NCBI Conserved Domain Search

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 206.49 E-value: 2.96e-62

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  914 LTDFSSEMPCLAEYADGLWYRAKIISIKEFNPLSVLVLFVDYGCTEKLTINRLRQIPVQLMQYPAQAIKVLLAGFKPPLS 993
Cdd:cd20418     1 LTDFRPEMPCLAEYSDGKWYRAKLLSILEFNPVKILVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPPLN 80

                          90       100
                  ....*....|....*....|....*
gi 568987884  994 DSGKTRIPYCPKWSMEALWTMIDCL 1018
Cdd:cd20418    81 DSETERIPYCPEWSMKALWAMIDLL 105

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 172.23 E-value: 2.87e-50

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  148 FLSLLKTIEEFYKGEDGENLEILCPLQNQACVAKFEDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFL 227
Cdd:cd20415     1 FLILTKKIQEFYKEGDDGGLEILCPVQGQACVALFEDGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKDDFL 80

                          90
                  ....*....|....*.
gi 568987884  228 EPPEKAIKCKLAYVEP 243
Cdd:cd20415    81 SLPEKARECRLAFIEP 96

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410488 Cd Length: 68 Bit Score: 141.80 E-value: 5.13e-40

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568987884  667 WKKGEPCAVRGSDTLWYRGKVMEVVGGTIRVQYLDHGFTEKIPQCHLYPILLYPDTPQFCIPCQLYQT 734
Cdd:cd20417     1 WKKGEGCVVRGSDTLWYRGKVLEVIGGMVRVQYVDQGYIEKIPQCHLYPMVLYPDIPQFCIPCQLYGT 68

third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410487 Cd Length: 82 Bit Score: 136.08 E-value: 8.75e-38

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  388 LEEKMVAAYEHSEWKPVKWECDMHCAVKVPAKNQWRRGQILRMVTDKLVEVLLYDVGVELVVNIHCLRELQENLKTMGRL 467
Cdd:cd20416     1 LQEKMIAEYENSKPEPVKWENDMHCAVQIQDKKQWRRGQIIRVVSDTLVEVFLYDFGNKEVVNIDCLRKLEENLKTIGKL 80


                  ..
gi 568987884  468 SL 469
Cdd:cd20416    81 AL 82

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 95.50 E-value: 3.79e-23

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884   619 SSFEAIVTCIGDDGTIFVVPKLSEFELIKMMDEIQSNLKCLGLLEPYSWKKGEPCAVRGSDTLWYRGKVMEVV-GGTIRV 697
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLdDGLVEV 80

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 568987884   698 QYLDHGFTEKIPQCHLYPILLYPD-TPQFCIPCQLY 732
Cdd:pfam00567   81 LFIDYGNTETVPLSDLRPLPPELEsLPPQAIKCQLA 116

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 87.02 E-value: 3.39e-20

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884   126 SVMVCHINSPTDFYLQLMENL-DFLSLLKTIEEFYKgEDGENLEILCPLQNQACVAKfEDGIWYRAKVIGLPGHREVEVK 204
Cdd:pfam00567    4 DVVVSHIESPSTFYIQPKSDSkKLEKLTEELQEYYA-SKPPESLPPAVGDGCVAAFS-EDGKWYRAKITESLDDGLVEVL 81

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 568987884   205 YVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLA 239
Cdd:pfam00567   82 FIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLA 116

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 84.46 E-value: 3.86e-19

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  125 VSVMVCHINSPTDFYLQLMENL-DFLSLLKTIEEFYK--GEDGENLEIlcplqnqACVAKF-EDGIWYRAKVIGLPGHRE 200
Cdd:cd20439    12 VDVKCSYVNSPGDFWCQLQTKSsELKSLMKQIQSYYLihNDPYKHGQI-------ACVAKYsKDGKWYRAAVLKQVSAKE 84

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 568987884  201 VEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKL 238
Cdd:cd20439    85 VDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSL 122

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 77.50 E-value: 1.09e-16

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  123 TEVSVMVCHINSPTDFYLQLMENLDFLS-LLKTIEEFYKGEDGEnleILCPLQNQACVAK-FEDGIWYRAKVIGLPGHRE 200
Cdd:cd20440    10 SEEEVYITHVYSPAKFYCQLDRNTEILEaLMEKIAEISKLFNSQ---ILDNCKTRLCLAKyFEDGQWYRALAHPVESSSH 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 568987884  201 VEVKYVDFGNTAKITLKDMRKIKDEFLE---PPEKAIKCKL 238
Cdd:cd20440    87 LSVYFVDYGNKQIVEKNEVLPIPDTAVDlllTPMQAIKCCL 127

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 70.36 E-value: 3.45e-14

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  879 HHGDTDDSGVSWESESENLEEALQRFNKNvetfpPLTDFSSEMP-----CLAEYADGLWYRAKIISIKEFN----PLSVL 949
Cdd:cd20435    12 HRSSDGEVTKSMSSTYLKLSMKLNMYYSD-----PSNRILHGKVkvgdlCAVEDENNLYHRVKVLEITEKDdktkPREVL 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 568987884  950 VLFVDYGCTEKLTINRLRQIPVQLMQYPAQAIKVLLAGFKPP 991
Cdd:cd20435    87 VKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVKPV 128

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 67.76 E-value: 1.80e-13

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884   895 ENLEEALQRFNKNVEtfPPLTDFSSEMPCLAEYA-DGLWYRAKIISIKEfNPLsVLVLFVDYGCTEKLTINRLRQIPVQL 973
Cdd:pfam00567   28 EKLTEELQEYYASKP--PESLPPAVGDGCVAAFSeDGKWYRAKITESLD-DGL-VEVLFIDYGNTETVPLSDLRPLPPEL 103

                           90
                   ....*....|....
gi 568987884   974 MQYPAQAIKVLLAG 987
Cdd:pfam00567  104 ESLPPQAIKCQLAG 117

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 67.78 E-value: 2.61e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  127 VMVCHINSPTDFYLQLM--ENLDFLSLLKT-IEEFYKGEDGENLEIlcPLQNQACVAKF-EDGIWYRAKVIGL-PGHREV 201
Cdd:cd20408     1 GTVTEFKNPGEFYIQIYtlEVLESLVKLTSqLKKTYASVNNHKEYI--PEVGEVCVAKYsEDQNWYRALVQTVdVQQKKA 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 568987884  202 EVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEPSKKSqWS 250
Cdd:cd20408    79 GVFYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGS-WS 126

