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Conserved domains on  [gi|568962739|ref|XP_006511689|]
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cadherin EGF LAG seven-pass G-type receptor 3 isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 646-743 3.64e-38

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 138.60  E-value: 3.64e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  646 PFQVSVLENAPLGHSVIHIQAVDADHGENSRLEYSLTGVASDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSP 725
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 568962739  726 PLSASASVTVTVLDVNDN 743
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 956-1054 1.21e-35

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 131.28  E-value: 1.21e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  956 HYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGeDGDGDFTIEPTSGIVRTVRRLDREAVPVYELTAYAVDRGV 1035
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG-NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 568962739 1036 PPLRTPVSIQVTVQDVNDN 1054
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 541-638 1.30e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 128.20  E-value: 1.30e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  541 YVAQVREDVRPHTVVLRVTATDKDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVMAPLDFEAEREYALRIRAQDAGRPP 620
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*...
gi 568962739  621 LSnNTGLASIQVVDINDH 638
Cdd:cd11304    82 LS-STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 321-420 6.47e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.27  E-value: 6.47e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  321 YQTLVPENEAAGTSVLRVVAQDPDPGEAGRLIYSLaalMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHG 400
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|
gi 568962739  401 SPRLSATTMVAVTVADRNDH 420
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 428-532 1.11e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.81  E-value: 1.11e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  428 QYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGSPAvrtaaAAAFEIDPRSGLISTSGRVDREHMESYELVVEAS 507
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*
gi 568962739  508 DQGQEpgPRSATVRVHITVLDENDN 532
Cdd:cd11304    76 DGGGP--PLSSTATVTITVLDVNDN 98
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1508-1691 3.06e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 123.68  E-value: 3.06e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739 1508 ARSFPPSSFVMFRGLR-QRFHLTLSLSFATVQPSGLLFYNGRLNeKHDFLALELVAGQVRLTYSTGESNTVVSPTVPggL 1586
Cdd:cd00110     1 GVSFSGSSYVRLPTLPaPRTRLSISFSFRTTSPNGLLLYAGSQN-GGDFLALELEDGRLVLRYDLGSGSLVLSSKTP--L 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739 1587 SDGQWHTVHLRYYNkprtdalggaqgpskdKVAVLSVDDCNVavalqfgAEIGnyscaaagvQTSSKKSLDLTGPLLLGG 1666
Cdd:cd00110    78 NDGQWHSVSVERNG----------------RSVTLSVDGERV-------VESG---------SPGGSALLNLDGPLYLGG 125

                         170       180
                  ....*....|....*....|....*.
gi 568962739 1667 VPNLPENFPV-SHKDFIGCMRDLHID 1691
Cdd:cd00110   126 LPEDLKSPGLpVSPGFVGCIRDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 853-948 4.96e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.18  E-value: 4.96e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  853 HYSVSMNEDRPVGSTVVVISASDDDVGENARITYLL--EDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIP 930
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 568962739  931 QKADTTYVEVMVNDVNDN 948
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1062-1156 3.08e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 115.87  E-value: 3.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739 1062 EFEVRVKENSIVGSVVAQITAVDPDDGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQAT---SA 1138
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATdggGP 80

                          90
                  ....*....|....*...
gi 568962739 1139 PLVSRATVHVRLVDQNDN 1156
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 751-845 3.21e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 3.21e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  751 EYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFAISTQGGVglVTLALPLDYKQERYFKLVLTASDR- 827
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNEDGLFSIDPSTGE--ITTAKPLDREEQSSYTLTVTATDGg 78

                          90       100
                  ....*....|....*....|
gi 568962739  828 --ALHDHCYVHINITDANTH 845
Cdd:cd11304    79 gpPLSSTATVTITVLDVNDN 98
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1755-1912 2.07e-20

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 89.78  E-value: 2.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739 1755 PYHFQGNGTLSwdFGNDMAVSVPWYLGLSFRTRATKGILMQV-QLGPHSVLLCKLDRGLLSVTLNRASGHTVhlLLDQMT 1833
Cdd:cd00110     1 GVSFSGSSYVR--LPTLPAPRTRLSISFSFRTTSPNGLLLYAgSQNGGDFLALELEDGRLVLRYDLGSGSLV--LSSKTP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739 1834 VSDGRWHDLRLElqeepggRRGHHIFMvSLDFTLFQDTMAMGGELQGLKVKQLHVGGLPPSSKEEGH---QGLVGCIQGV 1910
Cdd:cd00110    77 LNDGQWHSVSVE-------RNGRSVTL-SVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLpvsPGFVGCIRDL 148


                  ..
gi 568962739 1911 WI 1912
Cdd:cd00110   149 KV 150
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1176-1257 7.84e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.71  E-value: 7.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739 1176 DTFPSGIIGRIPAYDPDVSD--HLFYSFERGNELQLLVVNRTSGELRLSRKLDNNRPLVASMLVTVTD-GLHSVTAQCVL 1252
Cdd:cd11304     9 NAPPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDgGGPPLSSTATV 88


                  ....*
gi 568962739 1253 RVVII 1257
Cdd:cd11304    89 TITVL 93
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1717-1747 3.90e-08

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 50.84  E-value: 3.90e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568962739  1717 CASGPCKNNGFCSERWGGFSCDCPVGFGGKD 1747
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1973-2011 7.66e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 7.66e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 568962739 1973 VDACLL-NPCQNQGSCRHLQGaphGYTCDCVSGYFGQHCE 2011
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVG---SYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1428-1462 8.53e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 8.53e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568962739 1428 DLCYS-NPCRNGGACARREGGYTCVCRPRFTGEDCE 1462
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1939-1973 1.34e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 1.34e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568962739 1939 NPCASG-PCPPHADCKDLWQTFSCTCRPGYYGPGCV 1973
Cdd:cd00054     3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1472-1505 1.68e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.68e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568962739 1472 PGVCRNGGTCTNAPnGGFRCQCPAGgaFEGPRCE 1505
Cdd:cd00054     8 GNPCQNGGTCVNTV-GSYRCSCPPG--YTGRNCE 38
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1994-2033 1.54e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 41.18  E-value: 1.54e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568962739  1994 PHGYTCDCVSGYFGQHCEhrvdqQCPRGWWGSPTCGPCNC 2033
Cdd:pfam00053   15 PETGQCLCKPGVTGRHCD-----RCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 2030-2053 2.91e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 37.72  E-value: 2.91e-03
                          10        20
                  ....*....|....*....|....
gi 568962739 2030 PCNCDVHKGFDPNCNKTNGQCHCK 2053
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECK 24
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 9-276 9.80e-03

