NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568977686|ref|XP_006515122|]
View 

trafficking protein particle complex subunit 12 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
608-765 2.60e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 64.64  E-value: 2.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 608 RVLYSMANCLLLMKDYVLAVDAYLTVIKYYPEqEPQLLSGIGRILLQQiGDIKTAEKYFQDVEKVTQKLdglqgkIMVLM 687
Cdd:COG0457    9 EAYNNLGLAYRRLGRYEEAIEDYEKALELDPD-DAEALYNLGLAYLRL-GRYEEALADYEQALELDPDD------AEALN 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568977686 688 NRAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRHYlheSVLFNLTTMYE 765
Cdd:COG0457   81 NLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDA---DALYNLGIALE 155
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 1-380 8.48e-03

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.77  E-value: 8.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686    1 METAKDGEQSPSEASPSAQAGPENIPEPMSREEESQPlyheetiDLGGDEFASEENEPTSEGShnfgdklnehmmesvli 80
Cdd:PHA03307   96 APASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAP-------DLSEMLRPVGSPGPPPAAS----------------- 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686   81 SDSPNNSEGDVGDlgclqDVGEPPRGAtdhrLPSSTDKEVVDTLSNGSETDGDDTPRdiSDMTPDSRASLKEDST-QEDV 159
Cdd:PHA03307  152 PPAAGASPAAVAS-----DAASSRQAA----LPLSSPEETARAPSSPPAEPPPSTPP--AAASPRPPRRSSPISAsASSP 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686  160 TSMPALENAATEEVGPKDSLAPREEQTSEVSSNQSsskdePLPVCTIFSQAT--ATPSQPHlflqdgfesqmvkSPSFSS 237
Cdd:PHA03307  221 APAPGRSAADDAGASSSDSSSSESSGCGWGPENEC-----PLPRPAPITLPTriWEASGWN-------------GPSSRP 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686  238 TSETSAkTPPPMVQPSPSLSTFFGDTMSSNSLASDFFDSFTTStfiSVSNPNAGSPVPEKLSSLTAPVGEKSPDSTSPSY 317
Cdd:PHA03307  283 GPASSS-SSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRES---SSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPP 358

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568977686  318 STRMDRSesgvSRAPldvpeSPKPFSQIQAVFAGSDDPFATALSMSEMDRRNDAWLPSQATRE 380
Cdd:PHA03307  359 PADPSSP----RKRP-----RPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRP 412
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
608-765 2.60e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 64.64  E-value: 2.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 608 RVLYSMANCLLLMKDYVLAVDAYLTVIKYYPEqEPQLLSGIGRILLQQiGDIKTAEKYFQDVEKVTQKLdglqgkIMVLM 687
Cdd:COG0457    9 EAYNNLGLAYRRLGRYEEAIEDYEKALELDPD-DAEALYNLGLAYLRL-GRYEEALADYEQALELDPDD------AEALN 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568977686 688 NRAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRHYlheSVLFNLTTMYE 765
Cdd:COG0457   81 NLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDA---DALYNLGIALE 155
tol_pal_ybgF TIGR02795
tol-pal system protein YbgF; Members of this protein family are the product of one of seven ...
 600-671 3.49e-05

tol-pal system protein YbgF; Members of this protein family are the product of one of seven genes regularly clustered in operons to encode the proteins of the tol-pal system, which is critical for maintaining the integrity of the bacterial outer membrane. The gene for this periplasmic protein has been designated orf2 and ybgF. All members of the seed alignment were from unique tol-pal gene regions from completed bacterial genomes. The architecture of this protein is a signal sequence, a low-complexity region usually rich in Asn and Gln, a well-conserved region with tandem repeats that resemble the tetratricopeptide (TPR) repeat, involved in protein-protein interaction.


Pssm-ID: 188247 [Multi-domain]  Cd Length: 117  Bit Score: 43.81  E-value: 3.49e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568977686  600 QLWrsrLGRVLYSManclllmKDYVLAVDAYLTVIKYYPEQE--PQLLSGIGRIlLQQIGDIKTAEKYFQDVEK 671
Cdd:TIGR02795  40 HYW---LGEAYYAQ-------GDYADAAKAFLAVVKKYPKSPkaPDALLKLGMS-LQELGDKEKAKATLQQVIK 102
TPR_12 pfam13424
Tetratricopeptide repeat;
644-712 8.19e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.91  E-value: 8.19e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568977686  644 LLSGIGRILLQQiGDIKTAEKYFQDVEKVTQKLDGLQ--GKIMVLMNRAFLYLGQNNFAEAHKFFTEILRM 712
Cdd:pfam13424   5 ALNNLAAVLRRL-GRYDEALELLEKALEIARRLLGPDhpLTATTLLNLGRLYLELGRYEEALELLERALAL 74
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 608-639 5.71e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.11  E-value: 5.71e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568977686   608 RVLYSMANCLLLMKDYVLAVDAYLTVIKYYPE 639
Cdd:smart00028   2 EALYNLGNAYLKLGDYDEALEYYEKALELDPN 33
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1-380 8.48e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.77  E-value: 8.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686    1 METAKDGEQSPSEASPSAQAGPENIPEPMSREEESQPlyheetiDLGGDEFASEENEPTSEGShnfgdklnehmmesvli 80
Cdd:PHA03307   96 APASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAP-------DLSEMLRPVGSPGPPPAAS----------------- 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686   81 SDSPNNSEGDVGDlgclqDVGEPPRGAtdhrLPSSTDKEVVDTLSNGSETDGDDTPRdiSDMTPDSRASLKEDST-QEDV 159
Cdd:PHA03307  152 PPAAGASPAAVAS-----DAASSRQAA----LPLSSPEETARAPSSPPAEPPPSTPP--AAASPRPPRRSSPISAsASSP 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686  160 TSMPALENAATEEVGPKDSLAPREEQTSEVSSNQSsskdePLPVCTIFSQAT--ATPSQPHlflqdgfesqmvkSPSFSS 237
Cdd:PHA03307  221 APAPGRSAADDAGASSSDSSSSESSGCGWGPENEC-----PLPRPAPITLPTriWEASGWN-------------GPSSRP 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686  238 TSETSAkTPPPMVQPSPSLSTFFGDTMSSNSLASDFFDSFTTStfiSVSNPNAGSPVPEKLSSLTAPVGEKSPDSTSPSY 317
Cdd:PHA03307  283 GPASSS-SSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRES---SSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPP 358

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568977686  318 STRMDRSesgvSRAPldvpeSPKPFSQIQAVFAGSDDPFATALSMSEMDRRNDAWLPSQATRE 380
Cdd:PHA03307  359 PADPSSP----RKRP-----RPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRP 412
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
608-765 2.60e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 64.64  E-value: 2.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 608 RVLYSMANCLLLMKDYVLAVDAYLTVIKYYPEqEPQLLSGIGRILLQQiGDIKTAEKYFQDVEKVTQKLdglqgkIMVLM 687
Cdd:COG0457    9 EAYNNLGLAYRRLGRYEEAIEDYEKALELDPD-DAEALYNLGLAYLRL-GRYEEALADYEQALELDPDD------AEALN 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568977686 688 NRAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRHYlheSVLFNLTTMYE 765
Cdd:COG0457   81 NLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDA---DALYNLGIALE 155
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 604-750 3.35e-11

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 61.75  E-value: 3.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 604 SRLGRVLYSMANCLLLMKDYVLAVDAYLTVIKYYPEQePQLLSGIGRILLQQiGDIKTAEKYFQDVekvtqkLDGLQGKI 683
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDN-PEAFALLGEILLQL-GDLDEAIVLLHEA------LELDPDEP 72

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568977686 684 MVLMNRAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRH 750
Cdd:COG4783   73 EARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 608-789 3.63e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 61.67  E-value: 3.63e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 608 RVLYSMANCLLLMKDYVLAVDAYLTVIKYYPEQePQLLSGIGRILLQQiGDIKTAEKYFQDVEKVTQKldglqgKIMVLM 687
Cdd:COG2956   77 EALLELAQDYLKAGLLDRAEELLEKLLELDPDD-AEALRLLAEIYEQE-GDWEKAIEVLERLLKLGPE------NAHAYC 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 688 NRAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRHYlheSVLFNLTTMYElE 767
Cdd:COG2956  149 ELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYL---PALPRLAELYE-K 224

                        170       180
                 ....*....|....*....|..
gi 568977686 768 SSRSMQKKQSLLEAVASKEGDS 789
Cdd:COG2956  225 LGDPEEALELLRKALELDPSDD 246
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
608-741 1.92e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.86  E-value: 1.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 608 RVLYSMANCLLLMKDYVLAVDAYLTVIKYYPEQePQLLSGIGRILLQQiGDIKTAEKYFQdvekvtQKLDGLQGKIMVLM 687
Cdd:COG0457   43 EALYNLGLAYLRLGRYEEALADYEQALELDPDD-AEALNNLGLALQAL-GRYEEALEDYD------KALELDPDDAEALY 114

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568977686 688 NRAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLE 741
Cdd:COG0457  115 NLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLE 168
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 607-714 2.34e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 53.09  E-value: 2.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 607 GRVLYSMANCLLLMKDYVLAVDAYLTVIKYYPEqEPQLLSGIGRILLQQiGDIKTAEKYFQDVekvtQKLDGLQgkIMVL 686
Cdd:COG4235   17 AEGWLLLGRAYLRLGRYDEALAAYEKALRLDPD-NADALLDLAEALLAA-GDTEEAEELLERA----LALDPDN--PEAL 88

                         90       100
                 ....*....|....*....|....*...
gi 568977686 687 MNRAFLYLGQNNFAEAHKFFTEILRMDP 714
Cdd:COG4235   89 YLLGLAAFQQGDYAEAIAAWQKLLALLP 116
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 611-754 5.79e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 54.74  E-value: 5.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 611 YSMANCLLLMKDYVLAVDAYLTVIKYYPEQePQLLSGIGRILLQQiGDIKTAEKYFQDVEKVTQKldglqgKIMVLMNRA 690
Cdd:COG2956   12 YFKGLNYLLNGQPDKAIDLLEEALELDPET-VEAHLALGNLYRRR-GEYDRAIRIHQKLLERDPD------RAEALLELA 83

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568977686 691 FLYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPR--HYLHE 754
Cdd:COG2956   84 QDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPEnaHAYCE 149
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 615-714 1.17e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 51.88  E-value: 1.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 615 NCLLLMKDYVLAVDAYLTVIKYYPEqEPQLLSGIGRILLQQiGDIKTAEKYFQDVekvtQKLDglQGKIMVLMNRAFLYL 694
Cdd:COG5010   62 NLYNKLGDFEESLALLEQALQLDPN-NPELYYNLALLYSRS-GDKDEAKEYYEKA----LALS--PDNPNAYSNLAALLL 133

                         90       100
                 ....*....|....*....|
gi 568977686 695 GQNNFAEAHKFFTEILRMDP 714
Cdd:COG5010  134 SLGQDDEAKAALQRALGTSP 153
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
652-751 5.07e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 48.24  E-value: 5.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 652 LLQQIGDIKTAEKYFQDVekvtQKLDGlqGKIMVLMNRAFLYLGQNNFAEAHKFfTEILRMDPTNAVANNNAAVCLLYLG 731
Cdd:COG3063    1 LYLKLGDLEEAEEYYEKA----LELDP--DNADALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELG 73

                         90       100
                 ....*....|....*....|
gi 568977686 732 KLKDSLRQLEAMVQQDPRHY 751
Cdd:COG3063   74 DYDEALAYLERALELDPSAL 93
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 608-747 1.81e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.50  E-value: 1.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 608 RVLYSMANCLLLMKDYVLAVDAYLTVIKYYPEQEPQLLSgIGRILLQQiGDIKTAEKYFQDVEKvtQKLDGLQgkimVLM 687
Cdd:COG2956  145 HAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLL-LAELYLEQ-GDYEEAIAALERALE--QDPDYLP----ALP 216

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 688 NRAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVcLLYLGKLKDSLRQLEAMVQQD 747
Cdd:COG2956  217 RLAELYEKLGDPEEALELLRKALELDPSDDLLLALADL-LERKEGLEAALALLERQLRRH 275
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 574-786 2.00e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.53  E-value: 2.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 574 LANLEQGLAEDGGLSSVTQESRQASVQLWRSRLGRVLYSMANCLLLMKDYVLAVDAYLTVIKYYPEqEPQLLSGIGRILL 653
Cdd:COG3914   45 LLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPD-NAEALFNLGNLLL 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 654 QQiGDIKTAEKYFQDVEKVTQKLdglqgkIMVLMNRAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKL 733
Cdd:COG3914  124 AL-GRLEEALAALRRALALNPDF------AEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRL 196

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568977686 734 KDSLRQLEAMVQQDPRH-YLHESVLFnltTMYELESSRSMQKKQSLLEAVASKE 786
Cdd:COG3914  197 EEAIAAYRRALELDPDNaDAHSNLLF---ALRQACDWEVYDRFEELLAALARGP 247
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 617-748 4.23e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 47.26  E-value: 4.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 617 LLLMKDYVLAVDAYLTVIKYYPEQEPQLLSGIGRILLQQIGDIKTAEKYFQdvekvtQKLDGLQGKIMVLMNRAFLYLGQ 696
Cdd:COG5010   28 EAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLE------QALQLDPNNPELYYNLALLYSRS 101

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568977686 697 NNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDP 748
Cdd:COG5010  102 GDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 604-671 7.67e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 45.37  E-value: 7.67e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 604 SRLGRVLYSMANCLLLMKDYVLAVDAYLTVIKYYPEQE--PQLLSGIGRILLQQiGDIKTAEKYFQDVEK 671
Cdd:COG1729   27 PLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPkaPDALLKLGLSYLEL-GDYDKARATLEELIK 95
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 617-714 1.15e-05

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 44.98  E-value: 1.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 617 LLLMKDYVLAVDAYLTVIKYYPEQE--PQLLSGIGRILLQQiGDIKTAEKYFQDVEKV---TQKLDglqgkiMVLMNRAF 691
Cdd:COG1729    3 LLKAGDYDEAIAAFKAFLKRYPNSPlaPDALYWLGEAYYAL-GDYDEAAEAFEKLLKRypdSPKAP------DALLKLGL 75

                         90       100
                 ....*....|....*....|...
gi 568977686 692 LYLGQNNFAEAHKFFTEILRMDP 714
Cdd:COG1729   76 SYLELGDYDKARATLEELIKKYP 98
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 626-748 1.52e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 45.00  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 626 AVDAYLTVIKYYPEQePQLLSGIGRILLQQiGDIKTAEKYFQDVekvtQKLDGlqGKIMVLMNRAFLYLGQNNFAEAHKF 705
Cdd:COG4235    2 AIARLRQALAANPND-AEGWLLLGRAYLRL-GRYDEALAAYEKA----LRLDP--DNADALLDLAEALLAAGDTEEAEEL 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 568977686 706 FTEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDP 748
Cdd:COG4235   74 LERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLP 116
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 651-765 2.06e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 45.18  E-value: 2.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 651 ILLQQIGDIKTAEKYFQDVekvtqkLDGLQGKIMVLMNRAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYL 730
Cdd:COG4783   12 QALLLAGDYDEAEALLEKA------LELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKA 85

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 568977686 731 GKLKDSLRQLEAMVQQDPRHYlheSVLFNLTTMYE 765
Cdd:COG4783   86 GDYDEALALLEKALKLDPEHP---EAYLRLARAYR 117
tol_pal_ybgF TIGR02795
tol-pal system protein YbgF; Members of this protein family are the product of one of seven ...
 600-671 3.49e-05

tol-pal system protein YbgF; Members of this protein family are the product of one of seven genes regularly clustered in operons to encode the proteins of the tol-pal system, which is critical for maintaining the integrity of the bacterial outer membrane. The gene for this periplasmic protein has been designated orf2 and ybgF. All members of the seed alignment were from unique tol-pal gene regions from completed bacterial genomes. The architecture of this protein is a signal sequence, a low-complexity region usually rich in Asn and Gln, a well-conserved region with tandem repeats that resemble the tetratricopeptide (TPR) repeat, involved in protein-protein interaction.


Pssm-ID: 188247 [Multi-domain]  Cd Length: 117  Bit Score: 43.81  E-value: 3.49e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568977686  600 QLWrsrLGRVLYSManclllmKDYVLAVDAYLTVIKYYPEQE--PQLLSGIGRIlLQQIGDIKTAEKYFQDVEK 671
Cdd:TIGR02795  40 HYW---LGEAYYAQ-------GDYADAAKAFLAVVKKYPKSPkaPDALLKLGMS-LQELGDKEKAKATLQQVIK 102
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 686-765 6.33e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 40.37  E-value: 6.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 686 LMNRAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRhylHESVLFNLTTMYE 765
Cdd:COG4235   20 WLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPD---NPEALYLLGLAAF 96
TPR_12 pfam13424
Tetratricopeptide repeat;
644-712 8.19e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.91  E-value: 8.19e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568977686  644 LLSGIGRILLQQiGDIKTAEKYFQDVEKVTQKLDGLQ--GKIMVLMNRAFLYLGQNNFAEAHKFFTEILRM 712
Cdd:pfam13424   5 ALNNLAAVLRRL-GRYDEALELLEKALEIARRLLGPDhpLTATTLLNLGRLYLELGRYEEALELLERALAL 74
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 685-715 9.87e-04

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 37.12  E-value: 9.87e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 568977686  685 VLMNRAFLYLGQNNFAEAHKFFTEILRMDPT 715
Cdd:pfam07719   3 ALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
574-748 1.36e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 41.05  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 574 LANLEQGLAEDGGLSSVTQESRQASVQLWRsRLGRVLYSMANCLLLMKDYVLAVDAYLTVIKYYPEQepqllsgigrill 653
Cdd:COG4785   41 LADLALALAAAALAAAALAAERIDRALALP-DLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDL------------- 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 654 qqigdiktAEKYFqdvekvtqkldglqgkimvlmNRAFLYLGQNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKL 733
Cdd:COG4785  107 --------AEAYN---------------------NRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRY 157

                        170
                 ....*....|....*
gi 568977686 734 KDSLRQLEAMVQQDP 748
Cdd:COG4785  158 ELAIADLEKALELDP 172
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 636-766 1.60e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.94  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686 636 YYPEQEPQLLSGIGRILLQQIGDIKTAEKYFQDVEKVTQKLDGLQGKIMVLMNRAFLYLGQNNFAEAHKFFTEILRMDPT 715
Cdd:COG5010    7 FDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPN 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568977686 716 NAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRhylHESVLFNLTTMYEL 766
Cdd:COG5010   87 NPELYYNLALLYSRSGDKDEAKEYYEKALALSPD---NPNAYSNLAALLLS 134
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 608-639 5.71e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.11  E-value: 5.71e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568977686   608 RVLYSMANCLLLMKDYVLAVDAYLTVIKYYPE 639
Cdd:smart00028   2 EALYNLGNAYLKLGDYDEALEYYEKALELDPN 33
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1-380 8.48e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.77  E-value: 8.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686    1 METAKDGEQSPSEASPSAQAGPENIPEPMSREEESQPlyheetiDLGGDEFASEENEPTSEGShnfgdklnehmmesvli 80
Cdd:PHA03307   96 APASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAP-------DLSEMLRPVGSPGPPPAAS----------------- 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686   81 SDSPNNSEGDVGDlgclqDVGEPPRGAtdhrLPSSTDKEVVDTLSNGSETDGDDTPRdiSDMTPDSRASLKEDST-QEDV 159
Cdd:PHA03307  152 PPAAGASPAAVAS-----DAASSRQAA----LPLSSPEETARAPSSPPAEPPPSTPP--AAASPRPPRRSSPISAsASSP 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686  160 TSMPALENAATEEVGPKDSLAPREEQTSEVSSNQSsskdePLPVCTIFSQAT--ATPSQPHlflqdgfesqmvkSPSFSS 237
Cdd:PHA03307  221 APAPGRSAADDAGASSSDSSSSESSGCGWGPENEC-----PLPRPAPITLPTriWEASGWN-------------GPSSRP 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686  238 TSETSAkTPPPMVQPSPSLSTFFGDTMSSNSLASDFFDSFTTStfiSVSNPNAGSPVPEKLSSLTAPVGEKSPDSTSPSY 317
Cdd:PHA03307  283 GPASSS-SSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRES---SSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPP 358

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568977686  318 STRMDRSesgvSRAPldvpeSPKPFSQIQAVFAGSDDPFATALSMSEMDRRNDAWLPSQATRE 380
Cdd:PHA03307  359 PADPSSP----RKRP-----RPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRP 412
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 617-798 8.61e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 39.68  E-value: 8.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686  617 LLLMKDYVLAVDAYLTVIKYYPEqEPQLLSGIGRILLQQiGDIKTAEKYFQDV-EKVTQKLDGLQGKIMVlmnraflYLG 695
Cdd:TIGR02917 203 LLSLGNIELALAAYRKAIALRPN-NIAVLLALATILIEA-GEFEEAEKHADALlKKAPNSPLAHYLKALV-------DFQ 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977686  696 QNNFAEAHKFFTEILRMDPTNAVANNNAAVCLLYLGKLKDSLRQLEAMVQQDPRhyLHESVLfnLTTMYELESSRSMQKK 775
Cdd:TIGR02917 274 KKNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQILKYAPN--SHQARR--LLASIQLRLGRVDEAI 349

                         170       180
                  ....*....|....*....|...
gi 568977686  776 QSLLEAVASkegDSFNTQCLKLA 798
Cdd:TIGR02917 350 ATLSPALGL---DPDDPAALSLL 369
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH