NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568995581|ref|XP_006522311|]
View 

IQ calmodulin-binding motif-containing protein 1 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Adgb_C_mid-like super family cl41701
C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted ...
385-430 1.73e-05

C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif; Androglobin (Adgb, also known as Calpain-7-like protein, CAPN7L) is a large multidomain protein consisting of an N-terminal peptidase C2 family calpain-like domain, an IQ calmodulin-binding motif, and an internal, circularly permuted globin domain. The canonical secondary structure of hemoglobins is an 3-over-3 alpha-helical sandwich structure, where the eight alpha-helical segments are conventionally labeled, A-H, according to their sequential order; Adgbs differ from this in having helices C-H followed by A-B. Adgbs and other phylogenetically ancient globins, such as neuroglobins and globin X, form hexacoordinated heme iron complexes. Globins contain various highly conserved residues of the heme pocket: including a Phe in the interhelical position CD1 (Phe CD1, first position in the loop between the helices C and D) that is packed against the heme, a His at the 7th position of the E-helix (His E7) that binds the heme iron distally, and a His at the 8th position of the F-helix (His F8) that binds the heme iron proximally. Unlike other hexacoordinated globins, Adgbs have an E7 Gln; their hexacoordination scheme is [Gln]-Fe-[His]. In mammals, Adgb is mainly expressed in the testes and may play an important role in spermatogenesis. Arthropod Adgbs have degenerate globin domains (DOI:10.3389/fgene.2020.00858). This model spans the permuted globin domain, the IQ motif, and a conserved region of about 200 amino acid residues located C-terminal to the globin domain; it does not include the N-terminal protease domain or the large uncharacterized C-terminal domain of approximately 500 residues.


The actual alignment was detected with superfamily member cd22307:

Pssm-ID: 412094  Cd Length: 416  Bit Score: 47.55  E-value: 1.73e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 568995581 385 EMEEKSALTIQKHWRGYRERKNFRQQRPSLTEY-KAAVTLQRAVLKF 430
Cdd:cd22307  144 IEEHEAATKIQAFFRGTLVRKLLKAHKPGTKENlKVAETLKKIWEKI 190
COG5022 super family cl34868
Myosin heavy chain [General function prediction only];
293-408 3.71e-04

Myosin heavy chain [General function prediction only];


The actual alignment was detected with superfamily member COG5022:

Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 43.53  E-value: 3.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995581  293 KLHKAACLIQAYWKGFQTRKRL---KKLPSAVIALQRSFRSkrtkmmleLNRQKEEEDLRLKLQLQRQRAMRLSRESRLN 369
Cdd:COG5022   743 KLDNIATRIQRAIRGRYLRRRYlqaLKRIKKIQVIQHGFRL--------RRLVDYELKWRLFIKLQPLLSLLGSRKEYRS 814
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568995581  370 MLEIIHPGQV---------EKYNREMEEKSALTIQKHWRGYRERKNFR 408
Cdd:COG5022   815 YLACIIKLQKtikrekklrETEEVEFSLKAEVLIQKFGRSLKAKKRFS 862
 
Name Accession Description Interval E-value
Adgb_C_mid-like cd22307
C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted ...
385-430 1.73e-05

C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif; Androglobin (Adgb, also known as Calpain-7-like protein, CAPN7L) is a large multidomain protein consisting of an N-terminal peptidase C2 family calpain-like domain, an IQ calmodulin-binding motif, and an internal, circularly permuted globin domain. The canonical secondary structure of hemoglobins is an 3-over-3 alpha-helical sandwich structure, where the eight alpha-helical segments are conventionally labeled, A-H, according to their sequential order; Adgbs differ from this in having helices C-H followed by A-B. Adgbs and other phylogenetically ancient globins, such as neuroglobins and globin X, form hexacoordinated heme iron complexes. Globins contain various highly conserved residues of the heme pocket: including a Phe in the interhelical position CD1 (Phe CD1, first position in the loop between the helices C and D) that is packed against the heme, a His at the 7th position of the E-helix (His E7) that binds the heme iron distally, and a His at the 8th position of the F-helix (His F8) that binds the heme iron proximally. Unlike other hexacoordinated globins, Adgbs have an E7 Gln; their hexacoordination scheme is [Gln]-Fe-[His]. In mammals, Adgb is mainly expressed in the testes and may play an important role in spermatogenesis. Arthropod Adgbs have degenerate globin domains (DOI:10.3389/fgene.2020.00858). This model spans the permuted globin domain, the IQ motif, and a conserved region of about 200 amino acid residues located C-terminal to the globin domain; it does not include the N-terminal protease domain or the large uncharacterized C-terminal domain of approximately 500 residues.


Pssm-ID: 412094  Cd Length: 416  Bit Score: 47.55  E-value: 1.73e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 568995581 385 EMEEKSALTIQKHWRGYRERKNFRQQRPSLTEY-KAAVTLQRAVLKF 430
Cdd:cd22307  144 IEEHEAATKIQAFFRGTLVRKLLKAHKPGTKENlKVAETLKKIWEKI 190
COG5022 COG5022
Myosin heavy chain [General function prediction only];
293-408 3.71e-04

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 43.53  E-value: 3.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995581  293 KLHKAACLIQAYWKGFQTRKRL---KKLPSAVIALQRSFRSkrtkmmleLNRQKEEEDLRLKLQLQRQRAMRLSRESRLN 369
Cdd:COG5022   743 KLDNIATRIQRAIRGRYLRRRYlqaLKRIKKIQVIQHGFRL--------RRLVDYELKWRLFIKLQPLLSLLGSRKEYRS 814
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568995581  370 MLEIIHPGQV---------EKYNREMEEKSALTIQKHWRGYRERKNFR 408
Cdd:COG5022   815 YLACIIKLQKtikrekklrETEEVEFSLKAEVLIQKFGRSLKAKKRFS 862
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
387-408 4.45e-04

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 37.69  E-value: 4.45e-04
                           10        20
                   ....*....|....*....|..
gi 568995581   387 EEKSALTIQKHWRGYRERKNFR 408
Cdd:smart00015   2 LTRAAIIIQAAWRGYLARKRYK 23
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
388-408 1.47e-03

IQ calmodulin-binding motif; Calmodulin-binding motif.


Pssm-ID: 425778  Cd Length: 21  Bit Score: 36.14  E-value: 1.47e-03
                          10        20
                  ....*....|....*....|.
gi 568995581  388 EKSALTIQKHWRGYRERKNFR 408
Cdd:pfam00612   1 RKAAIKIQAAWRGYLARKRYK 21
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
295-315 9.86e-03

IQ calmodulin-binding motif; Calmodulin-binding motif.


Pssm-ID: 425778  Cd Length: 21  Bit Score: 33.83  E-value: 9.86e-03
                          10        20
                  ....*....|....*....|.
gi 568995581  295 HKAACLIQAYWKGFQTRKRLK 315
Cdd:pfam00612   1 RKAAIKIQAAWRGYLARKRYK 21
 
Name Accession Description Interval E-value
Adgb_C_mid-like cd22307
C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted ...
385-430 1.73e-05

C-terminal middle region of Androglobins (Adgbs) and related proteins; including permuted globin domain and IQ motif; Androglobin (Adgb, also known as Calpain-7-like protein, CAPN7L) is a large multidomain protein consisting of an N-terminal peptidase C2 family calpain-like domain, an IQ calmodulin-binding motif, and an internal, circularly permuted globin domain. The canonical secondary structure of hemoglobins is an 3-over-3 alpha-helical sandwich structure, where the eight alpha-helical segments are conventionally labeled, A-H, according to their sequential order; Adgbs differ from this in having helices C-H followed by A-B. Adgbs and other phylogenetically ancient globins, such as neuroglobins and globin X, form hexacoordinated heme iron complexes. Globins contain various highly conserved residues of the heme pocket: including a Phe in the interhelical position CD1 (Phe CD1, first position in the loop between the helices C and D) that is packed against the heme, a His at the 7th position of the E-helix (His E7) that binds the heme iron distally, and a His at the 8th position of the F-helix (His F8) that binds the heme iron proximally. Unlike other hexacoordinated globins, Adgbs have an E7 Gln; their hexacoordination scheme is [Gln]-Fe-[His]. In mammals, Adgb is mainly expressed in the testes and may play an important role in spermatogenesis. Arthropod Adgbs have degenerate globin domains (DOI:10.3389/fgene.2020.00858). This model spans the permuted globin domain, the IQ motif, and a conserved region of about 200 amino acid residues located C-terminal to the globin domain; it does not include the N-terminal protease domain or the large uncharacterized C-terminal domain of approximately 500 residues.


Pssm-ID: 412094  Cd Length: 416  Bit Score: 47.55  E-value: 1.73e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 568995581 385 EMEEKSALTIQKHWRGYRERKNFRQQRPSLTEY-KAAVTLQRAVLKF 430
Cdd:cd22307  144 IEEHEAATKIQAFFRGTLVRKLLKAHKPGTKENlKVAETLKKIWEKI 190
COG5022 COG5022
Myosin heavy chain [General function prediction only];
293-408 3.71e-04

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 43.53  E-value: 3.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995581  293 KLHKAACLIQAYWKGFQTRKRL---KKLPSAVIALQRSFRSkrtkmmleLNRQKEEEDLRLKLQLQRQRAMRLSRESRLN 369
Cdd:COG5022   743 KLDNIATRIQRAIRGRYLRRRYlqaLKRIKKIQVIQHGFRL--------RRLVDYELKWRLFIKLQPLLSLLGSRKEYRS 814
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 568995581  370 MLEIIHPGQV---------EKYNREMEEKSALTIQKHWRGYRERKNFR 408
Cdd:COG5022   815 YLACIIKLQKtikrekklrETEEVEFSLKAEVLIQKFGRSLKAKKRFS 862
IQ smart00015
Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln ...
387-408 4.45e-04

Calmodulin-binding motif; Short calmodulin-binding motif containing conserved Ile and Gln residues.


Pssm-ID: 197470 [Multi-domain]  Cd Length: 23  Bit Score: 37.69  E-value: 4.45e-04
                           10        20
                   ....*....|....*....|..
gi 568995581   387 EEKSALTIQKHWRGYRERKNFR 408
Cdd:smart00015   2 LTRAAIIIQAAWRGYLARKRYK 23
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
388-408 1.47e-03

IQ calmodulin-binding motif; Calmodulin-binding motif.


Pssm-ID: 425778  Cd Length: 21  Bit Score: 36.14  E-value: 1.47e-03
                          10        20
                  ....*....|....*....|.
gi 568995581  388 EKSALTIQKHWRGYRERKNFR 408
Cdd:pfam00612   1 RKAAIKIQAAWRGYLARKRYK 21
IQ pfam00612
IQ calmodulin-binding motif; Calmodulin-binding motif.
295-315 9.86e-03

IQ calmodulin-binding motif; Calmodulin-binding motif.


Pssm-ID: 425778  Cd Length: 21  Bit Score: 33.83  E-value: 9.86e-03
                          10        20
                  ....*....|....*....|.
gi 568995581  295 HKAACLIQAYWKGFQTRKRLK 315
Cdd:pfam00612   1 RKAAIKIQAAWRGYLARKRYK 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH