NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568967261|ref|XP_006513567|]
View 

alpha/beta hydrolase domain-containing protein 17A isoform X2 [Mus musculus]

Protein Classification

alpha/beta hydrolase( domain architecture ID 11437497)

alpha/beta hydrolase catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917|37582413

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 109-240 4.39e-24

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


:

Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 96.52  E-value: 4.39e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967261 109 GARYGISPDSIILYGQSIGTVPTVDLASRYE-CAAVVLHSPLTSGMRVA-----------FPDTKKTYCF-------DAF 169
Cdd:COG1073  101 RTLPGVDPERIGLLGISLGGGYALNAAATDPrVKAVILDSPFTSLEDLAaqrakeargayLPGVPYLPNVrlasllnDEF 180

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568967261 170 PNIEKVSKITSPVLIIHGTEDEVIDFSHGLALYERCPKAVEPLWVEGAGHNDI--ELYSQYLERLRRFISQEL 240
Cdd:COG1073  181 DPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEPKELLIVPGAGHVDLydRPEEEYFDKLAEFFKKNL 253
 
Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 109-240 4.39e-24

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 96.52  E-value: 4.39e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967261 109 GARYGISPDSIILYGQSIGTVPTVDLASRYE-CAAVVLHSPLTSGMRVA-----------FPDTKKTYCF-------DAF 169
Cdd:COG1073  101 RTLPGVDPERIGLLGISLGGGYALNAAATDPrVKAVILDSPFTSLEDLAaqrakeargayLPGVPYLPNVrlasllnDEF 180

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568967261 170 PNIEKVSKITSPVLIIHGTEDEVIDFSHGLALYERCPKAVEPLWVEGAGHNDI--ELYSQYLERLRRFISQEL 240
Cdd:COG1073  181 DPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEPKELLIVPGAGHVDLydRPEEEYFDKLAEFFKKNL 253
Abhydrolase_2 pfam02230
Phospholipase/Carboxylesterase; This family consists of both phospholipases and ...
 112-237 6.31e-05

Phospholipase/Carboxylesterase; This family consists of both phospholipases and carboxylesterases with broad substrate specificity, and is structurally related to alpha/beta hydrolases pfam00561.


Pssm-ID: 396693 [Multi-domain]  Cd Length: 217  Bit Score: 42.75  E-value: 6.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967261  112 YGISPDSIILYGQSIGtvptvdlasryecAAVVLHSPLTSGMR----VAF-----PDTKktycfdaFPNIEKVSKITSPV 182
Cdd:pfam02230 100 KGIPSSRIIIGGFSQG-------------AMLALYSALTLPLPlggiVAFsgflpLPTK-------FPSHPNLVTKKTPI 159

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568967261  183 LIIHGTEDEVIDFSHGLALYER---CPKAVEPLWVEGAGHndiELYSQYLERLRRFIS 237
Cdd:pfam02230 160 FLIHGEEDPVVPLALGKLAKEYlktSLNKVELKIYEGLAH---SICGREMQDIKKFLS 214
 
Name Accession Description Interval E-value
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 109-240 4.39e-24

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 96.52  E-value: 4.39e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967261 109 GARYGISPDSIILYGQSIGTVPTVDLASRYE-CAAVVLHSPLTSGMRVA-----------FPDTKKTYCF-------DAF 169
Cdd:COG1073  101 RTLPGVDPERIGLLGISLGGGYALNAAATDPrVKAVILDSPFTSLEDLAaqrakeargayLPGVPYLPNVrlasllnDEF 180

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568967261 170 PNIEKVSKITSPVLIIHGTEDEVIDFSHGLALYERCPKAVEPLWVEGAGHNDI--ELYSQYLERLRRFISQEL 240
Cdd:COG1073  181 DPLAKIEKISRPLLFIHGEKDEAVPFYMSEDLYEAAAEPKELLIVPGAGHVDLydRPEEEYFDKLAEFFKKNL 253
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
110-241 3.30e-15

