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Conserved domains on  [gi|568995654|ref|XP_006522347|]
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target of Nesh-SH3 isoform X33 [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10045852)

fibronectin type III (FN3) domain-containing protein with an immunoglobulin-like (Ig-like) fold similar to mammalian interleukin-9 and interleukin-21 receptors, and to immunoglobulin I-set domains (antibody intermediate domain-like) such as myomesin, contactin, neural cell adhesion molecule 1, roundabout homologs, and cell adhesion molecules, among others

CATH:  2.60.40.10
Gene Ontology:  GO:0005515
PubMed:  9541533|7833045|8981327|7932691

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 684-775 1.60e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.36  E-value: 1.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 684 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNP 761
Cdd:cd00063    2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 568995654 762 LGEGPASNTVAFST 775
Cdd:cd00063   80 GGESPPSESVTVTT 93
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 350-686 1.17e-10

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.12  E-value: 1.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  350 KEPVPKEPLHttSKPKMPPSPEVADTTSVPKDerlSLKPDPEVTHSETVLPPVTFRVEPPKTTIAP---LETRGI----- 421
Cdd:PHA03247 2471 GELFPGAPVY--RRPAEARFPFAAGAAPDPGG---GGPPDPDAPPAPSRLAPAILPDEPVGEPVHPrmlTWIRGLeelas 2545

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  422 -------PLIPVISPRPSqeelqtameeTDQSTQElfTTKIPRTTELAKTTQApHRLHTAP--VRPRIPGRPHGRP---- 488
Cdd:PHA03247 2546 ddagdppPPLPPAAPPAA----------PDRSVPP--PRPAPRPSEPAVTSRA-RRPDAPPqsARPRAPVDDRGDPrgpa 2612

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  489 ---ALNKTTTRPDKTKPRGTSHKNGVGTGTKQAPKPPSPGRNASVDSHAT---------RKPGSVSGTRRPPIPHRHSST 556
Cdd:PHA03247 2613 ppsPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSrprrarrlgRAAQASSPPQRPRRRAARPTV 2692

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  557 RPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGT--TTDFSSSPTKE 634
Cdd:PHA03247 2693 GSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARppTTAGPPAPAPP 2772

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568995654  635 TDPLGKPRFIGPHVRYIPKPENKPCSITDSVRRFPTEEATEGNATSPPQNPP 686
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASP 2824
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 114-195 2.20e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 2.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 114 PRKPLQLVVGTLTPSSVFLSWgfliNPHHDWTLPSHcpsdrFYTIRYREKDKE--KKWIFQLCPATETIVENLKPNTVYE 191
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSW----TPPEDDGGPIT-----GYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYE 71


                 ....
gi 568995654 192 FGVK 195
Cdd:cd00063   72 FRVR 75
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 684-775 1.60e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.36  E-value: 1.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 684 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNP 761
Cdd:cd00063    2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 568995654 762 LGEGPASNTVAFST 775
Cdd:cd00063   80 GGESPPSESVTVTT 93
PHA03247 PHA03247
large tegument protein UL36; Provisional
 350-686 1.17e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.12  E-value: 1.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  350 KEPVPKEPLHttSKPKMPPSPEVADTTSVPKDerlSLKPDPEVTHSETVLPPVTFRVEPPKTTIAP---LETRGI----- 421
Cdd:PHA03247 2471 GELFPGAPVY--RRPAEARFPFAAGAAPDPGG---GGPPDPDAPPAPSRLAPAILPDEPVGEPVHPrmlTWIRGLeelas 2545

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  422 -------PLIPVISPRPSqeelqtameeTDQSTQElfTTKIPRTTELAKTTQApHRLHTAP--VRPRIPGRPHGRP---- 488
Cdd:PHA03247 2546 ddagdppPPLPPAAPPAA----------PDRSVPP--PRPAPRPSEPAVTSRA-RRPDAPPqsARPRAPVDDRGDPrgpa 2612

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  489 ---ALNKTTTRPDKTKPRGTSHKNGVGTGTKQAPKPPSPGRNASVDSHAT---------RKPGSVSGTRRPPIPHRHSST 556
Cdd:PHA03247 2613 ppsPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSrprrarrlgRAAQASSPPQRPRRRAARPTV 2692

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  557 RPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGT--TTDFSSSPTKE 634
Cdd:PHA03247 2693 GSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARppTTAGPPAPAPP 2772

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568995654  635 TDPLGKPRFIGPHVRYIPKPENKPCSITDSVRRFPTEEATEGNATSPPQNPP 686
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASP 2824
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 685-765 9.38e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.00  E-value: 9.38e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654   685 PPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV-ISRENGSFSGKNKSIQITNQTFS-TVENLKPDTSYEFQVKPKNPL 762
Cdd:smart00060   3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVgYRVEYREEGSEWKEVNVTPSSTSyTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 568995654   763 GEG 765
Cdd:smart00060  81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
685-768 1.48e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 49.72  E-value: 1.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  685 PPTNLTVVTVEgcPSFVILDWEKP--LNDTVTEYEVISRENGSFSGKNkSIQITNQTFS-TVENLKPDTSYEFQVKPKNP 761
Cdd:pfam00041   2 APSNLTVTDVT--STSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWN-EITVPGTTTSvTLTGLKPGTEYEVRVQAVNG 78


