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Conserved domains on  [gi|568982295|ref|XP_006516890|]
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F-box and WD-40 domain protein 17 isoform X1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1903264)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl43672
WD40 repeat [General function prediction only];
73-387 2.82e-05

WD40 repeat [General function prediction only];


The actual alignment was detected with superfamily member COG2319:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.06  E-value: 2.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982295  73 GHTGMIDQLAYvSPheyrfdeGARSVVcTVSSDCTVRAWDLQEGSEIWSSAVQPAPlVNVVAY-PQLQLVVTVDIQGLIM 151
Cdd:COG2319  118 GHTGAVRSVAF-SP-------DGKTLA-SGSADGTVRLWDLATGKLLRTLTGHSGA-VTSVAFsPDGKLLASGSDDGTVR 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982295 152 GWKAKTGSEWAFFSLPAScSSMEACDHPEGPFLLVACDEGT--LYTMTVPQLQVVSRVPTFPHSSVSLtcSPDTQWVfVS 229
Cdd:COG2319  188 LWDLATGKLLRTLTGHTG-AVRSVAFSPDGKLLASGSADGTvrLWDLATGKLLRTLTGHSGSVRSVAF--SPDGRLL-AS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982295 230 AqGSDLGPKVFytqpllHPSEDRLPVSTTLPIRLSSRACWAPDeaARLMVIHRDDGGVHLV-ITTFELKATKSRDRLSIL 308
Cdd:COG2319  264 G-SADGTVRLW------DLATGELLRTLTGHSGGVNSVAFSPD--GKLLASGSDDGTVRLWdLATGKLLRTLTGHTGAVR 334

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982295 309 A-------QQLASfhlpdtmtphlmqGHGSQTILLTSRSElvlftihGLQLMAFQDHQRPITSMWVDPD--RVITAALDL 379
Cdd:COG2319  335 SvafspdgKTLAS-------------GSDDGTVRLWDLAT-------GELLRTLTGHTGAVTSVAFSPDgrTLASGSADG 394


                 ....*...
gi 568982295 380 SLRvyVWN 387
Cdd:COG2319  395 TVR--LWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
73-387 2.82e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.06  E-value: 2.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982295  73 GHTGMIDQLAYvSPheyrfdeGARSVVcTVSSDCTVRAWDLQEGSEIWSSAVQPAPlVNVVAY-PQLQLVVTVDIQGLIM 151
Cdd:COG2319  118 GHTGAVRSVAF-SP-------DGKTLA-SGSADGTVRLWDLATGKLLRTLTGHSGA-VTSVAFsPDGKLLASGSDDGTVR 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982295 152 GWKAKTGSEWAFFSLPAScSSMEACDHPEGPFLLVACDEGT--LYTMTVPQLQVVSRVPTFPHSSVSLtcSPDTQWVfVS 229
Cdd:COG2319  188 LWDLATGKLLRTLTGHTG-AVRSVAFSPDGKLLASGSADGTvrLWDLATGKLLRTLTGHSGSVRSVAF--SPDGRLL-AS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982295 230 AqGSDLGPKVFytqpllHPSEDRLPVSTTLPIRLSSRACWAPDeaARLMVIHRDDGGVHLV-ITTFELKATKSRDRLSIL 308
Cdd:COG2319  264 G-SADGTVRLW------DLATGELLRTLTGHSGGVNSVAFSPD--GKLLASGSDDGTVRLWdLATGKLLRTLTGHTGAVR 334

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982295 309 A-------QQLASfhlpdtmtphlmqGHGSQTILLTSRSElvlftihGLQLMAFQDHQRPITSMWVDPD--RVITAALDL 379
Cdd:COG2319  335 SvafspdgKTLAS-------------GSDDGTVRLWDLAT-------GELLRTLTGHTGAVTSVAFSPDgrTLASGSADG 394


                 ....*...
gi 568982295 380 SLRvyVWN 387
Cdd:COG2319  395 TVR--LWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
73-387 2.82e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.06  E-value: 2.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982295  73 GHTGMIDQLAYvSPheyrfdeGARSVVcTVSSDCTVRAWDLQEGSEIWSSAVQPAPlVNVVAY-PQLQLVVTVDIQGLIM 151
Cdd:COG2319  118 GHTGAVRSVAF-SP-------DGKTLA-SGSADGTVRLWDLATGKLLRTLTGHSGA-VTSVAFsPDGKLLASGSDDGTVR 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982295 152 GWKAKTGSEWAFFSLPAScSSMEACDHPEGPFLLVACDEGT--LYTMTVPQLQVVSRVPTFPHSSVSLtcSPDTQWVfVS 229
Cdd:COG2319  188 LWDLATGKLLRTLTGHTG-AVRSVAFSPDGKLLASGSADGTvrLWDLATGKLLRTLTGHSGSVRSVAF--SPDGRLL-AS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982295 230 AqGSDLGPKVFytqpllHPSEDRLPVSTTLPIRLSSRACWAPDeaARLMVIHRDDGGVHLV-ITTFELKATKSRDRLSIL 308
Cdd:COG2319  264 G-SADGTVRLW------DLATGELLRTLTGHSGGVNSVAFSPD--GKLLASGSDDGTVRLWdLATGKLLRTLTGHTGAVR 334

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982295 309 A-------QQLASfhlpdtmtphlmqGHGSQTILLTSRSElvlftihGLQLMAFQDHQRPITSMWVDPD--RVITAALDL 379
Cdd:COG2319  335 SvafspdgKTLAS-------------GSDDGTVRLWDLAT-------GELLRTLTGHTGAVTSVAFSPDgrTLASGSADG 394


                 ....*...
gi 568982295 380 SLRvyVWN 387
Cdd:COG2319  395 TVR--LWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
71-230 3.81e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 3.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982295  71 ISGHTGMIDQLAYvSPheyrfdeGARSVVcTVSSDCTVRAWDLQEGSEIWSSAVQPAPlVNVVAY-PQLQLVVTVDIQGL 149
Cdd:COG2319  242 LTGHSGSVRSVAF-SP-------DGRLLA-SGSADGTVRLWDLATGELLRTLTGHSGG-VNSVAFsPDGKLLASGSDDGT 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568982295 150 IMGWKAKTGSEwaFFSLPASCSSMEACD-HPEGPFLLVACDEGTLYTMTVPQLQVVSRVPTFPHSSVSLTCSPDTQWVfV 228
Cdd:COG2319  312 VRLWDLATGKL--LRTLTGHTGAVRSVAfSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTL-A 388


                 ..
gi 568982295 229 SA 230
Cdd:COG2319  389 SG 390
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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