSGKTALIHACI 94
Cdd:COG0666   58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLE--------IVKLLLEAGADVNARDKDGETPLHLAAY 129

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 568961636  95 RRAGgEVVSLLLENGADPSLEDRTGASALVYAINADDKDALKHLLDA 141
Cdd:COG0666  130 NGNL-EIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA 175
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
32-155 6.36e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 84.24  E-value: 6.36e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961636  32 EGGAYINESNDKGETALMVACITKHVDqqsiskskMVKYLLDNRADPNIQDKSGKTALIHAcIRRAGGEVVSLLLENGAD 111
Cdd:COG0666  174 EAGADVNARDNDGETPLHLAAENGHLE--------IVKLLLEAGADVNAKDNDGKTALDLA-AENGNLEIVKLLLEAGAD 244

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568961636 112 PSLEDRTGASALVYAINADDKDALKHLLDACKAKGKEVIIITTD 155
Cdd:COG0666  245 LNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
Ank_2 pfam12796
Ankyrin repeats (3 copies);
32-116 1.36e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.29  E-value: 1.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961636   32 EGGAYINESNDKGETALMVACITKHVDqqsiskskMVKYLLDNrADPNIQDKsGKTALIHACIRRAgGEVVSLLLENGAD 111
Cdd:pfam12796  18 ENGADANLQDKNGRTALHLAAKNGHLE--------IVKLLLEH-ADVNLKDN-GRTALHYAARSGH-LEIVKLLLEKGAD 86


                  ....*
gi 568961636  112 PSLED 116
Cdd:pfam12796  87 INVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
48-140 1.88e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 63.21  E-value: 1.88e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961636   48 LMVACITKHVDqqsiskskMVKYLLDNRADPNIQDKSGKTALIHACIRRAgGEVVSLLLENgADPSLEDRtGASALVYAI 127
Cdd:pfam12796   1 LHLAAKNGNLE--------LVKLLLENGADANLQDKNGRTALHLAAKNGH-LEIVKLLLEH-ADVNLKDN-GRTALHYAA 69

                          90
                  ....*....|...
gi 568961636  128 NADDKDALKHLLD 140
Cdd:pfam12796  70 RSGHLEIVKLLLE 82
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-141 1.22e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 62.66  E-value: 1.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961636   1 MMDDDTELRTDGNSLLKAVWLGRLRLTRLLLEGGAYINESNDKGETALMVAcitkhvdqQSISKSKMVKYLLDNRADPNI 80
Cdd:COG0666   11 LLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAA--------ALAGDLLVALLLLAAGADINA 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568961636  81 QDKSGKTALIHAcIRRAGGEVVSLLLENGADPSLEDRTGASALVYAINADDKDALKHLLDA 141
Cdd:COG0666   83 KDDGGNTLLHAA-ARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA 142
Ank_5 pfam13857
Ankyrin repeats (many copies);
37-92 1.22e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 51.19  E-value: 1.22e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568961636   37 INESNDKGETALMVACITKHVDqqsiskskMVKYLLDNRADPNIQDKSGKTALIHA 92
Cdd:pfam13857   9 LNRLDGEGYTPLHVAAKYGALE--------IVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 34-111 1.94e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 56.60  E-value: 1.94e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568961636  34 GAYINESNDKGETALMVACITKHVDqqsiskskMVKYLLDNRADPNIQDKSGKTALiHACIRRAGGEVVSLLLENGAD 111
Cdd:PHA03100 182 GVPINIKDVYGFTPLHYAVYNNNPE--------FVKYLLDLGANPNLVNKYGDTPL-HIAILNNNKEIFKLLLNNGPS 250
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 34-140 4.67e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 55.44  E-value: 4.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961636  34 GAYINESNDKGETALMVaCITKHVDQqsiskSKMVKYLLDNRADPNIQDKSGKTaLIHACIR--RAGGEVVSLLLENGAD 111
Cdd:PHA03100  96 GANVNAPDNNGITPLLY-AISKKSNS-----YSIVEYLLDNGANVNIKNSDGEN-LLHLYLEsnKIDLKILKLLIDKGVD 168

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 568961636 112 PSLEDRT----------------GASALVYAINADDKDALKHLLD 140
Cdd:PHA03100 169 INAKNRVnyllsygvpinikdvyGFTPLHYAVYNNNPEFVKYLLD 213
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 32-140 6.43e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.89  E-value: 6.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961636  32 EGGAYINESNDKGETALMVAciTKHVDQQSIskskmvKYLLDNRADPNIQDKSGKTAlIHACIRRAGGEVVSLLLENGAD 111
Cdd:PHA02874 112 DCGIDVNIKDAELKTFLHYA--IKKGDLESI------KMLFEYGADVNIEDDNGCYP-IHIAIKHNFFDIIKLLLEKGAY 182