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.31  E-value: 9.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739    9 GLPGPSTPvllLLLLSLFPFSREELGGGGDQDWDPGVATTTGPRAQIGSGAVAL----------CPESPGVWEDGDPGLG 78
Cdd:PHA03307  124 ASPPPSPA---PDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALplsspeetarAPSSPPAEPPPSTPPA 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   79 VREPvfmrlrvgRQNARNGRGAPEQPNAevvvQALGSREQEAGQGPGYLLCWHPEISSCGrTGPLRRGSLPLDALSPGDS 158
Cdd:PHA03307  201 AASP--------RPPRRSSPISASASSP----APAPGRSAADDAGASSSDSSSSESSGCG-WGPENECPLPRPAPITLPT 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  159 DLRNSS-PHPSELLAQPDGSRPvafqrnARRSIRKRVETSRCCGKLWEPGHKGQGERSAT------STVDRGPFRRDCL- 230
Cdd:PHA03307  268 RIWEASgWNGPSSRPGPASSSS------SPRERSPSPSPSSPGSGPAPSSPRASSSSSSSressssSTSSSSESSRGAAv 341

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 568962739  231 -PGSLGSGLGEDSAPRAVRTAPTPGSAPRESRTAPGRMRSRGLFRRR 276
Cdd:PHA03307  342 sPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRR 388
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 646-743 3.64e-38

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 138.60  E-value: 3.64e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  646 PFQVSVLENAPLGHSVIHIQAVDADHGENSRLEYSLTGVASDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSP 725
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 568962739  726 PLSASASVTVTVLDVNDN 743
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 956-1054 1.21e-35

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 131.28  E-value: 1.21e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  956 HYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGeDGDGDFTIEPTSGIVRTVRRLDREAVPVYELTAYAVDRGV 1035
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG-NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 568962739 1036 PPLRTPVSIQVTVQDVNDN 1054
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 541-638 1.30e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 128.20  E-value: 1.30e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  541 YVAQVREDVRPHTVVLRVTATDKDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVMAPLDFEAEREYALRIRAQDAGRPP 620
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*...
gi 568962739  621 LSnNTGLASIQVVDINDH 638
Cdd:cd11304    82 LS-STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 321-420 6.47e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.27  E-value: 6.47e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  321 YQTLVPENEAAGTSVLRVVAQDPDPGEAGRLIYSLaalMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHG 400
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|
gi 568962739  401 SPRLSATTMVAVTVADRNDH 420
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 428-532 1.11e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.81  E-value: 1.11e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  428 QYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGSPAvrtaaAAAFEIDPRSGLISTSGRVDREHMESYELVVEAS 507
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*
gi 568962739  508 DQGQEpgPRSATVRVHITVLDENDN 532
Cdd:cd11304    76 DGGGP--PLSSTATVTITVLDVNDN 98
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1508-1691 3.06e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 123.68  E-value: 3.06e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739 1508 ARSFPPSSFVMFRGLR-QRFHLTLSLSFATVQPSGLLFYNGRLNeKHDFLALELVAGQVRLTYSTGESNTVVSPTVPggL 1586
Cdd:cd00110     1 GVSFSGSSYVRLPTLPaPRTRLSISFSFRTTSPNGLLLYAGSQN-GGDFLALELEDGRLVLRYDLGSGSLVLSSKTP--L 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739 1587 SDGQWHTVHLRYYNkprtdalggaqgpskdKVAVLSVDDCNVavalqfgAEIGnyscaaagvQTSSKKSLDLTGPLLLGG 1666
Cdd:cd00110    78 NDGQWHSVSVERNG----------------RSVTLSVDGERV-------VESG---------SPGGSALLNLDGPLYLGG 125

                         170       180
                  ....*....|....*....|....*.
gi 568962739 1667 VPNLPENFPV-SHKDFIGCMRDLHID 1691
Cdd:cd00110   126 LPEDLKSPGLpVSPGFVGCIRDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 853-948 4.96e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.18  E-value: 4.96e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  853 HYSVSMNEDRPVGSTVVVISASDDDVGENARITYLL--EDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIP 930
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 568962739  931 QKADTTYVEVMVNDVNDN 948
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1062-1156 3.08e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 115.87  E-value: 3.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739 1062 EFEVRVKENSIVGSVVAQITAVDPDDGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQAT---SA 1138
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATdggGP 80

                          90
                  ....*....|....*...
gi 568962739 1139 PLVSRATVHVRLVDQNDN 1156
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 665-745 1.36e-29

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 113.21  E-value: 1.36e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739    665 QAVDADHGENSRLEYSLTGVASDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNR 744
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 568962739    745 P 745
Cdd:smart00112   81 P 81
LamG smart00282
Laminin G domain;
1529-1693 8.20e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 110.12  E-value: 8.20e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   1529 TLSLSFATVQPSGLLFYNGRLNeKHDFLALELVAGQVRLTYSTGESNTVVSPTvPGGLSDGQWHTVHLRYYNkprtdalg 1608
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKG-GGDYLALELRDGRLVLRYDLGSGPARLTSD-PTPLNDGQWHRVAVERNG-------- 70

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   1609 gaqgpskdKVAVLSVDDCNVAValqfgaeignyscaaaGVQTSSKKSLDLTGPLLLGGVPNLPENFP-VSHKDFIGCMRD 1687
Cdd:smart00282   71 --------RSVTLSVDGGNRVS----------------GESPGGLTILNLDGPLYLGGLPEDLKLPPlPVTPGFRGCIRN 126


                    ....*.
gi 568962739   1688 LHIDGR 1693
Cdd:smart00282  127 LKVNGK 132
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 975-1056 9.03e-28

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 108.21  E-value: 9.03e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739    975 SATDRDAHANGRVQYTFqNGEDGDGDFTIEPTSGIVRTVRRLDREAVPVYELTAYAVDRGVPPLRTPVSIQVTVQDVNDN 1054
Cdd:smart00112    1 SATDADSGENGKVTYSI-LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 568962739   1055 AP 1056
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
541-632 1.25e-27

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 108.16  E-value: 1.25e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   541 YVAQVREDVRPHTVVLRVTATDKDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVMAPLDFEAEREYALRIRAQDAGRPP 620
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 568962739   621 LSnNTGLASIQV 632
Cdd:pfam00028   81 LS-STATVTITV 91
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1534-1693 4.20e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 107.89  E-value: 4.20e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  1534 FATVQPSGLLFYNGrlNEKHDFLALELVAGQVRLTYSTGESNTVVSPTvPGGLSDGQWHTVHLRYynkprtdalggaqgp 1613
Cdd:pfam02210    1 FRTRQPNGLLLYAG--GGGSDFLALELVNGRLVLRYDLGSGPESLLSS-GKNLNDGQWHSVRVER--------------- 62

