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Conserved domains on  [gi|568979323|ref|XP_006515772|]
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heme transporter FLVCR2 isoform X1 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-236 7.68e-146

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17456:

Pssm-ID: 475125  Cd Length: 406  Bit Score: 414.56  E-value: 7.68e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323   1 MFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSLSYALATTDASYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLN 80
Cdd:cd17456  171 MFYGTAAVATLLFILVIIVFQEKPKIPPSQAQAAIQSIPSQDYSYLQSILRLLKNVNFILLVVSYGLNTGCFYALSTLLN 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  81 RMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFTLNLNHLWVVFITAGTLG 160
Cdd:cd17456  251 RMVIFHYPGEEVNAGRIGLTIVVAGMVGALISGIWLDRTKTYKQTTLAVYIMSLVGMVVYTFTLNLGHLWVVFITAGTLG 330

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568979323 161 FFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFLALGSALTAFIK 236
Cdd:cd17456  331 FFMTGYLPLGFEFAAELTYPESEGTSSGLLNVSAQVFGIIFTISQGQIIDNFGTKAGNIFLCAFLLVGTILTALIK 406
 
Name Accession Description Interval E-value
MFS_FLVCR2 cd17456
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator ...
 1-236 7.68e-146

Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) is also called calcium-chelate transporter (CCT). It functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. Mutations in the FLVCR2 gene cause Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH), also known as Fowler syndrome, a rare autosomal recessive disorder characterized by glomerular vasculopathy in the central nervous system, severe hydrocephaly, hypokinesia and arthrogryphosis. FLVCR2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341014  Cd Length: 406  Bit Score: 414.56  E-value: 7.68e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323   1 MFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSLSYALATTDASYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLN 80
Cdd:cd17456  171 MFYGTAAVATLLFILVIIVFQEKPKIPPSQAQAAIQSIPSQDYSYLQSILRLLKNVNFILLVVSYGLNTGCFYALSTLLN 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  81 RMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFTLNLNHLWVVFITAGTLG 160
Cdd:cd17456  251 RMVIFHYPGEEVNAGRIGLTIVVAGMVGALISGIWLDRTKTYKQTTLAVYIMSLVGMVVYTFTLNLGHLWVVFITAGTLG 330

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568979323 161 FFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFLALGSALTAFIK 236
Cdd:cd17456  331 FFMTGYLPLGFEFAAELTYPESEGTSSGLLNVSAQVFGIIFTISQGQIIDNFGTKAGNIFLCAFLLVGTILTALIK 406
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
1-245 2.17e-12

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 66.44  E-value: 2.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323   1 MFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSLsyalattdasyLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLN 80
Cdd:COG2223  161 AFLILGILLLVVAVLAWLFLRDPPAGAAAAAKAS-----------LRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLP 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  81 RMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKeTTLVVYIMTLVGMVVYTFTlnLNHLWVVFITAGTLG 160
Cdd:COG2223  230 PYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRR-VLLIVFALMALGLLLLALA--LGSLWLFLVLFLLLG 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323 161 FFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGT-MFGNIFLCVFLALGSALTAFIKSDL 239
Cdd:COG2223  307 LALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSyTAAFLVFAVLALVALVLTLLLYRRP 386


                 ....*.
gi 568979323 240 RRQRAN 245
Cdd:COG2223  387 RRAAAA 392
MFS_1 pfam07690
Major Facilitator Superfamily;
3-202 3.06e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 41.63  E-value: 3.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323    3 YIIGGVATFLFILVIIVFKEKPKHPPSRAQSLSYALATtdasylsSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNrM 82
Cdd:pfam07690 154 FLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLI-------VAWKALLRDPVLWLLLALLLFGFAFFGLLTYLP-L 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323   83 VILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFTLNLNHLWVVFITAgTLGFF 162
Cdd:pfam07690 226 YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALL-LLGFG 304

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 568979323  163 MTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFT 202
Cdd:pfam07690 305 FGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_FLVCR2 cd17456
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator ...
 1-236 7.68e-146

Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) is also called calcium-chelate transporter (CCT). It functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. Mutations in the FLVCR2 gene cause Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH), also known as Fowler syndrome, a rare autosomal recessive disorder characterized by glomerular vasculopathy in the central nervous system, severe hydrocephaly, hypokinesia and arthrogryphosis. FLVCR2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341014  Cd Length: 406  Bit Score: 414.56  E-value: 7.68e-146
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323   1 MFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSLSYALATTDASYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLN 80
Cdd:cd17456  171 MFYGTAAVATLLFILVIIVFQEKPKIPPSQAQAAIQSIPSQDYSYLQSILRLLKNVNFILLVVSYGLNTGCFYALSTLLN 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  81 RMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFTLNLNHLWVVFITAGTLG 160
Cdd:cd17456  251 RMVIFHYPGEEVNAGRIGLTIVVAGMVGALISGIWLDRTKTYKQTTLAVYIMSLVGMVVYTFTLNLGHLWVVFITAGTLG 330

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568979323 161 FFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFLALGSALTAFIK 236
Cdd:cd17456  331 FFMTGYLPLGFEFAAELTYPESEGTSSGLLNVSAQVFGIIFTISQGQIIDNFGTKAGNIFLCAFLLVGTILTALIK 406
MFS_FLVCR_like cd17398
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ...
 1-236 2.39e-122

Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340956 [Multi-domain]  Cd Length: 406  Bit Score: 355.01  E-value: 2.39e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323   1 MFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSLSYALATTDASYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLN 80
Cdd:cd17398  171 LFYGVAGICTALFILVIIFFKEKPPIPPSRAQAAAQELRSEDQSYLGSLKRLFKNKGFLLLLITYGINTGVYYAISTLLN 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  81 RMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFTLNLNHLWVVFITAGTLG 160
Cdd:cd17398  251 QMVLEYFPNEEVNAGWIGLTLVIAGLVGSVVAGIWLDKTKKYKETTIIVYILSFIGMVAFTFTLDLGSIWVVFLTAGALG 330

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568979323 161 FFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFLALGSALTAFIK 236
Cdd:cd17398  331 FFMTGYLPVGFEFAAELTYPEPEGTSSGLLNASAQIFGIIFTLVMGALLDKVGALASNIVLSVALLLGTILTAFIK 406
MFS_FLVCR1 cd17455
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator ...
 1-236 8.01e-105

Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) is also called feline leukemia virus subgroup C receptor (FLVCR). FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. Mutations in the FLVCR1 gene have been linked to vision impairment, posterior column ataxia, and sensory neurodegeneration with loss of pain perception. FLVCR1 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341013  Cd Length: 407  Bit Score: 310.61  E-value: 8.01e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323   1 MFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSLSYALATTDASYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLN 80
Cdd:cd17455  172 MFYGTAAVSTLLFILTIIVFKEKPPLPPSQAQAVLQGIPSEDYSYKQSIINLFKNVPFVLLLISYGIMTGTFYSVSTLLN 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  81 RMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFTLNLNHLWVVFITAGTLG 160
Cdd:cd17455  252 QMIITHYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVVFTFTLDLGYLIVVFVTGGVLG 331

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568979323 161 FFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFLALGSALTAFIK 236
Cdd:cd17455  332 FFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGIIFTLIQGKLTTDYGPQAGNIFLCAWIFVGIILTALIK 407
MFS_SLC49 cd17334
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ...
 1-236 8.27e-54

Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340892 [Multi-domain]  Cd Length: 407  Bit Score: 179.52  E-value: 8.27e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323   1 MFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSLSYALATTDASYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLN 80
Cdd:cd17334  169 VFYGEFGFACLLLALVLALFPPKPKYPPSAASARQQNSEHVILELQKSISELLRNEPFVLLAVAFSIMMGVFAGFSSVLA 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  81 RMvILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKtykETTLVVYIMTLVGMVVYTFTLNLNHL-------WVVF 153
Cdd:cd17334  249 QI-LLPFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRTR---MFKLIGLIILALGTVVCTFFMLLVDRyglpyvtLAFY 324