                         90       100
                 ....*....|....*....|....*....
gi 568961636 112 PSLEDRTGASALVYAINADDKDALKHLLD 140
Cdd:PHA02874 183 ANVKDNNGESPLHNAAEYGDYACIKLLID 211
PHA03095 PHA03095
ankyrin-like protein; Provisional
 34-145 7.32e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.56  E-value: 7.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961636  34 GAYINESNDKGETALMVACITKHVDqqsiskSKMVKYLLDNRADPNIQDKSGKTALiHACIRRAGG--EVVSLLLENGAD 111
Cdd:PHA03095 107 GADVNAKDKVGRTPLHVYLSGFNIN------PKVIRLLLRKGADVNALDLYGMTPL-AVLLKSRNAnvELLRLLIDAGAD 179

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568961636 112 psledrtgasalVYAINADDKDALKHLLDACKAK 145
Cdd:PHA03095 180 ------------VYAVDDRFRSLLHHHLQSFKPR 201
Ank_4 pfam13637
Ankyrin repeats (many copies);
46-106 2.43e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 44.57  E-value: 2.43e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568961636   46 TALMVACITKHVDqqsiskskMVKYLLDNRADPNIQDKSGKTALiHACIRRAGGEVVSLLL 106
Cdd:pfam13637   3 TALHAAAASGHLE--------LLRLLLEKGADINAVDGNGETAL-HFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 68-142 9.27e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 48.36  E-value: 9.27e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568961636  68 VKYLLDNRADPNIQDKSGKTALIHACIRRAGGeVVSLLLENGADPSLEDRTGASALVYAINADDKDALKHLLDAC 142
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQ-VVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHS 171
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 34-141 1.31e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 47.68  E-value: 1.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961636  34 GAYINES-NDKGETALMVACITKHVDqqsiskskMVKYLLDNRADPNIQDkSGKTALIHACIRRAGGEVVSLLLENGADP 112
Cdd:PHA02875  91 GKFADDVfYKDGMTPLHLATILKKLD--------IMKLLIARGADPDIPN-TDKFSPLHLAVMMGDIKGIELLIDHKACL 161

                         90       100
                 ....*....|....*....|....*....
gi 568961636 113 SLEDRTGASALVYAINADDKDALKHLLDA 141
Cdd:PHA02875 162 DIEDCCGCTPLIIAMAKGDIAICKMLLDS 190
Ank_2 pfam12796
Ankyrin repeats (3 copies);
90-148 2.68e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.80  E-value: 2.68e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568961636   90 IHACIRRAGGEVVSLLLENGADPSLEDRTGASALVYAINADDKDALKHLLDACKAKGKE 148
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD 59
Ank_5 pfam13857
Ankyrin repeats (many copies);
71-126 2.77e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.56  E-value: 2.77e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568961636   71 LLDNR-ADPNIQDKSGKTALIHACIRRAgGEVVSLLLENGADPSLEDRTGASALVYA 126
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGA-LEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 34-140 2.79e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.58  E-value: 2.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961636  34 GAYINESNDKGETALMVACITKHVDQQSIsksKMVKYLLDNRADPNIQDKSGKTALIHACIRRAGG-EVVSLLLENGADP 112
Cdd:PHA03100  58 GADINSSTKNNSTPLHYLSNIKYNLTDVK---EIVKLLLEYGANVNAPDNNGITPLLYAISKKSNSySIVEYLLDNGANV 134

                         90       100       110
                 ....*....|....*....|....*....|
gi 568961636 113 SLEDRTGASALVYAI--NADDKDALKHLLD 140
Cdd:PHA03100 135 NIKNSDGENLLHLYLesNKIDLKILKLLID 164
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 34-154 3.73e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.14  E-value: 3.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961636  34 GAYINESNDKGETALMVACITKHVdqqsisksKMVKYLLDNRADPNIQDKSGKTALIHAcIRRAGGEVVSLLLENGADPS 113
Cdd:PHA02875 125 GADPDIPNTDKFSPLHLAVMMGDI--------KGIELLIDHKACLDIEDCCGCTPLIIA-MAKGDIAICKMLLDSGANID 195

