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Conserved domains on  [gi|568962343|ref|XP_006511637|]
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little elongation complex subunit 2 isoform X2 [Mus musculus]

Protein Classification

NARG2_C domain-containing protein( domain architecture ID 10564709)

NARG2_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NARG2_C pfam10505
NMDA receptor-regulated gene protein 2 C-terminus; The transition of neuronal cells from ...
 691-901 5.71e-93

NMDA receptor-regulated gene protein 2 C-terminus; The transition of neuronal cells from pre-cursor to mature state is regulated by the N-methyl-d-aspartate (NMDA) receptor, a glutamate-gated ion channel that is permeable to Ca2+. NMDA receptors probably mediate this activity by permitting expression of NARG2. NARG2 is transiently expressed, being a regulatory protein that is present in the nucleus of dividing cells and then down-regulated as progenitors exit the cell cycle and begin to differentiate. NARG2 contains repeats of (S/T)PXX, (11 in mouse, six in human), a putative DNA-binding motif that is found in many gene-regulatory proteins including Kruppel, Hunchback and Antennapedi.


:

Pssm-ID: 463121  Cd Length: 208  Bit Score: 293.05  E-value: 5.71e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962343  691 SEYIAPQEGNFVYK----LFSLQDLLLLVRCSIQRVETRPRSKkrkkirrQFPVYVLPKVEYQGCYGVEALTESELCRFW 766
Cdd:pfam10505   1 QEYIAPAEGNVAYKlwslQVGESDLLLLVRSSVDAVRTLPGGK-------LLPVHLLPKLEYQPCYGVEILTKSELCRLW 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962343  767 TESLLHSNCSFYVGHIDAFTSKLFMLEEIASEELKEKLAALKISSLFNILQHILKKLCSLQEGSYLLSHAAEDSSLLIYK 846
Cdd:pfam10505  74 TELLLRPNTVLYRGRIDAFTSKLLLLEKLTLESLEEELSNFKPANSLNILHHILKKLSSLQPGSYLLRHTPKDPFVTIYK 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568962343  847 TSDGKVTRTAYNLHKAHCDLPGVPSSLSVPWVPLDPSYLLPYHIHHGRVPCTFPP 901
Cdd:pfam10505 154 SSTEKATRGSYNLHQAHSSLPTVPSSLSVPWVPIDPTLVLPLHRQHGRVPCTFPP 208
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 394-438 1.00e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 1.00e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568962343  394 AVPKIAAVPLAPATPVAPTMPVAPATPVTPTMPMAPATPEASATP 438
Cdd:PHA03247 2731 ASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAP 2775
 
Name Accession Description Interval E-value
NARG2_C pfam10505
NMDA receptor-regulated gene protein 2 C-terminus; The transition of neuronal cells from ...
 691-901 5.71e-93

NMDA receptor-regulated gene protein 2 C-terminus; The transition of neuronal cells from pre-cursor to mature state is regulated by the N-methyl-d-aspartate (NMDA) receptor, a glutamate-gated ion channel that is permeable to Ca2+. NMDA receptors probably mediate this activity by permitting expression of NARG2. NARG2 is transiently expressed, being a regulatory protein that is present in the nucleus of dividing cells and then down-regulated as progenitors exit the cell cycle and begin to differentiate. NARG2 contains repeats of (S/T)PXX, (11 in mouse, six in human), a putative DNA-binding motif that is found in many gene-regulatory proteins including Kruppel, Hunchback and Antennapedi.


Pssm-ID: 463121  Cd Length: 208  Bit Score: 293.05  E-value: 5.71e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962343  691 SEYIAPQEGNFVYK----LFSLQDLLLLVRCSIQRVETRPRSKkrkkirrQFPVYVLPKVEYQGCYGVEALTESELCRFW 766
Cdd:pfam10505   1 QEYIAPAEGNVAYKlwslQVGESDLLLLVRSSVDAVRTLPGGK-------LLPVHLLPKLEYQPCYGVEILTKSELCRLW 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962343  767 TESLLHSNCSFYVGHIDAFTSKLFMLEEIASEELKEKLAALKISSLFNILQHILKKLCSLQEGSYLLSHAAEDSSLLIYK 846
Cdd:pfam10505  74 TELLLRPNTVLYRGRIDAFTSKLLLLEKLTLESLEEELSNFKPANSLNILHHILKKLSSLQPGSYLLRHTPKDPFVTIYK 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568962343  847 TSDGKVTRTAYNLHKAHCDLPGVPSSLSVPWVPLDPSYLLPYHIHHGRVPCTFPP 901
Cdd:pfam10505 154 SSTEKATRGSYNLHQAHSSLPTVPSSLSVPWVPIDPTLVLPLHRQHGRVPCTFPP 208
PHA03247 PHA03247
large tegument protein UL36; Provisional
 394-438 1.00e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 1.00e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568962343  394 AVPKIAAVPLAPATPVAPTMPVAPATPVTPTMPMAPATPEASATP 438
Cdd:PHA03247 2731 ASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAP 2775
 
Name Accession Description Interval E-value
NARG2_C pfam10505
NMDA receptor-regulated gene protein 2 C-terminus; The transition of neuronal cells from ...
 691-901 5.71e-93

NMDA receptor-regulated gene protein 2 C-terminus; The transition of neuronal cells from pre-cursor to mature state is regulated by the N-methyl-d-aspartate (NMDA) receptor, a glutamate-gated ion channel that is permeable to Ca2+. NMDA receptors probably mediate this activity by permitting expression of NARG2. NARG2 is transiently expressed, being a regulatory protein that is present in the nucleus of dividing cells and then down-regulated as progenitors exit the cell cycle and begin to differentiate. NARG2 contains repeats of (S/T)PXX, (11 in mouse, six in human), a putative DNA-binding motif that is found in many gene-regulatory proteins including Kruppel, Hunchback and Antennapedi.