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 72.36  E-value: 3.30e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967261 110 ARYGISPDSIILYGQSIGTVPTVDLASRYE--CAAVVLHSPLTS-----------GMRVAFPDTKKTYCFDAFPNIEKVS 176
Cdd:COG1506   86 ARPYVDPDRIGIYGHSYGGYMALLAAARHPdrFKAAVALAGVSDlrsyygttreyTERLMGGPWEDPEAYAARSPLAYAD 165

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568967261 177 KITSPVLIIHGTEDEVIDFSHGLALYERCPKA---VEPLWVEGAGHNDIELYS-QYLERLRRFISQELP 241
Cdd:COG1506  166 KLKTPLLLIHGEADDRVPPEQAERLYEALKKAgkpVELLVYPGEGHGFSGAGApDYLERILDFLDRHLK 234
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
119-238 2.05e-13

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 66.95  E-value: 2.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967261 119 IILYGQSIGTVPTVDLASRY--ECAAVVLHSPLtsgmRVAFPDTKKTYCF-DAFPNIEKVSKITSPVLIIHGTEDEVIDF 195
Cdd:COG2267  101 VVLLGHSMGGLIALLYAARYpdRVAGLVLLAPA----YRADPLLGPSARWlRALRLAEALARIDVPVLVLHGGADRVVPP 176

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 568967261 196 SHGLALYERCPKAVEPLWVEGAGHNDI--ELYSQYLERLRRFISQ 238
Cdd:COG2267  177 EAARRLAARLSPDVELVLLPGARHELLnePAREEVLAAILAWLER 221
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 117-238 1.82e-10

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 58.86  E-value: 1.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967261 117 DSIILYGQSIGTVPTVDLASRY--ECAAVVLHSPLTSGMRVAFPDTKKTY--------CFDAFPNIEKVSKITSPVLIIH 186
Cdd:COG0596   89 ERVVLVGHSMGGMVALELAARHpeRVAGLVLVDEVLAALAEPLRRPGLAPealaallrALARTDLRERLARITVPTLVIW 168

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568967261 187 GTEDEVIDFSHGLALYERCPKAvEPLWVEGAGHN-DIELYSQYLERLRRFISQ 238
Cdd:COG0596  169 GEKDPIVPPALARRLAELLPNA-ELVVLPGAGHFpPLEQPEAFAAALRDFLAR 220
YpfH COG0400
Predicted esterase [General function prediction only];
110-241 5.38e-09

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 54.53  E-value: 5.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967261 110 ARYGISPDSIILYGQSIGTVPTVDLASRYE--CAAVVLHSPltsgmrvAFPdtkktycFDAFPNIEKVSKITSPVLIIHG 187
Cdd:COG0400   82 ARYGIDPERIVLAGFSQGAAMALSLALRRPelLAGVVALSG-------YLP-------GEEALPAPEAALAGTPVFLAHG 147

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568967261 188 TEDEVIDFSHGLALYERCPKA---VEPLWVEGaGHndiELYSQYLERLRRFISQELP 241
Cdd:COG0400  148 TQDPVIPVERAREAAEALEAAgadVTYREYPG-GH---EISPEELADARAWLAERLA 200
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
173-238 3.05e-08

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 52.64  E-value: 3.05e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568967261 173 EKVSKITSPVLIIHGTEDEVIDFSHGLALYERCP-KAVEPLWVEGAGH-----NDIElysQYLERLRRFISQ 238
Cdd:COG1647  175 RDLPKITAPTLIIQSRKDEVVPPESARYIYERLGsPDKELVWLEDSGHvitldKDRE---EVAEEILDFLER 243
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
175-242 3.44e-07

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 49.39  E-value: 3.44e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568967261 175 VSKITSPVLIIHGTEDEVIDFSHGLALYERCPKAVEPLWVEGAGHndieLYSQYLERLRRFISQELPS 242
Cdd:COG2945  138 LAPCPAPTLVIHGEQDEVVPPAEVLDWARPLSPPLPVVVVPGADH----FFHGKLDELKELVARYLPR 201
Abhydrolase_2 pfam02230
Phospholipase/Carboxylesterase; This family consists of both phospholipases and ...
 112-237 6.31e-05

Phospholipase/Carboxylesterase; This family consists of both phospholipases and carboxylesterases with broad substrate specificity, and is structurally related to alpha/beta hydrolases pfam00561.


