Izumo sperm-egg fusion, Ig domain-associated; This IZUMO family is a domain just upstream of the immunoglobulin domain on Izumo proteins in higher eukaryotes. The actual function of this region of the Izumo proteins is not known. The full-length protein is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo proteins bind to putative Izumo receptors on the oocyte. Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilization. There are cysteine residues thought to form a disulphide bridge. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif (Asn 204). There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968580   27 CLQCDPNFAEKFSFYRHHVNLKSW--WVGDIPVSGMLLSDWiqnTMKELHL-AIPAEITRKKLYQVAEAVYQRMDQLYQG 103
Cdd:pfam15005   1 CLQCDPSVVEALKSLRGDLVPSHLphRKQLMERQQALLLDF---SFKDYALnAFLGVVDEDTLDKVAWSLKNDLKRLTDS 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568968580  104 KMYFPGYFpNELRAIFREQVRLIQNAIIESRID--CQRHCvrdHLLQQ 149
Cdd:pfam15005  78 DLKGEPLL-KELLWMRQNQKKKLKKALKEFQKEacCPNKC---GVMLQ 121

Izumo sperm-egg fusion, Ig domain-associated; This IZUMO family is a domain just upstream of the immunoglobulin domain on Izumo proteins in higher eukaryotes. The actual function of this region of the Izumo proteins is not known. The full-length protein is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo proteins bind to putative Izumo receptors on the oocyte. Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilization. There are cysteine residues thought to form a disulphide bridge. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif (Asn 204). There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968580   27 CLQCDPNFAEKFSFYRHHVNLKSW--WVGDIPVSGMLLSDWiqnTMKELHL-AIPAEITRKKLYQVAEAVYQRMDQLYQG 103
Cdd:pfam15005   1 CLQCDPSVVEALKSLRGDLVPSHLphRKQLMERQQALLLDF---SFKDYALnAFLGVVDEDTLDKVAWSLKNDLKRLTDS 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568968580  104 KMYFPGYFpNELRAIFREQVRLIQNAIIESRID--CQRHCvrdHLLQQ 149
Cdd:pfam15005  78 DLKGEPLL-KELLWMRQNQKKKLKKALKEFQKEacCPNKC---GVMLQ 121

Izumo sperm-egg fusion, Ig domain-associated; This IZUMO family is a domain just upstream of the immunoglobulin domain on Izumo proteins in higher eukaryotes. The actual function of this region of the Izumo proteins is not known. The full-length protein is a molecule with a single immunoglobulin (Ig) domain. It is thought that Izumo proteins bind to putative Izumo receptors on the oocyte. Izumo is not detectable on the surface of fresh sperm but becomes exposed only after an exocytotic process, the acrosome reaction, has occurred. Studies have shown that knock-out mice (Izumo-/- males) were sterile despite normal mating behaviour and ejaculation, indicating the importance of the protein in fertilization. There are cysteine residues thought to form a disulphide bridge. Izumo is a typical type I membrane glycoprotein with one immunoglobulin-like domain and a putative N-glycoside link motif (Asn 204). There is a conserved GCL sequence motif. Izumo expression has been found to be testis-specific.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568968580   27 CLQCDPNFAEKFSFYRHHVNLKSW--WVGDIPVSGMLLSDWiqnTMKELHL-AIPAEITRKKLYQVAEAVYQRMDQLYQG 103
Cdd:pfam15005   1 CLQCDPSVVEALKSLRGDLVPSHLphRKQLMERQQALLLDF---SFKDYALnAFLGVVDEDTLDKVAWSLKNDLKRLTDS 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568968580  104 KMYFPGYFpNELRAIFREQVRLIQNAIIESRID--CQRHCvrdHLLQQ 149
Cdd:pfam15005  78 DLKGEPLL-KELLWMRQNQKKKLKKALKEFQKEacCPNKC---GVMLQ 121