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Conserved domains on  [gi|568987407|ref|XP_006518945|]
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homeobox-containing protein 1 isoform X1 [Mus musculus]

Protein Classification

HTH_XRE and homeodomain domain-containing protein( domain architecture ID 11153336)

HTH_XRE and homeodomain domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HNF-1_N pfam04814
Hepatocyte nuclear factor 1 (HNF-1), N-terminus; This family consists of the N-terminus of ...
25-227 6.64e-58

Hepatocyte nuclear factor 1 (HNF-1), N-terminus; This family consists of the N-terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


:

Pssm-ID: 428137  Cd Length: 178  Bit Score: 188.10  E-value: 6.64e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987407   25 EQIDLLQRLRRTGMTKHEILHALETLDRLDQEHSDK-FGRRSSYGGSSYG-----NSTNNVPASSSTATASTQTQHSGMS 98
Cdd:pfam04814   1 LQIELLQRLLRSGLTKEELIHALEDLEPLDPEFGVKlESLPLSPGGSCDSkpvfpTLANGHGPSSSSSSSSTSKLSGDEG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987407   99 PSPSNSYDTSPLPCTTNQNGRENNdrlstsngkmspsryhansmgqrsysfeasEEDLDVDDKVEELMRRDSSVIKEEIK 178
Cdd:pfam04814  81 SSDGNDFDTPPILDLGKELGRLDP------------------------------EEAAHQRAEVEELLREDPWRVAEMIK 130
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 568987407  179 AFLANRRISQAVVAQVTGISQSRISHWLLqQGSDLSEQKKRAFYRWYQL 227
Cdd:pfam04814 131 GYLQQHNIPQREVVDVTGLNQSHLSQHLN-KGTPMKTQKRAALYTWYVR 178
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
268-340 2.44e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039  Cd Length: 59  Bit Score: 55.71  E-value: 2.44e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568987407 268 RGSRFTWRKECLAVMESYFNENQYPDEAKREEIANACNaviqkpgkklsdlerVTSLKVYNWFANRRKEIKRR 340
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELG---------------LTERQVKIWFQNRRAKLKRS 58
 
Name Accession Description Interval E-value
HNF-1_N pfam04814
Hepatocyte nuclear factor 1 (HNF-1), N-terminus; This family consists of the N-terminus of ...
25-227 6.64e-58

Hepatocyte nuclear factor 1 (HNF-1), N-terminus; This family consists of the N-terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


Pssm-ID: 428137  Cd Length: 178  Bit Score: 188.10  E-value: 6.64e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987407   25 EQIDLLQRLRRTGMTKHEILHALETLDRLDQEHSDK-FGRRSSYGGSSYG-----NSTNNVPASSSTATASTQTQHSGMS 98
Cdd:pfam04814   1 LQIELLQRLLRSGLTKEELIHALEDLEPLDPEFGVKlESLPLSPGGSCDSkpvfpTLANGHGPSSSSSSSSTSKLSGDEG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987407   99 PSPSNSYDTSPLPCTTNQNGRENNdrlstsngkmspsryhansmgqrsysfeasEEDLDVDDKVEELMRRDSSVIKEEIK 178
Cdd:pfam04814  81 SSDGNDFDTPPILDLGKELGRLDP------------------------------EEAAHQRAEVEELLREDPWRVAEMIK 130
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 568987407  179 AFLANRRISQAVVAQVTGISQSRISHWLLqQGSDLSEQKKRAFYRWYQL 227
Cdd:pfam04814 131 GYLQQHNIPQREVVDVTGLNQSHLSQHLN-KGTPMKTQKRAALYTWYVR 178
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
268-340 2.44e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039  Cd Length: 59  Bit Score: 55.71  E-value: 2.44e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568987407 268 RGSRFTWRKECLAVMESYFNENQYPDEAKREEIANACNaviqkpgkklsdlerVTSLKVYNWFANRRKEIKRR 340
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELG---------------LTERQVKIWFQNRRAKLKRS 58
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
267-338 1.34e-08

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 50.71  E-value: 1.34e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568987407   267 RRGSRFTWRKECLAVMESYFNENQYPDEAKREEIANACNaviqkpgkkLSdlERVtslkVYNWFANRRKEIK 338
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLG---------LS--ERQ----VKVWFQNRRAKWK 57
Homeobox pfam00046
Homeobox domain;
271-334 5.37e-08

