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Conserved domains on  [gi|568984475|ref|XP_006517716|]
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cell division cycle protein 20 homolog B isoform X3 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
244-533 1.84e-30

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.10  E-value: 1.84e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 244 LVAVALGTSVYIWNGQNHSWIENIDLSVccHYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLSVVGALSW 323
Cdd:COG2319   93 LASASADGTVRLWDLATGLLLRTLTGHT--GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 324 NH--CTLSSGSRLGRVHHHDVRVAQhRVGTLY-HKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAGVQGLPLKViPQ 400
Cdd:COG2319  171 SPdgKLLASGSDDGTVRLWDLATGK-LLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLTG-HS 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 401 STAVKLAFS--------------------RTPLPVLLL----GTLQAMEWCPwQSEVLAVGGGvkDGCLHVLDINTGKNI 456
Cdd:COG2319  247 GSVRSVAFSpdgrllasgsadgtvrlwdlATGELLRTLtghsGGVNSVAFSP-DGKLLASGSD--DGTVRLWDLATGKLL 323

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568984475 457 QTPS-TQSQICSLIWLPKTKEIATgqGAPKNDVALWTCPTLFRSGGFFGHRDRVLHLSLSPDQTRLFSAAADGTACVW 533
Cdd:COG2319  324 RTLTgHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
244-533 1.84e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.10  E-value: 1.84e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 244 LVAVALGTSVYIWNGQNHSWIENIDLSVccHYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLSVVGALSW 323
Cdd:COG2319   93 LASASADGTVRLWDLATGLLLRTLTGHT--GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 324 NH--CTLSSGSRLGRVHHHDVRVAQhRVGTLY-HKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAGVQGLPLKViPQ 400
Cdd:COG2319  171 SPdgKLLASGSDDGTVRLWDLATGK-LLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLTG-HS 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 401 STAVKLAFS--------------------RTPLPVLLL----GTLQAMEWCPwQSEVLAVGGGvkDGCLHVLDINTGKNI 456
Cdd:COG2319  247 GSVRSVAFSpdgrllasgsadgtvrlwdlATGELLRTLtghsGGVNSVAFSP-DGKLLASGSD--DGTVRLWDLATGKLL 323

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568984475 457 QTPS-TQSQICSLIWLPKTKEIATgqGAPKNDVALWTCPTLFRSGGFFGHRDRVLHLSLSPDQTRLFSAAADGTACVW 533
Cdd:COG2319  324 RTLTgHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 237-534 4.64e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.33  E-value: 4.64e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 237 LDWSSQN--LVAVALGTSVYIWNgqnhsWIENIDLSVCC-HY--VSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNL 311
Cdd:cd00200   15 VAFSPDGklLATGSGDGTIKVWD-----LETGELLRTLKgHTgpVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 312 HGHLSVVGALSWNHCT--LSSGSRLGRVHHHDVRVAQHRVGTLYHKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAG 389
Cdd:cd00200   90 TGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW--DLRTG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 390 VqglPLKVIPQSTavklafsrtplpvlllGTLQAMEWCPwQSEVLAVGGGvkDGCLHVLDINTGKNIQT-PSTQSQICSL 468
Cdd:cd00200  168 K---CVATLTGHT----------------GEVNSVAFSP-DGEKLLSSSS--DGTIKLWDLSTGKCLGTlRGHENGVNSV 225

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568984475 469 IWLPkTKEIATGqGAPKNDVALWTCPTLFRSGGFFGHRDRVLHLSLSPDQTRLFSAAADGTACVWK 534
Cdd:cd00200  226 AFSP-DGYLLAS-GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 354-382 2.63e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.63e-05
                           10        20
                   ....*....|....*....|....*....
gi 568984475   354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIW 382
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
354-382 9.94e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 9.94e-05
                          10        20
                  ....*....|....*....|....*....
gi 568984475  354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIW 382
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
244-533 1.84e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.10  E-value: 1.84e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 244 LVAVALGTSVYIWNGQNHSWIENIDLSVccHYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLSVVGALSW 323
Cdd:COG2319   93 LASASADGTVRLWDLATGLLLRTLTGHT--GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 324 NH--CTLSSGSRLGRVHHHDVRVAQhRVGTLY-HKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAGVQGLPLKViPQ 400
Cdd:COG2319  171 SPdgKLLASGSDDGTVRLWDLATGK-LLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLW--DLATGKLLRTLTG-HS 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 401 STAVKLAFS--------------------RTPLPVLLL----GTLQAMEWCPwQSEVLAVGGGvkDGCLHVLDINTGKNI 456
Cdd:COG2319  247 GSVRSVAFSpdgrllasgsadgtvrlwdlATGELLRTLtghsGGVNSVAFSP-DGKLLASGSD--DGTVRLWDLATGKLL 323

