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Conserved domains on  [gi|568992311|ref|XP_006520966|]
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low-density lipoprotein receptor-related protein 12 isoform X2 [Mus musculus]

Protein Classification

CUB and LDLa domain-containing protein( domain architecture ID 10035864)

CUB and LDLa (low-density lipoprotein receptor class A) domain-containing protein similar to Homo sapiens low-density lipoprotein receptor-related protein 12 which may be involved in the internalization of lipophilic molecules and/or signal transduction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 37-139 1.95e-32

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 121.37  E-value: 1.95e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568992311  37 APSGIITSPGWPSDYPAQVNCSWLIRANPGEIITISFQDFDIQGSRRCTLDWLTI---ETYKNIESYRACGSTIPPPYIS 113
Cdd:cd00041    8 STSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydgPSTSSPLLGRFCGSTLPPPIIS 87

                         90       100
                 ....*....|....*....|....*.
gi 568992311 114 SQDHVWIRFHSDDSVSRKGFRLAYFS 139
Cdd:cd00041   88 SGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 249-353 3.52e-23

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 95.17  E-value: 3.52e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568992311 249 YGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGY--GDYVKIYDGLEENPRKLLRVLTafdSHAPLTVV 326
Cdd:cd00041   10 SGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNcsYDYLEIYDGPSTSSPLLGRFCG---STLPPPII 86

                         90       100
                 ....*....|....*....|....*..
gi 568992311 327 SSSGQIRVHFCADKVNAARGFNATYQV 353
Cdd:cd00041   87 SSGNSLTVRFRSDSSVTGRGFKATYSA 113
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 433-467 1.20e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 1.20e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 568992311 433 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 467
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 148-182 1.90e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 1.90e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 568992311 148 CACDQFRCGNGKCIPEAWKCNSMDECGDSSDEEVC 182
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 395-430 2.60e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.59  E-value: 2.60e-07
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 568992311 395 CQKEEFPCsRNGVCYPRSDRCNYQNHCPNGSDEKNC 430
Cdd:cd00112    1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 197-236 1.74e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 42.19  E-value: 1.74e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568992311 197 CAYNQFQCLSRftkvyTCLPESLKCDGNIDCLDLGDEIDC 236
Cdd:cd00112    1 CPPNEFRCANG-----RCIPSSWVCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 37-139 1.95e-32

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 121.37  E-value: 1.95e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568992311  37 APSGIITSPGWPSDYPAQVNCSWLIRANPGEIITISFQDFDIQGSRRCTLDWLTI---ETYKNIESYRACGSTIPPPYIS 113
Cdd:cd00041    8 STSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydgPSTSSPLLGRFCGSTLPPPIIS 87

                         90       100
                 ....*....|....*....|....*.
gi 568992311 114 SQDHVWIRFHSDDSVSRKGFRLAYFS 139
Cdd:cd00041   88 SGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
28-137 2.24e-32

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 121.25  E-value: 2.24e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568992311   28 CGEspeQIRAPSGIITSPGWPSDYPAQVNCSWLIRANPGEIITISFQDFDIQGSRRCTLDWLTI-----ETYKNIESYra 102
Cdd:pfam00431   1 CGG---VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIrdgpsASSPLLGRF-- 75

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 568992311  103 CGSTIPPPYISSQDHVWIRFHSDDSVSRKGFRLAY 137
Cdd:pfam00431  76 CGSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 40-137 6.40e-29

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 110.94  E-value: 6.40e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568992311    40 GIITSPGWPSDYPAQVNCSWLIRANPGEIITISFQDFDIQGSRRCTLDWLTI---ETYKNIESYRACGSTIPPPYISSQ- 115
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIydgPSASSPLLGRFCGSEAPPPVISSSs 80

                           90       100
                   ....*....|....*....|..
gi 568992311   116 DHVWIRFHSDDSVSRKGFRLAY 137
Cdd:smart00042  81 NSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 249-353 3.52e-23

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 95.17  E-value: 3.52e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568992311 249 YGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGY--GDYVKIYDGLEENPRKLLRVLTafdSHAPLTVV 326
Cdd:cd00041   10 SGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNcsYDYLEIYDGPSTSSPLLGRFCG---STLPPPII 86

                         90       100
                 ....*....|....*....|....*..
gi 568992311 327 SSSGQIRVHFCADKVNAARGFNATYQV 353
Cdd:cd00041   87 SSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
241-351 4.04e-21