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 67.10 E-value: 3.26e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  125 VSVMVCHINSPTDFYLQLMENLDFLSLLKTIEEFYKGEDGENLEILCPLQNQACVAKFEDGIWYRAKVIGLPGHREVEVK 204
Cdd:cd20425     2 TEVYVSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEVECESLQLGDLICAEYPEDGLWYRAVVKEKIPNNLVSVQ 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 568987884  205 YVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKL 238
Cdd:cd20425    82 FIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 67.54 E-value: 3.88e-13

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  127 VMVCHINSPTDFYLQLMEN-LDFLSLLKTIEEFYKGEDGENLEILCPLQNQACVAKFEDGIWYRAKVIGLPGhREVEVKY 205
Cdd:cd20422     4 AQVEFVKDPSEFWIRLGEHaVPFSKLMRSMTAFYSQASKLDGVVLKPQPGQLCCAKWKEDRYYRAIVTAVKG-KMVEVFL 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 568987884  206 VDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEPSKKSqWS 250
Cdd:cd20422    83 VDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGER-WS 126

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 64.07 E-value: 5.73e-13

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 568987884  175 NQACVAKFE-DGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKI 222
Cdd:cd20379     2 GDLCAAKYEeDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50

Tudor domain;

Pssm-ID: 425754 [Multi-domain] Cd Length: 117 Bit Score: 63.91 E-value: 4.19e-12

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884   363 VNICNVISPEKIYVQWLLTENLLNSLEEKMVAAYEHSEWKPVKWECDMHCAVKVPAKNQWRRGQILRMVTDKLVEVLLYD 442
Cdd:pfam00567    5 VVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVEVLFID 84

                           90       100       110
                   ....*....|....*....|....*....|.
gi 568987884   443 VGVELVVNIHCLRELQENLKTMGRLSLECSL 473
Cdd:pfam00567   85 YGNTETVPLSDLRPLPPELESLPPQAIKCQL 115

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 61.91 E-value: 4.46e-12

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 568987884    175 NQACVAKFEDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEF 226
Cdd:smart00333    6 GDKVAARWEDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPEEL 57

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 62.85 E-value: 9.91e-12

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568987884  172 PLQNQACVAKFE-DGIWYRAKVIGLpGHREVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLA 239
Cdd:cd20411    48 PRIGDACCARFTgDKNWYRAVVLET-SDSEVKVLYADYGNTETLPLSRILPITKSHLELPFQIIRCSLA 115

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 62.52 E-value: 1.61e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  124 EVSVMVCHINSPTDFYLQLMENLDFLSLLK-TIEEFYKgedgENLEILCPLQ-NQACVAKFEDGIWYRAKVIGLPghREV 201
Cdd:cd20424    13 EEEVYITYVNDPWTFYCQLARNAGVLDQLAsAISRLSS----EIRKLELSVNpGTLCLAKYSDQHWYRGIIITNK--NST 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 568987884  202 EVKYVDFGNTAKITLKDMRKIKD---EFLEPPEKAIKCKL 238
Cdd:cd20424    87 EVFFVDYGNTEKVEKEDMLPIPSdayELLLLPMQAIKCSL 126

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 60.68 E-value: 2.06e-11

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568987884  178 CVAKFEDGiWYRAKVIG-LPGHREVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEP 243
Cdd:cd20407    11 CAAPVMNA-WYRAQVVGvFEETDEVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410489 Cd Length: 105 Bit Score: 61.27 E-value: 3.03e-11

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568987884  178 CVAKFEDGIWYRAKVIGLPGHREVE--VKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEP 243
Cdd:cd20418    10 CLAEYSDGKWYRAKLLSILEFNPVKilVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKP 77

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410511 Cd Length: 127 Bit Score: 60.55 E-value: 8.89e-11

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  853 VQVKHIVSPDEMYICLDSEdsytqfnhhgdtddsgvsweseSENLEEALQRFNKNVETFP-PLTDFSSEMPCLAEY-ADG 930
Cdd:cd20440    14 VYITHVYSPAKFYCQLDRN----------------------TEILEALMEKIAEISKLFNsQILDNCKTRLCLAKYfEDG 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568987884  931 LWYRAKIISIKefNPLSVLVLFVDYGCTEKLTINRLRQIP---VQLMQYPAQAIKVLL 985
Cdd:cd20440    72 QWYRALAHPVE--SSSHLSVYFVDYGNKQIVEKNEVLPIPdtaVDLLLTPMQAIKCCL 127

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 58.65 E-value: 1.22e-10

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568987884  173 LQNQACVAKF-EDGIWYRAKVIGLPGHRE-VEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKL 238
Cdd:cd20423     4 LPNPVCLAKYsEDGKWCRALIDNVYEPVEmVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSL 71

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 59.37 E-value: 1.37e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  134 SPTDFYLQLMENLDflSLLKTIEEFYKG--EDGENLEILCpLQNQACVAKF-EDGIWYRAKVIGLPGHREVEVKYVDFGN 210
Cdd:cd20441     1 SPSRFFIQLSEDEK--VILQLAEELNETseKSRENAAVKL-KVGDLVAAEYdEDLALYRAVITAVLPGKSFKVEFIDYGN 77

                          90       100       110
                  ....*....|....*....|....*....|.
gi 568987884  211 TAKITLKDMRKIKDEFLEPPEKAIKCKLAYV 241
Cdd:cd20441    78 TAVVDKSNIYTLQEKFLSLPRLSIPCSLSGV 108

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410478 Cd Length: 76 Bit Score: 56.83 E-value: 4.35e-10

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568987884  923 CLAeYADGLWYRAKIISIKEfNPLSVLVLFVDYGCTEKLTINRLRQIPVQLMQYPAQAIKVLLAGFKP 990
Cdd:cd20407    11 CAA-PVMNAWYRAQVVGVFE-ETDEVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410494 Cd Length: 80 Bit Score: 57.11 E-value: 4.64e-10