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  1614 sKDKVAVLSVDDCNVAVALQFGAEIGnyscaaagvqtsskksLDLTGPLLLGGVPN-LPENFPVSHKDFIGCMRDLHIDG 1692
Cdd:pfam02210   63 -NGNTLTLSVDGQTVVSSLPPGESLL----------------LNLNGPLYLGGLPPlLLLPALPVRAGFVGCIRDVRVNG 125


                   .
gi 568962739  1693 R 1693
Cdd:pfam02210  126 E 126
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 559-640 7.11e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 102.81  E-value: 7.11e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739    559 TATDKDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVMAPLDFEAEREYALRIRAQDAGRPPLSnNTGLASIQVVDINDH 638
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLS-STATVTITVLDVNDN 79


                    ..
gi 568962739    639 AP 640
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 447-534 1.05e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 102.43  E-value: 1.05e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739    447 RATDGDAPPNANLRYRFVGSPAvrtaaAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEpgPRSATVRVHITV 526
Cdd:smart00112    1 SATDADSGENGKVTYSILSGND-----DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP--PLSSTATVTITV 73


                    ....*...
gi 568962739    527 LDENDNAP 534
Cdd:smart00112   74 LDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 872-950 2.54e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 101.27  E-value: 2.54e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739    872 SASDDDVGENARITYLLEDNLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNA 949
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDglFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 568962739    950 P 950
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
647-738 5.23e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 100.84  E-value: 5.23e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   647 FQVSVLENAPLGHSVIHIQAVDADHGENSRLEYSLTGVASDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPP 726
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 568962739   727 LSASASVTVTVL 738
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
957-1049 7.13e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 100.45  E-value: 7.13e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   957 YTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGdGDFTIEPTSGIVRTVRRLDREAVPVYELTAYAVDRGVP 1036
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPG-GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 568962739  1037 PLRTPVSIQVTVQ 1049
Cdd:pfam00028   80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 339-422 6.42e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 97.03  E-value: 6.42e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739    339 VAQDPDPGEAGRLIYSLAalmNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRN 418
Cdd:smart00112    1 SATDADSGENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 568962739    419 DHAP 422
Cdd:smart00112   78 DNAP 81
Cadherin pfam00028
Cadherin domain;
429-527 7.81e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 94.67  E-value: 7.81e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   429 YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGSPAVRTaaaaaFEIDPRSGLISTSGRVDREHMESYELVVEASD 508
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*....
gi 568962739   509 QGqePGPRSATVRVHITVL 527
Cdd:pfam00028   76 SG--GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1081-1158 1.91e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 1.91e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   1081 TAVDPDDGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQAT---SAPLVSRATVHVRLVDQNDNS 1157
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATdggGPPLSSTATVTITVLDVNDNA 80


                    .
gi 568962739   1158 P 1158
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 751-845 3.21e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 3.21e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  751 EYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFAISTQGGVglVTLALPLDYKQERYFKLVLTASDR- 827
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNEDGLFSIDPSTGE--ITTAKPLDREEQSSYTLTVTATDGg 78

                          90       100
                  ....*....|....*....|
gi 568962739  828 --ALHDHCYVHINITDANTH 845
Cdd:cd11304    79 gpPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
321-414 3.46e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 92.75  E-value: 3.46e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   321 YQTLVPENEAAGTSVLRVVAQDPDPGEAGRLIYSLaalMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHG 400
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....
gi 568962739   401 SPRLSATTMVAVTV 414
Cdd:pfam00028   78 GPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
854-942 2.28e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.44  E-value: 2.28e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   854 YSVSMNEDRPVGSTVVVISASDDDVGENARITY-LLEDNLPQ-FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQ 931
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYsILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 568962739   932 KADTTYVEVMV 942
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
1063-1150 2.54e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.05  E-value: 2.54e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  1063 FEVRVKENSIVGSVVAQITAVDPDDGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSA---P 1139
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSggpP 80

                           90
                   ....*....|.
gi 568962739  1140 LVSRATVHVRL 1150
Cdd:pfam00028   81 LSSTATVTITV 91
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1755-1912 2.07e-20

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 89.78  E-value: 2.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739 1755 PYHFQGNGTLSwdFGNDMAVSVPWYLGLSFRTRATKGILMQV-QLGPHSVLLCKLDRGLLSVTLNRASGHTVhlLLDQMT 1833
Cdd:cd00110     1 GVSFSGSSYVR--LPTLPAPRTRLSISFSFRTTSPNGLLLYAgSQNGGDFLALELEDGRLVLRYDLGSGSLV--LSSKTP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739 1834 VSDGRWHDLRLElqeepggRRGHHIFMvSLDFTLFQDTMAMGGELQGLKVKQLHVGGLPPSSKEEGH---QGLVGCIQGV 1910
Cdd:cd00110    77 LNDGQWHSVSVE-------RNGRSVTL-SVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLpvsPGFVGCIRDL 148


                  ..
gi 568962739 1911 WI 1912
Cdd:cd00110   149 KV 150
LamG smart00282
Laminin G domain;
1779-1912 1.42e-17

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 80.85  E-value: 1.42e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   1779 YLGLSFRTRATKGILMQV-QLGPHSVLLCKLDRGLLSVTLNRASGhTVHLLLDQMTVSDGRWHDLRLElqeepggRRGHH 1857
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgSKGGGDYLALELRDGRLVLRYDLGSG-PARLTSDPTPLNDGQWHRVAVE-------RNGRS 72

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 568962739   1858 IFMvSLDFTLFQDTMAMGGElQGLKVKQ-LHVGGLPPSSKEEG---HQGLVGCIQGVWI 1912
Cdd:smart00282   73 VTL-SVDGGNRVSGESPGGL-TILNLDGpLYLGGLPEDLKLPPlpvTPGFRGCIRNLKV 129
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1784-1913 5.00e-16

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 76.30  E-value: 5.00e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  1784 FRTRATKGILMQVQLGPHSVLLCKLDRGLLSVTLNrASGHTVHLLLDQMTVSDGRWHDLRLElqeepggRRGHHIFMvSL 1863
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYD-LGSGPESLLSSGKNLNDGQWHSVRVE-------RNGNTLTL-SV 71

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568962739  1864 DFTLFQDTMAMGGELQGLKVKQLHVGGLPPSSKEEG---HQGLVGCIQGVWIG 1913
Cdd:pfam02210   72 DGQTVVSSLPPGESLLLNLNGPLYLGGLPPLLLLPAlpvRAGFVGCIRDVRVN 124
Cadherin pfam00028
Cadherin domain;
752-840 5.07e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.03  E-value: 5.07e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   752 YHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFAISTQGGVglVTLALPLDYKQERYFKLVLTASDRAL 829
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDlgPNGRIFYSILGGGPGGNFRIDPDTGD--ISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 568962739   830 H---DHCYVHINIT 840
Cdd:pfam00028   79 PplsSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 770-847 1.69e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.46  E-value: 1.69e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739    770 TAVDRD--ANSAISYQITGGNTRNRFAISTQGGVglVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHINITDANT 844
Cdd:smart00112    1 SATDADsgENGKVTYSILSGNDDGLFSIDPETGE--ITTTKPLDREEQPEYTLTVEATDGGgppLSSTATVTITVLDVND 78


