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Conserved domains on  [gi|568995608|ref|XP_006522324|]
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target of Nesh-SH3 isoform X12 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 507-916 4.24e-15

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 81.52  E-value: 4.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  507 PSTPKRQSTPKPPRVKPAPEPETRPS--AQTTKAPRKTKKPGHHRLRRPKTTR-SPEVPKSKPALEPATVTPEILVPKIV 583
Cdd:PHA03247 2553 PPLPPAAPPAAPDRSVPPPRPAPRPSepAVTSRARRPDAPPQSARPRAPVDDRgDPRGPAPPSPLPPDTHAPDPPPPSPS 2632

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  584 PKPPQ----KPKATRRPEVPQVKPAHEPVTFGSEAPALAIVTTTDIEPVITRTKA------SVTTLAPKPPRPRTHRQRT 653
Cdd:PHA03247 2633 PAANEpdphPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAarptvgSLTSLADPPPPPPTPEPAP 2712

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  654 KYKTTQSPKIP-------HSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPEVPHTILVPATSLEPfIITEAPGTTL 726
Cdd:PHA03247 2713 HALVSATPLPPgpaaarqASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASL 2791

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  727 VPKLPQQPD----YPHPKPKTTRSPAASPTELVPTPVFEPVTPLKEDPVTTIVPitdLERVTDLETPVA----FRTEAPG 798
Cdd:PHA03247 2792 SESRESLPSpwdpADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP---PPPSLPLGGSVApggdVRRRPPS 2868

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  799 TTLASKISQRTHRPRPRPRPRPRPRPRPKATLSPQAPETKTVPAVVLEPVTLRPEVQVTTLAPQKTQKKHRPSPKPKPVP 878
Cdd:PHA03247 2869 RSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 568995608  879 SPEVTESKPVLPRVREPVTLRTETWVT------------TKAPKTPKRTR 916
Cdd:PHA03247 2949 PAGAGEPSGAVPQPWLGALVPGRVAVPrfrvpqpapsreAPASSTPPLTG 2998
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1366-1457 2.62e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.66  E-value: 2.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608 1366 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNP 1443
Cdd:cd00063     2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 568995608 1444 LGEGPASNTVAFST 1457
Cdd:cd00063    80 GGESPPSESVTVTT 93
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 1055-1369 2.12e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 2.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608 1055 PPKLKTPHSRMPAKEPVPKEPlhttSKPKMPPSPEVADTTSAPLETRGIPLIP-VISPRPSQEELqtAMEETDQSTQELF 1133
Cdd:PHA03247 2483 PAEARFPFAAGAAPDPGGGGP----PDPDAPPAPSRLAPAILPDEPVGEPVHPrMLTWIRGLEEL--ASDDAGDPPPPLP 2556

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608 1134 TTKIPRTTELAKTTqaphrlhtapvrPRIPGRPHGrPALNKTTTRPDKTKPRGTSHKNGVGTGTKQAPKPPSPgrnASVD 1213
Cdd:PHA03247 2557 PAAPPAAPDRSVPP------------PRPAPRPSE-PAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSP---LPPD 2620

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608 1214 SHATRKPGSVSGTRRPPIPHRHSSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKE 1293
Cdd:PHA03247 2621 THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLAD 2700

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568995608 1294 PTAPASEEEFGTTTDFSSSPTKETDPLGKPRFIGPHVRYIPKPENKPCSITDSVRRFPTEEATEG-NATSPPQNPPT 1369
Cdd:PHA03247 2701 PPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGpPAPAPPAAPAA 2777
fn3 pfam00041
Fibronectin type III domain;
116-195 1.84e-04

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 41.63  E-value: 1.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608   116 KPLQLVVGTLTPSSVFLSWgflinphhdwTLPSHCPSD-RFYTIRYREKDKEKKWIFQLCPATET--IVENLKPNTVYEF 192
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSW----------TPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTsvTLTGLKPGTEYEV 71


                   ...
gi 568995608   193 GVK 195
Cdd:pfam00041   72 RVQ 74
PRK11633 super family cl25866
cell division protein DedD; Provisional
 451-539 9.69e-03

cell division protein DedD; Provisional


The actual alignment was detected with superfamily member PRK11633:

Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 39.60  E-value: 9.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  451 RDPIlDSVPPKTSRTAEQP--------RATLAPIEALFESRNVEIFTSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVK 522
Cdd:PRK11633   50 RDEP-DMMPAATQALPTQPpegaaeavRAGDAAAPSLDPATVAPPNTPVEPEPAPVEPPKPKPVEKPKPKPKPQQKVEAP 128

                          90
                  ....*....|....*..
gi 568995608  523 PAPEPETRPSAQTTKAP 539
Cdd:PRK11633  129 PAPKPEPKPVVEEKAAP 145
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 507-916 4.24e-15

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 81.52  E-value: 4.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  507 PSTPKRQSTPKPPRVKPAPEPETRPS--AQTTKAPRKTKKPGHHRLRRPKTTR-SPEVPKSKPALEPATVTPEILVPKIV 583
Cdd:PHA03247 2553 PPLPPAAPPAAPDRSVPPPRPAPRPSepAVTSRARRPDAPPQSARPRAPVDDRgDPRGPAPPSPLPPDTHAPDPPPPSPS 2632

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  584 PKPPQ----KPKATRRPEVPQVKPAHEPVTFGSEAPALAIVTTTDIEPVITRTKA------SVTTLAPKPPRPRTHRQRT 653
Cdd:PHA03247 2633 PAANEpdphPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAarptvgSLTSLADPPPPPPTPEPAP 2712

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  654 KYKTTQSPKIP-------HSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPEVPHTILVPATSLEPfIITEAPGTTL 726
Cdd:PHA03247 2713 HALVSATPLPPgpaaarqASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASL 2791

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  727 VPKLPQQPD----YPHPKPKTTRSPAASPTELVPTPVFEPVTPLKEDPVTTIVPitdLERVTDLETPVA----FRTEAPG 798
Cdd:PHA03247 2792 SESRESLPSpwdpADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP---PPPSLPLGGSVApggdVRRRPPS 2868

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  799 TTLASKISQRTHRPRPRPRPRPRPRPRPKATLSPQAPETKTVPAVVLEPVTLRPEVQVTTLAPQKTQKKHRPSPKPKPVP 878
Cdd:PHA03247 2869 RSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 568995608  879 SPEVTESKPVLPRVREPVTLRTETWVT------------TKAPKTPKRTR 916
Cdd:PHA03247 2949 PAGAGEPSGAVPQPWLGALVPGRVAVPrfrvpqpapsreAPASSTPPLTG 2998
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1366-1457 2.62e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.66  E-value: 2.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608 1366 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNP 1443
Cdd:cd00063     2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 568995608 1444 LGEGPASNTVAFST 1457
Cdd:cd00063    80 GGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1367-1447 8.24e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 8.24e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608   1367 PPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV-ISRENGSFSGKNKSIQITNQTFS-TVENLKPDTSYEFQVKPKNPL 1444
Cdd:smart00060    3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVgYRVEYREEGSEWKEVNVTPSSTSyTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 568995608   1445 GEG 1447
Cdd:smart00060   81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
1367-1450 1.12e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.18  E-value: 1.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  1367 PPTNLTVVTVEgcPSFVILDWEKP--LNDTVTEYEVISRENGSFSGKNkSIQITNQTFS-TVENLKPDTSYEFQVKPKNP 1443
Cdd:pfam00041    2 APSNLTVTDVT--STSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWN-EITVPGTTTSvTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 568995608  1444 LGEGPAS 1450
Cdd:pfam00041   79 GGEGPPS 85
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 495-758 3.45e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 52.08  E-value: 3.45e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608   495 PTTAAPQQTTSIPSTPKRQS---TPKPPRVKPAPE-----PETRPSAQT----TKAPRKTKKPGHhrLRRPKTTRSPEVP 562
Cdd:pfam03154  313 PSPAAPGQSQQRIHTPPSQSqlqSQQPPREQPLPPaplsmPHIKPPPTTpipqLPNPQSHKHPPH--LSGPSPFQMNSNL 390

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608   563 KSKPALEPATVTPEILVPKIVPKPPQKPKATRRPEVPQVKPahepvtfgseapalaivtttdiePVITRTKASVTTLAPK 642
Cdd:pfam03154  391 PPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQP-----------------------PVLTQSQSLPPPAASH 447

