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Conserved domains on  [gi|568983831|ref|XP_006517537|]
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3-oxo-5-alpha-steroid 4-dehydrogenase 1 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Steroid_dh super family cl47745
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ...
 106-184 4.02e-34

3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.


The actual alignment was detected with superfamily member pfam02544:

Pssm-ID: 460585 [Multi-domain]  Cd Length: 150  Bit Score: 118.66  E-value: 4.02e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568983831  106 KPTLLFTFVLAFLFCTLNGYLQSRYLSQFAVYAEDWVTHPCFLTGFALWLVGMVINIHSDHILRNLRKPGETGYKIPRG 184
Cdd:pfam02544   1 ATMPLTIVAKAFAFCTLNGLIQGRYNSYYQPYAEDWVTDPRFLIGIGLFVTGMLINIKSDIILRTLRKPGNTGYKIPRG 79
ICMT super family cl21511
Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine ...
 18-184 2.41e-20

Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.


The actual alignment was detected with superfamily member PLN02392:

Pssm-ID: 473892  Cd Length: 260  Bit Score: 85.63  E-value: 2.41e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983831  18 FLAFVAFVGLQMVGSSYGRYSSQWSGRRVPARPAWFLQELPSMAWPLYecIRPAAARLGNLPNRVLLAMFLIHYVQRTLV 97
Cdd:PLN02392  18 LIGPPTFISLKFLQAPYGKHNRLGWGPTVSPPLAWFLMESPTLWLTLL--LFPLGQHFTNPKALLLMSPYLLHYFHRTCI 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983831  98 FPVLI------RGGKPTLLFTFVLAFLFCTLNGYLQSRYLSQF-AVYAEDWVTHPCFLTGFALWLVGMVINIHSDHILRN 170
Cdd:PLN02392  96 YPLRLyrstsqQNTKGFPVSMALLAFGFNLLNAYLQARWVSHYkDDYEDGGWFWWRFFGGLVVFLWGMRINVWSDRVLVG 175

                        170
                 ....*....|....
gi 568983831 171 LRKPGEtGYKIPRG 184
Cdd:PLN02392 176 LKREGG-GYKVPRG 188
 
Name Accession Description Interval E-value
Steroid_dh pfam02544
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ...
 106-184 4.02e-34

3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.


Pssm-ID: 460585 [Multi-domain]  Cd Length: 150  Bit Score: 118.66  E-value: 4.02e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568983831  106 KPTLLFTFVLAFLFCTLNGYLQSRYLSQFAVYAEDWVTHPCFLTGFALWLVGMVINIHSDHILRNLRKPGETGYKIPRG 184
Cdd:pfam02544   1 ATMPLTIVAKAFAFCTLNGLIQGRYNSYYQPYAEDWVTDPRFLIGIGLFVTGMLINIKSDIILRTLRKPGNTGYKIPRG 79
PLN02392 PLN02392
probable steroid reductase DET2
 18-184 2.41e-20

probable steroid reductase DET2


Pssm-ID: 178015  Cd Length: 260  Bit Score: 85.63  E-value: 2.41e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983831  18 FLAFVAFVGLQMVGSSYGRYSSQWSGRRVPARPAWFLQELPSMAWPLYecIRPAAARLGNLPNRVLLAMFLIHYVQRTLV 97
Cdd:PLN02392  18 LIGPPTFISLKFLQAPYGKHNRLGWGPTVSPPLAWFLMESPTLWLTLL--LFPLGQHFTNPKALLLMSPYLLHYFHRTCI 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983831  98 FPVLI------RGGKPTLLFTFVLAFLFCTLNGYLQSRYLSQF-AVYAEDWVTHPCFLTGFALWLVGMVINIHSDHILRN 170
Cdd:PLN02392  96 YPLRLyrstsqQNTKGFPVSMALLAFGFNLLNAYLQARWVSHYkDDYEDGGWFWWRFFGGLVVFLWGMRINVWSDRVLVG 175

                        170
                 ....*....|....
gi 568983831 171 LRKPGEtGYKIPRG 184
Cdd:PLN02392 176 LKREGG-GYKVPRG 188
PLN02560 PLN02560
enoyl-CoA reductase
 123-184 6.12e-06

enoyl-CoA reductase


Pssm-ID: 178174 [Multi-domain]  Cd Length: 308  Bit Score: 45.87  E-value: 6.12e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568983831 123 NGYLQSRYLSQFAVYAEDWVTHPCF--------LTGFALWLVGMVINIHSDHILRNLRKP-GETGYKIPRG 184
Cdd:PLN02560 162 NVFRNCAYYWTFGAYIAYFVNHPLYtpvsetqmKVGFGFGLVCQLANFYCHIILRNLRKPdGKGGYQIPRG 232
 
Name Accession Description Interval E-value
Steroid_dh pfam02544
3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid ...
 106-184 4.02e-34

3-oxo-5-alpha-steroid 4-dehydrogenase; This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalyzed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally. A related enzyme is also found in plants is DET2, a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development.


Pssm-ID: 460585 [Multi-domain]  Cd Length: 150  Bit Score: 118.66  E-value: 4.02e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568983831  106 KPTLLFTFVLAFLFCTLNGYLQSRYLSQFAVYAEDWVTHPCFLTGFALWLVGMVINIHSDHILRNLRKPGETGYKIPRG 184
Cdd:pfam02544   1 ATMPLTIVAKAFAFCTLNGLIQGRYNSYYQPYAEDWVTDPRFLIGIGLFVTGMLINIKSDIILRTLRKPGNTGYKIPRG 79
PLN02392 PLN02392
probable steroid reductase DET2
 18-184 2.41e-20

probable steroid reductase DET2


Pssm-ID: 178015  Cd Length: 260  Bit Score: 85.63  E-value: 2.41e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983831  18 FLAFVAFVGLQMVGSSYGRYSSQWSGRRVPARPAWFLQELPSMAWPLYecIRPAAARLGNLPNRVLLAMFLIHYVQRTLV 97
Cdd:PLN02392  18 LIGPPTFISLKFLQAPYGKHNRLGWGPTVSPPLAWFLMESPTLWLTLL--LFPLGQHFTNPKALLLMSPYLLHYFHRTCI 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568983831  98 FPVLI------RGGKPTLLFTFVLAFLFCTLNGYLQSRYLSQF-AVYAEDWVTHPCFLTGFALWLVGMVINIHSDHILRN 170
Cdd:PLN02392  96 YPLRLyrstsqQNTKGFPVSMALLAFGFNLLNAYLQARWVSHYkDDYEDGGWFWWRFFGGLVVFLWGMRINVWSDRVLVG 175

                        170
                 ....*....|....
gi 568983831 171 LRKPGEtGYKIPRG 184
Cdd:PLN02392 176 LKREGG-GYKVPRG 188
PLN02560 PLN02560
enoyl-CoA reductase
 123-184 6.12e-06

enoyl-CoA reductase


Pssm-ID: 178174 [Multi-domain]  Cd Length: 308  Bit Score: 45.87  E-value: 6.12e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568983831 123 NGYLQSRYLSQFAVYAEDWVTHPCF--------LTGFALWLVGMVINIHSDHILRNLRKP-GETGYKIPRG 184
Cdd:PLN02560 162 NVFRNCAYYWTFGAYIAYFVNHPLYtpvsetqmKVGFGFGLVCQLANFYCHIILRNLRKPdGKGGYQIPRG 232
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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