                    ...
gi 568962739    845 HRP 847
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1176-1257 7.84e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.71  E-value: 7.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739 1176 DTFPSGIIGRIPAYDPDVSD--HLFYSFERGNELQLLVVNRTSGELRLSRKLDNNRPLVASMLVTVTD-GLHSVTAQCVL 1252
Cdd:cd11304     9 NAPPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDgGGPPLSSTATV 88


                  ....*
gi 568962739 1253 RVVII 1257
Cdd:cd11304    89 TITVL 93
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1717-1747 3.90e-08

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 50.84  E-value: 3.90e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568962739  1717 CASGPCKNNGFCSERWGGFSCDCPVGFGGKD 1747
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1717-1748 4.26e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 4.26e-08
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568962739 1717 CASG-PCKNNGFCSERWGGFSCDCPVGFGGKDC 1748
Cdd:cd00054     5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1973-2011 7.66e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 7.66e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 568962739 1973 VDACLL-NPCQNQGSCRHLQGaphGYTCDCVSGYFGQHCE 2011
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVG---SYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1428-1462 8.53e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 8.53e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568962739 1428 DLCYS-NPCRNGGACARREGGYTCVCRPRFTGEDCE 1462
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1939-1973 1.34e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 1.34e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568962739 1939 NPCASG-PCPPHADCKDLWQTFSCTCRPGYYGPGCV 1973
Cdd:cd00054     3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1472-1505 1.68e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.68e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568962739 1472 PGVCRNGGTCTNAPnGGFRCQCPAGgaFEGPRCE 1505
Cdd:cd00054     8 GNPCQNGGTCVNTV-GSYRCSCPPG--YTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1976-2009 3.26e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 45.45  E-value: 3.26e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568962739  1976 CLLNPCQNQGSCRHLqgaPHGYTCDCVSGYFGQH 2009
Cdd:pfam00008    1 CAPNPCSNGGTCVDT---PGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1472-1505 3.62e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.62e-06
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 568962739   1472 PGVCRNGGTCTNAPnGGFRCQCPAGgaFE-GPRCE 1505
Cdd:smart00179    8 GNPCQNGGTCVNTV-GSYRCECPPG--YTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1430-1460 4.25e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 45.07  E-value: 4.25e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568962739  1430 CYSNPCRNGGACARREGGYTCVCRPRFTGED 1460
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1428-1462 1.09e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 1.09e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 568962739   1428 DLCYS-NPCRNGGACARREGGYTCVCRPRFT-GEDCE 1462
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1717-1748 3.05e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 3.05e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568962739   1717 CAS-GPCKNNGFCSERWGGFSCDCPVGF-GGKDC 1748
Cdd:smart00179    5 CASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1994-2033 1.54e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 41.18  E-value: 1.54e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568962739  1994 PHGYTCDCVSGYFGQHCEhrvdqQCPRGWWGSPTCGPCNC 2033
Cdd:pfam00053   15 PETGQCLCKPGVTGRHCD-----RCKPGYYGLPSDPPQGC 49
EGF_CA smart00179
Calcium-binding EGF-like domain;
1939-1973 3.16e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.16e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 568962739   1939 NPCAS-GPCPPHADCKDLWQTFSCTCRPGYY-GPGCV 1973
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1475-1496 4.53e-04

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 39.24  E-value: 4.53e-04
                           10        20
                   ....*....|....*....|..
gi 568962739  1475 CRNGGTCTNAPNgGFRCQCPAG 1496
Cdd:pfam12661    1 CQNGGTCVDGVN-GYKCQCPPG 21
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1935-1971 6.78e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 38.73  E-value: 6.78e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568962739  1935 CTVTNpcasGPCPPHADCKDLWQTFSCTCRPGYYGPG 1971
Cdd:pfam12947    1 CSDNN----GGCHPNATCTNTGGSFTCTCNDGYTGDG 33
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1188-1257 1.79e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 39.26  E-value: 1.79e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568962739   1188 AYDPDVSD--HLFYSFERGNELQLLVVNRTSGELRLSRKLDNNRPLVASMLVTVTD-GLHSVTAQCVLRVVII 1257
Cdd:smart00112    2 ATDADSGEngKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDgGGPPLSSTATVTITVL 74
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 2030-2053 2.91e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 37.72  E-value: 2.91e-03
                          10        20
                  ....*....|....*....|....
gi 568962739 2030 PCNCDVHKGFDPNCNKTNGQCHCK 2053
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECK 24
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
2031-2053 5.90e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 36.52  E-value: 5.90e-03
                            10        20
                    ....*....|....*....|...
gi 568962739   2031 CNCDVHKGFDPNCNKTNGQCHCK 2053
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECK 23
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 2031-2053 9.72e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.18  E-value: 9.72e-03
                           10        20
                   ....*....|....*....|...
gi 568962739  2031 CNCDVHKGFDPNCNKTNGQCHCK 2053
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCK 23
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 9-276 9.80e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.31  E-value: 9.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739    9 GLPGPSTPvllLLLLSLFPFSREELGGGGDQDWDPGVATTTGPRAQIGSGAVAL----------CPESPGVWEDGDPGLG 78
Cdd:PHA03307  124 ASPPPSPA---PDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALplsspeetarAPSSPPAEPPPSTPPA 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   79 VREPvfmrlrvgRQNARNGRGAPEQPNAevvvQALGSREQEAGQGPGYLLCWHPEISSCGrTGPLRRGSLPLDALSPGDS 158
Cdd:PHA03307  201 AASP--------RPPRRSSPISASASSP----APAPGRSAADDAGASSSDSSSSESSGCG-WGPENECPLPRPAPITLPT 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  159 DLRNSS-PHPSELLAQPDGSRPvafqrnARRSIRKRVETSRCCGKLWEPGHKGQGERSAT------STVDRGPFRRDCL- 230
Cdd:PHA03307  268 RIWEASgWNGPSSRPGPASSSS------SPRERSPSPSPSSPGSGPAPSSPRASSSSSSSressssSTSSSSESSRGAAv 341

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 568962739  231 -PGSLGSGLGEDSAPRAVRTAPTPGSAPRESRTAPGRMRSRGLFRRR 276
Cdd:PHA03307  342 sPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRR 388
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 646-743 3.64e-38