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 568961636 114 LEDRTG-ASALVYAINADDKDALKHLLdackAKGKEVIIITT 154
Cdd:PHA02875 196 YFGKNGcVAALCYAIENNKIDIVRLFI----KRGADCNIMFM 233
PHA03095 PHA03095
ankyrin-like protein; Provisional
 68-141 4.82e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.79  E-value: 4.82e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568961636  68 VKYLLDNRADPNIQDKSGKTALiHACIRRAGG---EVVSLLLENGADPSLEDRTGASAL-VYAINADDKDALKHLLDA 141
Cdd:PHA03095  30 VRRLLAAGADVNFRGEYGKTPL-HLYLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLIKA 106
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 43-83 6.53e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 6.53e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568961636   43 KGETALMVACI-TKHVDqqsiskskMVKYLLDNRADPNIQDK 83
Cdd:pfam00023   1 DGNTPLHLAAGrRGNLE--------IVKLLLSKGADVNARDK 34
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 64-127 1.05e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 44.66  E-value: 1.05e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568961636  64 KSKMVKYLLDNRADPNIQDKSGKTAL-IHACIR---RAGGEVVSLLLENGADPSLEDRTGASALVYAI 127
Cdd:PHA03100  47 NIDVVKILLDNGADINSSTKNNSTPLhYLSNIKynlTDVKEIVKLLLEYGANVNAPDNNGITPLLYAI 114
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 85-117 1.10e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.58  E-value: 1.10e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568961636   85 GKTALIHACIRRAGGEVVSLLLENGADPSLEDR 117
Cdd:pfam00023   2 GNTPLHLAAGRRGNLEIVKLLLSKGADVNARDK 34
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 32-139 5.21e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 42.64  E-value: 5.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961636  32 EGGAYINESNDKGETALM-------VACITKHVDQQS----------------ISKSKMVKYLLDNRADPNIQDKSGKTA 88
Cdd:PHA02874 178 EKGAYANVKDNNGESPLHnaaeygdYACIKLLIDHGNhimnkckngftplhnaIIHNRSAIELLINNASINDQDIDGSTP 257

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568961636  89 LIHACIRRAGGEVVSLLLENGADPSLEDRTGASALVYAINADDKDA-LKHLL 139
Cdd:PHA02874 258 LHHAINPPCDIDIIDILLYHKADISIKDNKGENPIDTAFKYINKDPvIKDII 309
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 43-80 7.53e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.80  E-value: 7.53e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568961636    43 KGETALMVACITKHVDqqsiskskMVKYLLDNRADPNI 80
Cdd:smart00248   1 DGRTPLHLAAENGNLE--------VVKLLLDKGADINA 30
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 53-140 1.13e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 41.59  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961636  53 ITKHVDQQSISKSKMvkyLLDNRADPNIQDKSGKTAlIHACIRRAGGEVVSLLLENGADPSLEDRTGASALVYAINADDK 132
Cdd:PHA02876 149 IKERIQQDELLIAEM---LLEGGADVNAKDIYCITP-IHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNI 224


                 ....*...
gi 568961636 133 DALKHLLD 140
Cdd:PHA02876 225 DTIKAIID 232
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 34-170 1.56e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.02  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961636  34 GAYINeSNDKGETALMVACITKhvdqqsiSKSKMVKYLLDNRADPNIQDKSGKTALIHACIRRAGGEVVSLLLENGADPS 113
Cdd:PHA02878 191 GANVN-IPDKTNNSPLHHAVKH-------YNKPIVHILLENGASTDARDKCGNTPLHISVGYCKDYDILKLLLEHGVDVN 262

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568961636 114 LEDRT-GASALVYAINADDKdaLKHLLDAckakGKEVIIITTDKSSSGTKTTKQYLNV 170
Cdd:PHA02878 263 AKSYIlGLTALHSSIKSERK--LKLLLEY----GADINSLNSYKLTPLSSAVKQYLCI 314
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 57-139 2.16e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 40.63  E-value: 2.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568961636  57 VDQQSISKSKMVKYLLDNRADPNIQDK-SGKTALiHACIRRAGGEVVSLLLENGADPSLEDRTGASALVYAINADDKDAL 135
Cdd:PHA02878 139 KSKDDIIEAEITKLLLSYGADINMKDRhKGNTAL-HYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIV 217


                 ....
gi 568961636 136 KHLL 139
Cdd:PHA02878 218 HILL 221
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 32-106 3.73e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.88  E-value: 3.73e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568961636  32 EGGAYINESNDKGETALMVACITKHVdqqsisksKMVKYLLDNRADPNIQDKSGKTALIHAcIRRAGGEVVSLLL 106
Cdd:PTZ00322 103 TGGADPNCRDYDGRTPLHIACANGHV--------QVVRVLLEFGADPTLLDKDGKTPLELA-EENGFREVVQLLS 168
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 43-80 4.30e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.93  E-value: 4.30e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568961636   43 KGETALMVACITKHVDqqsiskskMVKYLLDNRADPNI 80
Cdd:pfam13606   1 DGNTPLHLAARNGRLE--------IVKLLLENGADINA 30
PHA02917 PHA02917
ankyrin-like protein; Provisional
 77-139 8.72e-03

ankyrin-like protein; Provisional


Pssm-ID: 165231 [Multi-domain]  Cd Length: 661  Bit Score: 38.83  E-value: 8.72e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568961636  77 DPNIQDKSGKTaLIHACIRRAGGEVVSLLLENGADPSLEDRTGASALVYAINADDKDALKHLL 139
Cdd:PHA02917 444 DINMIDKRGET-LLHKAVRYNKQSLVSLLLESGSDVNIRSNNGYTCIAIAINESRNIELLKML 505
Ank_4 pfam13637
Ankyrin repeats (many copies);
87-139 9.33e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.56  E-value: 9.33e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568961636   87 TALIHACIRRAGGEVVSLLLENGADPSLEDRTGASALVYAINADDKDALKHLL 139
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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