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568984475 457 QTPS-TQSQICSLIWLPKTKEIATgqGAPKNDVALWTCPTLFRSGGFFGHRDRVLHLSLSPDQTRLFSAAADGTACVW 533
Cdd:COG2319  324 RTLTgHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
237-533 5.09e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.00  E-value: 5.09e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 237 LDWSSQNLVAVALGTSVYIWNGQNHSWIENIDLSVCCHYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLS 316
Cdd:COG2319   42 LAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 317 VVGALSW--NHCTLSSGSRLGRVHHHDVRVAQhRVGTLY-HKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAGVQGL 393
Cdd:COG2319  122 AVRSVAFspDGKTLASGSADGTVRLWDLATGK-LLRTLTgHSGAVTSVAFSPDGKLLASGSDDGTVRLW--DLATGKLLR 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 394 PLKViPQSTAVKLAFS--------------------RTPLPVLLL----GTLQAMEWCPwQSEVLAVGGGvkDGCLHVLD 449
Cdd:COG2319  199 TLTG-HTGAVRSVAFSpdgkllasgsadgtvrlwdlATGKLLRTLtghsGSVRSVAFSP-DGRLLASGSA--DGTVRLWD 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 450 INTGKNIQTPSTQSQ-ICSLIWLPKTKEIATGQGApkNDVALWTCPTLFRSGGFFGHRDRVLHLSLSPDQTRLFSAAADG 528
Cdd:COG2319  275 LATGELLRTLTGHSGgVNSVAFSPDGKLLASGSDD--GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDG 352


                 ....*
gi 568984475 529 TACVW 533
Cdd:COG2319  353 TVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 237-534 4.64e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.33  E-value: 4.64e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 237 LDWSSQN--LVAVALGTSVYIWNgqnhsWIENIDLSVCC-HY--VSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNL 311
Cdd:cd00200   15 VAFSPDGklLATGSGDGTIKVWD-----LETGELLRTLKgHTgpVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 312 HGHLSVVGALSWNHCT--LSSGSRLGRVHHHDVRVAQHRVGTLYHKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAG 389
Cdd:cd00200   90 TGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLW--DLRTG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 390 VqglPLKVIPQSTavklafsrtplpvlllGTLQAMEWCPwQSEVLAVGGGvkDGCLHVLDINTGKNIQT-PSTQSQICSL 468
Cdd:cd00200  168 K---CVATLTGHT----------------GEVNSVAFSP-DGEKLLSSSS--DGTIKLWDLSTGKCLGTlRGHENGVNSV 225

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568984475 469 IWLPkTKEIATGqGAPKNDVALWTCPTLFRSGGFFGHRDRVLHLSLSPDQTRLFSAAADGTACVWK 534
Cdd:cd00200  226 AFSP-DGYLLAS-GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
276-533 1.35e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.13  E-value: 1.35e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 276 VSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLSVVG--ALSWNHCTLSSGSRLGRVHHHDVRVAQHRVGTLY 353
Cdd:COG2319   39 VASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLsvAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIWphDPGAGVQGLPLKViPQSTAVKLAFSRtplpvlllgtlqamewcpwQSEV 433
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSADGTVRLW--DLATGKLLRTLTG-HSGAVTSVAFSP-------------------DGKL 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 434 LAVGGGvkDGCLHVLDINTGKNIQT-PSTQSQICSLIWLPKTKEIATgqGAPKNDVALWTCPTLFRSGGFFGHRDRVLHL 512
Cdd:COG2319  177 LASGSD--DGTVRLWDLATGKLLRTlTGHTGAVRSVAFSPDGKLLAS--GSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252