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 138.60  E-value: 3.64e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  646 PFQVSVLENAPLGHSVIHIQAVDADHGENSRLEYSLTGVASDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSP 725
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 568962739  726 PLSASASVTVTVLDVNDN 743
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 956-1054 1.21e-35

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 131.28  E-value: 1.21e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  956 HYTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGeDGDGDFTIEPTSGIVRTVRRLDREAVPVYELTAYAVDRGV 1035
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG-NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG 79

                          90
                  ....*....|....*....
gi 568962739 1036 PPLRTPVSIQVTVQDVNDN 1054
Cdd:cd11304    80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 541-638 1.30e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 128.20  E-value: 1.30e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  541 YVAQVREDVRPHTVVLRVTATDKDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVMAPLDFEAEREYALRIRAQDAGRPP 620
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*...
gi 568962739  621 LSnNTGLASIQVVDINDH 638
Cdd:cd11304    82 LS-STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 321-420 6.47e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 126.27  E-value: 6.47e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  321 YQTLVPENEAAGTSVLRVVAQDPDPGEAGRLIYSLaalMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHG 400
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|
gi 568962739  401 SPRLSATTMVAVTVADRNDH 420
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 428-532 1.11e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.81  E-value: 1.11e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  428 QYRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGSPAvrtaaAAAFEIDPRSGLISTSGRVDREHMESYELVVEAS 507
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                          90       100
                  ....*....|....*....|....*
gi 568962739  508 DQGQEpgPRSATVRVHITVLDENDN 532
Cdd:cd11304    76 DGGGP--PLSSTATVTITVLDVNDN 98
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1508-1691 3.06e-32

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 123.68  E-value: 3.06e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739 1508 ARSFPPSSFVMFRGLR-QRFHLTLSLSFATVQPSGLLFYNGRLNeKHDFLALELVAGQVRLTYSTGESNTVVSPTVPggL 1586
Cdd:cd00110     1 GVSFSGSSYVRLPTLPaPRTRLSISFSFRTTSPNGLLLYAGSQN-GGDFLALELEDGRLVLRYDLGSGSLVLSSKTP--L 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739 1587 SDGQWHTVHLRYYNkprtdalggaqgpskdKVAVLSVDDCNVavalqfgAEIGnyscaaagvQTSSKKSLDLTGPLLLGG 1666
Cdd:cd00110    78 NDGQWHSVSVERNG----------------RSVTLSVDGERV-------VESG---------SPGGSALLNLDGPLYLGG 125

                         170       180
                  ....*....|....*....|....*.
gi 568962739 1667 VPNLPENFPV-SHKDFIGCMRDLHID 1691
Cdd:cd00110   126 LPEDLKSPGLpVSPGFVGCIRDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 853-948 4.96e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.18  E-value: 4.96e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  853 HYSVSMNEDRPVGSTVVVISASDDDVGENARITYLL--EDNLPQFRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIP 930
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 568962739  931 QKADTTYVEVMVNDVNDN 948
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1062-1156 3.08e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 115.87  E-value: 3.08e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739 1062 EFEVRVKENSIVGSVVAQITAVDPDDGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQAT---SA 1138
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATdggGP 80

                          90
                  ....*....|....*...
gi 568962739 1139 PLVSRATVHVRLVDQNDN 1156
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 665-745 1.36e-29

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 113.21  E-value: 1.36e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739    665 QAVDADHGENSRLEYSLTGVASDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPPLSASASVTVTVLDVNDNR 744
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 568962739    745 P 745
Cdd:smart00112   81 P 81
LamG smart00282
Laminin G domain;
1529-1693 8.20e-28

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 110.12  E-value: 8.20e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   1529 TLSLSFATVQPSGLLFYNGRLNeKHDFLALELVAGQVRLTYSTGESNTVVSPTvPGGLSDGQWHTVHLRYYNkprtdalg 1608
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKG-GGDYLALELRDGRLVLRYDLGSGPARLTSD-PTPLNDGQWHRVAVERNG-------- 70

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   1609 gaqgpskdKVAVLSVDDCNVAValqfgaeignyscaaaGVQTSSKKSLDLTGPLLLGGVPNLPENFP-VSHKDFIGCMRD 1687
Cdd:smart00282   71 --------RSVTLSVDGGNRVS----------------GESPGGLTILNLDGPLYLGGLPEDLKLPPlPVTPGFRGCIRN 126


                    ....*.
gi 568962739   1688 LHIDGR 1693
Cdd:smart00282  127 LKVNGK 132
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 975-1056 9.03e-28

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 108.21  E-value: 9.03e-28
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739    975 SATDRDAHANGRVQYTFqNGEDGDGDFTIEPTSGIVRTVRRLDREAVPVYELTAYAVDRGVPPLRTPVSIQVTVQDVNDN 1054
Cdd:smart00112    1 SATDADSGENGKVTYSI-LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 568962739   1055 AP 1056
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
541-632 1.25e-27

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 108.16  E-value: 1.25e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   541 YVAQVREDVRPHTVVLRVTATDKDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVMAPLDFEAEREYALRIRAQDAGRPP 620
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 568962739   621 LSnNTGLASIQV 632
Cdd:pfam00028   81 LS-STATVTITV 91
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1534-1693 4.20e-27

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 107.89  E-value: 4.20e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  1534 FATVQPSGLLFYNGrlNEKHDFLALELVAGQVRLTYSTGESNTVVSPTvPGGLSDGQWHTVHLRYynkprtdalggaqgp 1613
Cdd:pfam02210    1 FRTRQPNGLLLYAG--GGGSDFLALELVNGRLVLRYDLGSGPESLLSS-GKNLNDGQWHSVRVER--------------- 62

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  1614 sKDKVAVLSVDDCNVAVALQFGAEIGnyscaaagvqtsskksLDLTGPLLLGGVPN-LPENFPVSHKDFIGCMRDLHIDG 1692
Cdd:pfam02210   63 -NGNTLTLSVDGQTVVSSLPPGESLL----------------LNLNGPLYLGGLPPlLLLPALPVRAGFVGCIRDVRVNG 125


                   .
gi 568962739  1693 R 1693
Cdd:pfam02210  126 E 126
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 559-640 7.11e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 102.81  E-value: 7.11e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739    559 TATDKDKDANGLVHYNIISGNSRGHFAIDSLTGEIQVMAPLDFEAEREYALRIRAQDAGRPPLSnNTGLASIQVVDINDH 638
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLS-STATVTITVLDVNDN 79


                    ..
gi 568962739    639 AP 640
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 447-534 1.05e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 102.43  E-value: 1.05e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739    447 RATDGDAPPNANLRYRFVGSPAvrtaaAAAFEIDPRSGLISTSGRVDREHMESYELVVEASDQGQEpgPRSATVRVHITV 526
Cdd:smart00112    1 SATDADSGENGKVTYSILSGND-----DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP--PLSSTATVTITV 73


