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Conserved domains on  [gi|568979767|ref|XP_006515990|]
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serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X3 [Mus musculus]

Protein Classification

phosphatase 2A regulatory subunit B56 family protein( domain architecture ID 12024732)

phosphatase 2A regulatory subunit B56 family protein functions as a regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulating substrate specificity, subcellular localization, and responsiveness to phosphorylation

CATH:  1.25.10.10
Gene Ontology:  GO:0007165|GO:0019888|GO:0000159
PubMed:  7592815
SCOP:  4001530

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
B56 pfam01603
Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a ...
30-410 0e+00

Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also pfam01240), this family is called the B56 family.


:

Pssm-ID: 460264  Cd Length: 404  Bit Score: 649.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979767   30 PTSEQPELFLKKLQQCCVIFDFMDTLSDLKMKEYKRSTLNELVDYITISRGCLTEQTYPEVVRMVSCNIFRTLPPSDSN- 108
Cdd:pfam01603   1 PPSEFQDLFLKKLQQCCVIFDFNDPNSDLKEKEIKRQTLKEIVDYVSNSGKVLTEEVYPEIFKMIAANLFRPLPPIPSSl 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979767  109 ---EFDPEEDEPTLEASWPHLQLVYEFFIRFLESQEFQPSIAKKYIDQKFVLQLLELFDSEDPRERDYLKTVLHRIYGKF 185
Cdd:pfam01603  81 yddLADPEEDEPFLEPAWPHLQLVYEILLRFVESPDFDPKVAKKYIDHSFVLRLLDLFDSEDPRERDYLKTFLHRIYGKF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979767  186 LGLRAFIRKQINNIFLRFVYETEHFNGVAELLEILGSIINGFALPLKAEHKQFLVKVLIPLHTVRSLSLFHAQLAYCIVQ 265
Cdd:pfam01603 161 LGLRPFIRKAINNIFYRFIYETERHNGIAELLEILGSIINGFALPLKEEHKIFLLRVLLPLHKPKHLSLYHQQLAYCVVQ 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979767  266 FLEKDPSLTEPVIRGLMKFWPKTCSQKEVMFLGELEEILDVIEPSQFVKIQEPLFKQIAKCVSSPHFQVAERALYYWNNE 345
Cdd:pfam01603 241 FIEKDPSLAEPVIRGLLKHWPKTNSQKEVMFLNELEEILEVIPPEEFQKIMVPLFKQLARCINSPHFQVAERALYLWNNE 320
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568979767  346 YIMSLIEENSNVILPIMFSSLYRISKEHWNPAIVALVYNVLKAFMEMNSTMFDELTATYKSDRQR 410
Cdd:pfam01603 321 YIVNLISDNSKVILPIIFPALEKNSKNHWNQTVRNLALNVLKLLMEMDPELFDECLAKYKEEKQK 385
 
Name Accession Description Interval E-value
B56 pfam01603
Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a ...
30-410 0e+00

Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also pfam01240), this family is called the B56 family.


Pssm-ID: 460264  Cd Length: 404  Bit Score: 649.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979767   30 PTSEQPELFLKKLQQCCVIFDFMDTLSDLKMKEYKRSTLNELVDYITISRGCLTEQTYPEVVRMVSCNIFRTLPPSDSN- 108
Cdd:pfam01603   1 PPSEFQDLFLKKLQQCCVIFDFNDPNSDLKEKEIKRQTLKEIVDYVSNSGKVLTEEVYPEIFKMIAANLFRPLPPIPSSl 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979767  109 ---EFDPEEDEPTLEASWPHLQLVYEFFIRFLESQEFQPSIAKKYIDQKFVLQLLELFDSEDPRERDYLKTVLHRIYGKF 185
Cdd:pfam01603  81 yddLADPEEDEPFLEPAWPHLQLVYEILLRFVESPDFDPKVAKKYIDHSFVLRLLDLFDSEDPRERDYLKTFLHRIYGKF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979767  186 LGLRAFIRKQINNIFLRFVYETEHFNGVAELLEILGSIINGFALPLKAEHKQFLVKVLIPLHTVRSLSLFHAQLAYCIVQ 265
Cdd:pfam01603 161 LGLRPFIRKAINNIFYRFIYETERHNGIAELLEILGSIINGFALPLKEEHKIFLLRVLLPLHKPKHLSLYHQQLAYCVVQ 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979767  266 FLEKDPSLTEPVIRGLMKFWPKTCSQKEVMFLGELEEILDVIEPSQFVKIQEPLFKQIAKCVSSPHFQVAERALYYWNNE 345
Cdd:pfam01603 241 FIEKDPSLAEPVIRGLLKHWPKTNSQKEVMFLNELEEILEVIPPEEFQKIMVPLFKQLARCINSPHFQVAERALYLWNNE 320
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568979767  346 YIMSLIEENSNVILPIMFSSLYRISKEHWNPAIVALVYNVLKAFMEMNSTMFDELTATYKSDRQR 410
Cdd:pfam01603 321 YIVNLISDNSKVILPIIFPALEKNSKNHWNQTVRNLALNVLKLLMEMDPELFDECLAKYKEEKQK 385
PLN00122 PLN00122
serine/threonine protein phosphatase 2A; Provisional
334-410 3.93e-26

serine/threonine protein phosphatase 2A; Provisional


Pssm-ID: 215064  Cd Length: 170  Bit Score: 103.64  E-value: 3.93e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568979767 334 VAERALYYWNNEYIMSLIEENSNVILPIMFSSLYRISKEHWNPAIVALVYNVLKAFMEMNSTMFDELTATYKSDRQR 410
Cdd:PLN00122  68 VAERALFLWNNDHIVNLIAQNRQVILPIIFPALEKNTRGHWNQAVHGLTLNVRKMFSEMDPELFEECLRKFEEDEAK 144
 
Name Accession Description Interval E-value
B56 pfam01603
Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a ...
30-410 0e+00

Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also pfam01240), this family is called the B56 family.


Pssm-ID: 460264  Cd Length: 404  Bit Score: 649.29  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979767   30 PTSEQPELFLKKLQQCCVIFDFMDTLSDLKMKEYKRSTLNELVDYITISRGCLTEQTYPEVVRMVSCNIFRTLPPSDSN- 108
Cdd:pfam01603   1 PPSEFQDLFLKKLQQCCVIFDFNDPNSDLKEKEIKRQTLKEIVDYVSNSGKVLTEEVYPEIFKMIAANLFRPLPPIPSSl 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979767  109 ---EFDPEEDEPTLEASWPHLQLVYEFFIRFLESQEFQPSIAKKYIDQKFVLQLLELFDSEDPRERDYLKTVLHRIYGKF 185
Cdd:pfam01603  81 yddLADPEEDEPFLEPAWPHLQLVYEILLRFVESPDFDPKVAKKYIDHSFVLRLLDLFDSEDPRERDYLKTFLHRIYGKF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979767  186 LGLRAFIRKQINNIFLRFVYETEHFNGVAELLEILGSIINGFALPLKAEHKQFLVKVLIPLHTVRSLSLFHAQLAYCIVQ 265
Cdd:pfam01603 161 LGLRPFIRKAINNIFYRFIYETERHNGIAELLEILGSIINGFALPLKEEHKIFLLRVLLPLHKPKHLSLYHQQLAYCVVQ 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568979767  266 FLEKDPSLTEPVIRGLMKFWPKTCSQKEVMFLGELEEILDVIEPSQFVKIQEPLFKQIAKCVSSPHFQVAERALYYWNNE 345
Cdd:pfam01603 241 FIEKDPSLAEPVIRGLLKHWPKTNSQKEVMFLNELEEILEVIPPEEFQKIMVPLFKQLARCINSPHFQVAERALYLWNNE 320
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568979767  346 YIMSLIEENSNVILPIMFSSLYRISKEHWNPAIVALVYNVLKAFMEMNSTMFDELTATYKSDRQR 410
Cdd:pfam01603 321 YIVNLISDNSKVILPIIFPALEKNSKNHWNQTVRNLALNVLKLLMEMDPELFDECLAKYKEEKQK 385
PLN00122 PLN00122
serine/threonine protein phosphatase 2A; Provisional
334-410 3.93e-26

serine/threonine protein phosphatase 2A; Provisional


Pssm-ID: 215064  Cd Length: 170  Bit Score: 103.64  E-value: 3.93e-26
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568979767 334 VAERALYYWNNEYIMSLIEENSNVILPIMFSSLYRISKEHWNPAIVALVYNVLKAFMEMNSTMFDELTATYKSDRQR 410
Cdd:PLN00122  68 VAERALFLWNNDHIVNLIAQNRQVILPIIFPALEKNTRGHWNQAVHGLTLNVRKMFSEMDPELFEECLRKFEEDEAK 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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