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608   643 PPRPRTHRQRTKYKTTQSPKIPHSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPeVPHTilvPATSLEPFIITEAP 722
Cdd:pfam03154  448 PPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGP-VPAA---VSCPLPPVQIKEEA 523

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 568995608   723 gttlvPKLPQQPDYPHPKPkttRSPAASPTeLVPTP 758
Cdd:pfam03154  524 -----LDEAEEPESPPPPP---RSPSPEPT-VVNTP 550
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1055-1369 2.12e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 2.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608 1055 PPKLKTPHSRMPAKEPVPKEPlhttSKPKMPPSPEVADTTSAPLETRGIPLIP-VISPRPSQEELqtAMEETDQSTQELF 1133
Cdd:PHA03247 2483 PAEARFPFAAGAAPDPGGGGP----PDPDAPPAPSRLAPAILPDEPVGEPVHPrMLTWIRGLEEL--ASDDAGDPPPPLP 2556

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608 1134 TTKIPRTTELAKTTqaphrlhtapvrPRIPGRPHGrPALNKTTTRPDKTKPRGTSHKNGVGTGTKQAPKPPSPgrnASVD 1213
Cdd:PHA03247 2557 PAAPPAAPDRSVPP------------PRPAPRPSE-PAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSP---LPPD 2620

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608 1214 SHATRKPGSVSGTRRPPIPHRHSSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKE 1293
Cdd:PHA03247 2621 THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLAD 2700

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568995608 1294 PTAPASEEEFGTTTDFSSSPTKETDPLGKPRFIGPHVRYIPKPENKPCSITDSVRRFPTEEATEG-NATSPPQNPPT 1369
Cdd:PHA03247 2701 PPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGpPAPAPPAAPAA 2777
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1351-1462 1.25e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 46.53  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608 1351 PTEEATEGNATSPPqNPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEvISRENGSfSGKNKSIQITNQTFSTVENLKP 1430
Cdd:COG3401   220 PSNEVSVTTPTTPP-SAPTGLTATADT--PGSVTLSWDPVTESDATGYR-VYRSNSG-DGPFTKVATVTTTSYTDTGLTN 294

                          90       100       110
                  ....*....|....*....|....*....|...
gi 568995608 1431 DTSYEFQVKPKNPLG-EGPASNTVAFSTESADP 1462
Cdd:COG3401   295 GTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP 327
fn3 pfam00041
Fibronectin type III domain;
116-195 1.84e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 41.63  E-value: 1.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608   116 KPLQLVVGTLTPSSVFLSWgflinphhdwTLPSHCPSD-RFYTIRYREKDKEKKWIFQLCPATET--IVENLKPNTVYEF 192
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSW----------TPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTsvTLTGLKPGTEYEV 71


                   ...
gi 568995608   193 GVK 195
Cdd:pfam00041   72 RVQ 74
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 950-1254 2.03e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.06  E-value: 2.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608   950 VPATVVLATALTPVTLRTKAPKTTTLAPNVQRTRRPHPrpktTASTGVSESKSAPTELqslvlkpvTSPSleiiqsqsvs 1029
Cdd:pfam05109  405 ITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFAAP----NTTTGLPSSTHVPTNL--------TAPA---------- 462

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  1030 ddlelvafsteSPQKTIAPRQTTSMPPKLKTPHSRMPAKEPVPKEPLHTTSKPKMpPSPEVADTTSAPLETRGIPLIPVI 1109
Cdd:pfam05109  463 -----------STGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDM-TSPTSAVTTPTPNATSPTPAVTTP 530

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  1110 SPRPSQEELQTAmeetdqSTQELFTTKIPRTTELAKTTQAPHRLHTAPVRPRI-PGRPHGRPALNKTTTRPDKTKPRGTS 1188
Cdd:pfam05109  531 TPNATSPTLGKT------SPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTsPTSAVTTPTPNATSPTVGETSPQANT 604

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568995608  1189 HKNGVGtGTKQAPKPPSPGRNA-------------SVDSHATRKPGSVSGTRRPPIPHRHSSTRPVSPERRPLPPNNVT 1254
Cdd:pfam05109  605 TNHTLG-GTSSTPVVTSPPKNAtsavttgqhnitsSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTSAHPTGGENIT 682
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 114-195 2.49e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 2.49e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608    114 PRKPLQLVVGTLTPSSVFLSWgflinphhdwtLPSHCPSDRFYTIRYREKDKEKKWIFQLCPA----TETIVENLKPNTV 189
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSW-----------EPPPDDGITGYIVGYRVEYREEGSEWKEVNVtpssTSYTLTGLKPGTE 69


                    ....*.
gi 568995608    190 YEFGVK 195
Cdd:smart00060   70 YEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 114-195 2.60e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 41.71  E-value: 2.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  114 PRKPLQLVVGTLTPSSVFLSWgfliNPHHDWTLPSHcpsdrFYTIRYREKDKE--KKWIFQLCPATETIVENLKPNTVYE 191
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSW----TPPEDDGGPIT-----GYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYE 71


                  ....
gi 568995608  192 FGVK 195
Cdd:cd00063    72 FRVR 75
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 491-703 4.28e-04

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 44.76  E-value: 4.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  491 PEVRPTTAAPQ---QTTSIPSTPKRQSTPKPPRVKPAPEPETrPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKPA 567
Cdd:NF033839  286 EPGNKKPSAPKpgmQPSPQPEKKEVKPEPETPKPEVKPQLEK-PKPEVKPQPEKPKPEVKPQLETPKPEVKPQPEKPKPE 364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  568 LEPATVTPEilvpKIVPKPPQKPKATRRPEVPQVKPAHEPvtfGSEAPalaivtTTDIEPVITRTKASVTTlAPKPPRPR 647
Cdd:NF033839  365 VKPQPEKPK----PEVKPQPETPKPEVKPQPEKPKPEVKP---QPEKP------KPEVKPQPEKPKPEVKP-QPEKPKPE 430

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568995608  648 THRQRTKYKttqspkiPHSKPADLGPITSEPPLASTTKKVRRP---RPKPQTTPHPEVP 703
Cdd:NF033839  431 VKPQPEKPK-------PEVKPQPEKPKPEVKPQPETPKPEVKPqpeKPKPEVKPQPEKP 482
Not5 COG5665
CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];
428-770 3.81e-03

CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];


Pssm-ID: 444384 [Multi-domain]  Cd Length: 874  Bit Score: 41.96  E-value: 3.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  428 ATYDVISSSTTSDETEIEIHTATR-------DPILDSVPPKTSRTAEQPRATLAPIEALFESRNVEIFTSPEVR------ 494
Cdd:COG5665   208 STPQAFNASATSGRSQHIVQAAKRvgvewwgDPSLLATPPATPATEEKSSQQPKSQPTSPSGGTTPPSTNQLTTsntpts 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  495 --------PTTAAPQQTTSIPSTPKRQSTPKPPRV--KPAPEPETRPSAQTTKAPRKTKKPGHhrlrRPKTTRSPEVPKS 564
Cdd:COG5665   288 takaqpqpPTKKQPAKEPPSDTASGNPSAPSVLINsdSPTSEDPATASVPTTEETTAFTTPSS----VPSTPAEKDTPAT 363

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  565 KPALEPATVTPEILV-PKIVPKPPQKPKATrrpevpqvkpAHEPVTFGSEAPalaivtttdiepvitrtkASVTTLAPKP 643
Cdd:COG5665   364 DLATPVSPTPPETSVdKKVSPDSATSSTKS----------EKEGGTASSPMP------------------PNIAIGAKDD 415

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  644 PRPRTHRQRTKYKTTQSPKIPHSKPADLGPITSEPPLAS--------TTKKVRRPRPKPQTTPHPEVPHTILVPATSLEP 715
Cdd:COG5665   416 VDATDPSQEAKEYTKNAPMTPEADSAPESSVRTEASPSAgsdlepenTTLRDPAPNAIPPPEDPSTIGRLSSGDKLANET 495

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  716 FIITEAPGTTLVPKLPQQ--PDYPHPKPKTT---RSPAASPTELVPTPVFEPVTPLKEDP 770
Cdd:COG5665   496 GPPVIRRDSTPSSTADQSivGVLAFGLDQRTqaeISVEAASRSNPLLNSQVKSFPLGKRS 555
PRK11633 PRK11633
cell division protein DedD; Provisional
 451-539 9.69e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 39.60  E-value: 9.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  451 RDPIlDSVPPKTSRTAEQP--------RATLAPIEALFESRNVEIFTSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVK 522
Cdd:PRK11633   50 RDEP-DMMPAATQALPTQPpegaaeavRAGDAAAPSLDPATVAPPNTPVEPEPAPVEPPKPKPVEKPKPKPKPQQKVEAP 128

                          90
                  ....*....|....*..
gi 568995608  523 PAPEPETRPSAQTTKAP 539
Cdd:PRK11633  129 PAPKPEPKPVVEEKAAP 145
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 507-916 4.24e-15

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 81.52  E-value: 4.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  507 PSTPKRQSTPKPPRVKPAPEPETRPS--AQTTKAPRKTKKPGHHRLRRPKTTR-SPEVPKSKPALEPATVTPEILVPKIV 583
Cdd:PHA03247 2553 PPLPPAAPPAAPDRSVPPPRPAPRPSepAVTSRARRPDAPPQSARPRAPVDDRgDPRGPAPPSPLPPDTHAPDPPPPSPS 2632

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  584 PKPPQ----KPKATRRPEVPQVKPAHEPVTFGSEAPALAIVTTTDIEPVITRTKA------SVTTLAPKPPRPRTHRQRT 653
Cdd:PHA03247 2633 PAANEpdphPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAarptvgSLTSLADPPPPPPTPEPAP 2712

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  654 KYKTTQSPKIP-------HSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPEVPHTILVPATSLEPfIITEAPGTTL 726
Cdd:PHA03247 2713 HALVSATPLPPgpaaarqASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASL 2791

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  727 VPKLPQQPD----YPHPKPKTTRSPAASPTELVPTPVFEPVTPLKEDPVTTIVPitdLERVTDLETPVA----FRTEAPG 798
Cdd:PHA03247 2792 SESRESLPSpwdpADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP---PPPSLPLGGSVApggdVRRRPPS 2868

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  799 TTLASKISQRTHRPRPRPRPRPRPRPRPKATLSPQAPETKTVPAVVLEPVTLRPEVQVTTLAPQKTQKKHRPSPKPKPVP 878
Cdd:PHA03247 2869 RSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTD 2948

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 568995608  879 SPEVTESKPVLPRVREPVTLRTETWVT------------TKAPKTPKRTR 916
Cdd:PHA03247 2949 PAGAGEPSGAVPQPWLGALVPGRVAVPrfrvpqpapsreAPASSTPPLTG 2998
PHA03247 PHA03247
large tegument protein UL36; Provisional
 456-1095 1.43e-12

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 73.43  E-value: 1.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  456 DSVPPKTSRTAEQPRATLAPIEALFESRNveifTSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEPETRPSaqt 535
Cdd:PHA03247 2558 AAPPAAPDRSVPPPRPAPRPSEPAVTSRA----RRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPS--- 2630

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  536 tKAPRKTKKPGHHRLRRPKttrsPEVPKSKPAlePATVTPEILVPKIvPKPPQKPKATRRPEVPQVKPAHEPVTFGSEAP 615
Cdd:PHA03247 2631 -PSPAANEPDPHPPPTVPP----PERPRDDPA--PGRVSRPRRARRL-GRAAQASSPPQRPRRRAARPTVGSLTSLADPP 2702

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  616 AlaivtttdiepvitrtkasvttlAPKPPRPRTHRQRTKYKTTQSPKIPH--SKPADLGPITSEPPLASTTKKVRRPRPK 693
Cdd:PHA03247 2703 P-----------------------PPPTPEPAPHALVSATPLPPGPAAARqaSPALPAAPAPPAVPAGPATPGGPARPAR 2759

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  694 PQTTPHPEVPHTILVPATSLEPfIITEAPGTTLVPKLPQQPD----YPHPKPKTTRSPAASPTELVPTPVFEPVTPLKED 769
Cdd:PHA03247 2760 PPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASLSESRESLPSpwdpADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTA 2838

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  770 PVTTIVPitdLERVTDLETPVA----FRTEAPGTTLASKISQRTHRPRPRPRPRPRPRPRPKATLSPQAPETKTVPAVVL 845
Cdd:PHA03247 2839 PPPPPGP---PPPSLPLGGSVApggdVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPP 2915

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  846 EPVTLRPEVQVTTLAPQKTQKKHRPSPKPKPVPSPEVTESKPVLPrvrepvtlrtETWVTTKAPKTPKRTRRPRPkpqtt 925
Cdd:PHA03247 2916 PPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVP----------QPWLGALVPGRVAVPRFRVP----- 2980

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  926 ptpetpltkpvaatdlePSALSTEVPAtvvlataltpvtlrtkaPKTTTlapnvqRTRRPHPRPKTTASTGVSESKSAPt 1005
Cdd:PHA03247 2981 -----------------QPAPSREAPA-----------------SSTPP------LTGHSLSRVSSWASSLALHEETDP- 3019

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608 1006 elqslvlkpvtsPSLEIIQSQSVSDDLElvafstespqKTIAPRQTTSMPPKLKTPhsrmpAKEPVPKEPLHTTSKPKMP 1085
Cdd:PHA03247 3020 ------------PPVSLKQTLWPPDDTE----------DSDADSLFDSDSERSDLE-----ALDPLPPEPHDPFAHEPDP 3072

                         650
                  ....*....|
gi 568995608 1086 PSPEVADTTS 1095
Cdd:PHA03247 3073 ATPEAGARES 3082
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 509-776 1.55e-12

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 72.80  E-value: 1.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  509 TPKRQSTPKPPRV-----KPAPEPETRPSA--QTTKAPRKTKKPGHHRlrRPKTTRSPEVPKS--KPALEPATVTPEILV 579
Cdd:PTZ00449  542 EPKEGGKPGETKEgevgkKPGPAKEHKPSKipTLSKKPEFPKDPKHPK--DPEEPKKPKRPRSaqRPTRPKSPKLPELLD 619

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  580 PKIVPKPPQKPKATRRPevpqvkpahepvtfgseapalaivtttdiepvitrtkasvttlaPKPPRPRTHRQRTKYKTTQ 659
Cdd:PTZ00449  620 IPKSPKRPESPKSPKRP--------------------------------------------PPPQRPSSPERPEGPKIIK 655

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  660 SPKIPHSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPEVPHTILVPATSLEPFIITEAPgTTLVPKLPQQPDYPHP 739
Cdd:PTZ00449  656 SPKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTP-RPLPPKLPRDEEFPFE 734

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 568995608  740 KPKTTRSPAASPTELVPTPVfEPVTPLKEDPVTTIVP 776
Cdd:PTZ00449  735 PIGDPDAEQPDDIEFFTPPE-EERTFFHETPADTPLP 770
PHA03247 PHA03247
large tegument protein UL36; Provisional
 448-743 2.50e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 65.73  E-value: 2.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  448 TATRDPILDSVPPKTSRTAEQPRATLAPIEALFESRNVEIFTSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEP 527
Cdd:PHA03247 2696 TSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAP 2775

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  528 ETRPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKP-ALEPATVTPEILVP---KIVPKPPQKPKATRRPEVPQVKP 603
Cdd:PHA03247 2776 AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPaAALPPAASPAGPLPpptSAQPTAPPPPPGPPPPSLPLGGS 2855

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  604 AHEPVTFGSEAPALAIVTTtdiepVITRTKASVTTLAPKPPRPRTHRQRTKYKTTQSPKIPHSKPADLGPITSEPPLAST 683
Cdd:PHA03247 2856 VAPGGDVRRRPPSRSPAAK-----PAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQ 2930

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568995608  684 TKKVRRPRPKPQTTPHPEVPHTILVPATSLEPFIITEAPGTTLVPKL---PQQPDYPHPKPKT 743
Cdd:PHA03247 2931 PPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFrvpQPAPSREAPASST 2993
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1366-1457 2.62e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 58.66  E-value: 2.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608 1366 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNP 1443
Cdd:cd00063     2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|....
gi 568995608 1444 LGEGPASNTVAFST 1457
Cdd:cd00063    80 GGESPPSESVTVTT 93
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 494-844 6.22e-08

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 57.78  E-value: 6.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  494 RPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEpetrpSAQTTKAPRKTKKPGhhRLRRPKTTRSPEVPKSKPALEPATV 573
Cdd:PTZ00449  560 KPGPAKEHKPSKIPTLSKKPEFPKDPKHPKDPE-----EPKKPKRPRSAQRPT--RPKSPKLPELLDIPKSPKRPESPKS 632

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  574 tpeilvPKiVPKPPQKPKATRRPEVPQV----KPAHEP-VTFGseaPALAIVTTTDIEPVITRTKASVTTLAPKpprpRT 648
Cdd:PTZ00449  633 ------PK-RPPPPQRPSSPERPEGPKIikspKPPKSPkPPFD---PKFKEKFYDDYLDAAAKSKETKTTVVLD----ES 698

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  649 HRQRTKYKTTQSPKIPHSKPADLGPITSEPPLASTT--KKVRRPRPKPQTTPHPEVPHTILV---PATSLEPFIITEAPG 723
Cdd:PTZ00449  699 FESILKETLPETPGTPFTTPRPLPPKLPRDEEFPFEpiGDPDAEQPDDIEFFTPPEEERTFFhetPADTPLPDILAEEFK 778

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  724 TTLVPKLPQQPDYPHPKPKttrspaaSPTELVPTPVFE-PVTPLK----------------------EDPVTTIVPITDL 780
Cdd:PTZ00449  779 EEDIHAETGEPDEAMKRPD-------SPSEHEDKPPGDhPSLPKKrhrldglalsttdlesdagriaKDASGKIVKLKRS 851

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  781 ERVTDLET--------PVAFR-------TEAPGT-TLASKISQRTHRPRPRPRPRPRPRPRPKATLSPQAPETKTVPAVV 844
Cdd:PTZ00449  852 KSFDDLTTveeaeemgAEARKivvdddgTEADDEdTHPPEEKHKSEVRRRRPPKKPSKPKKPSKPKKPKKPDSAFIPSII 931
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1367-1447 8.24e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.08  E-value: 8.24e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608   1367 PPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV-ISRENGSFSGKNKSIQITNQTFS-TVENLKPDTSYEFQVKPKNPL 1444
Cdd:smart00060    3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVgYRVEYREEGSEWKEVNVTPSSTSyTLTGLKPGTEYEFRVRAVNGA 80


                    ...
gi 568995608   1445 GEG 1447
Cdd:smart00060   81 GEG 83
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 381-767 1.23e-07

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 56.62  E-value: 1.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  381 KRFPEFPEAKTAFPLEKPRGSWASSEEPwVVPGAKTSEdSRVVQPQTATYDVISSSTTSDETEIEI---------HTATR 451
Cdd:PTZ00449  494 KKLAPIEEEDSDKHDEPPEGPEASGLPP-KAPGDKEGE-EGEHEDSKESDEPKEGGKPGETKEGEVgkkpgpakeHKPSK 571

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  452 DPILDSVP-----PKTSRTAEQPRATLAPIEAlfesrnveiftSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRvkpAPE 526
Cdd:PTZ00449  572 IPTLSKKPefpkdPKHPKDPEEPKKPKRPRSA-----------QRPTRPKSPKLPELLDIPKSPKRPESPKSPK---RPP 637

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  527 PETRPSAQttkaprktkkpghhrlRRPKTTRSPEVPKSKPAlepatvtpeilvpkivPKPPQKPKATRRPEVPQVKPAHE 606
Cdd:PTZ00449  638 PPQRPSSP----------------ERPEGPKIIKSPKPPKS----------------PKPPFDPKFKEKFYDDYLDAAAK 685

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  607 PVTFGSEAPALAIVTTTDIEPVITRTKASVTTLAPKPP-RPRThrqrtkykttqsPKIPHSKPADlgpitsePPLASTTK 685
Cdd:PTZ00449  686 SKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPkLPRD------------EEFPFEPIGD-------PDAEQPDD 746

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  686 KVRRPRPKPQTTPHPEvphtilVPATSLEPFIITEAPGTTLVPKLPQQPDYPHPKPKttrspaaSPTELVPTPVFE-PVT 764
Cdd:PTZ00449  747 IEFFTPPEEERTFFHE------TPADTPLPDILAEEFKEEDIHAETGEPDEAMKRPD-------SPSEHEDKPPGDhPSL 813


                  ...
gi 568995608  765 PLK 767
Cdd:PTZ00449  814 PKK 816
PHA03247 PHA03247
large tegument protein UL36; Provisional
 545-1116 1.25e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.87  E-value: 1.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  545 PGHHRLRRPKTTRSPEVPKSKPalEPATVTPEilvPKIVPKPPQKPKATRRPEVPQVKPAHEPV-------------TFG 611
Cdd:PHA03247 2475 PGAPVYRRPAEARFPFAAGAAP--DPGGGGPP---DPDAPPAPSRLAPAILPDEPVGEPVHPRMltwirgleelasdDAG 2549

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  612 SEAPALAivttTDIEPVITRTKASVTTLAPKPPRPRTHRQRTKYKTTQSPKIPHSKPADLGPitsepplasttkkvrrPR 691
Cdd:PHA03247 2550 DPPPPLP----PAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGD----------------PR 2609

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  692 PKPQTTPHPEVPHTILVPATSLEPFIITEAPGTTLVPKLPQQPDYPHPKPKTTRSPAASPTELVPTPVFEPVTPLKEDPV 771
Cdd:PHA03247 2610 GPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAAR 2689

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  772 TTIVPITDLErvtdletpvafRTEAPGTTLASKISQRTHRPRPRPRPRPRPRPRPKATLSPQAPETKTVPAVVLEPVtlR 851
Cdd:PHA03247 2690 PTVGSLTSLA-----------DPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPA--R 2756

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  852 PEVQVTTLAPqktqkkhrpspkpkpvpspevteSKPVLPRVREPVTLRTETwVTTKAPKTPKRTRRPRPKPQTTPTPETP 931
Cdd:PHA03247 2757 PARPPTTAGP-----------------------PAPAPPAAPAAGPPRRLT-RPAVASLSESRESLPSPWDPADPPAAVL 2812

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  932 LTKPVAATDLEPSALSTEVPATVVLATALTPVTLRTKAPKTTTLAPNVQRTRRPHPRPKTTASTgvsesksAPTElqslv 1011
Cdd:PHA03247 2813 APAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPA-------APAR----- 2880

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608 1012 lkpvtsPSLEIIQSQSVSDDLELVAFSTESPQKtiaPRQTTSMPPKLKTPHSRMPakePVPKEPLHTTSKPKMPPSPEvA 1091
Cdd:PHA03247 2881 ------PPVRRLARPAVSRSTESFALPPDQPER---PPQPQAPPPPQPQPQPPPP---PQPQPPPPPPPRPQPPLAPT-T 2947

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|
gi 568995608 1092 DTTSAPLETRGIP------LIP---------VISPRPSQE 1116
Cdd:PHA03247 2948 DPAGAGEPSGAVPqpwlgaLVPgrvavprfrVPQPAPSRE 2987
PHA03247 PHA03247
large tegument protein UL36; Provisional
 524-1052 1.57e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 56.49  E-value: 1.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  524 APEPETRPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKskPALEPATVTPEILVPKIV-------------------P 584
Cdd:PHA03247 2477 APVYRRPAEARFPFAAGAAPDPGGGGPPDPDAPPAPSRLA--PAILPDEPVGEPVHPRMLtwirgleelasddagdpppP 2554

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  585 KPPQKPKATRRPEVPQVKPAHEPvtfgSEAPALAIVTTTDIEPVITRTKASV-------TTLAPKPPRPRTHR------- 650
Cdd:PHA03247 2555 LPPAAPPAAPDRSVPPPRPAPRP----SEPAVTSRARRPDAPPQSARPRAPVddrgdprGPAPPSPLPPDTHApdpppps 2630

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  651 QRTKYKTTQSPKIPHSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPEVPHTILVPATSlepfiiteAPGTTLVpKL 730
Cdd:PHA03247 2631 PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTV--------GSLTSLA-DP 2701