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323 154 ITAGTLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFLALGSALTA 233
Cdd:cd17334  325 LLCGLLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLGPTPTESKYLLWFILCTVGSCLGA 404


                 ...
gi 568979323 234 FIK 236
Cdd:cd17334  405 LFF 407
MFS_MFSD7 cd17399
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ...
 1-205 9.77e-30

Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340957  Cd Length: 419  Bit Score: 115.83  E-value: 9.77e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323   1 MFYIIGGVATFLfiLVIIVFKEKPKHPPSRAQslsyalATTDASYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLN 80
Cdd:cd17399  172 IYTIPALIAVVL--ATFGVRSSVPPTPPSASA------AHESEPFFVGLKQLFKNKQYLILMLCFGGGIGLFNALSTLLE 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  81 RmvILHFPGEEVN-AGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFTLNL-NHLWVVFITAGT 158
Cdd:cd17399  244 Q--ILCPSGYSNNfAGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVSRFpNQSVLLAVLCGL 321

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 568979323 159 LGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQ 205
Cdd:cd17399  322 FGFFGFAIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVFIM 368
MFS_DIRC2 cd17397
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ...
 3-225 3.27e-28

Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340955 [Multi-domain]  Cd Length: 381  Bit Score: 111.24  E-value: 3.27e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323   3 YIIGGVATFLFILVIIVFKEKPKHPPSRAQSlsyalaTTDASYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNrm 82
Cdd:cd17397  158 YLEFGWSALIFLAMLIYFPSKPPTPPSVSAS------TQRLSYKSGILSLLKNKRFWLIALAYGIPTGVYAGWSGVLD-- 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  83 VILHFPG-EEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTY-KETTLVVYIMTLVGMVVYTFTLNL---NHLWVVFITAG 157
Cdd:cd17397  230 VNLTPFGvSQVEAGWIGFYSTVAGCVGGIIVGRFADRFGGRmKLILLLLFSGATGSFLWFTLICLKllpFSTVSLYTSCI 309

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568979323 158 TLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTIsqGQIIDNHGT------MFGNIFLCVFL 225
Cdd:cd17397  310 LLGVFLNGSVPLFYELAVEAAYPVPEGITSGVLTFLNNVFGLVFLL--ILIIPNIGTswmnwcLLGSCLLSVPL 381
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-234 3.11e-14

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 71.69  E-value: 3.11e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323   1 MFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSLSYAlattdaSYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLN 80
Cdd:cd06174  154 VFLIAAALALLAAILLLLVVPDPPESARAKNEEASSK------SVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLP 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  81 RMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTykeTTLVVYIMTLVGMVVYTFTLNLNHLWVVFITAGTLG 160
Cdd:cd06174  228 LFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG---RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLG 304

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568979323 161 FFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFLALGSALTAF 234
Cdd:cd06174  305 FGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
1-245 2.17e-12

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 66.44  E-value: 2.17e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323   1 MFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSLsyalattdasyLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLN 80
Cdd:COG2223  161 AFLILGILLLVVAVLAWLFLRDPPAGAAAAAKAS-----------LRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLP 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  81 RMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKeTTLVVYIMTLVGMVVYTFTlnLNHLWVVFITAGTLG 160
Cdd:COG2223  230 PYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRR-VLLIVFALMALGLLLLALA--LGSLWLFLVLFLLLG 306

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323 161 FFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGT-MFGNIFLCVFLALGSALTAFIKSDL 239
Cdd:COG2223  307 LALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSyTAAFLVFAVLALVALVLTLLLYRRP 386


                 ....*.
gi 568979323 240 RRQRAN 245
Cdd:COG2223  387 RRAAAA 392
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
56-241 3.75e-12

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 65.66  E-value: 3.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  56 LNFVLLVITYGLNAGAFYALSTLLNRMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKskTYKETTLVVYIMTLV 135
Cdd:COG2271  180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR--LGRRRKLVLAIGLLL 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323 136 GMVVYTFTLNLNHLWVVFITAGTLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTM 215
Cdd:COG2271  258 AALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQ 337

                        170       180
                 ....*....|....*....|....*.
gi 568979323 216 FGNIFLCVFLALGSALTAFIKSDLRR 241
Cdd:COG2271  338 AAFLLLAALALLAALLALLLLRETRK 363
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-198 1.06e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 55.37  E-value: 1.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323   1 MFYIIGGVATFLFILVIIVFKEKPKHPPSRAqslsyalattdasyLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLN 80
Cdd:COG2814  166 VFLVNAVLALLALLLLLRLLPESRPAARARL--------------RGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLP 231

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  81 RMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKeTTLVVYIMTLVGMVVYTFTlnlNHLWVVFITAGTLG 160
Cdd:COG2814  232 LYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRR-LLLIGLLLLALGLLLLALA---GSLWLLLLALFLLG 307

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 568979323 161 FFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFG 198
Cdd:COG2814  308 FGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 2-233 1.43e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 51.78  E-value: 1.43e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323   2 FYIIGGVAtflFILVIIVFKEKPKHPPSRAQSLSYalattdasyLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNr 81
Cdd:cd17324  156 FLAIAVLA---LLAALLLWRLLPSLPPKKPGSLGL---------LSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLA- 222

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  82 mVILHFPGEEVNAGRIGLTIV--IAGMFGAMISGIWLDKSKTYKettlVVYIMTLVGMVVYTFTLNLNHLWVVFITAGTL 159
Cdd:cd17324  223 -PFLTDVPGFSSSAIIGLLLLfgVAGVVGSPLAGRLADRGGRRA----LLIALLLLAAALLLLTLLGPSPLLLLVGLVLW 297

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568979323 160 GFFMTGYLPLGFEFAVELTyPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFLALGSALTA 233
Cdd:cd17324  298 GLGFFAAHSALQTRVLRLA-PEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
1-169 2.21e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 51.44  E-value: 2.21e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323   1 MFYIIGGVATFLFILVIIVFKEKPKHPPSRaqslsyalattdASYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLN 80
Cdd:COG2211  185 TALIFAVLGLLAFLLTFFGTKERPVPEEEK------------VSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLL 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  81 RMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDK-SKtyKETTLVVYIMTLVGMVVYTFtLNLNHLWVVFITAGTL 159
Cdd:COG2211  253 YYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRfGK--KKAFIIGLLLAALGLLLLFF-LGPGNLWLLLVLAALA 329

                        170
                 ....*....|
gi 568979323 160 GFFMTGYLPL 169
Cdd:COG2211  330 GIGLGAILVL 339
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 1-233 1.60e-05

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 45.64  E-value: 1.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323   1 MFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSlsyalattdASYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLN 80
Cdd:cd17320  155 IFVFLALLGLLLLLLVLLFLPETLPEEKRKPLL---------SSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAP 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  81 RMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFTLNLNHLWVVFITAGTLG 160
Cdd:cd17320  226 FIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLI 305

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568979323 161 FFMTGYL-PLGFEFAVELtYPESEGVSSGLLNvSAQVFGIVFTISQGQIIDNHGT--MFGNIFLCVFLALGSALTA 233
Cdd:cd17320  306 FFGFGLIfPNATSLALEP-FPHVAGTASALLG-FLQFLIGALAGALVGLLPNGTAlpMGLLILVLGLLALLLLILL 379
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 1-235 3.06e-05

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 44.93  E-value: 3.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323   1 MFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSLSYALATTDASYLSSIVRLFKNLNFVLLVITYGLNA-GAFYALSTLL 79
Cdd:cd17313  181 PFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPSLGEVLKSLLKLLKIMPRSLLRLLLVIFFWWIAfFPFELFFTDY 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  80 NRMVILHFP-------GEEVNAGRIGLTIV-IAGMFGAMISGIWLDKSKTyKETTLVVYIMTLVGMVVYTFTLNLNHLWV 151
Cdd:cd17313  261 MGEEVYHGTsaasshyGAGVRMGAWGLLIFsLAFLIFSLPIGKLGKKIGR-KKVYLIGLVLFAVGMALMALVHNVTVALV 339

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323 152 VFITAGtLGFFMTGYLPlgFEFAVELT--YPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNhgtmFGNIFLCVFLALGS 229
Cdd:cd17313  340 LFALGG-IGWATININP--YPLVSDYHseSGRGQGTDTGLLNLAISLAQILVSLLAGPIIDV----KGYGTVFPVAAVAS 412


                 ....*.
gi 568979323 230 ALTAFI 235
Cdd:cd17313  413 FLSLVG 418
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 57-235 6.65e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 43.71  E-value: 6.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  57 NFVLLVITYGLNAGAFYALSTLLNRMVI--LHFPGEEVnaGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVyIMTL 134
Cdd:cd17319  180 QVWGLALGYFGINYALYGLLTWLPTYLKqaRGFSLKQV--GLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVII-IGLL 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323 135 VGMVVYTFTLNLNHLWVVFITAGTLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIID-NHG 213
Cdd:cd17319  257 LAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDaTGS 336

                        170       180
                 ....*....|....*....|..
gi 568979323 214 TMFGNIFLCVFLALGSALTAFI 235
Cdd:cd17319  337 YTAAFLFLAAVALLAALLVLLL 358
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 47-235 6.77e-05

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 43.70  E-value: 6.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  47 SSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVILHfpGEEVNAGRIGLTIV-IAGMFGAMISGIWLDKSKTYKeT 125
Cdd:cd17352  174 GLLLRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSL--GIDESDAAFLLSIIgISDIVGRILLGLLADKPRIGR-L 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323 126 TLVVYIMTLVGMVVYTFTLnLNHLWVVFITAGTLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQ 205
Cdd:cd17352  251 YLYIFTLLILGLSLLAFPL-ATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIA 329

                        170       180       190
                 ....*....|....*....|....*....|
gi 568979323 206 GQIIDNHGTMFGNIFLCVFLALGSALTAFI 235
Cdd:cd17352  330 GLLRDYTGDYDAAFYFCGACLLLSGVLLFL 359
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 3-233 8.30e-05

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 43.38  E-value: 8.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323   3 YIIGGVATFLFILVIIVFKEKPKHPPSRAQSLSYALAttdasylsSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNRM 82
Cdd:cd17475  153 FVVAGLVSILAAVLFWLFYREPPAASAATESASTLLR--------SLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLF 224

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  83 VILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDK--SKTYKETTLVVYIMTLVGMVVYTFTLNLNHLWVVFITAGTLG 160
Cdd:cd17475  225 LHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRvfGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLG 304

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568979323 161 FFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIID-NHGTMFGNIFLCVFLALGSALTA 233
Cdd:cd17475  305 LFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDaTHSYAPAWLALALLLVLAALLLL 378
MFS_1 pfam07690
Major Facilitator Superfamily;
3-202 3.06e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 41.63  E-value: 3.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323    3 YIIGGVATFLFILVIIVFKEKPKHPPSRAQSLSYALATtdasylsSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNrM 82
Cdd:pfam07690 154 FLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLI-------VAWKALLRDPVLWLLLALLLFGFAFFGLLTYLP-L 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323   83 VILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFTLNLNHLWVVFITAgTLGFF 162
Cdd:pfam07690 226 YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALL-LLGFG 304

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 568979323  163 MTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFT 202
Cdd:pfam07690 305 FGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 2-234 6.34e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 40.62  E-value: 6.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323   2 FYIIGGVATFLFILVIIVFKEKPKHPPSRAQSLSYALATTDASYLSSIVRLFknlnfVLLVITYGLNAGAFYALSTLLNR 81
Cdd:cd17478  146 FGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRAL-----LLLLIIVFLRSWVLSSLTTFLPF 220

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  82 MVILHFpGEEVNAGRIGLTIVIAGMFGAMISGIWLDKsktYKETTlvVYIMTLVGMVVYTFTLNLNHLWVVFITAGTLGF 161
Cdd:cd17478  221 YLVQRG-YSLVFAGLLLSLFLFAGAIGTLIGGPLSDR---FGRRR--VIIASLLLAAPFLLLFLLTPGIWSYILLVLAGF 294