Pssm-ID: 463121  Cd Length: 208  Bit Score: 293.05  E-value: 5.71e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962343  691 SEYIAPQEGNFVYK----LFSLQDLLLLVRCSIQRVETRPRSKkrkkirrQFPVYVLPKVEYQGCYGVEALTESELCRFW 766
Cdd:pfam10505   1 QEYIAPAEGNVAYKlwslQVGESDLLLLVRSSVDAVRTLPGGK-------LLPVHLLPKLEYQPCYGVEILTKSELCRLW 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962343  767 TESLLHSNCSFYVGHIDAFTSKLFMLEEIASEELKEKLAALKISSLFNILQHILKKLCSLQEGSYLLSHAAEDSSLLIYK 846
Cdd:pfam10505  74 TELLLRPNTVLYRGRIDAFTSKLLLLEKLTLESLEEELSNFKPANSLNILHHILKKLSSLQPGSYLLRHTPKDPFVTIYK 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568962343  847 TSDGKVTRTAYNLHKAHCDLPGVPSSLSVPWVPLDPSYLLPYHIHHGRVPCTFPP 901
Cdd:pfam10505 154 SSTEKATRGSYNLHQAHSSLPTVPSSLSVPWVPIDPTLVLPLHRQHGRVPCTFPP 208
PHA03247 PHA03247
large tegument protein UL36; Provisional
 394-438 1.00e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.47  E-value: 1.00e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568962343  394 AVPKIAAVPLAPATPVAPTMPVAPATPVTPTMPMAPATPEASATP 438
Cdd:PHA03247 2731 ASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAP 2775
PHA03247 PHA03247
large tegument protein UL36; Provisional
 394-438 1.66e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 1.66e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568962343  394 AVPKIAAVPLAPATPVAPTMPVAPATPVTPTMPMAPATPEASATP 438
Cdd:PHA03247 2740 APPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLT 2784
PHA02030 PHA02030
hypothetical protein
 392-434 3.40e-04

hypothetical protein


Pssm-ID: 222843 [Multi-domain]  Cd Length: 336  Bit Score: 43.81  E-value: 3.40e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568962343 392 VHAVPKI--AAVPLAPATPVAPTMP--------VAPATPVTPTMPMAPATPEA 434
Cdd:PHA02030 284 VPAAAAAvaQAAPSVPQVPNVAVLPdvpqvapvAAPAAPEVPAVPVVPAAPQV 336
PHA03247 PHA03247
large tegument protein UL36; Provisional
 396-441 1.45e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.45e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 568962343  396 PKIAAVPLAPATPVA----PTMPVAPATPVTPTMPMAPATPEASATPNIT 441
Cdd:PHA03247 2714 ALVSATPLPPGPAAArqasPALPAAPAPPAVPAGPATPGGPARPARPPTT 2763
PHA03247 PHA03247
large tegument protein UL36; Provisional
 394-438 3.29e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 3.29e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568962343  394 AVPKIAAVPLAPATPVAPTMPVAPATPVTPTMPMAPATPEASATP 438
Cdd:PHA03247 2749 ATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSE 2793
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 389-438 5.42e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.83  E-value: 5.42e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 568962343 389 MTDVHAVPKIAAVPLAPATPVAPTMPVAPATPVTPTMPMAPATPEASATP 438
Cdd:PTZ00449 617 LLDIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPPKSPKPP 666
PHA02030 PHA02030
hypothetical protein
 391-442 5.62e-03

hypothetical protein


Pssm-ID: 222843 [Multi-domain]  Cd Length: 336  Bit Score: 39.96  E-value: 5.62e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962343 391 DVHAVPkiaAVPlAPATPVAPTMPVAPATPVTPTMP--------MAPATPEASATPNITD 442
Cdd:PHA02030 277 GSAAAP---AVP-AAAAAVAQAAPSVPQVPNVAVLPdvpqvapvAAPAAPEVPAVPVVPA 332
PRK05641 PRK05641
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
 398-440 7.83e-03

putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated


Pssm-ID: 235540 [Multi-domain]  Cd Length: 153  Bit Score: 37.92  E-value: 7.83e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 568962343 398 IAAVPLAPATPVAPTMPVAPATPvTPTMPMAPATPEASATPNI 440
Cdd:PRK05641  45 LSAVQEQVPTPAPAPAPAVPSAP-TPVAPAAPAPAPASAGENV 86
PHA03247 PHA03247
large tegument protein UL36; Provisional
 394-438 7.85e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 7.85e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568962343  394 AVPKIAAVPLAPATPVAPTMPVAPATPVTPTMPMAPATPEASATP 438
Cdd:PHA03247 2752 GGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRE 2796
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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