                  ....*..
gi 568995654  762 LGEGPAS 768
Cdd:pfam00041  79 GGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
569-780 4.69e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.39  E-value: 4.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 569 NNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDFSSSPTKETDPLGKPrfiGPHV 648
Cdd:COG3401  129 TAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEP---GTTY 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 649 RYIPKpenkpcSITDSVRRFPTEEATEGNATSPPqNPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEvISRENGSfSG 728
Cdd:COG3401  206 YYRVA------ATDTGGESAPSNEVSVTTPTTPP-SAPTGLTATADT--PGSVTLSWDPVTESDATGYR-VYRSNSG-DG 274

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568995654 729 KNKSIQITNQTFSTVENLKPDTSYEFQVKPKNPLG-EGPASNTVAFSTESADP 780
Cdd:COG3401  275 PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP 327
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
669-820 6.44e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.00  E-value: 6.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 669 PTEEATEGNATSPPQnPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV--ISRENGSFSGKNKSIqitNQTFSTVENL 746
Cdd:COG3401  314 PSNVVSVTTDLTPPA-APSGLTATAVG--SSSITLSWTASSDADVTGYNVyrSTSGGGTYTKIAETV---TTTSYTDTGL 387

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 747 KPDTSYEFQVKPKNPLG-EGPASNTVAFSTESADPRVS----------EPISAGRDAIWTERPFNSDSYSECKGKQYVKR 815
Cdd:COG3401  388 TPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESltasvdavplTDVAGATAAASAASNPGVSAAVLADGGDTGNA 467


                 ....*
gi 568995654 816 TWYKK 820
Cdd:COG3401  468 VPFTT 472
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 114-195 2.20e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 2.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 114 PRKPLQLVVGTLTPSSVFLSWgfliNPHHDWTLPSHcpsdrFYTIRYREKDKE--KKWIFQLCPATETIVENLKPNTVYE 191
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSW----TPPEDDGGPIT-----GYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYE 71


                 ....
gi 568995654 192 FGVK 195
Cdd:cd00063   72 FRVR 75
fn3 pfam00041
Fibronectin type III domain;
116-195 2.80e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.17  E-value: 2.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  116 KPLQLVVGTLTPSSVFLSWgflinphhdwTLPSHCPSD-RFYTIRYREKDKEKKWIFQLCPATET--IVENLKPNTVYEF 192
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSW----------TPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTsvTLTGLKPGTEYEV 71


                  ...
gi 568995654  193 GVK 195
Cdd:pfam00041  72 RVQ 74
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 114-195 3.71e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 3.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654   114 PRKPLQLVVGTLTPSSVFLSWgflinphhdwtLPSHCPSDRFYTIRYREKDKEKKWIFQLCPA----TETIVENLKPNTV 189
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSW-----------EPPPDDGITGYIVGYRVEYREEGSEWKEVNVtpssTSYTLTGLKPGTE 69


                   ....*.
gi 568995654   190 YEFGVK 195
Cdd:smart00060  70 YEFRVR 75
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 329-680 2.38e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 44.91  E-value: 2.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  329 APRQTTSMPPKLKTPHSrmpAKEPVPKEPLHTTSKPKmppSPEVADTTSvpKDERLSLKPDPEVTHSETVLPPVTfrvEP 408
Cdd:pfam05109 441 APNTTTGLPSSTHVPTN---LTAPASTGPTVSTADVT---SPTPAGTTS--GASPVTPSPSPRDNGTESKAPDMT---SP 509

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  409 PKTTIAPLETRGIPLIPVISPRPSQeelqTAMEETDQSTQELFTTKIPRTTELAKTTQAPHRLHTAPVRPRI-PGRPHGR 487
Cdd:pfam05109 510 TSAVTTPTPNATSPTPAVTTPTPNA----TSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTsPTSAVTT 585

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  488 PALNKTTTRPDKTKPRGTSHKNGVGtGTKQAPKPPSPGRNA-------------SVDSHATRKPGSVSGTRRPPIPHRHS 554
Cdd:pfam05109 586 PTPNATSPTVGETSPQANTTNHTLG-GTSSTPVVTSPPKNAtsavttgqhnitsSSTSSMSLRPSSISETLSPSTSDNST 664

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  555 STRPVSPERRPLPPNNVTgkpgragivsssRVTspPLKATLHPIGTAT--ARPGAeqkepTAPASEEEFGTTtdfSSSPT 632
Cdd:pfam05109 665 SHMPLLTSAHPTGGENIT------------QVT--PASTSTHHVSTSSpaPRPGT-----TSQASGPGNSST---STKPG 722