                    ....*...
gi 568962739    527 LDENDNAP 534
Cdd:smart00112   74 LDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 872-950 2.54e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 101.27  E-value: 2.54e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739    872 SASDDDVGENARITYLLEDNLPQ--FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQKADTTYVEVMVNDVNDNA 949
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDglFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 568962739    950 P 950
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
647-738 5.23e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 100.84  E-value: 5.23e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   647 FQVSVLENAPLGHSVIHIQAVDADHGENSRLEYSLTGVASDTPFVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPP 726
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 568962739   727 LSASASVTVTVL 738
Cdd:pfam00028   81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
957-1049 7.13e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 100.45  E-value: 7.13e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   957 YTGLVSEDAPPFTSVLQISATDRDAHANGRVQYTFQNGEDGdGDFTIEPTSGIVRTVRRLDREAVPVYELTAYAVDRGVP 1036
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPG-GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 568962739  1037 PLRTPVSIQVTVQ 1049
Cdd:pfam00028   80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 339-422 6.42e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 97.03  E-value: 6.42e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739    339 VAQDPDPGEAGRLIYSLAalmNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRLSATTMVAVTVADRN 418
Cdd:smart00112    1 SATDADSGENGKVTYSIL---SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 568962739    419 DHAP 422
Cdd:smart00112   78 DNAP 81
Laminin_G_1 pfam00054
Laminin G domain;
1534-1696 5.01e-23

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 96.62  E-value: 5.01e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  1534 FATVQPSGLLFYNGRlNEKHDFLALELVAGQVRLTYSTGESNTVVSPTVPggLSDGQWHTVHLrYYNKprtdalggaqgp 1613
Cdd:pfam00054    1 FRTTEPSGLLLYNGT-QTERDFLALELRDGRLEVSYDLGSGAAVVRSGDK--LNDGKWHSVEL-ERNG------------ 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  1614 skdKVAVLSVDDCNVAVALQfgaeignyscaaagvQTSSKKSLDLTGPLLLGGVPNL---PENFPVSHkDFIGCMRDLHI 1690
Cdd:pfam00054   65 ---RSGTLSVDGEARPTGES---------------PLGATTDLDVDGPLYVGGLPSLgvkKRRLAISP-SFDGCIRDVIV 125


                   ....*.
gi 568962739  1691 DGRRMD 1696
Cdd:pfam00054  126 NGKPLD 131
Cadherin pfam00028
Cadherin domain;
429-527 7.81e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 94.67  E-value: 7.81e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   429 YRETLRENVEEGYPILQLRATDGDAPPNANLRYRFVGSPAVRTaaaaaFEIDPRSGLISTSGRVDREHMESYELVVEASD 508
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-----FRIDPDTGDISTTKPLDRESIGEYELTVEATD 75

                           90
                   ....*....|....*....
gi 568962739   509 QGqePGPRSATVRVHITVL 527
Cdd:pfam00028   76 SG--GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1081-1158 1.91e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 93.18  E-value: 1.91e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   1081 TAVDPDDGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQAT---SAPLVSRATVHVRLVDQNDNS 1157
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATdggGPPLSSTATVTITVLDVNDNA 80


                    .
gi 568962739   1158 P 1158
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 751-845 3.21e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 3.21e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  751 EYHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFAISTQGGVglVTLALPLDYKQERYFKLVLTASDR- 827
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNEDGLFSIDPSTGE--ITTAKPLDREEQSSYTLTVTATDGg 78

                          90       100
                  ....*....|....*....|
gi 568962739  828 --ALHDHCYVHINITDANTH 845
Cdd:cd11304    79 gpPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
321-414 3.46e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 92.75  E-value: 3.46e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   321 YQTLVPENEAAGTSVLRVVAQDPDPGEAGRLIYSLaalMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHG 400
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI---LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....
gi 568962739   401 SPRLSATTMVAVTV 414
Cdd:pfam00028   78 GPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
854-942 2.28e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.44  E-value: 2.28e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   854 YSVSMNEDRPVGSTVVVISASDDDVGENARITY-LLEDNLPQ-FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQ 931
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYsILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|.
gi 568962739   932 KADTTYVEVMV 942
Cdd:pfam00028   81 LSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
1063-1150 2.54e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.05  E-value: 2.54e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  1063 FEVRVKENSIVGSVVAQITAVDPDDGPNAHIMYQIVEGNIPELFQMDIFSGELTALIDLDYEARQEYVIVVQATSA---P 1139
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSggpP 80

                           90
                   ....*....|.
gi 568962739  1140 LVSRATVHVRL 1150
Cdd:pfam00028   81 LSSTATVTITV 91
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1755-1912 2.07e-20

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 89.78  E-value: 2.07e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739 1755 PYHFQGNGTLSwdFGNDMAVSVPWYLGLSFRTRATKGILMQV-QLGPHSVLLCKLDRGLLSVTLNRASGHTVhlLLDQMT 1833
Cdd:cd00110     1 GVSFSGSSYVR--LPTLPAPRTRLSISFSFRTTSPNGLLLYAgSQNGGDFLALELEDGRLVLRYDLGSGSLV--LSSKTP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739 1834 VSDGRWHDLRLElqeepggRRGHHIFMvSLDFTLFQDTMAMGGELQGLKVKQLHVGGLPPSSKEEGH---QGLVGCIQGV 1910
Cdd:cd00110    77 LNDGQWHSVSVE-------RNGRSVTL-SVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLpvsPGFVGCIRDL 148


                  ..
gi 568962739 1911 WI 1912
Cdd:cd00110   149 KV 150
LamG smart00282
Laminin G domain;
1779-1912 1.42e-17

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 80.85  E-value: 1.42e-17
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   1779 YLGLSFRTRATKGILMQV-QLGPHSVLLCKLDRGLLSVTLNRASGhTVHLLLDQMTVSDGRWHDLRLElqeepggRRGHH 1857
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAgSKGGGDYLALELRDGRLVLRYDLGSG-PARLTSDPTPLNDGQWHRVAVE-------RNGRS 72

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 568962739   1858 IFMvSLDFTLFQDTMAMGGElQGLKVKQ-LHVGGLPPSSKEEG---HQGLVGCIQGVWI 1912
Cdd:smart00282   73 VTL-SVDGGNRVSGESPGGL-TILNLDGpLYLGGLPEDLKLPPlpvTPGFRGCIRNLKV 129
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1784-1913 5.00e-16