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568987884  921 MPCLAEYA-DGLWYRAKIISIKEfNPLSVLVLFVDYGCTEKLTINRLRQIPVQLMQYPAQAIKVLLAGFKPP 991
Cdd:cd20423     7 PVCLAKYSeDGKWCRALIDNVYE-PVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQP 77

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 57.86 E-value: 5.37e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  138 FYLQLMENLDFLSLLKTIEEfYKGEDGENLE-ILCPLQNQACVAKFE-DGIWYRAKVIGLP------GHREVEVKYVDFG 209
Cdd:cd20443     4 FYVQVVSDQRLSSIQQQLEG-LSLKDKANPPgGFNPKKGELVLAQFSaDNSWNRAMVVNAPrqgtqsPKDEYEVFYIDYG 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 568987884  210 NTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEP 243
Cdd:cd20443    83 NQETVPLSALRPLDPSVSSAPGLAQLCSLAHIKV 116

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 57.81 E-value: 5.70e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  123 TEVSVMVCHINSPTDFYLQLME-NLDFLSLLKTIEEFYKGEDGENLEilcPLQN--QACVAKFEDGIWYRAKVIGLPGHR 199
Cdd:cd20437     3 TTEKVKITAAVSPSKFYCQLLSwEPELSKLTTQMTLHYESVSKELNP---SCENfgLLCAAKGKDGQWHRGFLQQLLPPS 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 568987884  200 EVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLA 239
Cdd:cd20437    80 QVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSLS 119

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 56.67 E-value: 7.88e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  898 EEALQRFNKNVETFPPLTDfsseMPCLAEYADGLWYRAKIISIKEFNplSVLVLFVDYGCTEKLTINRLRQIPVQLMQYP 977
Cdd:cd20415    10 EFYKEGDDGGLEILCPVQG----QACVALFEDGAWYRARIIGLPGHR--EVEVKYVDFGNTATVTIKHVRKIKDDFLSLP 83

                          90
                  ....*....|...
gi 568987884  978 AQAIKVLLAGFKP 990
Cdd:cd20415    84 EKARECRLAFIEP 96

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 55.21 E-value: 8.17e-10

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 568987884  921 MPCLAEY-ADGLWYRAKIISIKEFNplSVLVLFVDYGCTEKLTINRLRQI 969
Cdd:cd20379     3 DLCAAKYeEDGKWYRARVLEVLSND--KVEVFFVDYGNTETVPLSDLRPL 50

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 55.92 E-value: 9.88e-10

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  895 ENLEEALQRFNKNVETFPPLTDFSSEM--PCLAEY-ADGLWYRAKIISIKefNPLSVLVLFVDYGCTEKLTINRLRQIPV 971
Cdd:cd20409     2 RQLAELQESLSAYCKVAPASSDFSPAVgeVCCAQFtEDNQWYRASVLAYS--SEDSVLVGYIDFGNSEEVALSRLRPIPP 79


                  ...
gi 568987884  972 QLM 974
Cdd:cd20409    80 SLL 82

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 57.51 E-value: 1.27e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  132 INSPTDFYLQL-MENLDFLSllKTIEEFYKGEDGENLEILCPLQNQACVAKF-EDGIWYRAKVIGLPGHReVEVKYVDFG 209
Cdd:cd20426     8 VDSPEYFWCQFaTEKIQCLA--VKVQEAGEQVADRGNFIPSIYVGDPCIVKYsEDNHWYRALVTKINDNL-VSVRFVDYG 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 568987884  210 NTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEPSKKSqWS 250
Cdd:cd20426    85 NEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEGL-WS 124

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 54.44 E-value: 1.44e-09

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 568987884  669 KGEPCAVRGSDT-LWYRGKVMEVV-GGTIRVQYLDHGFTEKIPQCHLYPI 716
Cdd:cd20379     1 VGDLCAAKYEEDgKWYRARVLEVLsNDKVEVFFVDYGNTETVPLSDLRPL 50

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 55.38 E-value: 1.56e-09

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 568987884  178 CVAKF-EDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEF 226
Cdd:cd20433    34 CAAKFvEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALPPAF 83

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 57.10 E-value: 2.06e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  129 VCHINSPTDFYLQLME-NLDFLSLLKTIEEFYKGEDGENLEILCPLQNQACVAKF-EDGIWYRAKVIGLPGHrEVEVKYV 206
Cdd:cd20438    11 VEYVLNPSNFWIRTDEyNNEFQALMKNIADIYNLCGNDEELLKKPEPGLLCCARYsKDRHYYRAVITEVLDL-KVSVYFL 89

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 568987884  207 DFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEP 243
Cdd:cd20438    90 DFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAHVFP 126

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 54.22 E-value: 5.39e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  146 LDflSLLKTIEEFYkgEDGENLEILCPLQ-NQACVAKFE-DGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIK 223
Cdd:cd20412     6 LD--KLVQEMTQYY--ESEENRHTLLTVQvGDIVAAPFRhDGSWYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRALR 81

                          90
                  ....*....|...
gi 568987884  224 DEFLEPPEKAIKC 236
Cdd:cd20412    82 SDFLSLPFQAIEC 94

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 55.51 E-value: 5.53e-09

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  113 YHPPILPEEMTEvSVMVCHINSPTDFYLQLM---ENLDFLSLlkTIEEFYKGEDGENLEILCPLQNQACVAKFEDGIWYR 189
Cdd:cd20421     2 YFYPQLQVGVTE-TVVVTEVTDPHRIFCQLRslsQELKRLSE--SMHQYYEGRVGSGYETRPEKLGSPCAARGSDGRWYR 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 568987884  190 AKVIG-LPGHREVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKL 238
Cdd:cd20421    79 AVLQQvFSANRVVEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCAL 128

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 52.66 E-value: 8.07e-09

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 568987884    665 YSWKKGEPCAVRGSDTLWYRGKVMEVVG-GTIRVQYLDHGFTEKIPQCHLYPI 716
Cdd:smart00333    1 PTFKVGDKVAARWEDGEWYRARIVKVDGeQLYEVFFIDYGNEEVVPPSDLRQL 53

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410450 Cd Length: 50 Bit Score: 52.13 E-value: 1.11e-08