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 89.28  E-value: 4.04e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568992311  241 CGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTG--YGDYVKIYDGLEENPRKLLRvltaF- 317
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDecGYDYVEIRDGPSASSPLLGR----Fc 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 568992311  318 DSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY 351
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 250-351 1.12e-19

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 84.75  E-value: 1.12e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568992311   250 GTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGT---GYgDYVKIYDGLEENPRKLLRVLTafDSHAPLTVV 326
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSdncEY-DYVEIYDGPSASSPLLGRFCG--SEAPPPVIS 77

                           90       100
                   ....*....|....*....|....*
gi 568992311   327 SSSGQIRVHFCADKVNAARGFNATY 351
Cdd:smart00042  78 SSSNSLTLTFVSDSSVQKRGFSARY 102
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 433-467 1.20e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 1.20e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 568992311 433 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 467
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
433-467 1.72e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.49  E-value: 1.72e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568992311  433 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 467
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 433-464 1.82e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.49  E-value: 1.82e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568992311   433 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDE 464
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 148-182 1.90e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 1.90e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 568992311 148 CACDQFRCGNGKCIPEAWKCNSMDECGDSSDEEVC 182
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 148-179 9.03e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 9.03e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568992311   148 CACDQFRCGNGKCIPEAWKCNSMDECGDSSDE 179
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
147-182 8.86e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 8.86e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568992311  147 DCACDQFRCGNGKCIPEAWKCNSMDECGDSSDEEVC 182
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 395-430 2.60e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.59  E-value: 2.60e-07
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 568992311 395 CQKEEFPCsRNGVCYPRSDRCNYQNHCPNGSDEKNC 430
Cdd:cd00112    1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 197-236 1.74e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 42.19  E-value: 1.74e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568992311 197 CAYNQFQCLSRftkvyTCLPESLKCDGNIDCLDLGDEIDC 236
Cdd:cd00112    1 CPPNEFRCANG-----RCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 395-427 5.73e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 40.69  E-value: 5.73e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568992311   395 CQKEEFPCsRNGVCYPRSDRCNYQNHCPNGSDE 427
Cdd:smart00192   2 CPPGEFQC-DNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
395-430 1.72e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 39.54  E-value: 1.72e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568992311  395 CQKEEFPCsRNGVCYPRSDRCNYQNHCPNGSDEKNC 430
Cdd:pfam00057   3 CSPNEFQC-GSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 197-233 2.40e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 39.15  E-value: 2.40e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568992311   197 CAYNQFQCLSRftkvyTCLPESLKCDGNIDCLDLGDE 233
Cdd:smart00192   2 CPPGEFQCDNG-----RCIPSSWVCDGVDDCGDGSDE 33
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 37-139 1.95e-32

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 121.37  E-value: 1.95e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568992311  37 APSGIITSPGWPSDYPAQVNCSWLIRANPGEIITISFQDFDIQGSRRCTLDWLTI---ETYKNIESYRACGSTIPPPYIS 113
Cdd:cd00041    8 STSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIydgPSTSSPLLGRFCGSTLPPPIIS 87

                         90       100
                 ....*....|....*....|....*.
gi 568992311 114 SQDHVWIRFHSDDSVSRKGFRLAYFS 139
Cdd:cd00041   88 SGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
28-137 2.24e-32

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 121.25  E-value: 2.24e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568992311   28 CGEspeQIRAPSGIITSPGWPSDYPAQVNCSWLIRANPGEIITISFQDFDIQGSRRCTLDWLTI-----ETYKNIESYra 102
Cdd:pfam00431   1 CGG---VLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIrdgpsASSPLLGRF-- 75

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 568992311  103 CGSTIPPPYISSQDHVWIRFHSDDSVSRKGFRLAY 137
Cdd:pfam00431  76 CGSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 40-137 6.40e-29

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 110.94  E-value: 6.40e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568992311    40 GIITSPGWPSDYPAQVNCSWLIRANPGEIITISFQDFDIQGSRRCTLDWLTI---ETYKNIESYRACGSTIPPPYISSQ- 115
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIydgPSASSPLLGRFCGSEAPPPVISSSs 80

                           90       100
                   ....*....|....*....|..
gi 568992311   116 DHVWIRFHSDDSVSRKGFRLAY 137
Cdd:smart00042  81 NSLTLTFVSDSSVQKRGFSARY 102
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 249-353 3.52e-23

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 95.17  E-value: 3.52e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568992311 249 YGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGY--GDYVKIYDGLEENPRKLLRVLTafdSHAPLTVV 326
Cdd:cd00041   10 SGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNcsYDYLEIYDGPSTSSPLLGRFCG---STLPPPII 86

