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Conserved domains on  [gi|568981400|ref|XP_006516550|]
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ATP-dependent 6-phosphofructokinase, platelet type isoform X1 [Mus musculus]

Protein Classification

6-phosphofructokinase( domain architecture ID 807)

6-phosphofructokinase catalyzes the conversion of fructose-6-phosphate to fructose-1, 6-diphosphate and is a key regulatory enzyme of glycolysis

Gene Ontology:  GO:0003872|GO:0006002|GO:0046872

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PFK super family cl00204
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 21-728 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


The actual alignment was detected with superfamily member cd00764:

Pssm-ID: 469655 [Multi-domain]  Cd Length: 762  Bit Score: 1242.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  21 GDGKAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGGSNIVEAKWDCVSSILQVGGTIIGSARCKAF 100
Cdd:cd00764    1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 101 RSREGRLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGDIDNDTVQKYSYLNVVGMVGSIDNDFCGT 180
Cdd:cd00764   81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 181 DMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDWEENMCLKLSENRA 260
Cdd:cd00764  161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 261 RKKRLNIIIVSEGAIDMQNKPITSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPETP 340
Cdd:cd00764  241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 341 ACVVSLRGNQAVRLPLMECVQMTQDVQKAMDERRFKEAVKLRGRRFEGNLNTYKRLAIKLPDEKIVKSNCNVAVINVGAP 420
Cdd:cd00764  321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPQPLPEKTNLNIAIVNVGAP 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 421 AAGMNAAVRSAVRVGIADGHKMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTLPGKYLEKIAEQMHSHSIN 500
Cdd:cd00764  401 AAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGID 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 501 ALLIIGGFE---------------------------------------------------TCDRIKQSASGTKRRVFIIE 529
Cdd:cd00764  481 GLIIVGGFEaykgllqlreareqyeefcipmvlipatvsnnvpgtdfslgsdtalnalmkYCDRIKQSASGTKRRVFIVE 560

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 530 TMGGYCGYLANMGALAAGADAAYIFEEPFDIGDLQSNVVHLTEKMKTSIQRGLVLRNESCSVNYTTDFIYQLYSEEGKGV 609
Cdd:cd00764  561 TMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGV 640

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 610 FDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAMEWISAKLKGSQGTGKKFVSDDSICVLGICKRDLLFQPVAELKKVTDF 689
Cdd:cd00764  641 FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTTF 720

                        730       740       750
                 ....*....|....*....|....*....|....*....
gi 568981400 690 EHRIPKEQWWLKLRPIMKILAKYEASYDMSDSGKLESLQ 728
Cdd:cd00764  721 EHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVT 759
 
Name Accession Description Interval E-value
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 21-728 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1242.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  21 GDGKAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGGSNIVEAKWDCVSSILQVGGTIIGSARCKAF 100
Cdd:cd00764    1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 101 RSREGRLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGDIDNDTVQKYSYLNVVGMVGSIDNDFCGT 180
Cdd:cd00764   81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 181 DMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDWEENMCLKLSENRA 260
Cdd:cd00764  161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 261 RKKRLNIIIVSEGAIDMQNKPITSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPETP 340
Cdd:cd00764  241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 341 ACVVSLRGNQAVRLPLMECVQMTQDVQKAMDERRFKEAVKLRGRRFEGNLNTYKRLAIKLPDEKIVKSNCNVAVINVGAP 420
Cdd:cd00764  321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPQPLPEKTNLNIAIVNVGAP 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 421 AAGMNAAVRSAVRVGIADGHKMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTLPGKYLEKIAEQMHSHSIN 500
Cdd:cd00764  401 AAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGID 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 501 ALLIIGGFE---------------------------------------------------TCDRIKQSASGTKRRVFIIE 529
Cdd:cd00764  481 GLIIVGGFEaykgllqlreareqyeefcipmvlipatvsnnvpgtdfslgsdtalnalmkYCDRIKQSASGTKRRVFIVE 560

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 530 TMGGYCGYLANMGALAAGADAAYIFEEPFDIGDLQSNVVHLTEKMKTSIQRGLVLRNESCSVNYTTDFIYQLYSEEGKGV 609
Cdd:cd00764  561 TMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGV 640

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 610 FDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAMEWISAKLKGSQGTGKKFVSDDSICVLGICKRDLLFQPVAELKKVTDF 689
Cdd:cd00764  641 FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTTF 720

                        730       740       750
                 ....*....|....*....|....*....|....*....
gi 568981400 690 EHRIPKEQWWLKLRPIMKILAKYEASYDMSDSGKLESLQ 728
Cdd:cd00764  721 EHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVT 759
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 24-712 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1157.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400   24 KAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGGSNIVEAKWDCVSSILQVGGTIIGSARCKAFRSR 103
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  104 EGRLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGDIDNDTVQKYSYLNVVGMVGSIDNDFCGTDMT 183
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  184 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDWEENMCLKLSENRARKK 263
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  264 RLNIIIVSEGAIDMQNKPITSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPETPACV 343
Cdd:TIGR02478 241 RKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSPV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  344 VSLRGNQAVRLPLMECVQMTQDVQKAMDERRFKEAVKLRGRRFEGNLNTYKRLAIKLPDEKIVKSNC---NVAVINVGAP 420
Cdd:TIGR02478 321 ISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPSEAsrlRIAIIHVGAP 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  421 AAGMNAAVRSAVRVGIADGHKMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTLPGKYLEKIAEQMHSHSIN 500
Cdd:TIGR02478 401 AGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHKID 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  501 ALLIIGGFE---------------------------------------------------TCDRIKQSASGTKRRVFIIE 529
Cdd:TIGR02478 481 GLIIIGGFEafealyqldaarekypafripmvvipatisnnvpgteyslgsdtalneiteYCDNIKQSASASKRRVFVVE 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  530 TMGGYCGYLANMGALAAGADAAYIFEEPFDIGDLQSNVVHLTEKMKTSIQRGLVLRNESCSVNYTTDFIYQLYSEEGKGV 609
Cdd:TIGR02478 561 TMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEGKGR 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  610 FDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAMEWISAKLKGSQGTGKKFVSDDSICVLGICKRDLLFQPVA-ELKKVTD 688
Cdd:TIGR02478 641 FDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSADDTSAVVIGIRGSNVLFTPVKqLLANETD 720

                         730       740
                  ....*....|....*....|....
gi 568981400  689 FEHRIPKEQWWLKLRPIMKILAKY 712
Cdd:TIGR02478 721 FEHRRPKNQWWLQLRPLVRILAGR 744
PFK pfam00365
Phosphofructokinase;
26-329 3.30e-145

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 425.22  E-value: 3.30e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400   26 IGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGgsNIVEAKWDCVSSILQVGGTIIGSARCKAFRSREG 105
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEG--DIDELTWRDVSGILNRGGTILGTSRSKPFKTEEG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  106 RLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSglleelarngdidndtvqkysyLNVVGMVGSIDNDFCGTDMTIG 185
Cdd:pfam00365  80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  186 TDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDweeNMCLKLsENRARKKRL 265
Cdd:pfam00365 138 FDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIE---ELCEKI-KELRKGKRF 213

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568981400  266 NIIIVSEGAIDmqnkpitSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAV 329
Cdd:pfam00365 214 SIIVVAEGASD-------GEFLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAV 270
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
24-381 3.41e-125

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 375.57  E-value: 3.41e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  24 KAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGgsNIVEAKWDCVSSILQVGGTIIGSARCKAFRSR 103
Cdd:PRK03202   2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 104 EGRLKAACNLARLGITNLCVIGGDGSLTGANLfrkewsglleeLARNGdidndtvqkysyLNVVGMVGSIDNDFCGTDMT 183
Cdd:PRK03202  80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAKR-----------LTEHG------------IPVIGLPGTIDNDIAGTDYT 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 184 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDweeNMCLKLSENRARKK 263
Cdd:PRK03202 137 IGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIE---ELCAKIKKGRERGK 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 264 RLNIIIVSEGAIDMqnkpitsEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEatpETPACV 343
Cdd:PRK03202 214 KHAIIVVAEGVMPA-------EELAKEIEERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLE---GKGGRM 283

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 568981400 344 VSLRGNQAVRLPLMECV-QMTQDVqkamDERRFKEAVKL 381
Cdd:PRK03202 284 VGIQNNKIVHVPIEEAVeNMKHPF----DKDLYELAKKL 318
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 24-381 5.25e-123

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 370.94  E-value: 5.25e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  24 KAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGgsNIVEAKWDCVSSILQVGGTIIGSARCKAFRSR 103
Cdd:COG0205    2 KRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEG--DIIDLTREDVSGILQRGGTILGSSRSKPFKTE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 104 EGRLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSglleelarngdidndtvqkysyLNVVGMVGSIDNDFCGTDMT 183
Cdd:COG0205   80 EGREKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG----------------------IPVVGIPKTIDNDLPGTDYT 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 184 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDweeNMCLKLSENRARKK 263
Cdd:COG0205  138 IGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLD---KLLEKLKERRKRGK 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 264 RLNIIIVSEGAIDMQNKPI---------------TSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEA 328
Cdd:COG0205  215 GYSIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAA 294

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568981400 329 VIALLEatpETPACVVSLRGNQAVRLPLMECVQMTQDVQKAMDerRFKEAVKL 381
Cdd:COG0205  295 VELLLE---GKTGVMVGIRRGEIVLVPLEEVANKEKPVDPDSP--LIQLAREL 342
 
Name Accession Description Interval E-value
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 21-728 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1242.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  21 GDGKAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGGSNIVEAKWDCVSSILQVGGTIIGSARCKAF 100
Cdd:cd00764    1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 101 RSREGRLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGDIDNDTVQKYSYLNVVGMVGSIDNDFCGT 180
Cdd:cd00764   81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 181 DMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDWEENMCLKLSENRA 260
Cdd:cd00764  161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 261 RKKRLNIIIVSEGAIDMQNKPITSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPETP 340
Cdd:cd00764  241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 341 ACVVSLRGNQAVRLPLMECVQMTQDVQKAMDERRFKEAVKLRGRRFEGNLNTYKRLAIKLPDEKIVKSNCNVAVINVGAP 420
Cdd:cd00764  321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPQPLPEKTNLNIAIVNVGAP 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 421 AAGMNAAVRSAVRVGIADGHKMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTLPGKYLEKIAEQMHSHSIN 500
Cdd:cd00764  401 AAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGID 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 501 ALLIIGGFE---------------------------------------------------TCDRIKQSASGTKRRVFIIE 529
Cdd:cd00764  481 GLIIVGGFEaykgllqlreareqyeefcipmvlipatvsnnvpgtdfslgsdtalnalmkYCDRIKQSASGTKRRVFIVE 560

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 530 TMGGYCGYLANMGALAAGADAAYIFEEPFDIGDLQSNVVHLTEKMKTSIQRGLVLRNESCSVNYTTDFIYQLYSEEGKGV 609
Cdd:cd00764  561 TMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGV 640

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 610 FDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAMEWISAKLKGSQGTGKKFVSDDSICVLGICKRDLLFQPVAELKKVTDF 689
Cdd:cd00764  641 FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTTF 720

                        730       740       750
                 ....*....|....*....|....*....|....*....
gi 568981400 690 EHRIPKEQWWLKLRPIMKILAKYEASYDMSDSGKLESLQ 728
Cdd:cd00764  721 EHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVT 759
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 24-712 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1157.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400   24 KAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGGSNIVEAKWDCVSSILQVGGTIIGSARCKAFRSR 103
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  104 EGRLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGDIDNDTVQKYSYLNVVGMVGSIDNDFCGTDMT 183
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  184 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDWEENMCLKLSENRARKK 263
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  264 RLNIIIVSEGAIDMQNKPITSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPETPACV 343
Cdd:TIGR02478 241 RKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSPV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  344 VSLRGNQAVRLPLMECVQMTQDVQKAMDERRFKEAVKLRGRRFEGNLNTYKRLAIKLPDEKIVKSNC---NVAVINVGAP 420
Cdd:TIGR02478 321 ISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPSEAsrlRIAIIHVGAP 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  421 AAGMNAAVRSAVRVGIADGHKMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTLPGKYLEKIAEQMHSHSIN 500
Cdd:TIGR02478 401 AGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHKID 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  501 ALLIIGGFE---------------------------------------------------TCDRIKQSASGTKRRVFIIE 529
Cdd:TIGR02478 481 GLIIIGGFEafealyqldaarekypafripmvvipatisnnvpgteyslgsdtalneiteYCDNIKQSASASKRRVFVVE 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  530 TMGGYCGYLANMGALAAGADAAYIFEEPFDIGDLQSNVVHLTEKMKTSIQRGLVLRNESCSVNYTTDFIYQLYSEEGKGV 609
Cdd:TIGR02478 561 TMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEGKGR 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  610 FDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAMEWISAKLKGSQGTGKKFVSDDSICVLGICKRDLLFQPVA-ELKKVTD 688
Cdd:TIGR02478 641 FDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSADDTSAVVIGIRGSNVLFTPVKqLLANETD 720

                         730       740
                  ....*....|....*....|....
gi 568981400  689 FEHRIPKEQWWLKLRPIMKILAKY 712
Cdd:TIGR02478 721 FEHRRPKNQWWLQLRPLVRILAGR 744
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 24-380 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 533.03  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  24 KAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGgsNIVEAKWDCVSSILQVGGTIIGSARCKAFRSR 103
Cdd:cd00363    1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEG--DIKELDWESVSDIINRGGTIIGSARCKEFRTE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 104 EGRLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSGlleelarngdidndtvqKYSYLNVVGMVGSIDNDFCGTDMT 183
Cdd:cd00363   79 EGRAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPS-----------------KYQGFNVIGLPGTIDNDIKGTDYT 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 184 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDWEENMCLKLSENRARKK 263
Cdd:cd00363  142 IGFDTALKTIVEAIDRIRDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEWEEEMVDVIKKRRERGK 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 264 RLNIIIVSEGAIDMQNKPITSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPETPACV 343
Cdd:cd00363  222 RHGIVIVAEGAIDFIPKPITEKLLAKLVEERLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGTPVGI 301

                        330       340       350
                 ....*....|....*....|....*....|....*..
gi 568981400 344 VSLRGNQAVRLPLMECVQMTQDVQKAMDERRFKEAVK 380
Cdd:cd00363  302 QNLNENQVVRHPLTEAVNMTKRVGVDLEGRPFKKFAK 338
PFK pfam00365
Phosphofructokinase;
26-329 3.30e-145

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 425.22  E-value: 3.30e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400   26 IGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGgsNIVEAKWDCVSSILQVGGTIIGSARCKAFRSREG 105
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEG--DIDELTWRDVSGILNRGGTILGTSRSKPFKTEEG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  106 RLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSglleelarngdidndtvqkysyLNVVGMVGSIDNDFCGTDMTIG 185
Cdd:pfam00365  80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  186 TDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDweeNMCLKLsENRARKKRL 265
Cdd:pfam00365 138 FDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIE---ELCEKI-KELRKGKRF 213

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568981400  266 NIIIVSEGAIDmqnkpitSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAV 329
Cdd:pfam00365 214 SIIVVAEGASD-------GEFLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAV 270
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
24-381 3.41e-125

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 375.57  E-value: 3.41e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  24 KAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGgsNIVEAKWDCVSSILQVGGTIIGSARCKAFRSR 103
Cdd:PRK03202   2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 104 EGRLKAACNLARLGITNLCVIGGDGSLTGANLfrkewsglleeLARNGdidndtvqkysyLNVVGMVGSIDNDFCGTDMT 183
Cdd:PRK03202  80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAKR-----------LTEHG------------IPVIGLPGTIDNDIAGTDYT 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 184 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDweeNMCLKLSENRARKK 263
Cdd:PRK03202 137 IGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIE---ELCAKIKKGRERGK 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 264 RLNIIIVSEGAIDMqnkpitsEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEatpETPACV 343
Cdd:PRK03202 214 KHAIIVVAEGVMPA-------EELAKEIEERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLE---GKGGRM 283

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 568981400 344 VSLRGNQAVRLPLMECV-QMTQDVqkamDERRFKEAVKL 381
Cdd:PRK03202 284 VGIQNNKIVHVPIEEAVeNMKHPF----DKDLYELAKKL 318
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 24-381 5.25e-123

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 370.94  E-value: 5.25e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  24 KAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGgsNIVEAKWDCVSSILQVGGTIIGSARCKAFRSR 103
Cdd:COG0205    2 KRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEG--DIIDLTREDVSGILQRGGTILGSSRSKPFKTE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 104 EGRLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSglleelarngdidndtvqkysyLNVVGMVGSIDNDFCGTDMT 183
Cdd:COG0205   80 EGREKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG----------------------IPVVGIPKTIDNDLPGTDYT 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 184 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDweeNMCLKLSENRARKK 263
Cdd:COG0205  138 IGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLD---KLLEKLKERRKRGK 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 264 RLNIIIVSEGAIDMQNKPI---------------TSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEA 328
Cdd:COG0205  215 GYSIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAA 294

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568981400 329 VIALLEatpETPACVVSLRGNQAVRLPLMECVQMTQDVQKAMDerRFKEAVKL 381
Cdd:COG0205  295 VELLLE---GKTGVMVGIRRGEIVLVPLEEVANKEKPVDPDSP--LIQLAREL 342
PFKA_ATP TIGR02482
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ...
 26-358 2.41e-109

6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213713 [Multi-domain]  Cd Length: 301  Bit Score: 334.32  E-value: 2.41e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400   26 IGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGgsNIVEAKWDCVSSILQVGGTIIGSARCKAFRSREG 105
Cdd:TIGR02482   2 IGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLING--KIEPLESKNVSGIIHRGGTILGTARCPEFKTEEV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  106 RLKAACNLARLGITNLCVIGGDGSLTGANLFRKEwsglleelarnGDIdndtvqkysylNVVGMVGSIDNDFCGTDMTIG 185
Cdd:TIGR02482  80 REKAVENLKKLGIEGLVVIGGDGSYTGAQKLYEE-----------GGI-----------PVIGLPGTIDNDIPGTDYTIG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  186 TDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDweeNMCLKLSENRARKKRL 265
Cdd:TIGR02482 138 FDTALNTIIDAVDKIRDTATSHERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYDID---ELIQRLKEQHEAGKKH 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  266 NIIIVSEGAIDMQNKPItSEKIKELVvknlGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPETpacVVS 345
Cdd:TIGR02482 215 SIIIVAEGNIVGSAKEV-AKKIEEKT----GIETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLEGKGGV---MIG 286

                         330
                  ....*....|...
gi 568981400  346 LRGNQAVRLPLME 358
Cdd:TIGR02482 287 IQNNKIVTHPIEE 299
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 24-370 8.01e-98

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 304.72  E-value: 8.01e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  24 KAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGgsNIVEAKWDCVSSILQVGGTIIGSARCKAFRSR 103
Cdd:cd00763    1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAG--DIVPLDRYSVSDIINRGGTFLGSARFPEFKDE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 104 EGRLKAACNLARLGITNLCVIGGDGSLTGANLfrkewsglleeLARNGdidndtvqkysyLNVVGMVGSIDNDFCGTDMT 183
Cdd:cd00763   79 EGQAKAIEQLKKHGIDALVVIGGDGSYMGAMR-----------LTEHG------------FPCVGLPGTIDNDIPGTDYT 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 184 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEedwEENMCLKLSENRARKK 263
Cdd:cd00763  136 IGFDTALNTVVEAIDRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFD---REEVANRIKAGIERGK 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 264 RLNIIIVSEGAIDmqnkpitSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEAtpeTPACV 343
Cdd:cd00763  213 KHAIVVVAEGVYD-------VDELAKEIEEATGFETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLAG---KGGLA 282

                        330       340
                 ....*....|....*....|....*..
gi 568981400 344 VSLRGNQAVRLPLMECVQMTQDVQKAM 370
Cdd:cd00763  283 VGIQNEQLVHHDIIDAIENMKPFKKDW 309
PFK_mixed TIGR02483
phosphofructokinase; Members of this family that are characterized, save one, are ...
 26-360 1.62e-83

phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 274155 [Multi-domain]  Cd Length: 324  Bit Score: 267.63  E-value: 1.62e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400   26 IGVLTSGGDAQGMNAAVRAVVRMGIYT-GAKVYFIYEGYQGLVDGGSnIVEAKWDCVSSILQVGGTIIGSARCKAFRS-R 103
Cdd:TIGR02483   2 IGVLTGGGDCPGLNAVIRGVVRRAIAEyGWEVIGIRDGWRGLLEGDT-VPLLDLEDVRGILPRGGTILGSSRTNPFKYeE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  104 EGRLKAACNLARLGITNLCVIGGDGSLTGANlfrkewsglleELARNGdidndtvqkysyLNVVGMVGSIDNDFCGTDMT 183
Cdd:TIGR02483  81 DGDDKIVANLKELGLDALIAIGGDGTLGIAR-----------RLADKG------------LPVVGVPKTIDNDLEATDYT 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  184 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPeeDWEEnMCLKLSENRARKK 263
Cdd:TIGR02483 138 FGFDTAVEIATEALDRLHTTAESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEIPF--DIDS-VCEKVRERFARGK 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  264 RLNIIIVSEGA--------IDMQNKPI--------TSEKIKELVVKNLGFDTRVTILGHVQRGGTPSAFDRILASRMGVE 327
Cdd:TIGR02483 215 RFAIVVVAEGAkpkggemvVQEGVKDAfghvrlggIGNWLAEEIERRTGIETRATVLGHLQRGGSPSAFDRVLATRFGVA 294

                         330       340       350
                  ....*....|....*....|....*....|...
gi 568981400  328 AVIALLEATPETpacVVSLRGNQAVRLPLMECV 360
Cdd:TIGR02483 295 AVDLVHEGQFGH---MVALRGTDIVYVPIAEAV 324
PFK pfam00365
Phosphofructokinase;
411-643 3.43e-77

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 249.18  E-value: 3.43e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  411 NVAVINVGAPAAGMNAAVRSAVRVGIADGHKMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTLPGK---YL 487
Cdd:pfam00365   1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKteeGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  488 EKIAEQMHSHSINALLIIGGFET---------------------------------------------CDRIKQSASGTk 522
Cdd:pfam00365  81 EKIAENLKKLGIDALVVIGGDGSltganklseergipvvgipktidndipgtdytigfdtalntiveaIDRIRDTASSH- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  523 RRVFIIETMGGYCGYLANMGALAAGADAAYIFEEPFDIGDLQSNVVHLTEKMKTSIqrglVLRNESCSvnyTTDFIYQLY 602
Cdd:pfam00365 160 NRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKELRKGKRFSI----IVVAEGAS---DGEFLAKLI 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 568981400  603 sEEGKGvFDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAME 643
Cdd:pfam00365 233 -EEGTG-IETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
21-367 4.77e-62

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 211.85  E-value: 4.77e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  21 GDGKAIGVLTSGGDAQGMNAAVRAVVR--MGIYtGAKVYFIYEGYQGLVDGGSNIVEAKWDCVSSILQVGGTIIGSARcK 98
Cdd:PRK14071   2 GEKKRIGILTSGGDCAGLNAVIRAVVHraRGTY-GWEVIGIRDATQGLMARPPQYIELDLDQVDDLLRMGGTILGTTN-K 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  99 ----AFRSREGRLKAACN-----LARLGITNLCVIGGDGSLtganlfrkewsGLLEELARNGDIdndtvqkysylNVVGM 169
Cdd:PRK14071  80 gdpfAFPMPDGSLRDRSQeiidgYHSLGLDALIGIGGDGSL-----------AILRRLAQQGGI-----------NLVGI 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 170 VGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPpeedWE- 248
Cdd:PRK14071 138 PKTIDNDVGATEVSIGFDTAVNIATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIP----YTl 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 249 ENMCLKLSENRARKKRLNIIIVSEGAIDMQNKPITSEK-------------IKELVVKNLGFDTRVTILGHVQRGGTPSA 315
Cdd:PRK14071 214 ENVCKKIRERQEEGKNFCLVVVSEAVRTEEGEQVTKTQalgedryggigqyLAEQIAERTGAETRVTVLGHIQRGGIPSP 293

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568981400 316 FDRILASRMGVEAVIALLEATPETpacVVSLRGNQAVRLPLMECVQMTQDVQ 367
Cdd:PRK14071 294 RDRLLASAFGVAAVDLIAQGKFDR---MVAWQNRQVVSVPIAEAIATYRAVD 342
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 13-350 1.35e-54

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 200.64  E-value: 1.35e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400   13 PKYLEHLSGDGKAIGVLTSGGDAQGMNAAVRAVVRMGIYTGAKVYFIYEGYQGLVDGGsnIVEAKWDCVSSILQVGGTII 92
Cdd:TIGR02478 379 DKKLVPSEASRLRIAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHD--VRELTWSDVEGWVGEGGSEL 456

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400   93 GSARCKAFRSREgrlKAACNLARLGITNLCVIGGDGSLTGANLFRKewsglleelARngdidndtvQKYSYLNV--VGMV 170
Cdd:TIGR02478 457 GTNRSLPGDDLG---TIAYYFQQHKIDGLIIIGGFEAFEALYQLDA---------AR---------EKYPAFRIpmVVIP 515

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  171 GSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQ-SHQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEEDWEE 249
Cdd:TIGR02478 516 ATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASaSKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQ 595

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  250 NMCLKLSENRARKKRLNIIIVSEGAIdmqnKPITSEKIKEL---VVKNLgFDTRVTILGHVQRGGTPSAFDRILASRMGV 326
Cdd:TIGR02478 596 EDIEHLKETFAEGRAGKLILRNEKAS----KVYTTDFIARIiseEGKGR-FDARTAVLGHMQQGGSPSPFDRVRATRLAI 670

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 568981400  327 EAVIALLEATP-----------ETPACVVSLRGNQ 350
Cdd:TIGR02478 671 RAVDFIEEKIKankhadklsadDTSAVVIGIRGSN 705
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 411-708 3.85e-36

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 139.44  E-value: 3.85e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 411 NVAVINVGAPAAGMNAAVRSAVRVGIADGHKMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTLPGK---YL 487
Cdd:COG0205    3 RIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFKteeGR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 488 EKIAEQMHSHSINALLIIG-------------------------------------GFETC--------DRIKQSASGTk 522
Cdd:COG0205   83 EKALENLKKLGIDALVVIGgdgsldgaaklaeeygipvvgipktidndlpgtdytiGFDTAvntaaeaiDRLRDTAASH- 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 523 RRVFIIETMGGYCGYLANMGALAAGADAAYIFEEPFDIGDLqsnVVHLTEKMKTSIQRGLVL--------RNESCSVNYT 594
Cdd:COG0205  162 ERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKL---LEKLKERRKRGKGYSIIVvaegagdeDGEAVLEADT 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 595 TDFIYQLYSEEGKGV---------FDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAMEWISAKLKGsqgtgkkfvsddsi 665
Cdd:COG0205  239 DAFGHVRLGGIGEYLakeieertgIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELLLEGKTG-------------- 304

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 568981400 666 CVLGICKRDLLFQPvaeLKKVTDFEHRIPKEQWWLKLRPIMKI 708
Cdd:COG0205  305 VMVGIRRGEIVLVP---LEEVANKEKPVDPDSPLIQLARELGI 344
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
421-643 3.23e-34

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 133.28  E-value: 3.23e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 421 AAGMNAAVRSAVRVGIADGHKMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTLPGKYLE---KIAEQMHSH 497
Cdd:PRK03202  13 APGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEEgraKAIENLKKL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 498 SINALLIIGG------------------------------------FETC--------DRIKQSASgTKRRVFIIETMGG 533
Cdd:PRK03202  93 GIDALVVIGGdgsymgakrltehgipviglpgtidndiagtdytigFDTAlntaveaiDRLRDTAS-SHERVFIVEVMGR 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 534 YCGYLANMGALAAGADAAYIFEEPFDIGDlqsnvvhLTEKMKTSIQRG----LVLRNES-CSVNYTTDFIyqlyseEGKG 608
Cdd:PRK03202 172 HAGDLALHAGIAGGAEVILIPEVPFDIEE-------LCAKIKKGRERGkkhaIIVVAEGvMPAEELAKEI------EERT 238

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 568981400 609 VFDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAME 643
Cdd:PRK03202 239 GLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVE 273
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 411-643 8.19e-34

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 132.42  E-value: 8.19e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 411 NVAVINVGAPAAGMNAAVRSAVRVGIADGHKMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTLPGKYLE-- 488
Cdd:cd00363    2 KIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGDIKELDWESVSDIINRGGTIIGSARCKEFRTEEgr 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 489 -KIAEQMHSHSINALLIIG------------------------------------------GFETC--------DRIKQS 517
Cdd:cd00363   82 aKAAENLKKHGIDALVVIGgdgsytgadllteewpskyqgfnviglpgtidndikgtdytiGFDTAlktiveaiDRIRDT 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 518 ASgTKRRVFIIETMGGYCGYLANMGALAAGADAAYIFEEPFDIGDLQsnvvHLTEKMKTSIQRG----LVLRNEScsvny 593
Cdd:cd00363  162 AS-SHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEWEE----EMVDVIKKRRERGkrhgIVIVAEG----- 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568981400 594 TTDFIYQLYSEEG-------KGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAME 643
Cdd:cd00363  232 AIDFIPKPITEKLlaklveeRLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVE 288
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 412-643 9.18e-32

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 125.99  E-value: 9.18e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 412 VAVINVGAPAAGMNAAVRSAVRVGIADGHKMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTLPGKYLE--- 488
Cdd:cd00763    3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSARFPEFKDEEgqa 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 489 KIAEQMHSHSINALLIIGG------------------------------------FETC--------DRIKQSASgTKRR 524
Cdd:cd00763   83 KAIEQLKKHGIDALVVIGGdgsymgamrltehgfpcvglpgtidndipgtdytigFDTAlntvveaiDRIRDTSS-SHQR 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 525 VFIIETMGGYCGYLANMGALAAGADAAYIFEEPFDIGDLQSNVVHLTEKMKTSiqrGLVLRNESCsvnYTTDFIYQLYSE 604
Cdd:cd00763  162 ISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGKKH---AIVVVAEGV---YDVDELAKEIEE 235

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 568981400 605 EGKgvFDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAME 643
Cdd:cd00763  236 ATG--FETRATVLGHIQRGGSPTAFDRILASRMGAYAVE 272
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
 11-274 2.06e-25

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 110.13  E-value: 2.06e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  11 AYPKYLEHLSGDGKAIGVLTSGGDAQGMNAAVRAVVRMGIYT-GAK-VYFIYEGYQGLVDGGSniVEAKWDCVSSILQVG 88
Cdd:PTZ00286  75 AGPRKHLYFNPKEVKAGIVTCGGLCPGLNVVIRELVMNLINNyGVKtIYGAKYGYKGLYKEDW--IKLDPKDVKTIHRLG 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  89 GTIIGSARckafrSREGRLKAACNLARLGITNLCVIGGDGSLTGANlfrkewsGLLEELARNGdidndtvqkySYLNVVG 168
Cdd:PTZ00286 153 GTILGSSR-----GGFDPKVMVDTLIRHGINILFTLGGDGTHRGAL-------AIYKELRRRK----------LNISVVG 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 169 MVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTF-VLEVMGRHCGYLALVSALTCG-ADWVFLPESppeeD 246
Cdd:PTZ00286 211 IPKTIDNDIPIIDESFGFQTAVEEAQNAIRAAYVEAKSAKNGVgIVKLMGRDSGFIALHASVASAdVNVCLIPEF----D 286

                        250       260
                 ....*....|....*....|....*...
gi 568981400 247 WEENMCLKLSENRARKKRLNIIIVSEGA 274
Cdd:PTZ00286 287 IPLEGVLEYIEQRLQKKGHCVIVVAEGA 314
PRK06830 PRK06830
ATP-dependent 6-phosphofructokinase;
27-274 1.17e-21

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235869  Cd Length: 443  Bit Score: 98.40  E-value: 1.17e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  27 GVLTSGGDAQGMNAAVRAVVrMGIYTGAKVYFIY---EGYQGLV-DGGSNIVEAKWDCVSSILQVGGTIIGSARckafrs 102
Cdd:PRK06830  84 AIVTCGGLCPGLNDVIRAIV-LELHHHYGVRRILgirYGYQGLIpRYGHDPVELTPEVVADIHEFGGTILGSSR------ 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 103 reGRLKAAC---NLARLGITNLCVIGGDGSLTGAnlfrkewSGLLEELARNGdidndtvQKYSylnVVGMVGSIDNDFCG 179
Cdd:PRK06830 157 --GPQDPEEivdTLERMNINILFVIGGDGTLRGA-------SAIAEEIERRG-------LKIS---VIGIPKTIDNDINF 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 180 TDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVL-EVMGRHCGYLALVSALTCG-ADWVFLPESPPEEDwEENMCLKLSE 257
Cdd:PRK06830 218 IQKSFGFETAVEKATEAIRCAHVEANGAPNGIGLvKLMGRHSGFIAAYAALASKdVNFVLIPEVPFDLE-GPNGLLAALE 296

                        250
                 ....*....|....*..
gi 568981400 258 NRARKKRLNIIIVSEGA 274
Cdd:PRK06830 297 KRLAERGHAVIVVAEGA 313
PLN02884 PLN02884
6-phosphofructokinase
 27-329 1.78e-14

6-phosphofructokinase


Pssm-ID: 178472 [Multi-domain]  Cd Length: 411  Bit Score: 76.00  E-value: 1.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  27 GVLTSGGDAQGMNAAVRAVV-RMGIYTGAKVYFIYEGYQGLVDGGSNIVEAKWDCVSSILQVGGTIIGSARCKAFRSreg 105
Cdd:PLN02884  57 AIVTCGGLCPGLNDVIRQIVfTLEIYGVKNIVGIPFGYRGFFEKGLSEMPLSRKVVQNIHLSGGSLLGVSRGGAKTS--- 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 106 rlKAACNLARLGITNLCVIGGDGSLTGANLfrkewsglleelarngdIDNDTVQKYSYLNVVGMVGSIDNDFCGTDMTIG 185
Cdd:PLN02884 134 --DIVDSIEARGINMLFVLGGNGTHAGANA-----------------IHNECRKRKMKVSVVGVPKTIDNDILLMDKTFG 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 186 TDSALHRIIEVVDAIMTTAQSHQRTF-VLEVMGRHCGYLALVSALTCG-ADWVFLPESPPEEDWEENMcLKLSENRARKK 263
Cdd:PLN02884 195 FDTAVEEAQRAINSAYIEAHSAYHGIgLVKLMGRSSGFIAMHASLASGqVDICLIPEVPFTLDGPNGV-LRHLEHLIETK 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 264 RLNIIIVSEGA-IDMQNKPITSEKIKELVVKNLGFDTRVTILGHVQRGGTPS-----------------AFDRILASRMG 325
Cdd:PLN02884 274 GSAVVCVAEGAgQDLLQKTNATDASGNPVLGDIGVHLQQEIKKHFKDIGVPAdvkyidptymiracranASDAILCTVLG 353


                 ....
gi 568981400 326 VEAV 329
Cdd:PLN02884 354 QNAV 357
PRK14072 PRK14072
diphosphate--fructose-6-phosphate 1-phosphotransferase;
156-334 4.22e-14

diphosphate--fructose-6-phosphate 1-phosphotransferase;


Pssm-ID: 237600 [Multi-domain]  Cd Length: 416  Bit Score: 74.90  E-value: 4.22e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 156 DTVQKYS-------Y-LNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVV-----D-AIMTTaqsHQRTFVLEVMGRHCG 221
Cdd:PRK14072 117 DTALKVSqlakkmgYpIRCIGIPKTIDNDLPGTDHCPGFGSAAKYIATSVleaalDvAAMAN---TSKVFILEVMGRHAG 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 222 YLALVSALTC-----GADWVFLPESPPEedwEENMCLKLSENRARKKRLnIIIVSEGAIDMQNKPITSEK---------- 286
Cdd:PRK14072 194 WLAAAAALAKqnpddAPHLIYLPERPFD---EEKFLADVRAIVKRYGYC-VVVVSEGIRDADGKFIAEAGlaedafghaq 269

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568981400 287 -------IKELVVKNLGFDTRVTILGHVQR--GGTPSAFDRILASRMGVEAVIALLE 334
Cdd:PRK14072 270 lggvapvLANLIKEKLGKKVHWAVLDYLQRaaRHIASKTDVEEAYAVGKAAVEYALA 326
PLN02564 PLN02564
6-phosphofructokinase
 28-274 1.04e-13

6-phosphofructokinase


Pssm-ID: 178178  Cd Length: 484  Bit Score: 74.01  E-value: 1.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  28 VLTSGGDAQGMNAAVRAVVrMGI---YTGAKVYFIYEGYQGLVdgGSNIVEAKWDCVSSILQVGGTIIGSarckafrSRE 104
Cdd:PLN02564  92 IVTCGGLCPGLNTVIREIV-CGLsymYGVTRILGIDGGYRGFY--SRNTIPLTPKVVNDIHKRGGTILGT-------SRG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 105 GR--LKAACNLARLGITNLCVIGGDGSLTGANLfrkewsgLLEELARNGdidndtvqkySYLNVVGMVGSIDNDFCGTDM 182
Cdd:PLN02564 162 GHdtSKIVDSIQDRGINQVYIIGGDGTQKGASV-------IYEEIRRRG----------LKVAVAGIPKTIDNDIPVIDK 224

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 183 TIGTDSALHRIIEVVDAIMTTAQS-HQRTFVLEVMGRHCGYLALVSALTC-GADWVFLPESPPEEDWEENMcLKLSENRA 260
Cdd:PLN02564 225 SFGFDTAVEEAQRAINAAHVEAESvENGIGLVKLMGRYSGFIAMYATLASrDVDCCLIPESPFYLEGKGGL-FEFIEKRL 303

                        250
                 ....*....|....
gi 568981400 261 RKKRLNIIIVSEGA 274
Cdd:PLN02564 304 KENGHMVIVVAEGA 317
PRK06555 PRK06555
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
 24-274 1.71e-11

pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated


Pssm-ID: 180620 [Multi-domain]  Cd Length: 403  Bit Score: 66.57  E-value: 1.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  24 KAIGVLTSGGDAQGMNAAVRAVVRMgiYT--GAKVYFIY--EGYQGLVDGGS-NIVEAKWDCVSSILQVGGTIIGSARCK 98
Cdd:PRK06555   4 KKVALLTAGGLAPCLSSAVGGLIER--YTeiAPEVEIIAyrSGYQGLLLGDSiEITPAVRANAGLLHRYGGSPIGNSRVK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  99 AFRS---------REGR--LK-AACNLARLGITNLCVIGGDGSLTGAnlfrkewSGLLEELARNGdidndtvqkYSyLNV 166
Cdd:PRK06555  82 LTNVadcvkrglvKEGEnpLKvAAERLAADGVDILHTIGGDDTNTTA-------ADLAAYLAENG---------YD-LTV 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 167 VGMVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVL-EVMGRHCGYLALVSA-----LTCGADW----- 235
Cdd:PRK06555 145 VGLPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVINEHSANPRMLIIhEVMGRNCGWLTAATArayreWLDRQEYvpgfg 224

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 568981400 236 ----------VFLPESPPEEDWEENmclKLSENRARKKRLNiIIVSEGA 274
Cdd:PRK06555 225 lsaerwdihaVYLPEMAFDLEAEAE---RLKAVMDEVGNVN-IFLSEGA 269
PTZ00287 PTZ00287
6-phosphofructokinase; Provisional
 26-276 1.27e-09

6-phosphofructokinase; Provisional


Pssm-ID: 240345 [Multi-domain]  Cd Length: 1419  Bit Score: 61.98  E-value: 1.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400   26 IGVLTSGGDAQGMNAAVRavvrmGIYTGAKVYFIYE---GYQGLVDG--GSNIVEAKWDCVSSILQVGG-TIIGSARCKA 99
Cdd:PTZ00287  180 IGIILSGGPAPGGHNVIS-----GIYDYAKRYNEQSqviGFLGGIDGlySKNYVTITDSLMNRFRNLGGfNMLWSGRGKV 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  100 fRSREGRLKAACNLARLGITNLCVIGGDGSLTGANLFRKEWSglleelarngdidndtvQKYSYLNVVGMVGSIDNDFC- 178
Cdd:PTZ00287  255 -RNKDDLIAIENIVAKLKLNGLVIIGGDGSNSNAALISEYFA-----------------ERQIPISIIGIPKTIDGDLKs 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  179 -GTDMTIGTDSALHRIIEVVDAIMTTAQS-HQRTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEE-----DWEENM 251
Cdd:PTZ00287  317 eAIEISFGFDTATKTYSEVIGNLCTDVKTgHNVYHVVRVMGRSASHVVLECALQTRPNIVLIGEEVEKEnlslkDIVSNI 396

                         250       260
                  ....*....|....*....|....*
gi 568981400  252 CLKLSENRARKKRLNIIIVSEGAID 276
Cdd:PTZ00287  397 VNTILKRRSLNKNYGVILIPEGLIE 421
PTZ00468 PTZ00468
phosphofructokinase family protein; Provisional
 24-276 1.70e-08

phosphofructokinase family protein; Provisional


Pssm-ID: 185647 [Multi-domain]  Cd Length: 1328  Bit Score: 58.06  E-value: 1.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400   24 KAIGVLTSGGDAQGMNAAVravvrMGIYTGAKVYFIYEGYQGLVDGGSNI-----VEAKWDCVSSILQVGG-TIIGSARC 97
Cdd:PTZ00468  103 RRIGVVLSGGQASGGHNVI-----AGLMSYIKLCNQSSQLFGFLGGPEGVyseryRELTEDDINGILNQGGfNIICSGRH 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400   98 KAfrSREGRLKAACNLA-RLGITNLCVIGGDGSLTGANLfrkewsgLLEELARNGdidndtvqkySYLNVVGMVGSIDND 176
Cdd:PTZ00468  178 KI--ETEEQMRASLEICeKLKLHGLVVIGGDDSNTNAAV-------LAEYFKRNS----------SSTVVVGCPKTIDGD 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  177 FCG--TDMTIGTDSALHRIIEVVDAIMTTAQSHQ-RTFVLEVMGRHCGYLALVSALTCGADWVFLPESPPEE-------- 245
Cdd:PTZ00468  239 LKNevIETSFGYDTAVKTYSEQIGSIMDAIKTEGyGYYFVRLMGRSASHITLECGLQTRANMILIGEEIKEEnrslmsiv 318

                         250       260       270
                  ....*....|....*....|....*....|.
gi 568981400  246 DWEENMCLKlseNRARKKRLNIIIVSEGAID 276
Cdd:PTZ00468  319 DEIVEMILK---RDSLGKKHGIVLLPEGLIE 346
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
412-647 5.30e-06

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 49.30  E-value: 5.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 412 VAVINVGAPAAGMNAAVRSAVRVGIAD-GHKMFAIYDGFEGFANG--QIKEIGWADVGGWTGQGGSILGTKR-------- 480
Cdd:PRK14071   7 IGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARppQYIELDLDQVDDLLRMGGTILGTTNkgdpfafp 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 481 ----TLPGKYLEkIAEQMHSHSINALLIIGG-------------------------------------FETC-------- 511
Cdd:PRK14071  87 mpdgSLRDRSQE-IIDGYHSLGLDALIGIGGdgslailrrlaqqgginlvgipktidndvgatevsigFDTAvniateal 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 512 DRIKQSASgTKRRVFIIETMGGYCGYLANMGALAAGADAAYIFEEPFDIGDLQSNVVHLTEKMKtsiQRGLVLRNESC-- 589
Cdd:PRK14071 166 DRLHFTAA-SHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYTLENVCKKIRERQEEGK---NFCLVVVSEAVrt 241

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568981400 590 ----SVNYTTDF-------IYQLYSEE--GKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISAKAMEWISA 647
Cdd:PRK14071 242 eegeQVTKTQALgedryggIGQYLAEQiaERTGAETRVTVLGHIQRGGIPSPRDRLLASAFGVAAVDLIAQ 312
PRK07085 PRK07085
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
 17-290 2.77e-05

diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional


Pssm-ID: 235930  Cd Length: 555  Bit Score: 47.22  E-value: 2.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  17 EHLSGDGKAIGVLTSGGDAQG-MNaavravVRMGIYTGAKVY--------FIyEGYQGLVDGgsNIVEAKWDCVSSILQV 87
Cdd:PRK07085  64 SESSSKPLKVGVILSGGQAPGgHN------VIAGLFDGLKKLnpdsklfgFI-GGPLGLLNG--KYIEITEEVIDEYRNT 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400  88 GG-TIIGSARCKaFRSREGRLKAACNLARLGITNLCVIGGDGSLTGANLfrkewsgLLEELARNGdidNDTVqkysylnV 166
Cdd:PRK07085 135 GGfDMIGSGRTK-IETEEQKEACLETVKKLKLDGLVIIGGDDSNTNAAI-------LAEYFAKHG---CKTQ-------V 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 167 VGMVGSIDNDFCGT--DMTIGTDSALHRIIEVVDAIMTTAQSHQRT--FVlEVMGRHCGYLALVSALTCGADWVFLpesp 242
Cdd:PRK07085 197 IGVPKTIDGDLKNEfiETSFGFDTATKTYSEMIGNISRDALSAKKYwhFI-KLMGRSASHIALECALQTHPNICLI---- 271

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568981400 243 PEEDWEENMCLK-LSE-------NRARK-KRLNIIIVSEGAIDMqnKPITSEKIKEL 290
Cdd:PRK07085 272 SEEVAEKKMSLQdIVHyiasviaDRAAKgKNYGVILIPEGLIEF--IPEMKSLIKEL 326
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
 412-507 1.09e-04

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 45.42  E-value: 1.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568981400 412 VAVINVGAPAAGMNAAVRSAVRVGIADGH--KMFAIYDGFEGFANGQIKEIGWADVGGWTGQGGSILGTKRTlpGKYLEK 489
Cdd:PTZ00286  90 AGIVTCGGLCPGLNVVIRELVMNLINNYGvkTIYGAKYGYKGLYKEDWIKLDPKDVKTIHRLGGTILGSSRG--GFDPKV 167

                         90
                 ....*....|....*...
gi 568981400 490 IAEQMHSHSINALLIIGG 507
Cdd:PTZ00286 168 MVDTLIRHGINILFTLGG 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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