Homeobox domain;


Pssm-ID: 425441  Cd Length: 54  Bit Score: 49.04  E-value: 5.37e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568987407  271 RFTwrKECLAVMESYFNENQYPDEAKREEIANACNaviqkpgkkLSdlERVtslkVYNWFANRR 334
Cdd:pfam00046   4 TFT--PEQLEELEKEFQENPYPSREEREELAAQLG---------LT--ERQ----VKVWFQNRR 50
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
175-205 7.88e-03

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 34.45  E-value: 7.88e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 568987407 175 EEIKAFLANRRISQAVVAQVTGISQSRISHW 205
Cdd:cd00093    2 ERLKELRKEKGLTQEELAEKLGVSRSTISRI 32
 
Name Accession Description Interval E-value
HNF-1_N pfam04814
Hepatocyte nuclear factor 1 (HNF-1), N-terminus; This family consists of the N-terminus of ...
25-227 6.64e-58

Hepatocyte nuclear factor 1 (HNF-1), N-terminus; This family consists of the N-terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


Pssm-ID: 428137  Cd Length: 178  Bit Score: 188.10  E-value: 6.64e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987407   25 EQIDLLQRLRRTGMTKHEILHALETLDRLDQEHSDK-FGRRSSYGGSSYG-----NSTNNVPASSSTATASTQTQHSGMS 98
Cdd:pfam04814   1 LQIELLQRLLRSGLTKEELIHALEDLEPLDPEFGVKlESLPLSPGGSCDSkpvfpTLANGHGPSSSSSSSSTSKLSGDEG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987407   99 PSPSNSYDTSPLPCTTNQNGRENNdrlstsngkmspsryhansmgqrsysfeasEEDLDVDDKVEELMRRDSSVIKEEIK 178
Cdd:pfam04814  81 SSDGNDFDTPPILDLGKELGRLDP------------------------------EEAAHQRAEVEELLREDPWRVAEMIK 130
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 568987407  179 AFLANRRISQAVVAQVTGISQSRISHWLLqQGSDLSEQKKRAFYRWYQL 227
Cdd:pfam04814 131 GYLQQHNIPQREVVDVTGLNQSHLSQHLN-KGTPMKTQKRAALYTWYVR 178
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
268-340 2.44e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039  Cd Length: 59  Bit Score: 55.71  E-value: 2.44e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568987407 268 RGSRFTWRKECLAVMESYFNENQYPDEAKREEIANACNaviqkpgkklsdlerVTSLKVYNWFANRRKEIKRR 340
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELG---------------LTERQVKIWFQNRRAKLKRS 58
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
267-338 1.34e-08

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 50.71  E-value: 1.34e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568987407   267 RRGSRFTWRKECLAVMESYFNENQYPDEAKREEIANACNaviqkpgkkLSdlERVtslkVYNWFANRRKEIK 338
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLG---------LS--ERQ----VKVWFQNRRAKWK 57
Homeobox pfam00046
Homeobox domain;
271-334 5.37e-08

Homeobox domain;


Pssm-ID: 425441  Cd Length: 54  Bit Score: 49.04  E-value: 5.37e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568987407  271 RFTwrKECLAVMESYFNENQYPDEAKREEIANACNaviqkpgkkLSdlERVtslkVYNWFANRR 334
Cdd:pfam00046   4 TFT--PEQLEELEKEFQENPYPSREEREELAAQLG---------LT--ERQ----VKVWFQNRR 50
HTH_37 pfam13744
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain.
164-217 2.92e-03

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain.


Pssm-ID: 433449 [Multi-domain]  Cd Length: 80  Bit Score: 36.43  E-value: 2.92e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568987407  164 ELMRRdssvIKEEIKAflanRRISQAVVAQVTGISQSRISHWLLQQGSDLSEQK 217
Cdd:pfam13744  18 QLARA----IARLIEG----RGLSQQEAAALLGIAQPKVSALLKGKLSRFSLDK 63
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
175-205 7.88e-03

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 34.45  E-value: 7.88e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 568987407 175 EEIKAFLANRRISQAVVAQVTGISQSRISHW 205
Cdd:cd00093    2 ERLKELRKEKGLTQEELAEKLGVSRSTISRI 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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