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Conserved domains on  [gi|568994812|ref|XP_006521945|]
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F-box only protein 40 isoform X1 [Mus musculus]

Protein Classification

F-box protein( domain architecture ID 11240040)

F-box protein containing a TRAF-like zinc-finger, may function as the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50
Gene Ontology:  GO:0019005|GO:0005515|GO:0008270
PubMed:  31898225|11178263|17210253|12665246
SCOP:  4001927

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box_4 pfam15966
F-box;
571-686 4.27e-67

F-box;


:

Pssm-ID: 464958  Cd Length: 116  Bit Score: 216.00  E-value: 4.27e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994812  571 SLNSLTSLPLEVLQYIAGFLDSISLSQLSQVSVLMRNICATLLQERGMVLSQWKKKRYSHGGTSWKVHNQIWQFSSLFSK 650
Cdd:pfam15966   1 NLDSLSSLPFEVLQHIASFLDSFSLSQLSLVSRLMREVCASLLQERGMVALQWEKKRYSHGGTSWQIKKKVWQFSTLFSP 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 568994812  651 INSWEFNDVTSMSEHLKTCPFNIVERKTDPIRLTSM 686
Cdd:pfam15966  81 VDSWKFDDVPSMSEHLKVCPFYEVERRTEPVPLPSM 116
zf-TRAF_2 pfam15965
TRAF-like zinc-finger;
12-103 3.33e-58

TRAF-like zinc-finger;


:

Pssm-ID: 464957  Cd Length: 92  Bit Score: 191.39  E-value: 3.33e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994812   12 HRHCEGCFNRHCHVPVEPSVSCLVISCHLLCGATFHMCKESEHTLLCPLEQVPCLNSEYGCPLSMARHKLAKHLQVCPAS 91
Cdd:pfam15965   1 HEHCESCFSRRCQVKVEPSVSCAVISCPLGCGAVFHSCKLEEHQLLCPNEKVPCLNASYGCPFTLPRKQLAKHLEVCPAS 80

                          90
                  ....*....|..
gi 568994812   92 VVCCSMEWIRWP 103
Cdd:pfam15965  81 VVCCSMEWNRWP 92
 
Name Accession Description Interval E-value
F-box_4 pfam15966
F-box;
571-686 4.27e-67

F-box;


Pssm-ID: 464958  Cd Length: 116  Bit Score: 216.00  E-value: 4.27e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994812  571 SLNSLTSLPLEVLQYIAGFLDSISLSQLSQVSVLMRNICATLLQERGMVLSQWKKKRYSHGGTSWKVHNQIWQFSSLFSK 650
Cdd:pfam15966   1 NLDSLSSLPFEVLQHIASFLDSFSLSQLSLVSRLMREVCASLLQERGMVALQWEKKRYSHGGTSWQIKKKVWQFSTLFSP 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 568994812  651 INSWEFNDVTSMSEHLKTCPFNIVERKTDPIRLTSM 686
Cdd:pfam15966  81 VDSWKFDDVPSMSEHLKVCPFYEVERRTEPVPLPSM 116
zf-TRAF_2 pfam15965
TRAF-like zinc-finger;
12-103 3.33e-58

TRAF-like zinc-finger;


Pssm-ID: 464957  Cd Length: 92  Bit Score: 191.39  E-value: 3.33e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994812   12 HRHCEGCFNRHCHVPVEPSVSCLVISCHLLCGATFHMCKESEHTLLCPLEQVPCLNSEYGCPLSMARHKLAKHLQVCPAS 91
Cdd:pfam15965   1 HEHCESCFSRRCQVKVEPSVSCAVISCPLGCGAVFHSCKLEEHQLLCPNEKVPCLNASYGCPFTLPRKQLAKHLEVCPAS 80

                          90
                  ....*....|..
gi 568994812   92 VVCCSMEWIRWP 103
Cdd:pfam15965  81 VVCCSMEWNRWP 92
F-box_FBXO40 cd22175
F-box domain found in F-box only protein 40 (FBXO40) and similar proteins; FBXO40, also called ...
 575-623 1.64e-24

F-box domain found in F-box only protein 40 (FBXO40) and similar proteins; FBXO40, also called FBX40, or muscle disease-related protein, is a probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438946  Cd Length: 49  Bit Score: 96.50  E-value: 1.64e-24
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 568994812 575 LTSLPLEVLQYIAGFLDSISLSQLSQVSVLMRNICATLLQERGMVLSQW 623
Cdd:cd22175    1 LSSLPLEILRHIAGFLDSFSLSQLSQVSVLMRDVCATLLQERGMVSLVW 49
 
Name Accession Description Interval E-value
F-box_4 pfam15966
F-box;
571-686 4.27e-67

F-box;


Pssm-ID: 464958  Cd Length: 116  Bit Score: 216.00  E-value: 4.27e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994812  571 SLNSLTSLPLEVLQYIAGFLDSISLSQLSQVSVLMRNICATLLQERGMVLSQWKKKRYSHGGTSWKVHNQIWQFSSLFSK 650
Cdd:pfam15966   1 NLDSLSSLPFEVLQHIASFLDSFSLSQLSLVSRLMREVCASLLQERGMVALQWEKKRYSHGGTSWQIKKKVWQFSTLFSP 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 568994812  651 INSWEFNDVTSMSEHLKTCPFNIVERKTDPIRLTSM 686
Cdd:pfam15966  81 VDSWKFDDVPSMSEHLKVCPFYEVERRTEPVPLPSM 116
zf-TRAF_2 pfam15965
TRAF-like zinc-finger;
12-103 3.33e-58

TRAF-like zinc-finger;


Pssm-ID: 464957  Cd Length: 92  Bit Score: 191.39  E-value: 3.33e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568994812   12 HRHCEGCFNRHCHVPVEPSVSCLVISCHLLCGATFHMCKESEHTLLCPLEQVPCLNSEYGCPLSMARHKLAKHLQVCPAS 91
Cdd:pfam15965   1 HEHCESCFSRRCQVKVEPSVSCAVISCPLGCGAVFHSCKLEEHQLLCPNEKVPCLNASYGCPFTLPRKQLAKHLEVCPAS 80

                          90
                  ....*....|..
gi 568994812   92 VVCCSMEWIRWP 103
Cdd:pfam15965  81 VVCCSMEWNRWP 92
F-box_FBXO40 cd22175
F-box domain found in F-box only protein 40 (FBXO40) and similar proteins; FBXO40, also called ...
 575-623 1.64e-24

F-box domain found in F-box only protein 40 (FBXO40) and similar proteins; FBXO40, also called FBX40, or muscle disease-related protein, is a probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438946  Cd Length: 49  Bit Score: 96.50  E-value: 1.64e-24
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 568994812 575 LTSLPLEVLQYIAGFLDSISLSQLSQVSVLMRNICATLLQERGMVLSQW 623
Cdd:cd22175    1 LSSLPLEILRHIAGFLDSFSLSQLSQVSVLMRDVCATLLQERGMVSLVW 49
F-box_FBXO30-like cd22101
F-box domain found in F-box only protein 30 (FBXO30), F-box only protein 40 (FBXO40) and ...
 575-619 4.81e-19

F-box domain found in F-box only protein 30 (FBXO30), F-box only protein 40 (FBXO40) and similar proteins; FBXO30, also called FBX30, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It is required for muscle atrophy following denervation. FBXO30 regulates mammopoiesis by targeting the bipolar mitotic kinesin Eg5. FBXO40, also called FBX40, or muscle disease-related protein, is a probable substrate-recognition component of an SCF-type E3 ubiquitin ligase complex that may function in myogenesis. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438873  Cd Length: 45  Bit Score: 80.88  E-value: 4.81e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 568994812 575 LTSLPLEVLQYIAGFLDSISLSQLSQVSVLMRNICATLLQERGMV 619
Cdd:cd22101    1 LSSLPFEILQHIARFLDSFSLCNLSLVSRLMREVCCSLLEERGMV 45
F-box_FBXO30 cd22174
F-box domain found in F-box only protein 30 (FBXO30) and similar proteins; FBXO30, also called ...
 575-623 6.43e-17

F-box domain found in F-box only protein 30 (FBXO30) and similar proteins; FBXO30, also called FBX30, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It is required for muscle atrophy following denervation. FBXO30 regulates mammopoiesis by targeting the bipolar mitotic kinesin Eg5. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438945  Cd Length: 49  Bit Score: 74.92  E-value: 6.43e-17
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 568994812 575 LTSLPLEVLQYIAGFLDSISLSQLSQVSVLMRNICATLLQERGMVLSQW 623
Cdd:cd22174    1 LSSLPFEVLQHIAGFLDGFSLCQLSRVSRLMRDVCASLLQARGMVILLW 49
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 576-609 3.98e-04

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 38.19  E-value: 3.98e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 568994812 576 TSLPLEVLQYIAGFLDSISLSQLSQVSVLMRNIC 609
Cdd:cd09917    1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELA 34
F-box_FBXL4 cd22117
F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also ...
 578-614 4.22e-04

F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438889  Cd Length: 47  Bit Score: 38.37  E-value: 4.22e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 568994812 578 LPLEVLQYIAGFLDSISLSQLSQVSVLMRNICATLLQ 614
Cdd:cd22117    4 LPYELIQLILSYLDLPSLCRLSQTCKLFRKHCYDPLL 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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