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 568987884  409 DMHCAVKVPAKNQWRRGQILRMVTDKLVEVLLYDVGVELVVNIHCLREL 457
Cdd:cd20379     2 GDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 53.55 E-value: 1.16e-08

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568987884  912 PPLTDFSSEMPCLAEYADGL---WYRAKIISIkefNPLSVLVLFVDYGCTEKLTINRLRQIPVQLMQYP 977
Cdd:cd20431    36 PLTTKPVPNLLCLAPFTDADmkkYYRAKILYV---SGSSAEVFFVDYGNTSQVPSSLLREIPETLLTLP 101

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410480 Cd Length: 82 Bit Score: 52.84 E-value: 1.34e-08

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568987884  171 CPLQNQACVAKF-EDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFL 227
Cdd:cd20409    25 SPAVGEVCCAQFtEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLRPIPPSLL 82

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410497 Cd Length: 140 Bit Score: 54.43 E-value: 1.47e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  892 SESENLEEALQRFNKNVETfppLTDFSSEM----PCLAEYA-DGLWYRAKIISIKEfNPLSVLvlFVDYGCTEKLTINRL 966
Cdd:cd20426    21 EKIQCLAVKVQEAGEQVAD---RGNFIPSIyvgdPCIVKYSeDNHWYRALVTKIND-NLVSVR--FVDYGNEEDVVREQV 94

                          90       100
                  ....*....|....*....|..
gi 568987884  967 RQIPVQLMQYPAQAIKVLLAGF 988
Cdd:cd20426    95 RALPSELLKIPVQAFPCCLSGF 116

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 52.30 E-value: 2.13e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  895 ENLEEALQRFNknvETFPPLT--------DFssempCLAEY-ADGLWYRAKIISIKefNPLSVLVLFVDYGCTEKLTINR 965
Cdd:cd20433     6 EKLMEKLRFEI---ASNPPLPgsytprkgDL-----CAAKFvEDGEWYRAKVEKVE--GDKKVHVLYIDYGNREVLPSTR 75


                  ....*
gi 568987884  966 LRQIP 970
Cdd:cd20433    76 LAALP 80

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410502 Cd Length: 101 Bit Score: 52.78 E-value: 2.18e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  163 DGENLEILCPL-----QNQ------------ACVAKFEDGI---WYRAKVIGLPGHrEVEVKYVDFGNTAKITLKDMRKI 222
Cdd:cd20431    15 DENSSEILQQLtaeinQRQlvplttkpvpnlLCLAPFTDADmkkYYRAKILYVSGS-SAEVFFVDYGNTSQVPSSLLREI 93


                  ....*...
gi 568987884  223 KDEFLEPP 230
Cdd:cd20431    94 PETLLTLP 101

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410495 Cd Length: 126 Bit Score: 53.66 E-value: 2.22e-08

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568987884  923 CLAEYADGLWYRAKIISIKEfnplSVLVLFVDYGCTEKLTINRLRQIP---VQLMQYPAQAIKVLL 985
Cdd:cd20424    65 CLAKYSDQHWYRGIIITNKN----STEVFFVDYGNTEKVEKEDMLPIPsdaYELLLLPMQAIKCSL 126

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 51.19 E-value: 2.73e-08

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568987884  172 PLQNQACVAKF-EDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFL 227
Cdd:cd20410     3 PIVGEPCCAFFsGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 52.84 E-value: 3.06e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  129 VCHINSPTDFYLQLMENLD---FLSLLKTIEEFYKGEDGENLEIL---CPLQNQACVAKF-EDGIWYRAKVIGLPGHREV 201
Cdd:cd20419     2 VEYIESPSQFYVRFYSKDTsemLEDMMIEMRRCYSNEHVSERYVMpeaFIQPGQVCCVRIpEDVWWYRVIIHQVLNKQEV 81

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 568987884  202 EVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKL 238
Cdd:cd20419    82 EVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 52.43 E-value: 3.26e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  895 ENLEEALQRFNKNVETFPPLTDFSSEMPCLAEYADGLWYRAKIISIKEfnpLSVLVLFVDYGCTEKLTINRLRQIPVQLM 974
Cdd:cd20427     1 EQMEDEMKEFYSKSSTAMCLRSPSVGQLVAVKAEEDAWLRAQVIEVEE---DKVKVYYVDHGFSEVVERSKLFKLNKQFY 77

                          90
                  ....*....|....*.
gi 568987884  975 QYPAQAIKVLLAGFKP 990
Cdd:cd20427    78 SLPFQATKCKLAGLEP 93

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 52.76 E-value: 5.30e-08

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  897 LEEALQRFNKNVETFPPLTDFSSEMpCLAEYA-DGLWYRAKIisiKEFNPL--SVLVLFVDYGCTEKLTINRLRQIPVQL 973
Cdd:cd20408    28 LTSQLKKTYASVNNHKEYIPEVGEV-CVAKYSeDQNWYRALV---QTVDVQqkKAGVFYIDYGNEETVPLNRIQPLKKDI 103

                          90
                  ....*....|....*...
gi 568987884  974 MQYPAQAIKVLLAGFKPP 991
Cdd:cd20408   104 ELFPPCAIKCCLANVKPP 121

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).

Pssm-ID: 197660 Cd Length: 57 Bit Score: 49.58 E-value: 9.06e-08

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 568987884    921 MPCLAEYADGLWYRAKIISIKEFNplSVLVLFVDYGCTEKLTINRLRQIP 970
Cdd:smart00333    7 DKVAARWEDGEWYRARIVKVDGEQ--LYEVFFIDYGNEEVVPPSDLRQLP 54

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 50.50 E-value: 1.27e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  155 IEEFYKgEDGENLEILCPLQNQACVAKFEDGIWYRAKVIGLPGHReVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAI 234
Cdd:cd20427     7 MKEFYS-KSSTAMCLRSPSVGQLVAVKAEEDAWLRAQVIEVEEDK-VKVYYVDHGFSEVVERSKLFKLNKQFYSLPFQAT 84


                  ....*....
gi 568987884  235 KCKLAYVEP 243
Cdd:cd20427    85 KCKLAGLEP 93

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 48.49 E-value: 2.70e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  668 KKGEPC-AVRGSDTLWYRGKVMEVV-GGTIRVQYLDHGFTEKIPQCHLYPIllypdTPQF 725
Cdd:cd20410     4 IVGEPCcAFFSGDGNWYRAMVKEILpGGAVKVHFVDYGNVEEVTLDKLRKI-----TSTF 58

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 49.72 E-value: 3.70e-07

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  363 VNICNVISPEKIYVQWLLTENLLNSLEEKMVAAYE--HSEWKPVKWECDMHCAVKvPAKNQWRRGQILRMVTDKLVEVLL 440
Cdd:cd20437     7 VKITAAVSPSKFYCQLLSWEPELSKLTTQMTLHYEsvSKELNPSCENFGLLCAAK-GKDGQWHRGFLQQLLPPSQVKVWF 85

                          90       100       110
                  ....*....|....*....|....*....|...
gi 568987884  441 YDVGVELVVNIHCLRELQENLKTMGRLSLECSL 473
Cdd:cd20437    86 IDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410481 [Multi-domain] Cd Length: 59 Bit Score: 47.72 E-value: 4.77e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568987884  922 PCLAEYA-DGLWYRAKIISIkeFNPLSVLVLFVDYGCTEKLTINRLRQIPVQLM 974
Cdd:cd20410     8 PCCAFFSgDGNWYRAMVKEI--LPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410516 Cd Length: 56 Bit Score: 47.03 E-value: 7.52e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568987884  175 NQACVAKFEDGiWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEFLEPP 230
Cdd:cd20445     2 NELCIAKYMDK-WYRAVCLESVGDGRPTVLFCDYGNILMARLTDIRPFPPTFATEP 56

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 48.91 E-value: 1.16e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  636 VVPKLSEFELikMMDEIQSNLKCLgllEPYSWKKGEPCAVRGS-DTLWYRGKVMEV--VGGTIRVQYLDHGFTEKIPQCH 712
Cdd:cd20408    21 VLESLVKLTS--QLKKTYASVNNH---KEYIPEVGEVCVAKYSeDQNWYRALVQTVdvQQKKAGVFYIDYGNEETVPLNR 95

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 568987884  713 LYPilLYPDTPQFC---IPCQLYQTLPVGNTWQPDAI 746
Cdd:cd20408    96 IQP--LKKDIELFPpcaIKCCLANVKPPSGSWSEECI 130

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410504 [Multi-domain] Cd Length: 84 Bit Score: 47.30 E-value: 1.18e-06

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568987884  644 ELIKMMD----EIQSNLKCLGllePYSWKKGEPCAVRGS-DTLWYRGKVMEVVG-GTIRVQYLDHGFTEKIPQCHLYPI 716
Cdd:cd20433     4 QLEKLMEklrfEIASNPPLPG---SYTPRKGDLCAAKFVeDGEWYRAKVEKVEGdKKVHVLYIDYGNREVLPSTRLAAL 79

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 47.51 E-value: 3.42e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  923 CLAEYADGLWYRAKIISIKEfnpLSVLVLFVDYGCTEKLTINRLRQIPVQLMQYPAQAIKVLLAgfkpplsDSGktriPY 1002
Cdd:cd20422    56 CCAKWKEDRYYRAIVTAVKG---KMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLA-------DIC----PL 121


                  ....*....
gi 568987884 1003 CPKWSMEAL 1011
Cdd:cd20422   122 GERWSPEAI 130

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 47.06 E-value: 3.66e-06

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568987884  923 CLAEYA-DGLWYRAKIISIKEfnpLSVLVLFVDYGCTEKLTINRLRQIPVQLMQYPAQAIKVLLAG 987
Cdd:cd20411    54 CCARFTgDKNWYRAVVLETSD---SEVKVLYADYGNTETLPLSRILPITKSHLELPFQIIRCSLAG 116

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 47.44 E-value: 3.67e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  127 VMVCHINSPTDFYLQL-MENLDFLS-LLKTIEEFYKGED-GENLEILCPLQNQACVAKFEdGIWYRAKVIGLPGHREVEV 203
Cdd:cd20428     4 VRVTNVCSDGTLYCQVpSKGLSKLNeILDKIEYYFHSRQmTSEYFVSLPFCGKICLARYK-GKWARVEITNVHSSRALDV 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 568987884  204 KYVDFGNTAKITLKDMRKIKDEFLEP----PEKAIKCKLA 239
Cdd:cd20428    83 HFLDTGTVASVKVSELREIPPPFLRElisiPPQALKCCLA 122

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 46.30 E-value: 6.05e-06

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  853 VQVKHIVSPDEMYICLDSEDSytQFNHHGDTDDSGvsWESESENLEEALQRfnknvetfppltdfsSEMPClAEYA-DGL 931
Cdd:cd20425     4 VYVSHVNSPSDFYVQLAQDED--ELSMISEKLNAS--KANDEEVECESLQL---------------GDLIC-AEYPeDGL 63

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 568987884  932 WYRAkIISIKEFNPLsVLVLFVDYGCTEKLTINRLRQIPVQLMQYPAQAI 981
Cdd:cd20425    64 WYRA-VVKEKIPNNL-VSVQFIDYGNTSVVQPSKIHRLPKELLSIPALSI 111

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410510 Cd Length: 125 Bit Score: 45.94 E-value: 1.01e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568987884  923 CLAEYA-DGLWYRAKIIsiKEFNPLSVLVLFVDYGCTEKLTINRLRQIPVQLMQYPAQAIKVLLAGF 988
Cdd:cd20439    61 CVAKYSkDGKWYRAAVL--KQVSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410509 Cd Length: 141 Bit Score: 45.93 E-value: 1.29e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  668 KKGEP----CAVRGSDTLWYRGKVMEVVGGTIRVQYLDHGFTEKIPQCHLYPIL-LYPDTPQFCIPCQLYQTLPVGNTWQ 742
Cdd:cd20438    53 KKPEPgllcCARYSKDRHYYRAVITEVLDLKVSVYFLDFGNTDTVPFYDVKTLLpEFSELPALAMCCSLAHVFPVEEVWT 132


                  ....*....
gi 568987884  743 PDAIELLQE 751
Cdd:cd20438   133 KNANDFFKK 141

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410499 Cd Length: 140 Bit Score: 45.90 E-value: 1.35e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568987884  923 CLAEYAdGLWYRAKIISIKEFNPLSVLvlFVDYGCTEKLTINRLRQIPVQ----LMQYPAQAIKVLLAGFKP 990
Cdd:cd20428    58 CLARYK-GKWARVEITNVHSSRALDVH--FLDTGTVASVKVSELREIPPPflreLISIPPQALKCCLADLPL 126

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410514 [Multi-domain] Cd Length: 117 Bit Score: 45.15 E-value: 1.41e-05

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568987884  924 LAEY-ADGLWYRAKIIS---------IKEFNplsvlVLFVDYGCTEKLTINRLRQIPVQLMQYPAQAIKVLLAGFKPP 991
Cdd:cd20443    45 LAQFsADNSWNRAMVVNaprqgtqspKDEYE-----VFYIDYGNQETVPLSALRPLDPSVSSAPGLAQLCSLAHIKVP 117

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 44.72 E-value: 3.44e-05

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568987884  668 KKGEPCAVRGSDTLWYRGKVMEVVGG--TIRVQYLDHGFTEKIPQCHLYPILL-YPDTPQFCIPCQLY 732
Cdd:cd20421    62 KLGSPCAARGSDGRWYRAVLQQVFSAnrVVEVLHVDYGRKEVVSVSNLRYLAPeYFRMPVVTYPCALF 129

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410455 Cd Length: 55 Bit Score: 41.83 E-value: 5.19e-05

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568987884  178 CVAKFEDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKD 218
Cdd:cd20384    11 CLAKYDDGLWYPATVTDIDEDGKYTVKFDSYGEVAVVELDD 51

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410455 Cd Length: 55 Bit Score: 41.83 E-value: 5.84e-05

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568987884  916 DFSS---EMPCLAEYADGLWYRAKIISIKEFNPLSV 948
Cdd:cd20384     1 DFSSlkeGSRCLAKYDDGLWYPATVTDIDEDGKYTV 36

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410486 Cd Length: 96 Bit Score: 42.81 E-value: 5.95e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  645 LIKMMDEI--QSNLKCLGLLEPYswkKGEPCAVRGSDTLWYRGKVMEVVGG-TIRVQYLDHGFTEKIPQCHLYPIllyPD 721
Cdd:cd20415     4 LTKKIQEFykEGDDGGLEILCPV---QGQACVALFEDGAWYRARIIGLPGHrEVEVKYVDFGNTATVTIKHVRKI---KD 77

                          90
                  ....*....|....
gi 568987884  722 T----PQFCIPCQL 731
Cdd:cd20415    78 DflslPEKARECRL 91

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 44.04 E-value: 6.48e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  407 ECDMHCAVKVpAKNQWRRGQILRmVTDKLVEVLLYDVGVELVVNIHCLRELQENLKTMGRLSLECSLVDIRPTGgsDKWT 486
Cdd:cd20422    51 QPGQLCCAKW-KEDRYYRAIVTA-VKGKMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLG--ERWS 126


                  ....*.
gi 568987884  487 ATACDC 492
Cdd:cd20422   127 PEAISA 132

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 43.95 E-value: 7.54e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  365 ICNVISPEKIYVQWlltENLLNSLEEKMVAAYE----HSEWKPVKWECDMHCAVKVPAKNQWRRGQILRmVTDKLVEVLL 440
Cdd:cd20436     5 THRVCHPKEVLVKF---QGQYNSICELDYHILQneiqNATKSKSSWGVGEFCLVEDTTSGEWYRGRVLE-KIDEKYEVFL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 568987884  441 YDVGVELVVNIHCLRELQENLKTMGRLSLECSLVDIRPTGGsdKWTATACDCLS 494
Cdd:cd20436    81 IDRGEVLNVHATNMASASGELFQLPPKAVCGIFANILPIGE--KWSSTAVNYFS 132

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 42.83 E-value: 9.76e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  363 VNICNVISPEKIYVQWLLTENLLNSLEEKMVAAYEHSEW--KPVKWECDMHCAVkVPAKNQWRRGQILRMVTDKLVEVLL 440
Cdd:cd20425     4 VYVSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEveCESLQLGDLICAE-YPEDGLWYRAVVKEKIPNNLVSVQF 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 568987884  441 YDVGVELVVNIHCLRELQENLKTMGRLSLECSL 473
Cdd:cd20425    83 IDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 43.39 E-value: 9.77e-05

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  134 SPTDFYLQLME------------NLDFLSLLKTIEEFYKgeDGENLEILCPLQ-NQACVAKFEDGIWYRAKVIGLP---- 196
Cdd:cd20435     1 DATHYSARILEhrssdgevtksmSSTYLKLSMKLNMYYS--DPSNRILHGKVKvGDLCAVEDENNLYHRVKVLEITekdd 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 568987884  197 --GHREVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAI 234
Cdd:cd20435    79 ktKPREVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAV 118

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410549 Cd Length: 50 Bit Score: 40.31 E-value: 1.39e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 568987884  921 MPCLAEYA-DGLWYRAKIISIKEfNPLSVLVLFVDYGCTEKLTINRLRQI 969
Cdd:cd21182     2 DKCLAPYSdDGKYYEATIEEITE-ESDTATVVFDGYGNSEEVPLSDLKPL 50

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 41.12 E-value: 1.63e-04

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 568987884  180 AKF-EDGIWYRAKVIGLPGHREVEVKYVDFGNTAKITLKDMRKIKDEF 226
Cdd:cd20430    27 GKFsEDNCWYRCKVKSILSDEKCTVQYIDYGNTETVSRSSIVELPPDL 74

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 43.10 E-value: 1.71e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568987884  178 CVAKFEDGI-WYRAKVIGL-PGHREVEVKYVDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEPSKKS 247
Cdd:cd20442    56 CLAKSKKNLkWYRAVVEHLyPETEKMLVFFVDHGITEVVSMGNIKQLSNDLLQIPRQAVLCRWNWPESSKEL 127

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410506 Cd Length: 134 Bit Score: 42.62 E-value: 1.88e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  617 NTSSFEA-IVTCIGDDGTIFVVPKLSEFELIKMMDEI---QSNLKCLGLLepyswKKGEPCAVRGSDTLWYRGKVMEVVG 692
Cdd:cd20435     1 DATHYSArILEHRSSDGEVTKSMSSTYLKLSMKLNMYysdPSNRILHGKV-----KVGDLCAVEDENNLYHRVKVLEITE 75

                          90       100
                  ....*....|....*....|....*....
gi 568987884  693 -------GTIRVQYLDHGFTEKIPQCHLY 714
Cdd:cd20435    76 kddktkpREVLVKFIDEGRVETVVVSQLL 104

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410479 Cd Length: 130 Bit Score: 42.36 E-value: 1.92e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  370 SPEKIYVQWLLTENL--LNSLEEKMVAAY----EHSEWKPVKWECdmhCAVKVPAKNQWRRGQIL-RMVTDKLVEVLLYD 442
Cdd:cd20408     8 NPGEFYIQIYTLEVLesLVKLTSQLKKTYasvnNHKEYIPEVGEV---CVAKYSEDQNWYRALVQtVDVQQKKAGVFYID 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568987884  443 VGVELVVNIHCLRELQENLKTMGRLSLECSLVDIRPTGGSdkWTATAC 490
Cdd:cd20408    85 YGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGS--WSEECI 130

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410482 Cd Length: 116 Bit Score: 41.66 E-value: 2.67e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  623 AIVTCIGDDGTIFVVPK---LSEFELIKMMDEIQSNLKCLGLLEPYSWKKGEPCAVR-GSDTLWYRGKVMEVVGGTIRVQ 698
Cdd:cd20411     1 ALVLEVISPDLFYALPKtgqVNVEKLKALMTELAEYCSKQSVPQQFRPRIGDACCARfTGDKNWYRAVVLETSDSEVKVL 80

                          90
                  ....*....|....*...
gi 568987884  699 YLDHGFTEKIPQCHLYPI 716
Cdd:cd20411    81 YADYGNTETLPLSRILPI 98

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410492 Cd Length: 130 Bit Score: 41.26 E-value: 4.15e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568987884  922 PCLAEYADGLWYRAKIISIKEFNPLsVLVLFVDYGCTEKLTINRLRQIPVQLMQYP 977
Cdd:cd20421    66 PCAARGSDGRWYRAVLQQVFSANRV-VEVLHVDYGRKEVVSVSNLRYLAPEYFRMP 120

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 41.95 E-value: 4.98e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568987884  921 MPCLAEYADGL-WYRAKIISIKEfNPLSVLVLFVDYGCTEKLTINRLRQIPVQLMQYPAQAI 981
Cdd:cd20442    54 LECLAKSKKNLkWYRAVVEHLYP-ETEKMLVFFVDHGITEVVSMGNIKQLSNDLLQIPRQAV 114

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410513 Cd Length: 160 Bit Score: 41.56 E-value: 5.58e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  363 VNICNVISPEKIYVQWLLTENLLNSLEEKMV-AAYEHSEWKPVKWECDMHCAVKVPAKNQWRRGQILRMVTDKL-VEVLL 440
Cdd:cd20442     6 GTLLSVSKNGTFYVRLLRNSEQLTDLESLIAkEAKKCKFVPVEDIKEGLECLAKSKKNLKWYRAVVEHLYPETEkMLVFF 85

                          90       100       110
                  ....*....|....*....|....*....|.
gi 568987884  441 YDVGVELVVNIHCLRELQENLKTMGRLSLEC 471
Cdd:cd20442    86 VDHGITEVVSMGNIKQLSNDLLQIPRQAVLC 116

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410496 Cd Length: 115 Bit Score: 40.52 E-value: 6.51e-04

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568987884  673 CAVRGSDTLWYRGKVME-VVGGTIRVQYLDHGFTEKIPQCHLY---PILLypDTPQFCIPCQL 731
Cdd:cd20425    55 CAEYPEDGLWYRAVVKEkIPNNLVSVQFIDYGNTSVVQPSKIHrlpKELL--SIPALSIHCFL 115

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410493 Cd Length: 135 Bit Score: 40.96 E-value: 7.06e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  661 LLEPyswKKGEPCAVRGSDTLWYRGKVMEVVGGTIRVQYLDHGFTEKIPQCHLYPILL-YPDTPQFCIPCQLYQTLPVGN 739
Cdd:cd20422    47 VLKP---QPGQLCCAKWKEDRYYRAIVTAVKGKMVEVFLVDRGNTEMVDWYDVKKLLPqFRELPALALKCCLADICPLGE 123


                  ....*..
gi 568987884  740 TWQPDAI 746
Cdd:cd20422   124 RWSPEAI 130

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410500 Cd Length: 91 Bit Score: 39.78 E-value: 7.69e-04

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568987884  385 LNSLEEKMVAAYEHSEWKPVKWECDMHCAVKVpaKNQWRRGQILRMVTDKLVEVLLYDVGVELVVNIHCLRELQE 459
Cdd:cd20429     9 LEVLMEEMILYYNKTEERPVAIEKNKVYAAKI--ENNWYRVLVKGILTNGLVSVYELDYGKHELVSIRKVQPLIE 81

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410483 Cd Length: 95 Bit Score: 39.59 E-value: 7.70e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568987884  929 DGLWYRAKIISIKEfnPLSVLVLFVDYGCTEKLTINRLRQIPVQLMQYPAQAI 981
Cdd:cd20412    42 DGSWYRARVLGFLE--NGNLDLYFVDYGDSGYVPLEDLRALRSDFLSLPFQAI 92

second Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410516 Cd Length: 56 Bit Score: 38.56 E-value: 8.20e-04

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568987884  923 CLAEYADGlWYRAkiISIKEFNPLSVLVLFVDYGCTEKLTINRLRQIPVQLMQYP 977
Cdd:cd20445     5 CIAKYMDK-WYRA--VCLESVGDGRPTVLFCDYGNILMARLTDIRPFPPTFATEP 56

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 37.57 E-value: 1.52e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 568987884  175 NQACVAKF-EDGIWYRAKVIGLPGHREVEVKYVDfGNTAKITLKDMR 220
Cdd:cd04508     1 GDRVEAKWsDDGQWYPATVVAVNDDGKYTVLFDD-GNEEEVSEDDIR 46