                         90       100
                 ....*....|....*....|....*..
gi 568992311 327 SSSGQIRVHFCADKVNAARGFNATYQV 353
Cdd:cd00041   87 SSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
241-351 4.04e-21

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 89.28  E-value: 4.04e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568992311  241 CGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTG--YGDYVKIYDGLEENPRKLLRvltaF- 317
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDecGYDYVEIRDGPSASSPLLGR----Fc 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 568992311  318 DSHAPLTVVSSSGQIRVHFCADKVNAARGFNATY 351
Cdd:pfam00431  77 GSGIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 250-351 1.12e-19

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 84.75  E-value: 1.12e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568992311   250 GTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGT---GYgDYVKIYDGLEENPRKLLRVLTafDSHAPLTVV 326
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSdncEY-DYVEIYDGPSASSPLLGRFCG--SEAPPPVIS 77

                           90       100
                   ....*....|....*....|....*
gi 568992311   327 SSSGQIRVHFCADKVNAARGFNATY 351
Cdd:smart00042  78 SSSNSLTLTFVSDSSVQKRGFSARY 102
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 433-467 1.20e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 59.53  E-value: 1.20e-11
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 568992311 433 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 467
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
433-467 1.72e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 56.49  E-value: 1.72e-10
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 568992311  433 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 467
Cdd:pfam00057   3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 433-464 1.82e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 56.49  E-value: 1.82e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568992311   433 CQPGNFHCKNNRCVFESWVCDSQDDCGDGSDE 464
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 148-182 1.90e-10

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 56.45  E-value: 1.90e-10
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 568992311 148 CACDQFRCGNGKCIPEAWKCNSMDECGDSSDEEVC 182
Cdd:cd00112    1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 148-179 9.03e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 54.18  E-value: 9.03e-10
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568992311   148 CACDQFRCGNGKCIPEAWKCNSMDECGDSSDE 179
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
147-182 8.86e-08

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 48.78  E-value: 8.86e-08
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568992311  147 DCACDQFRCGNGKCIPEAWKCNSMDECGDSSDEEVC 182
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 395-430 2.60e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.59  E-value: 2.60e-07
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 568992311 395 CQKEEFPCsRNGVCYPRSDRCNYQNHCPNGSDEKNC 430
Cdd:cd00112    1 CPPNEFRC-ANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 197-236 1.74e-05

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 42.19  E-value: 1.74e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 568992311 197 CAYNQFQCLSRftkvyTCLPESLKCDGNIDCLDLGDEIDC 236
Cdd:cd00112    1 CPPNEFRCANG-----RCIPSSWVCDGEDDCGDGSDEENC 35
PRKCSH-like pfam12999
Glucosidase II beta subunit-like; The sequences found in this family are similar to a region ...
 378-468 5.57e-05

Glucosidase II beta subunit-like; The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II, which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyzes the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum.


Pssm-ID: 372423 [Multi-domain]  Cd Length: 176  Bit Score: 44.78  E-value: 5.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568992311  378 DGYWHCPNgRDEINCTMCQKEEfpcsrngvcyprsDRCNyqnhCPNGSDEKNCFFCQPGNFHCKNNRcvFES-------- 449
Cdd:pfam12999  35 NGNWKCLN-HSEIKLSFDQVND-------------DYCD----CPDGSDEPGTNACSNGKFYCANEG--FIPgyipsfkv 94

                          90       100
                  ....*....|....*....|...
gi 568992311  450 --WVCDsQDDCGDGSDEE--NCP 468
Cdd:pfam12999  95 ddGVCD-YDICCDGSDEAlgKCP 116
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 395-427 5.73e-05

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 40.69  E-value: 5.73e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 568992311   395 CQKEEFPCsRNGVCYPRSDRCNYQNHCPNGSDE 427
Cdd:smart00192   2 CPPGEFQC-DNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
395-430 1.72e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 39.54  E-value: 1.72e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568992311  395 CQKEEFPCsRNGVCYPRSDRCNYQNHCPNGSDEKNC 430
Cdd:pfam00057   3 CSPNEFQC-GSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 197-233 2.40e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 39.15  E-value: 2.40e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 568992311   197 CAYNQFQCLSRftkvyTCLPESLKCDGNIDCLDLGDE 233
Cdd:smart00192   2 CPPGEFQCDNG-----RCIPSSWVCDGVDDCGDGSDE 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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