Pssm-ID: 396693 [Multi-domain]  Cd Length: 217  Bit Score: 42.75  E-value: 6.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967261  112 YGISPDSIILYGQSIGtvptvdlasryecAAVVLHSPLTSGMR----VAF-----PDTKktycfdaFPNIEKVSKITSPV 182
Cdd:pfam02230 100 KGIPSSRIIIGGFSQG-------------AMLALYSALTLPLPlggiVAFsgflpLPTK-------FPSHPNLVTKKTPI 159

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568967261  183 LIIHGTEDEVIDFSHGLALYER---CPKAVEPLWVEGAGHndiELYSQYLERLRRFIS 237
Cdd:pfam02230 160 FLIHGEEDPVVPLALGKLAKEYlktSLNKVELKIYEGLAH---SICGREMQDIKKFLS 214
UPF0227 pfam05728
Uncharacterized protein family (UPF0227); Despite being classed as uncharacterized proteins, ...
 114-235 5.50e-04

Uncharacterized protein family (UPF0227); Despite being classed as uncharacterized proteins, the members of this family are almost certainly enzymes that are distantly related to the pfam00561.


Pssm-ID: 283403 [Multi-domain]  Cd Length: 187  Bit Score: 39.70  E-value: 5.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967261  114 ISPDSIILYGQSIGTVPTVDLASRYECAAVVL------HSPLTSGM-RVAFPDTKKTYCFDAFPNIE----KVSKITSPV 182
Cdd:pfam05728  56 LGDDNPLLVGSSLGGYYATWLGFRCGLRQVLFnpavrpYENLAGKLgEQANPYTGQTYVLEEYHDIElkclEVFRLKNPD 135

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568967261  183 --LIIHGTEDEVIDFSHGLALYERCPKAVEplwvEGAGHNdIELYSQYLERLRRF 235
Cdd:pfam05728 136 rcLVLLQKGDEVLDYRRAAAHYRPYYEIVW----DGGDHK-FKDFSRHLQQIKAF 185
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
109-240 6.07e-04

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 39.86  E-value: 6.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568967261 109 GARYGISPDSIILYGQS--------IGTVPTVDLASRYecAAVVLHSPLTSgMRVAfPDTkktYCFDAFPniekvskits 180
Cdd:COG0657   78 AAELGIDPDRIAVAGDSagghlaaaLALRARDRGGPRP--AAQVLIYPVLD-LTAS-PLR---ADLAGLP---------- 140

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568967261 181 PVLIIHGTEDEVIDfsHGLALYERCPKA---VEPLWVEGAGH-----NDIELYSQYLERLRRFISQEL 240
Cdd:COG0657  141 PTLIVTGEADPLVD--ESEALAAALRAAgvpVELHVYPGGGHgfgllAGLPEARAALAEIAAFLRRAL 206
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 177-219 7.67e-04

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 39.51  E-value: 7.67e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568967261  177 KITSPVLIIHGTEDEVIDFSHGLALYERCPKA-VEPLWVEGAGH 219
Cdd:pfam12146 188 AITVPLLLLHGGADRVVDPAGSREFYERAGSTdKTLKLYPGLYH 231
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
170-219 1.23e-03

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 38.79  E-value: 1.23e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568967261 170 PNIEKVSKITSPVLIIHGTEDEVIDFSHGLALYERCPKA---VEPLWVEGAGH 219
Cdd:COG0412  147 DLLDLAARIKAPVLLLYGEKDPLVPPEQVAALEAALAAAgvdVELHVYPGAGH 199
FSH1 pfam03959
Serine hydrolase (FSH1); This is a family of serine hydrolases.
 176-219 2.34e-03

Serine hydrolase (FSH1); This is a family of serine hydrolases.


Pssm-ID: 461110  Cd Length: 208  Bit Score: 38.03  E-value: 2.34e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 568967261  176 SKITSPVLIIHGTEDEVIDFSHGLALYERCPKAVEPLWVEGaGH 219
Cdd:pfam03959 155 DPIQTPSLHVIGELDTVVPEERSEKLAEACKNSPTVLEHPG-GH 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH