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Conserved domains on  [gi|568977916|ref|XP_006515229|]
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eIF5-mimic protein 1 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
W2 super family cl17013
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ...
 218-369 1.65e-77

C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.


The actual alignment was detected with superfamily member cd11560:

Pssm-ID: 473053 [Multi-domain]  Cd Length: 194  Bit Score: 237.50  E-value: 1.65e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977916 218 ELFPVNRQSVDHFAKYFTDAGLKELSDFLRVQQSLGTRKELQKELQERLSQECPIKEVVLYVKEEMKRNDLPETAVIGLL 297
Cdd:cd11560    1 EFFPPNKRTEEHFAEHFKEEGLDELVEFYRKQASQEIKKELQQELKEMIAEEEPVKEIIAAVKEQMKKSSLPEHEVVGLL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568977916 298 WTCIMNAVEWNKKEELVAEQALKHLKQYAPLLAVFSSQGQSELVLLQKVQEYCYDNIHFMKAFQKIVVLFYK 369
Cdd:cd11560   81 WTALMDAVEWSKKEDQIAEQALRHLKKYAPLLAAFCTTARAELALLNKIQEYCYENMKFMKVFQKIVKLLYK 152
 
Name Accession Description Interval E-value
W2_eIF5C_like cd11560
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ...
 218-369 1.65e-77

C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211398 [Multi-domain]  Cd Length: 194  Bit Score: 237.50  E-value: 1.65e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977916 218 ELFPVNRQSVDHFAKYFTDAGLKELSDFLRVQQSLGTRKELQKELQERLSQECPIKEVVLYVKEEMKRNDLPETAVIGLL 297
Cdd:cd11560    1 EFFPPNKRTEEHFAEHFKEEGLDELVEFYRKQASQEIKKELQQELKEMIAEEEPVKEIIAAVKEQMKKSSLPEHEVVGLL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568977916 298 WTCIMNAVEWNKKEELVAEQALKHLKQYAPLLAVFSSQGQSELVLLQKVQEYCYDNIHFMKAFQKIVVLFYK 369
Cdd:cd11560   81 WTALMDAVEWSKKEDQIAEQALRHLKKYAPLLAAFCTTARAELALLNKIQEYCYENMKFMKVFQKIVKLLYK 152
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
327-368 1.80e-05

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 42.66  E-value: 1.80e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568977916   327 PLLAVFSSQGQSELVLLQKVQEYCYDNIHFMKAFQKIVVLFY 368
Cdd:smart00515   2 PLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLY 43
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 339-369 6.26e-03

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 35.20  E-value: 6.26e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 568977916  339 ELVLLQKVQEYCYDNIHFMKAFQKIVVLFYK 369
Cdd:pfam02020   1 QVDLLLALQEFCAKLEELLKLLLKILKALYD 31
 
Name Accession Description Interval E-value
W2_eIF5C_like cd11560
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ...
 218-369 1.65e-77

C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211398 [Multi-domain]  Cd Length: 194  Bit Score: 237.50  E-value: 1.65e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977916 218 ELFPVNRQSVDHFAKYFTDAGLKELSDFLRVQQSLGTRKELQKELQERLSQECPIKEVVLYVKEEMKRNDLPETAVIGLL 297
Cdd:cd11560    1 EFFPPNKRTEEHFAEHFKEEGLDELVEFYRKQASQEIKKELQQELKEMIAEEEPVKEIIAAVKEQMKKSSLPEHEVVGLL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568977916 298 WTCIMNAVEWNKKEELVAEQALKHLKQYAPLLAVFSSQGQSELVLLQKVQEYCYDNIHFMKAFQKIVVLFYK 369
Cdd:cd11560   81 WTALMDAVEWSKKEDQIAEQALRHLKKYAPLLAAFCTTARAELALLNKIQEYCYENMKFMKVFQKIVKLLYK 152
W2 cd11473
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ...
 255-369 2.20e-14

C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.


Pssm-ID: 211395  Cd Length: 135  Bit Score: 69.43  E-value: 2.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568977916 255 RKELQKELQERLSQECP-IKEVVLYVKEEMKRNDLPETAVIGLLWTCIMNAVEWNK-KEELVAEQALKHLKQYAPLLAVF 332
Cdd:cd11473    3 NKKLRDSLLKELEEDKSsDVESVKAAKSKLDLDPISLEEVVKVLLTAVVNAVESADsISLTQKEQLVLVLKKYGPVLREL 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568977916 333 SS-QGQSELVLLQKVQEYCY--DNIHFMKAFQKIVVLFYK 369
Cdd:cd11473   83 LKlIKKDQLYLLLKIEKLCLqlKLSELISLLEKILDLLYD 122
eIF5C smart00515
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
327-368 1.80e-05

Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;


Pssm-ID: 214705  Cd Length: 83  Bit Score: 42.66  E-value: 1.80e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 568977916   327 PLLAVFSSQGQSELVLLQKVQEYCYDNIHFMKAFQKIVVLFY 368
Cdd:smart00515   2 PLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLY 43
W2 pfam02020
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ...
 339-369 6.26e-03

eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.


Pssm-ID: 460415  Cd Length: 76  Bit Score: 35.20  E-value: 6.26e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 568977916  339 ELVLLQKVQEYCYDNIHFMKAFQKIVVLFYK 369
Cdd:pfam02020   1 QVDLLLALQEFCAKLEELLKLLLKILKALYD 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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