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 76.30  E-value: 5.00e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  1784 FRTRATKGILMQVQLGPHSVLLCKLDRGLLSVTLNrASGHTVHLLLDQMTVSDGRWHDLRLElqeepggRRGHHIFMvSL 1863
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYD-LGSGPESLLSSGKNLNDGQWHSVRVE-------RNGNTLTL-SV 71

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 568962739  1864 DFTLFQDTMAMGGELQGLKVKQLHVGGLPPSSKEEG---HQGLVGCIQGVWIG 1913
Cdd:pfam02210   72 DGQTVVSSLPPGESLLLNLNGPLYLGGLPPLLLLPAlpvRAGFVGCIRDVRVN 124
Cadherin pfam00028
Cadherin domain;
752-840 5.07e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.03  E-value: 5.07e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   752 YHLRLNEDAAVGTSVVSVTAVDRD--ANSAISYQITGGNTRNRFAISTQGGVglVTLALPLDYKQERYFKLVLTASDRAL 829
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDlgPNGRIFYSILGGGPGGNFRIDPDTGD--ISTTKPLDRESIGEYELTVEATDSGG 78

                           90
                   ....*....|....
gi 568962739   830 H---DHCYVHINIT 840
Cdd:pfam00028   79 PplsSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 770-847 1.69e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.46  E-value: 1.69e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739    770 TAVDRD--ANSAISYQITGGNTRNRFAISTQGGVglVTLALPLDYKQERYFKLVLTASDRA---LHDHCYVHINITDANT 844
Cdd:smart00112    1 SATDADsgENGKVTYSILSGNDDGLFSIDPETGE--ITTTKPLDREEQPEYTLTVEATDGGgppLSSTATVTITVLDVND 78


                    ...
gi 568962739    845 HRP 847
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1176-1257 7.84e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 57.71  E-value: 7.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739 1176 DTFPSGIIGRIPAYDPDVSD--HLFYSFERGNELQLLVVNRTSGELRLSRKLDNNRPLVASMLVTVTD-GLHSVTAQCVL 1252
Cdd:cd11304     9 NAPPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDgGGPPLSSTATV 88


                  ....*
gi 568962739 1253 RVVII 1257
Cdd:cd11304    89 TITVL 93
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 957-1054 1.91e-09

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 56.58  E-value: 1.91e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  957 YTGLVSEDAPPFtsVLQIsATDRDAHANGRVQYTFQNGEDGDGDFTIEPTSGIVRTVRRLDREAVPVYELTAYAVDRGVP 1036
Cdd:cd00031     4 GSAVEGRSRGSF--RVSI-PTDLIASSGEIIKISAAGKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGAN 80

                          90
                  ....*....|....*...
gi 568962739 1037 PLRTPVSIQVTVQDVNDN 1054
Cdd:cd00031    81 VPQTSSVFSIEVYDENDN 98
Laminin_G_1 pfam00054
Laminin G domain;
1784-1913 4.66e-09

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 56.56  E-value: 4.66e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  1784 FRTRATKGILMQVQLGPHSV-LLCKLDRGLLSVTLNRASGHTVHLLLDqmTVSDGRWHDLRLElqeepggrRGHHIFMVS 1862
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERDfLALELRDGRLEVSYDLGSGAAVVRSGD--KLNDGKWHSVELE--------RNGRSGTLS 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 568962739  1863 LDFTLFQDTMAMGGELQGLKV-KQLHVGGLPPSSKEEGHQ----GLVGCIQGVWIG 1913
Cdd:pfam00054   71 VDGEARPTGESPLGATTDLDVdGPLYVGGLPSLGVKKRRLaispSFDGCIRDVIVN 126
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1717-1747 3.90e-08

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 50.84  E-value: 3.90e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568962739  1717 CASGPCKNNGFCSERWGGFSCDCPVGFGGKD 1747
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1717-1748 4.26e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.71  E-value: 4.26e-08
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568962739 1717 CASG-PCKNNGFCSERWGGFSCDCPVGFGGKDC 1748
Cdd:cd00054     5 CASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1973-2011 7.66e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 7.66e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 568962739 1973 VDACLL-NPCQNQGSCRHLQGaphGYTCDCVSGYFGQHCE 2011
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVG---SYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1428-1462 8.53e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 8.53e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568962739 1428 DLCYS-NPCRNGGACARREGGYTCVCRPRFTGEDCE 1462
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1939-1973 1.34e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 1.34e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568962739 1939 NPCASG-PCPPHADCKDLWQTFSCTCRPGYYGPGCV 1973
Cdd:cd00054     3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1472-1505 1.68e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.68e-07
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568962739 1472 PGVCRNGGTCTNAPnGGFRCQCPAGgaFEGPRCE 1505
Cdd:cd00054     8 GNPCQNGGTCVNTV-GSYRCSCPPG--YTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1976-2009 3.26e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 45.45  E-value: 3.26e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 568962739  1976 CLLNPCQNQGSCRHLqgaPHGYTCDCVSGYFGQH 2009
Cdd:pfam00008    1 CAPNPCSNGGTCVDT---PGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1472-1505 3.62e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.62e-06
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 568962739   1472 PGVCRNGGTCTNAPnGGFRCQCPAGgaFE-GPRCE 1505
Cdd:smart00179    8 GNPCQNGGTCVNTV-GSYRCECPPG--YTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1430-1460 4.25e-06

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 45.07  E-value: 4.25e-06
                           10        20        30
                   ....*....|....*....|....*....|.
gi 568962739  1430 CYSNPCRNGGACARREGGYTCVCRPRFTGED 1460
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 650-743 7.94e-06

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 46.18  E-value: 7.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  650 SVLENAPLGHSVIHIQAvdaDHGENSRLEYSLTGVASDTP---FVINSATGWVSVSGPLDRESVEHYFFGVEARDHGSPP 726
Cdd:cd00031     5 SAVEGRSRGSFRVSIPT---DLIASSGEIIKISAAGKEALpswLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANV 81

                          90
                  ....*....|....*..
gi 568962739  727 LSASASVTVTVLDVNDN 743
Cdd:cd00031    82 PQTSSVFSIEVYDENDN 98
EGF_CA smart00179
Calcium-binding EGF-like domain;
1428-1462 1.09e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 1.09e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 568962739   1428 DLCYS-NPCRNGGACARREGGYTCVCRPRFT-GEDCE 1462
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 325-420 1.53e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 45.41  E-value: 1.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  325 VPENEAAGTSVLRVVAqdpDPGEAGRLIYSLAALMNSRSLELFSIDPQSGLIRTAAALDRESMERHYLRVTAQDHGSPRL 404
Cdd:cd00031     6 AVEGRSRGSFRVSIPT---DLIASSGEIIKISAAGKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVP 82

                          90
                  ....*....|....*.
gi 568962739  405 SATTMVAVTVADRNDH 420
Cdd:cd00031    83 QTSSVFSIEVYDENDN 98
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1432-1462 1.76e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 43.23  E-value: 1.76e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 568962739 1432 SNPCRNGGACARREGGYTCVCRPRFTGE-DCE 1462
Cdd:cd00053     5 SNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1717-1746 1.98e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 43.23  E-value: 1.98e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 568962739 1717 CA-SGPCKNNGFCSERWGGFSCDCPVGFGGK 1746
Cdd:cd00053     2 CAaSNPCSNGGTCVNTPGSYRCVCPPGYTGD 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1717-1748 3.05e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 3.05e-05
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568962739   1717 CAS-GPCKNNGFCSERWGGFSCDCPVGF-GGKDC 1748
Cdd:smart00179    5 CASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1940-1971 5.78e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 42.08  E-value: 5.78e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568962739 1940 PCA-SGPCPPHADCKDLWQTFSCTCRPGYYGPG 1971
Cdd:cd00053     1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1472-1505 9.45e-05

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 41.31  E-value: 9.45e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568962739 1472 PGVCRNGGTCTNAPnGGFRCQCPAGgaFEGP-RCE 1505
Cdd:cd00053     5 SNPCSNGGTCVNTP-GSYRCVCPPG--YTGDrSCE 36
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1979-2011 1.31e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 40.92  E-value: 1.31e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 568962739 1979 NPCQNQGSCRHLQGaphGYTCDCVSGYFGQ-HCE 2011
Cdd:cd00053     6 NPCSNGGTCVNTPG---SYRCVCPPGYTGDrSCE 36
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1994-2033 1.54e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 41.18  E-value: 1.54e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568962739  1994 PHGYTCDCVSGYFGQHCEhrvdqQCPRGWWGSPTCGPCNC 2033
Cdd:pfam00053   15 PETGQCLCKPGVTGRHCD-----RCKPGYYGLPSDPPQGC 49
EGF_CA smart00179
Calcium-binding EGF-like domain;
1939-1973 3.16e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.16e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 568962739   1939 NPCAS-GPCPPHADCKDLWQTFSCTCRPGYY-GPGCV 1973
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 854-948 3.88e-04

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 41.56  E-value: 3.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  854 YSVSMNEDRPvgSTVVVISAS-DDDVGENARITYLLEDNLPQ-FRIDADSGAITLQAPLDYEDQVTYTLAITARDNGIPQ 931
Cdd:cd00031     4 GSAVEGRSRG--SFRVSIPTDlIASSGEIIKISAAGKEALPSwLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANV 81

                          90
                  ....*....|....*..
gi 568962739  932 KADTTYVEVMVNDVNDN 948
Cdd:cd00031    82 PQTSSVFSIEVYDENDN 98
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1475-1496 4.53e-04

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 39.24  E-value: 4.53e-04
                           10        20
                   ....*....|....*....|..
gi 568962739  1475 CRNGGTCTNAPNgGFRCQCPAG 1496
Cdd:pfam12661    1 CQNGGTCVDGVN-GYKCQCPPG 21
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1935-1971 6.78e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 38.73  E-value: 6.78e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568962739  1935 CTVTNpcasGPCPPHADCKDLWQTFSCTCRPGYYGPG 1971
Cdd:pfam12947    1 CSDNN----GGCHPNATCTNTGGSFTCTCNDGYTGDG 33
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1722-1743 1.15e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 38.08  E-value: 1.15e-03
                           10        20
                   ....*....|....*....|..
gi 568962739  1722 CKNNGFCSERWGGFSCDCPVGF 1743
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1188-1257 1.79e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 39.26  E-value: 1.79e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568962739   1188 AYDPDVSD--HLFYSFERGNELQLLVVNRTSGELRLSRKLDNNRPLVASMLVTVTD-GLHSVTAQCVLRVVII 1257
Cdd:smart00112    2 ATDADSGEngKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDgGGPPLSSTATVTITVL 74
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1941-1970 2.82e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.82e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 568962739  1941 CASGPCPPHADCKDLWQTFSCTCRPGYYGP 1970
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 2030-2053 2.91e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 37.72  E-value: 2.91e-03
                          10        20
                  ....*....|....*....|....
gi 568962739 2030 PCNCDVHKGFDPNCNKTNGQCHCK 2053
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECK 24
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 1981-2010 4.31e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 36.56  E-value: 4.31e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 568962739  1981 CQNQGSCRHLQGaphgyTCDCVSGYFGQHC 2010
Cdd:pfam07974    2 CSGRGTCVNQCG-----KCVCDSGYQGATC 26
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
2031-2053 5.90e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 36.52  E-value: 5.90e-03
                            10        20
                    ....*....|....*....|...
gi 568962739   2031 CNCDVHKGFDPNCNKTNGQCHCK 2053
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECK 23
EGF smart00181
Epidermal growth factor-like domain;
1717-1748 8.30e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 35.96  E-value: 8.30e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 568962739   1717 CAS-GPCKNnGFCSERWGGFSCDCPVGF-GGKDC 1748
Cdd:smart00181    2 CASgGPCSN-GTCINTPGSYTCSCPPGYtGDKRC 34
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 2031-2053 9.72e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.18  E-value: 9.72e-03
                           10        20
                   ....*....|....*....|...
gi 568962739  2031 CNCDVHKGFDPNCNKTNGQCHCK 2053
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCK 23
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 9-276 9.80e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.31  E-value: 9.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739    9 GLPGPSTPvllLLLLSLFPFSREELGGGGDQDWDPGVATTTGPRAQIGSGAVAL----------CPESPGVWEDGDPGLG 78
Cdd:PHA03307  124 ASPPPSPA---PDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALplsspeetarAPSSPPAEPPPSTPPA 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739   79 VREPvfmrlrvgRQNARNGRGAPEQPNAevvvQALGSREQEAGQGPGYLLCWHPEISSCGrTGPLRRGSLPLDALSPGDS 158
Cdd:PHA03307  201 AASP--------RPPRRSSPISASASSP----APAPGRSAADDAGASSSDSSSSESSGCG-WGPENECPLPRPAPITLPT 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568962739  159 DLRNSS-PHPSELLAQPDGSRPvafqrnARRSIRKRVETSRCCGKLWEPGHKGQGERSAT------STVDRGPFRRDCL- 230
Cdd:PHA03307  268 RIWEASgWNGPSSRPGPASSSS------SPRERSPSPSPSSPGSGPAPSSPRASSSSSSSressssSTSSSSESSRGAAv 341

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 568962739  231 -PGSLGSGLGEDSAPRAVRTAPTPGSAPRESRTAPGRMRSRGLFRRR 276
Cdd:PHA03307  342 sPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRR 388
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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