IQ calmodulin-binding motif-containing protein 1 isoform X1 [Mus musculus]
List of domain hits
Name | Accession | Description | Interval | E-value | |||
Adgb_C_mid-like super family | cl41701 | C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted ... |
385-430 | 1.73e-05 | |||
C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif; Androglobin (Adgb, also known as Calpain-7-like protein, CAPN7L) is a large multidomain protein consisting of an N-terminal peptidase C2 family calpain-like domain, an IQ calmodulin-binding motif, and an internal, circularly permuted globin domain. The canonical secondary structure of hemoglobins is an 3-over-3 alpha-helical sandwich structure, where the eight alpha-helical segments are conventionally labeled, A-H, according to their sequential order; Adgbs differ from this in having helices C-H followed by A-B. Adgbs and other phylogenetically ancient globins, such as neuroglobins and globin X, form hexacoordinated heme iron complexes. Globins contain various highly conserved residues of the heme pocket: including a Phe in the interhelical position CD1 (Phe CD1, first position in the loop between the helices C and D) that is packed against the heme, a His at the 7th position of the E-helix (His E7) that binds the heme iron distally, and a His at the 8th position of the F-helix (His F8) that binds the heme iron proximally. Unlike other hexacoordinated globins, Adgbs have an E7 Gln; their hexacoordination scheme is [Gln]-Fe-[His]. In mammals, Adgb is mainly expressed in the testes and may play an important role in spermatogenesis. Arthropod Adgbs have degenerate globin domains (DOI:10.3389/fgene.2020.00858). This model spans the permuted globin domain, the IQ motif, and a conserved region of about 200 amino acid residues located C-terminal to the globin domain; it does not include the N-terminal protease domain or the large uncharacterized C-terminal domain of approximately 500 residues. The actual alignment was detected with superfamily member cd22307: Pssm-ID: 412094 Cd Length: 416 Bit Score: 47.55 E-value: 1.73e-05
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COG5022 super family | cl34868 | Myosin heavy chain [General function prediction only]; |
293-408 | 3.71e-04 | |||
Myosin heavy chain [General function prediction only]; The actual alignment was detected with superfamily member COG5022: Pssm-ID: 227355 [Multi-domain] Cd Length: 1463 Bit Score: 43.53 E-value: 3.71e-04
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Name | Accession | Description | Interval | E-value | |||
Adgb_C_mid-like | cd22307 | C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted ... |
385-430 | 1.73e-05 | |||
C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif; Androglobin (Adgb, also known as Calpain-7-like protein, CAPN7L) is a large multidomain protein consisting of an N-terminal peptidase C2 family calpain-like domain, an IQ calmodulin-binding motif, and an internal, circularly permuted globin domain. The canonical secondary structure of hemoglobins is an 3-over-3 alpha-helical sandwich structure, where the eight alpha-helical segments are conventionally labeled, A-H, according to their sequential order; Adgbs differ from this in having helices C-H followed by A-B. Adgbs and other phylogenetically ancient globins, such as neuroglobins and globin X, form hexacoordinated heme iron complexes. Globins contain various highly conserved residues of the heme pocket: including a Phe in the interhelical position CD1 (Phe CD1, first position in the loop between the helices C and D) that is packed against the heme, a His at the 7th position of the E-helix (His E7) that binds the heme iron distally, and a His at the 8th position of the F-helix (His F8) that binds the heme iron proximally. Unlike other hexacoordinated globins, Adgbs have an E7 Gln; their hexacoordination scheme is [Gln]-Fe-[His]. In mammals, Adgb is mainly expressed in the testes and may play an important role in spermatogenesis. Arthropod Adgbs have degenerate globin domains (DOI:10.3389/fgene.2020.00858). This model spans the permuted globin domain, the IQ motif, and a conserved region of about 200 amino acid residues located C-terminal to the globin domain; it does not include the N-terminal protease domain or the large uncharacterized C-terminal domain of approximately 500 residues. Pssm-ID: 412094 Cd Length: 416 Bit Score: 47.55 E-value: 1.73e-05
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COG5022 | COG5022 | Myosin heavy chain [General function prediction only]; |
293-408 | 3.71e-04 | |||
Myosin heavy chain [General function prediction only]; Pssm-ID: 227355 [Multi-domain] Cd Length: 1463 Bit Score: 43.53 E-value: 3.71e-04
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IQ | smart00015 | Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ... |
387-408 | 4.45e-04 | |||
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues. Pssm-ID: 197470 [Multi-domain] Cd Length: 23 Bit Score: 37.69 E-value: 4.45e-04
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IQ | pfam00612 | IQ calmodulin-binding motif; Calmodulin-binding motif. |
388-408 | 1.47e-03 | |||
IQ calmodulin-binding motif; Calmodulin-binding motif. Pssm-ID: 425778 Cd Length: 21 Bit Score: 36.14 E-value: 1.47e-03
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IQ | pfam00612 | IQ calmodulin-binding motif; Calmodulin-binding motif. |
295-315 | 9.86e-03 | |||
IQ calmodulin-binding motif; Calmodulin-binding motif. Pssm-ID: 425778 Cd Length: 21 Bit Score: 33.83 E-value: 9.86e-03
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Name | Accession | Description | Interval | E-value | |||
Adgb_C_mid-like | cd22307 | C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted ... |
385-430 | 1.73e-05 | |||
C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif; Androglobin (Adgb, also known as Calpain-7-like protein, CAPN7L) is a large multidomain protein consisting of an N-terminal peptidase C2 family calpain-like domain, an IQ calmodulin-binding motif, and an internal, circularly permuted globin domain. The canonical secondary structure of hemoglobins is an 3-over-3 alpha-helical sandwich structure, where the eight alpha-helical segments are conventionally labeled, A-H, according to their sequential order; Adgbs differ from this in having helices C-H followed by A-B. Adgbs and other phylogenetically ancient globins, such as neuroglobins and globin X, form hexacoordinated heme iron complexes. Globins contain various highly conserved residues of the heme pocket: including a Phe in the interhelical position CD1 (Phe CD1, first position in the loop between the helices C and D) that is packed against the heme, a His at the 7th position of the E-helix (His E7) that binds the heme iron distally, and a His at the 8th position of the F-helix (His F8) that binds the heme iron proximally. Unlike other hexacoordinated globins, Adgbs have an E7 Gln; their hexacoordination scheme is [Gln]-Fe-[His]. In mammals, Adgb is mainly expressed in the testes and may play an important role in spermatogenesis. Arthropod Adgbs have degenerate globin domains (DOI:10.3389/fgene.2020.00858). This model spans the permuted globin domain, the IQ motif, and a conserved region of about 200 amino acid residues located C-terminal to the globin domain; it does not include the N-terminal protease domain or the large uncharacterized C-terminal domain of approximately 500 residues. Pssm-ID: 412094 Cd Length: 416 Bit Score: 47.55 E-value: 1.73e-05
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COG5022 | COG5022 | Myosin heavy chain [General function prediction only]; |
293-408 | 3.71e-04 | |||
Myosin heavy chain [General function prediction only]; Pssm-ID: 227355 [Multi-domain] Cd Length: 1463 Bit Score: 43.53 E-value: 3.71e-04
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IQ | smart00015 | Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ... |
387-408 | 4.45e-04 | |||
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues. Pssm-ID: 197470 [Multi-domain] Cd Length: 23 Bit Score: 37.69 E-value: 4.45e-04
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IQ | pfam00612 | IQ calmodulin-binding motif; Calmodulin-binding motif. |
388-408 | 1.47e-03 | |||
IQ calmodulin-binding motif; Calmodulin-binding motif. Pssm-ID: 425778 Cd Length: 21 Bit Score: 36.14 E-value: 1.47e-03
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IQ | pfam00612 | IQ calmodulin-binding motif; Calmodulin-binding motif. |
295-315 | 9.86e-03 | |||
IQ calmodulin-binding motif; Calmodulin-binding motif. Pssm-ID: 425778 Cd Length: 21 Bit Score: 33.83 E-value: 9.86e-03
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Blast search parameters | ||||
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