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 40.10 E-value: 1.56e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  642 EFELIKMMDEIQSNLKclgllEPYSWKKGEPCAVRGSDT-LWYRGKVMEVVGGTIRVQYLDHGFTEKIPQCHLYPIllyP 720
Cdd:cd20436    27 ELDYHILQNEIQNATK-----SKSSWGVGEFCLVEDTTSgEWYRGRVLEKIDEKYEVFLIDRGEVLNVHATNMASA---S 98

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 568987884  721 DT----PQFCIPCQLYQTLPVGNTWQPDAIELLQELLSKR 756
Cdd:cd20436    99 GElfqlPPKAVCGIFANILPIGEKWSSTAVNYFSSLIGSQ 138

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410490 Cd Length: 118 Bit Score: 39.35 E-value: 1.57e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  367 NVISPEKIYVQWL--LTENLLNSLEEKMVAAYE---HSEWKPVKwECDMH----CAVKVPAKNQWRRGQILRMVTDKLVE 437
Cdd:cd20419     4 YIESPSQFYVRFYskDTSEMLEDMMIEMRRCYSnehVSERYVMP-EAFIQpgqvCCVRIPEDVWWYRVIIHQVLNKQEVE 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 568987884  438 VLLYDVGVELVVNIHCLRELQENLKTMGRLSLECSL 473
Cdd:cd20419    83 VFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410512 Cd Length: 108 Bit Score: 38.95 E-value: 1.76e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  639 KLSEFE--LIKMMDEIQSNLKCLGLLEPYSWKKGEPCAVRGS-DTLWYRGKVMEVVGG-TIRVQYLDHGFTEKIPQCHLY 714
Cdd:cd20441     8 QLSEDEkvILQLAEELNETSEKSRENAAVKLKVGDLVAAEYDeDLALYRAVITAVLPGkSFKVEFIDYGNTAVVDKSNIY 87

                          90       100
                  ....*....|....*....|.
gi 568987884  715 PIllyPDT----PQFCIPCQL 731
Cdd:cd20441    88 TL---QEKflslPRLSIPCSL 105

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410498 Cd Length: 98 Bit Score: 38.56 E-value: 2.22e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  647 KMMDEIQSNLKCLGLLEPyswKKGEPCAVRGSDTLWYRGKVMEVVGGTIRVQYLDHGFTEKIPQCHLYPIllypdTPQFC 726
Cdd:cd20427     6 EMKEFYSKSSTAMCLRSP---SVGQLVAVKAEEDAWLRAQVIEVEEDKVKVYYVDHGFSEVVERSKLFKL-----NKQFY 77

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.

Pssm-ID: 410449 [Multi-domain] Cd Length: 47 Bit Score: 36.80 E-value: 2.64e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 568987884  923 CLAEY-ADGLWYRAKIISIKEFNplSVLVLFvDYGCTEKLTINRLR 967
Cdd:cd04508     4 VEAKWsDDGQWYPATVVAVNDDG--KYTVLF-DDGNEEEVSEDDIR 46

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 38.94 E-value: 2.67e-03

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568987884  670 GEPCAVRGSDTLWYRGKVMEV-VGGTIRVQYLDHGFTEKIPQCHLYPilLYPD---TPQFCIPCQL 731
Cdd:cd20437    55 GLLCAAKGKDGQWHRGFLQQLlPPSQVKVWFIDYGNSEAVSSHSVLK--LPPDffsLPLMSFPCSL 118

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410508 Cd Length: 120 Bit Score: 38.55 E-value: 3.12e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  888 VSWESESENLEEALQRF--NKNVETFPPLTDFSseMPCLAEYADGLWYRAKIISIkeFNPLSVLVLFVDYGCTEKLTINR 965
Cdd:cd20437    23 LSWEPELSKLTTQMTLHyeSVSKELNPSCENFG--LLCAAKGKDGQWHRGFLQQL--LPPSQVKVWFIDYGNSEAVSSHS 98

                          90       100
                  ....*....|....*....|.
gi 568987884  966 LRQIPVQLMQYPAQAIKVLLA 986
Cdd:cd20437    99 VLKLPPDFFSLPLMSFPCSLS 119

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410515 Cd Length: 55 Bit Score: 36.51 E-value: 3.48e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 568987884  172 PLQNQACVAKFeDGIWYRAKVIGlPGHREVE--VKYVDFGNTAKITLKDMRKIKDEF 226
Cdd:cd20444     1 PTPGQMVIAKF-DGNHYRAIVLR-VLNPDLKilVRFVDFGNVEVMKLENLYECPEYL 55

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410488 Cd Length: 68 Bit Score: 36.64 E-value: 4.47e-03

                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568987884  176 QACVAKFEDGIWYRAKVIGLPGHrEVEVKYVDFGNTAKI 214
Cdd:cd20417     5 EGCVVRGSDTLWYRGKVLEVIGG-MVRVQYVDQGYIEKI 42

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410507 Cd Length: 147 Bit Score: 38.56 E-value: 4.64e-03

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568987884  185 GIWYRAKVIglpghREVEVKY----VDFGNTAKITLKDMRKIKDEFLEPPEKAIKCKLAYVEPSkKSQWS 250
Cdd:cd20436    61 GEWYRGRVL-----EKIDEKYevflIDRGEVLNVHATNMASASGELFQLPPKAVCGIFANILPI-GEKWS 124

Tudor domain found in Schizosaccharomyces pombe splicing factor spf30 (SpSPF30) and similar proteins; SpSPF30, also called survival of motor neuron-related-splicing factor 30, is necessary for spliceosome assembly. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410517 Cd Length: 56 Bit Score: 35.93 E-value: 5.85e-03

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 568987884  923 CLAEY--ADGLWYRAKIISIKEF--NPLsVLVLFVDYGCTEKLTINRLRQI 969
Cdd:cd20446     7 VMARWksGDGKFYPARITSITGSsiNPI-YTVKFLDYGEIDTVYLKDIRPL 56

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.

Pssm-ID: 410501 [Multi-domain] Cd Length: 75 Bit Score: 36.12 E-value: 8.12e-03

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 568987884  929 DGLWYRAKIISIKEFNplSVLVLFVDYGCTEKLTINRLRQIPVQL 973
Cdd:cd20430    32 DNCWYRCKVKSILSDE--KCTVQYIDYGNTETVSRSSIVELPPDL 74