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568979323 162 FMTGYLPLGFEFAVELTyPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGnIFLCVFLALGSALTAF 234
Cdd:cd17478  295 LLFASFPVTVVLAQELL-PGNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESV-LLILALLPLLGALLAF 365
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 57-234 1.33e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 39.51  E-value: 1.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  57 NFVLLVITYGLNAGAFYALSTLLNRMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKsKTYKETTLVVYIMTLVG 136
Cdd:cd17316  178 RTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDR-IGRKKTLVIGLILSGIL 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323 137 MVVYTFTLNLNhLWVVFITAGTLGFFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMF 216
Cdd:cd17316  257 ALPLFYLLSGS-PTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTG 335

                        170
                 ....*....|....*...
gi 568979323 217 GNIFLCVFLALGSALTAF 234
Cdd:cd17316  336 VPALILALLAIVALIVAL 353
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
1-242 1.44e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.45  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323   1 MFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSLSyalattdasylSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLN 80
Cdd:COG0738  166 PYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSA-----------ASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLP 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  81 RMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKettlVVYIMTLVGMVVYTFTLNLNHLWVVFITAGTLG 160
Cdd:COG0738  235 LYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVR----LLRLSALLAAVGLLLALLAPGPWLALIGLALVG 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323 161 FFMTGYLPLGFEFAVELTYPESEGVSSGLLnVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFLALGSALTAFIKSDLR 240
Cdd:COG0738  311 LGLSLMFPTIFSLALDGLGKRTAAAVSAVL-IMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRR 389


                 ..
gi 568979323 241 RQ 242
Cdd:COG0738  390 KK 391
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 51-202 2.10e-03

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 39.15  E-value: 2.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  51 RLFKNLNFVLLVITYGLNAGAFYALSTLLNRMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVY 130
Cdd:cd06179  257 LLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKHIKWQLVAGF 336

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568979323 131 IMTLVGMVVY-TFTLNLNHLWVVFITAGTLGFFMTGYLPLgfeFAVELTYPESE-GVSSGLLNVSAQVFGIVFT 202
Cdd:cd06179  337 VLFTAFLALLaLITPDNKALAIAFSVLAGIGIGGPLVLAI---VIVQLSVPPEDiGTASGLLGSARALGGAVGT 407
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-236 2.13e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 39.10  E-value: 2.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323   1 MFYIIGGVATFLFILVIIVFKEKPKHPPSRAQSlsyalattDASYLSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLN 80
Cdd:cd17325  152 PFLVCAALALLALVLALLLLPEPRPPPNKRAVS--------AARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLP 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  81 RMVILHFPGEEVNAGRIGLTIVIAGMFGAMISGIWLDKsKTYKETTLVVYIMTLVGMVVYTFTLNlnhLWVVFITAGTLG 160
Cdd:cd17325  224 LYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDR-IGRKPLILIGLLLSAVALLLLPLATS---FWLLLLLLALLG 299

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568979323 161 FFMTGYLPLGFEFAVELTYPESEGVSSGLLNVSAQVFGIVFTISQGQIIDNHGTMFGNIFLCVFLALGSALTAFIK 236
Cdd:cd17325  300 LGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
4-178 3.33e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 38.32  E-value: 3.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323   4 IIGGVATFLFILVIIVFKEKPKHPPSRAQSlsyalattdasylSSIVRLFKNLNFVLLVITYGLNAGAFYALSTLLNRMV 83
Cdd:COG2807  176 VWALLALLALLLWLPLLRRRPAAAAAAPAA-------------ASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPIL 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979323  84 I-LHFPGEEvnAGRIGLTIVIAGMFGAMISGIWLDKSKTYKETTLVVYIMTLVGMVVYTFT-LNLNHLWVVFITAGTLGF 161
Cdd:COG2807  243 RdAGLSAAT--AGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLApGSLPWLWAVLLGLGQGGL 320

                        170
                 ....*....|....*..
gi 568979323 162 FmtgylPLGFEFAVELT 178
Cdd:COG2807  321 F-----PLALTLIGLRA 332
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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