                        250       260
                 ....*....|....*....|.
gi 568984475 513 SLSPDQTRLFSAAADGTACVW 533
Cdd:COG2319  253 AFSPDGRLLASGSADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 274-533 2.13e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.55  E-value: 2.13e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 274 HYVSSVTWMREGSCLAVGTSEGEVQLWDAITKKQLRNLHGHLSVVGALSW--NHCTLSSGSRlgrvhHHDVRV----AQH 347
Cdd:cd00200   10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSS-----DKTIRLwdleTGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 348 RVGTLY-HKEAVCSLKWSPDGRLLSSGCNDGLLTIWPhdpgaGVQGLPLKVIP--QSTAVKLAFSRTplpvlllGTLqam 424
Cdd:cd00200   85 CVRTLTgHTSYVSSVAFSPDGRILSSSSRDKTIKVWD-----VETGKCLTTLRghTDWVNSVAFSPD-------GTF--- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 425 ewcpwqsevlaVGGGVKDGCLHVLDINTGKNIQT-PSTQSQICSLIWLPKTKEIATgqGAPKNDVALWTCPTLFRSGGFF 503
Cdd:cd00200  150 -----------VASSSQDGTIKLWDLRTGKCVATlTGHTGEVNSVAFSPDGEKLLS--SSSDGTIKLWDLSTGKCLGTLR 216

                        250       260       270
                 ....*....|....*....|....*....|
gi 568984475 504 GHRDRVLHLSLSPDQTRLFSAAADGTACVW 533
Cdd:cd00200  217 GHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
288-533 1.90e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 72.25  E-value: 1.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 288 LAVGTSEGEVQLWDAITKKQLRNLHGHLSVVGALSWNHC--TLSSGSRLGRVHHHDVRVAQHRVGTLYHKEAVCSLKWSP 365
Cdd:COG2319    9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDgaRLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 366 DGRLLSSGCNDGLLTIWPHDPGAGVQGLplkVIPQSTAVKLAFSRtplpvlllgtlqamewcpwQSEVLAVGGGvkDGCL 445
Cdd:COG2319   89 DGRLLASASADGTVRLWDLATGLLLRTL---TGHTGAVRSVAFSP-------------------DGKTLASGSA--DGTV 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 446 HVLDINTGKNIQTPST-QSQICSLIWLPKTKEIATGQGApkNDVALWTCPTLFRSGGFFGHRDRVLHLSLSPDQTRLFSA 524
Cdd:COG2319  145 RLWDLATGKLLRTLTGhSGAVTSVAFSPDGKLLASGSDD--GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASG 222


                 ....*....
gi 568984475 525 AADGTACVW 533
Cdd:COG2319  223 SADGTVRLW 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 354-533 5.55e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.51  E-value: 5.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIWPHDPGAGVQGLPLKVIPQSTAVklafsrtplpvlllgtlqameWCPWQSEV 433
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVA---------------------ASADGTYL 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568984475 434 LAVGggvKDGCLHVLDINTGKNIQT-PSTQSQICSLIWLPKTKEIATGQGApkNDVALWTCPTLFRSGGFFGHRDRVLHL 512
Cdd:cd00200   67 ASGS---SDKTIRLWDLETGECVRTlTGHTSYVSSVAFSPDGRILSSSSRD--KTIKVWDVETGKCLTTLRGHTDWVNSV 141

                        170       180
                 ....*....|....*....|.
gi 568984475 513 SLSPDQTRLFSAAADGTACVW 533
Cdd:cd00200  142 AFSPDGTFVASSSQDGTIKLW 162
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 354-382 2.63e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.63e-05
                           10        20
                   ....*....|....*....|....*....
gi 568984475   354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIW 382
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
354-382 9.94e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 9.94e-05
                          10        20
                  ....*....|....*....|....*....
gi 568984475  354 HKEAVCSLKWSPDGRLLSSGCNDGLLTIW 382
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 502-534 1.50e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.50e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568984475   502 FFGHRDRVLHLSLSPDQTRLFSAAADGTACVWK 534
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
502-533 4.35e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.35e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 568984475  502 FFGHRDRVLHLSLSPDQTRLFSAAADGTACVW 533
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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