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  731 PQQPDYPHPKPKTTRSpaASPTELVPTPVFEPVTPLKEDPVTTIVPITDLERVTDLETPVAFRTEAPGTTLASKISQRTH 810
Cdd:PHA03247 2702 PPPPPTPEPAPHALVS--ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGP 2779

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  811 RPRPRPRPRPRPRPRPKATLSPQAPETKTVPAVVLEPVTLRPEVQVTTLAPQKTQKKHRPSPKPKPVPSPEVTESKpVLP 890
Cdd:PHA03247 2780 PRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGS-VAP 2858

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  891 rvREPVTLRTETWVTTKAPKTPKRTRRPRPKPQTTPTPEtpltkpvaatdlEPSALSTEVPATVVLATALTPVTLRTKAP 970
Cdd:PHA03247 2859 --GGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRST------------ESFALPPDQPERPPQPQAPPPPQPQPQPP 2924

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  971 KTTTLAPNVQRTRRPHPRPKTTAST-GVSESKSAPTELQSLVLKPVTSPSLEIIQSQSvSDDLELVAFSTESPQKTIAPR 1049
Cdd:PHA03247 2925 PPPQPQPPPPPPPRPQPPLAPTTDPaGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQP-APSREAPASSTPPLTGHSLSR 3003


                  ...
gi 568995608 1050 QTT 1052
Cdd:PHA03247 3004 VSS 3006
fn3 pfam00041
Fibronectin type III domain;
1367-1450 1.12e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.18  E-value: 1.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  1367 PPTNLTVVTVEgcPSFVILDWEKP--LNDTVTEYEVISRENGSFSGKNkSIQITNQTFS-TVENLKPDTSYEFQVKPKNP 1443
Cdd:pfam00041    2 APSNLTVTDVT--STSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWN-EITVPGTTTSvTLTGLKPGTEYEVRVQAVNG 78


                   ....*..
gi 568995608  1444 LGEGPAS 1450
Cdd:pfam00041   79 GGEGPPS 85
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 495-758 3.45e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 52.08  E-value: 3.45e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608   495 PTTAAPQQTTSIPSTPKRQS---TPKPPRVKPAPE-----PETRPSAQT----TKAPRKTKKPGHhrLRRPKTTRSPEVP 562
Cdd:pfam03154  313 PSPAAPGQSQQRIHTPPSQSqlqSQQPPREQPLPPaplsmPHIKPPPTTpipqLPNPQSHKHPPH--LSGPSPFQMNSNL 390

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608   563 KSKPALEPATVTPEILVPKIVPKPPQKPKATRRPEVPQVKPahepvtfgseapalaivtttdiePVITRTKASVTTLAPK 642
Cdd:pfam03154  391 PPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQP-----------------------PVLTQSQSLPPPAASH 447

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608   643 PPRPRTHRQRTKYKTTQSPKIPHSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPeVPHTilvPATSLEPFIITEAP 722
Cdd:pfam03154  448 PPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGP-VPAA---VSCPLPPVQIKEEA 523

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 568995608   723 gttlvPKLPQQPDYPHPKPkttRSPAASPTeLVPTP 758
Cdd:pfam03154  524 -----LDEAEEPESPPPPP---RSPSPEPT-VVNTP 550
PHA03377 PHA03377
EBNA-3C; Provisional
 517-703 5.56e-06

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 51.21  E-value: 5.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  517 KPPRVKPAPEPETRPSAQT---TKAPRKTKKPGHHRLRRPKTTRSPEVPkskpaLEPATVTPEILVPKIVPKPPQKPKAT 593
Cdd:PHA03377  414 RKPRTLPWPTPKTHPVKRTlvkTSGRSDEAEQAQSTPERPGPSDQPSVP-----VEPAHLTPVEHTTVILHQPPQSPPTV 488

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  594 rrpevpQVKPAHEPVTFGSEApalAIVTTTDIEPVITRTKASVTTLAPKPPRPRTHRQRTKYKTTQSPK---IPHSKPAD 670
Cdd:PHA03377  489 ------AIKPAPPPSRRRRGA---CVVYDDDIIEVIDVETTEEEESVTQPAKPHRKVQDGFQRSGRRQKratPPKVSPSD 559

                         170       180       190
                  ....*....|....*....|....*....|...
gi 568995608  671 LGPITSEPPLASTTKKVRRPRPKPQTTPHPEVP 703
Cdd:PHA03377  560 RGPPKASPPVMAPPSTGPRVMATPSTGPRDMAP 592
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1055-1369 2.12e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 2.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608 1055 PPKLKTPHSRMPAKEPVPKEPlhttSKPKMPPSPEVADTTSAPLETRGIPLIP-VISPRPSQEELqtAMEETDQSTQELF 1133
Cdd:PHA03247 2483 PAEARFPFAAGAAPDPGGGGP----PDPDAPPAPSRLAPAILPDEPVGEPVHPrMLTWIRGLEEL--ASDDAGDPPPPLP 2556

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608 1134 TTKIPRTTELAKTTqaphrlhtapvrPRIPGRPHGrPALNKTTTRPDKTKPRGTSHKNGVGTGTKQAPKPPSPgrnASVD 1213
Cdd:PHA03247 2557 PAAPPAAPDRSVPP------------PRPAPRPSE-PAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSP---LPPD 2620

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608 1214 SHATRKPGSVSGTRRPPIPHRHSSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKE 1293
Cdd:PHA03247 2621 THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLAD 2700

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568995608 1294 PTAPASEEEFGTTTDFSSSPTKETDPLGKPRFIGPHVRYIPKPENKPCSITDSVRRFPTEEATEG-NATSPPQNPPT 1369
Cdd:PHA03247 2701 PPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGpPAPAPPAAPAA 2777
PHA03247 PHA03247
large tegument protein UL36; Provisional
 957-1388 3.67e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 3.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  957 ATALTPVTLRTKAPKTTTLAPNVQRTRRPHPRPKTTASTGvSESKSAPTELQSLVLKPVTSPSLEIIQSQSVSDDLELVA 1036
Cdd:PHA03247 2596 ARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAA-NEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAA 2674

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608 1037 FSTESPQK--------TIAPRQTTSMPP-KLKTPHSRMPAKEPVPKEPLHTTSKPKMPPSPEVADTTSAPLETRGIPLIP 1107
Cdd:PHA03247 2675 QASSPPQRprrraarpTVGSLTSLADPPpPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGP 2754

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608 1108 VISPRPSqeelQTAMEETDQSTQELFTTKIPRTTELAKTTQAPHRlhTAPVRPRIPGrPHGRPALNKTTTRPDKTKPRGT 1187
Cdd:PHA03247 2755 ARPARPP----TTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESR--ESLPSPWDPA-DPPAAVLAPAAALPPAASPAGP 2827

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608 1188 SHKNgvGTGTKQAPKPPSPGRNASVDSHATRKPGSvSGTRRPPiphrhSSTRPVSPERRPLPPNNVTGKPGRAGIVSSSR 1267
Cdd:PHA03247 2828 LPPP--TSAQPTAPPPPPGPPPPSLPLGGSVAPGG-DVRRRPP-----SRSPAAKPAAPARPPVRRLARPAVSRSTESFA 2899

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608 1268 VTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDFSSSPTKETDPLGKPRFIGPHvryiPKPENKPCSITDSV 1347
Cdd:PHA03247 2900 LPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQ----PWLGALVPGRVAVP 2975

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 568995608 1348 RRFPTEEATEGNATSPPQNPPTNLTVVTVEGCPSFVILDWE 1388
Cdd:PHA03247 2976 RFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEE 3016
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1351-1462 1.25e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 46.53  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608 1351 PTEEATEGNATSPPqNPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEvISRENGSfSGKNKSIQITNQTFSTVENLKP 1430
Cdd:COG3401   220 PSNEVSVTTPTTPP-SAPTGLTATADT--PGSVTLSWDPVTESDATGYR-VYRSNSG-DGPFTKVATVTTTSYTDTGLTN 294

                          90       100       110
                  ....*....|....*....|....*....|...
gi 568995608 1431 DTSYEFQVKPKNPLG-EGPASNTVAFSTESADP 1462
Cdd:COG3401   295 GTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP 327
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1351-1505 1.66e-04

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 46.15  E-value: 1.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608 1351 PTEEATEGNATSPPQnPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV--ISRENGSFSGKNKSIqitNQTFSTVENL 1428
Cdd:COG3401   314 PSNVVSVTTDLTPPA-APSGLTATAVG--SSSITLSWTASSDADVTGYNVyrSTSGGGTYTKIAETV---TTTSYTDTGL 387

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568995608 1429 KPDTSYEFQVKPKNPLG-EGPASNTVAFSTESADPRVSEPISAGRDAIWTERPFNSDSYSECKGKQYVKRTWYKKFVG 1505
Cdd:COG3401   388 TPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSAAVLADGGDTG 465
fn3 pfam00041
Fibronectin type III domain;
116-195 1.84e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 41.63  E-value: 1.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608   116 KPLQLVVGTLTPSSVFLSWgflinphhdwTLPSHCPSD-RFYTIRYREKDKEKKWIFQLCPATET--IVENLKPNTVYEF 192
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSW----------TPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTsvTLTGLKPGTEYEV 71


                   ...
gi 568995608   193 GVK 195
Cdd:pfam00041   72 RVQ 74
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 950-1254 2.03e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.06  E-value: 2.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608   950 VPATVVLATALTPVTLRTKAPKTTTLAPNVQRTRRPHPrpktTASTGVSESKSAPTELqslvlkpvTSPSleiiqsqsvs 1029
Cdd:pfam05109  405 ITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFAAP----NTTTGLPSSTHVPTNL--------TAPA---------- 462

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  1030 ddlelvafsteSPQKTIAPRQTTSMPPKLKTPHSRMPAKEPVPKEPLHTTSKPKMpPSPEVADTTSAPLETRGIPLIPVI 1109
Cdd:pfam05109  463 -----------STGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDM-TSPTSAVTTPTPNATSPTPAVTTP 530

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  1110 SPRPSQEELQTAmeetdqSTQELFTTKIPRTTELAKTTQAPHRLHTAPVRPRI-PGRPHGRPALNKTTTRPDKTKPRGTS 1188
Cdd:pfam05109  531 TPNATSPTLGKT------SPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTsPTSAVTTPTPNATSPTVGETSPQANT 604

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568995608  1189 HKNGVGtGTKQAPKPPSPGRNA-------------SVDSHATRKPGSVSGTRRPPIPHRHSSTRPVSPERRPLPPNNVT 1254
Cdd:pfam05109  605 TNHTLG-GTSSTPVVTSPPKNAtsavttgqhnitsSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTSAHPTGGENIT 682
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 114-195 2.49e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 2.49e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608    114 PRKPLQLVVGTLTPSSVFLSWgflinphhdwtLPSHCPSDRFYTIRYREKDKEKKWIFQLCPA----TETIVENLKPNTV 189
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSW-----------EPPPDDGITGYIVGYRVEYREEGSEWKEVNVtpssTSYTLTGLKPGTE 69


                    ....*.
gi 568995608    190 YEFGVK 195
Cdd:smart00060   70 YEFRVR 75
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 114-195 2.60e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 41.71  E-value: 2.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  114 PRKPLQLVVGTLTPSSVFLSWgfliNPHHDWTLPSHcpsdrFYTIRYREKDKE--KKWIFQLCPATETIVENLKPNTVYE 191
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSW----TPPEDDGGPIT-----GYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYE 71


                  ....
gi 568995608  192 FGVK 195
Cdd:cd00063    72 FRVR 75
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 491-703 4.28e-04

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 44.76  E-value: 4.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  491 PEVRPTTAAPQ---QTTSIPSTPKRQSTPKPPRVKPAPEPETrPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKPA 567
Cdd:NF033839  286 EPGNKKPSAPKpgmQPSPQPEKKEVKPEPETPKPEVKPQLEK-PKPEVKPQPEKPKPEVKPQLETPKPEVKPQPEKPKPE 364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  568 LEPATVTPEilvpKIVPKPPQKPKATRRPEVPQVKPAHEPvtfGSEAPalaivtTTDIEPVITRTKASVTTlAPKPPRPR 647
Cdd:NF033839  365 VKPQPEKPK----PEVKPQPETPKPEVKPQPEKPKPEVKP---QPEKP------KPEVKPQPEKPKPEVKP-QPEKPKPE 430

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 568995608  648 THRQRTKYKttqspkiPHSKPADLGPITSEPPLASTTKKVRRP---RPKPQTTPHPEVP 703
Cdd:NF033839  431 VKPQPEKPK-------PEVKPQPEKPKPEVKPQPETPKPEVKPqpeKPKPEVKPQPEKP 482
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 515-626 5.05e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 44.80  E-value: 5.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  515 TPKPPRVKPAPEPETRPSAQTTKAPRKTKKPGHHRLRRPKttrsPEVPKSKPalePATVTPEILVPKIVPKPPQKPKATR 594
Cdd:PRK14950  361 VPVPAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPK----EPVRETAT---PPPVPPRPVAPPVPHTPESAPKLTR 433

                          90       100       110
                  ....*....|....*....|....*....|..
gi 568995608  595 RPEVPQVKPAHEPVTFGSEAPALAIVTTTDIE 626
Cdd:PRK14950  434 AAIPVDEKPKYTPPAPPKEEEKALIADGDVLE 465
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 553-775 8.62e-04

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 43.76  E-value: 8.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  553 PKTTRSPEVPKSKPalePATVTPEILVPKIVPKPPQKPKATRRPEVP-----QVKPAHEPVTFGSEAPALAIVTTTDIEP 627
Cdd:PLN03209  330 PKESDAADGPKPVP---TKPVTPEAPSPPIEEEPPQPKAVVPRPLSPytayeDLKPPTSPIPTPPSSSPASSKSVDAVAK 406

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  628 VITRTKASVTTLAPKPPRPRTHRQRTKyktTQSPKIPHSKPADLGPITSepplasttkkvrrPRPKPQTTPHPEVPHTIL 707
Cdd:PLN03209  407 PAEPDVVPSPGSASNVPEVEPAQVEAK---KTRPLSPYARYEDLKPPTS-------------PSPTAPTGVSPSVSSTSS 470

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568995608  708 VPATSLEP----FIITEAPGTTLVPKLPQQPDYPHPKPKTTRSPAASPTELVPTPVFEPVTPLKEDPVTTIV 775
Cdd:PLN03209  471 VPAVPDTApataATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSAPPTALA 542
PHA03378 PHA03378
EBNA-3B; Provisional
 491-705 9.55e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.90  E-value: 9.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  491 PEVRPTTAapQQTTSIPSTPKRqSTPKPPRVKPAPEPETRPSAQTTKAPRKTKKPGH----HRLRRPKTTRSPEV---PK 563
Cdd:PHA03378  576 PLTSPTTS--QLASSAPSYAQT-PWPVPHPSQTPEPPTTQSHIPETSAPRQWPMPLRpipmRPLRMQPITFNVLVfptPH 652

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  564 SKPALEPATVTPEILVPKIVP-----------KPPQKPKATRRPEVPQVKPAHEPVTFGSEAPALAIVTTTDIEPVITRT 632
Cdd:PHA03378  653 QPPQVEITPYKPTWTQIGHIPyqpsptgantmLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPG 732

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568995608  633 KASVTTLAPKPPRPRTHRQRTKYKTTQSPKIPHSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPEVPHT 705
Cdd:PHA03378  733 RARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPT 805
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 420-747 1.37e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.54  E-value: 1.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  420 SRVVQPQTATYDVI---------SSSTTSDETEIEIHTATRDPILDSVPPKTSRTA-EQPRATLAPIEALFESRNVeIFT 489
Cdd:PRK10263  297 NRATQPEYDEYDPLlngapitepVAVAAAATTATQSWAAPVEPVTQTPPVASVDVPpAQPTVAWQPVPGPQTGEPV-IAP 375

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  490 SPEVRPTTAAPQQTTSIPSTPKRQSTP--KPPRVKPAPEPETRPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKPA 567
Cdd:PRK10263  376 APEGYPQQSQYAQPAVQYNEPLQQPVQpqQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQST 455

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  568 LEP-ATVTPEILVPKIVPKPP---------QKPKATRRPEVPQVKPAHEPVTFGSEapalaivtttdIEPVITRTKASVT 637
Cdd:PRK10263  456 FAPqSTYQTEQTYQQPAAQEPlyqqpqpveQQPVVEPEPVVEETKPARPPLYYFEE-----------VEEKRAREREQLA 524

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  638 TLAPKPPRPrthrqrTKYKTTQSPKIPHSKPADLGPITSEPPLASTTKKVRrprpkpQTTPHPEVPHTILVPATSLepfi 717
Cdd:PRK10263  525 AWYQPIPEP------VKEPEPIKSSLKAPSVAAVPPVEAAAAVSPLASGVK------KATLATGAAATVAAPVFSL---- 588

                         330       340       350
                  ....*....|....*....|....*....|
gi 568995608  718 iteAPGTTLVPKLPQQPDYPHPKPKTTRSP 747
Cdd:PRK10263  589 ---ANSGGPRPQVKEGIGPQLPRPKRIRVP 615
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
458-771 1.50e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 43.30  E-value: 1.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  458 VPPKTSRTAEQPRATLAP---IEALFESRNVEIFTSPEVRPTTAAPQQTTsIPSTPKRQSTPKP-------PRVKPAPEP 527
Cdd:PRK07003  372 VPARVAGAVPAPGARAAAavgASAVPAVTAVTGAAGAALAPKAAAAAAAT-RAEAPPAAPAPPAtadrgddAADGDAPVP 450

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  528 ---ETRPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKPALEPATVTPEILVPKIVPKPPQ--------KPKATRRP 596
Cdd:PRK07003  451 akaNARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAaasredapAAAAPPAP 530

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  597 EVPQVKPA--HEPVTFGSEAPALAIVTTTDIEPVITRTK--------ASVTTLAPKPPRPRTHRQrtkyktTQSPKIPHS 666
Cdd:PRK07003  531 EARPPTPAaaAPAARAGGAAAALDVLRNAGMRVSSDRGAraaaaakpAAAPAAAPKPAAPRVAVQ------VPTPRARAA 604

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  667 KPADLGPITSEPPLASTTkkvRRPRPkpqttPHPEVPHTILVPATSLEPFIiteAPGTTLVPKLPQQPDYPHPKPKTTRS 746
Cdd:PRK07003  605 TGDAPPNGAARAEQAAES---RGAPP-----PWEDIPPDDYVPLSADEGFG---GPDDGFVPVFDSGPDDVRVAPKPADA 673

                         330       340
                  ....*....|....*....|....*
gi 568995608  747 PAAsPTELVPTPvfePVTPLkeDPV 771
Cdd:PRK07003  674 PAP-PVDTRPLP---PAIPL--DAI 692
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 490-618 1.86e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 42.93  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  490 SPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEPETRPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEV-PKSKPAL 568
Cdd:PRK07994  370 VPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKKSePAAASRA 449

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568995608  569 EPATVTPEIL-----VPKIVPKPPQKPKATR-RPEVPQVKPAHEPVTFGSEAPALA 618
Cdd:PRK07994  450 RPVNSALERLasvrpAPSALEKAPAKKEAYRwKATNPVEVKKEPVATPKALKKALE 505
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 491-766 2.08e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.83  E-value: 2.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608   491 PEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEPETRPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKPALEP 570
Cdd:pfam03154  172 PVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQP 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608   571 ATVT--PEILVPKIVPKPPQKPKATRRPEVPQVKPAHEPvtfgseapalaivtttdiepvitrtkasvttlAPKPPRPRT 648
Cdd:pfam03154  252 MTQPppPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQ--------------------------------HPVPPQPFP 299

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608   649 hrqrTKYKTTQSPKIPHSKPADLGPITSEPPLASTTKKVRRPRPkPQTTPHPEVPhtilVPATSLEPfiiteaPGTTLVP 728
Cdd:pfam03154  300 ----LTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQP-PREQPLPPAP----LSMPHIKP------PPTTPIP 364

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 568995608   729 KLPQQPDYPHPKPKTTRSPAASPTELVPTPVFEPVTPL 766
Cdd:pfam03154  365 QLPNPQSHKHPPHLSGPSPFQMNSNLPPPPALKPLSSL 402
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 480-628 2.17e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 42.49  E-value: 2.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  480 FESRNVEIFTSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEPETRPSAQTTKAPRKTKKPghhrLRRPKTTRSP 559
Cdd:PRK14950  351 LELAVIEALLVPVPAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRP----VAPPVPHTPE 426

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568995608  560 EVPKSKPALEPATVTPEILVPkivPKPPQKPKATRRPEV--PQVKPAHEPVT--FGSEAPALAIVTTTDIEPV 628
Cdd:PRK14950  427 SAPKLTRAAIPVDEKPKYTPP---APPKEEEKALIADGDvlEQLEAIWKQILrdVPPRSPAVQALLSSGVRPV 496
dnaA PRK14086
chromosomal replication initiator protein DnaA;
515-718 2.36e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 42.51  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  515 TPKPPRVKPAPEPETRPSAQTTKAPRKTKKP----GHHRL--RRPKTTRSPEVPKSKPALEPATVTPE--ILVPKIVPKP 586
Cdd:PRK14086   87 TVDPSAGEPAPPPPHARRTSEPELPRPGRRPyegyGGPRAddRPPGLPRQDQLPTARPAYPAYQQRPEpgAWPRAADDYG 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  587 PQKPKATRRPEVPQVKPAHEPVTFGSEAPALAivtttDIEPVITRTKASVTTLAPKPPRPRTHRQRTKYKTTQSPKIPHS 666
Cdd:PRK14086  167 WQQQRLGFPPRAPYASPASYAPEQERDREPYD-----AGRPEYDQRRRDYDHPRPDWDRPRRDRTDRPEPPPGAGHVHRG 241

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568995608  667 KPADLGPItSEPPLASTTKKVRRPRPKPQTTPHPEVPHTILVPATSLEPFII 718
Cdd:PRK14086  242 GPGPPERD-DAPVVPIRPSAPGPLAAQPAPAPGPGEPTARLNPKYTFDTFVI 292
PHA03369 PHA03369
capsid maturational protease; Provisional
 491-779 2.56e-03

capsid maturational protease; Provisional


Pssm-ID: 223061 [Multi-domain]  Cd Length: 663  Bit Score: 42.29  E-value: 2.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  491 PEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEPETRPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKPALEP 570
Cdd:PHA03369  362 AAAKVAVIAAPQTHTGPADRQRPQRPDGIPYSVPARSPMTAYPPVPQFCGDPGLVSPYNPQSPGTSYGPEPVGPVPPQPT 441

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  571 ATVTPEILVPKIVPKPPQKPKATRRPEVPQVKPAHEPVTFGSEAPalaivtTTDIEPVITRTKASVTTLAPKPPRPRTHR 650
Cdd:PHA03369  442 NPYVMPISMANMVYPGHPQEHGHERKRKRGGELKEELIETLKLVK------KLKEEQESLAKELEATAHKSEIKKIAESE 515

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  651 QRTKYKTTQSPKIPHSKPADLGPITSEPPLASTTKKVRRPRPKPQTTPHPEVPHTILVPATSLEPFIITEAPGT------ 724
Cdd:PHA03369  516 FKNAGAKTAAANIEPNCSADAAAPATKRARPETKTELEAVVRFPYQIRNMESPAFVHSFTSTTLAAAAGQGSDTaealag 595

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 568995608  725 ---TLVPKLPQQPDYPHpkpktTRSPAASPTELVPTPVFEPVTPLKEDPVTTIVPITD 779
Cdd:PHA03369  596 aieTLLTQASAQPAGLS-----LPAPAVPVNASTPASTPPPLAPQEPPQPGTSAPSLE 648
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 469-600 3.47e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 3.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  469 PRATLAPIEALfESRNVEIFTSPEVRPT----TAAPQQTTSIPSTPKRQSTPKPPRVkPAPEPETRPSAQTTKAPRKTKK 544
Cdd:PRK07764  371 ERGLLARLERL-ERRLGVAGGAGAPAAAapsaAAAAPAAAPAPAAAAPAAAAAPAPA-AAPQPAPAPAPAPAPPSPAGNA 448

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568995608  545 PGHHRLRRPKTTRSPEVPKSKPALEPATVTPEILVPKIVPKPPQKPKATRRPEVPQ 600
Cdd:PRK07764  449 PAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPA 504
Not5 COG5665
CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];
428-770 3.81e-03

CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];


Pssm-ID: 444384 [Multi-domain]  Cd Length: 874  Bit Score: 41.96  E-value: 3.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  428 ATYDVISSSTTSDETEIEIHTATR-------DPILDSVPPKTSRTAEQPRATLAPIEALFESRNVEIFTSPEVR------ 494
Cdd:COG5665   208 STPQAFNASATSGRSQHIVQAAKRvgvewwgDPSLLATPPATPATEEKSSQQPKSQPTSPSGGTTPPSTNQLTTsntpts 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  495 --------PTTAAPQQTTSIPSTPKRQSTPKPPRV--KPAPEPETRPSAQTTKAPRKTKKPGHhrlrRPKTTRSPEVPKS 564
Cdd:COG5665   288 takaqpqpPTKKQPAKEPPSDTASGNPSAPSVLINsdSPTSEDPATASVPTTEETTAFTTPSS----VPSTPAEKDTPAT 363

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  565 KPALEPATVTPEILV-PKIVPKPPQKPKATrrpevpqvkpAHEPVTFGSEAPalaivtttdiepvitrtkASVTTLAPKP 643
Cdd:COG5665   364 DLATPVSPTPPETSVdKKVSPDSATSSTKS----------EKEGGTASSPMP------------------PNIAIGAKDD 415

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  644 PRPRTHRQRTKYKTTQSPKIPHSKPADLGPITSEPPLAS--------TTKKVRRPRPKPQTTPHPEVPHTILVPATSLEP 715
Cdd:COG5665   416 VDATDPSQEAKEYTKNAPMTPEADSAPESSVRTEASPSAgsdlepenTTLRDPAPNAIPPPEDPSTIGRLSSGDKLANET 495

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  716 FIITEAPGTTLVPKLPQQ--PDYPHPKPKTT---RSPAASPTELVPTPVFEPVTPLKEDP 770
Cdd:COG5665   496 GPPVIRRDSTPSSTADQSivGVLAFGLDQRTqaeISVEAASRSNPLLNSQVKSFPLGKRS 555
PHA03247 PHA03247
large tegument protein UL36; Provisional
 531-802 4.23e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 4.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  531 PSAQTTKAPRKTKKPGHHRlrrpKTTRSPEVPKSKPALEPATVTPEILVPKIVPKPPQKPKATRRPEVPqvkPAHEPVTF 610
Cdd:PHA03247  255 PAPPPVVGEGADRAPETAR----GATGPPPPPEAAAPNGAAAPPDGVWGAALAGAPLALPAPPDPPPPA---PAGDAEEE 327

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  611 GSEAPALAIVTttdiePVitrtkasvttlapkpPRPRTHRQRTKYKTTQSPKIPHSKPADLGPITSEPPLASTTKKVRRp 690
Cdd:PHA03247  328 DDEDGAMEVVS-----PL---------------PRPRQHYPLGFPKRRRPTWTPPSSLEDLSAGRHHPKRASLPTRKRR- 386

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  691 rpkpqTTPHPEVPHTiLVPATSLEPFIITEAPGTTLVPKLPQQPDYPHPKPKTTRSPAASPTELVPTPVFEPVTPLKEDP 770
Cdd:PHA03247  387 -----SARHAATPFA-RGPGGDDQTRPAAPVPASVPTPAPTPVPASAPPPPATPLPSAEPGSDDGPAPPPERQPPAPATE 460

                         250       260       270
                  ....*....|....*....|....*....|...
gi 568995608  771 VTTivPITDLERVTDLETPVAFRT-EAPGTTLA 802
Cdd:PHA03247  461 PAP--DDPDDATRKALDALRERRPpEPPGADLA 491
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 515-612 4.23e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 41.85  E-value: 4.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  515 TPKPPRVKPAPEPETrPSAQTTKAPRKTKKPGhhrlRRPKTTRSPEvpkSKPAlePATVTPeilVPKIVPKPPqKPKATR 594
Cdd:PRK14954  385 AGSPDVKKKAPEPDL-PQPDRHPGPAKPEAPG----ARPAELPSPA---SAPT--PEQQPP---VARSAPLPP-SPQASA 450

                          90
                  ....*....|....*...
gi 568995608  595 RPEVPQVKPAhepVTFGS 612
Cdd:PRK14954  451 PRNVASGKPG---VDLGS 465
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
491-673 5.32e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 5.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  491 PEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEPETRPSAQTTKAPRKTKKPGHHRLRRPKTTRSPEVPKSKPALEP 570
Cdd:PRK12323  383 AQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAA 462

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  571 ATVTPEIL---VPKIVPKPPQKPKATRRPEVPQVKPAHE-PVTFGSEAPA------LAIVTTTDIEPVITRTKASVTTLA 640
Cdd:PRK12323  463 RPAAAGPRpvaAAAAAAPARAAPAAAPAPADDDPPPWEElPPEFASPAPAqpdaapAGWVAESIPDPATADPDDAFETLA 542

                         170       180       190
                  ....*....|....*....|....*....|...
gi 568995608  641 PKPPRPRTHRQRTKYKTTQSPKIPHSKPADLGP 673
Cdd:PRK12323  543 PAPAAAPAPRAAAATEPVVAPRPPRASASGLPD 575
COG3979 COG3979
Chitodextrinase [Carbohydrate transport and metabolism];
1363-1462 7.62e-03

Chitodextrinase [Carbohydrate transport and metabolism];


Pssm-ID: 443178 [Multi-domain]  Cd Length: 369  Bit Score: 40.53  E-value: 7.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608 1363 PPQNPpTNLTVVTVEgcPSFVILDWEK-PLNDTVTEYEVisrengsFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPK 1441
Cdd:COG3979     2 APTAP-TGLTASNVT--SSSVSLSWDAsTDNVGVTGYDV-------YRGGDQVATVTGLTAWTVTGLTPGTEYTFTVGAC 71

                          90       100
                  ....*....|....*....|.
gi 568995608 1442 nplgeGPASNTVAFSTESADP 1462
Cdd:COG3979    72 -----DAAGNVSAASGTSTAM 87
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 471-748 8.54e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 40.68  E-value: 8.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  471 ATLAPIEALFESrnveiftSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVKPAPEPEtRPSAQttkAPRKTKKPGHHRL 550
Cdd:PLN03209  311 APLTPMEELLAK-------IPSQRVPPKESDAADGPKPVPTKPVTPEAPSPPIEEEPP-QPKAV---VPRPLSPYTAYED 379

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  551 RRPKTTRSPEVPKSKPA----------LEPATVTPEILVPKIVP--KPPQKPKATRRPEVPQVK-PAHEPVTFGSEAPAL 617
Cdd:PLN03209  380 LKPPTSPIPTPPSSSPAssksvdavakPAEPDVVPSPGSASNVPevEPAQVEAKKTRPLSPYARyEDLKPPTSPSPTAPT 459

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  618 AIVTTTDIEPVITRT------KASVTTLAPKPPRPRthrqrtkykttqsPKIPHSKPADLGPITSEPPLAsttkkvrrPR 691
Cdd:PLN03209  460 GVSPSVSSTSSVPAVpdtapaTAATDAAAPPPANMR-------------PLSPYAVYDDLKPPTSPSPAA--------PV 518

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568995608  692 PKPQTTPHPEVPhtilvPATSLEPFIITEAPGTTLVPKlpQQPDYPHP-----KPKTTRSPA 748
Cdd:PLN03209  519 GKVAPSSTNEVV-----KVGNSAPPTALADEQHHAQPK--PRPLSPYTmyedlKPPTSPTPS 573
PRK11633 PRK11633
cell division protein DedD; Provisional
 451-539 9.69e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 39.60  E-value: 9.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995608  451 RDPIlDSVPPKTSRTAEQP--------RATLAPIEALFESRNVEIFTSPEVRPTTAAPQQTTSIPSTPKRQSTPKPPRVK 522
Cdd:PRK11633   50 RDEP-DMMPAATQALPTQPpegaaeavRAGDAAAPSLDPATVAPPNTPVEPEPAPVEPPKPKPVEKPKPKPKPQQKVEAP 128

                          90
                  ....*....|....*..
gi 568995608  523 PAPEPETRPSAQTTKAP 539
Cdd:PRK11633  129 PAPKPEPKPVVEEKAAP 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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