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 568995654  633 KETDPLGKPrfigphvryiPKPENKPCSITDSVRRFPTEEATEGNATS 680
Cdd:pfam05109 723 EVNVTKGTP----------PKNATSPQAPSGQKTAVPTVTSTGGKANS 760
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 684-775 1.60e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.36  E-value: 1.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 684 NPPTNLTVVTVEgcPSFVILDWEKPLNDT--VTEYEVISRENGSFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPKNP 761
Cdd:cd00063    2 SPPTNLRVTDVT--STSVTLSWTPPEDDGgpITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|....
gi 568995654 762 LGEGPASNTVAFST 775
Cdd:cd00063   80 GGESPPSESVTVTT 93
PHA03247 PHA03247
large tegument protein UL36; Provisional
 350-686 1.17e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.12  E-value: 1.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  350 KEPVPKEPLHttSKPKMPPSPEVADTTSVPKDerlSLKPDPEVTHSETVLPPVTFRVEPPKTTIAP---LETRGI----- 421
Cdd:PHA03247 2471 GELFPGAPVY--RRPAEARFPFAAGAAPDPGG---GGPPDPDAPPAPSRLAPAILPDEPVGEPVHPrmlTWIRGLeelas 2545

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  422 -------PLIPVISPRPSqeelqtameeTDQSTQElfTTKIPRTTELAKTTQApHRLHTAP--VRPRIPGRPHGRP---- 488
Cdd:PHA03247 2546 ddagdppPPLPPAAPPAA----------PDRSVPP--PRPAPRPSEPAVTSRA-RRPDAPPqsARPRAPVDDRGDPrgpa 2612

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  489 ---ALNKTTTRPDKTKPRGTSHKNGVGTGTKQAPKPPSPGRNASVDSHAT---------RKPGSVSGTRRPPIPHRHSST 556
Cdd:PHA03247 2613 ppsPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSrprrarrlgRAAQASSPPQRPRRRAARPTV 2692

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  557 RPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGT--TTDFSSSPTKE 634
Cdd:PHA03247 2693 GSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARppTTAGPPAPAPP 2772

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 568995654  635 TDPLGKPRFIGPHVRYIPKPENKPCSITDSVRRFPTEEATEGNATSPPQNPP 686
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASP 2824
PHA03247 PHA03247
large tegument protein UL36; Provisional
 311-686 1.33e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 62.65  E-value: 1.33e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  311 PAESKTPEVEKLAGQPVTAPRQTTSMPPKLKTPHSRMPAKEPVPKEPlhTTSKPKMPPSPEVADTTSVPKDERLSLKPDP 390
Cdd:PHA03247 2592 PPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEP--DPHPPPTVPPPERPRDDPAPGRVSRPRRARR 2669

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  391 EVTHSETVLPPVTFRVEPPKTTIAPLETRGIPLIPVISPRPSQEELQTAMEETdqstqeLFTTKIPRTTELAKTTQAPHR 470
Cdd:PHA03247 2670 LGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLP------PGPAAARQASPALPAAPAPPA 2743

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  471 LHTAPVRPRIPGRPHGRPAlnkTTTRPDKTKPRGTshkngVGTGTKQAPKPPSPGRNASVDS-HATRKPGSVSGTRRPPI 549
Cdd:PHA03247 2744 VPAGPATPGGPARPARPPT---TAGPPAPAPPAAP-----AAGPPRRLTRPAVASLSESRESlPSPWDPADPPAAVLAPA 2815

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  550 PHRHSSTRPVSPErrPLPPNNVTGKPGRagivsssrvTSPPLKATLHPIGTAT-----ARPGAEQKEPTAPASEEEFGTT 624
Cdd:PHA03247 2816 AALPPAASPAGPL--PPPTSAQPTAPPP---------PPGPPPPSLPLGGSVApggdvRRRPPSRSPAAKPAAPARPPVR 2884

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568995654  625 TDFSSSPTKETDPLGKPRfigphvryiPKPENKPCSITDSVRRFPTEEATEGNATSPPQNPP 686
Cdd:PHA03247 2885 RLARPAVSRSTESFALPP---------DQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP 2937
PHA03247 PHA03247
large tegument protein UL36; Provisional
 311-706 1.35e-09

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 62.65  E-value: 1.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  311 PAESKTPEVEKLAGQPVTAPRQTTSmPPKLKTPH-SRMPAKEPVPKEPLHTTSKPKMPPSpeVADTTSV--PKDERLSLK 387
Cdd:PHA03247 2633 PAANEPDPHPPPTVPPPERPRDDPA-PGRVSRPRrARRLGRAAQASSPPQRPRRRAARPT--VGSLTSLadPPPPPPTPE 2709

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  388 PDPEVTHSETVLPPVT--FRVEPPKTTIAPLeTRGIPLIPVI--SPRPSQEELQTAMEETDQSTQELFTTKIPRTTELAK 463
Cdd:PHA03247 2710 PAPHALVSATPLPPGPaaARQASPALPAAPA-PPAVPAGPATpgGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAV 2788

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  464 TTQAPHRlHTAPVrPRIPGrPHGRPALNKTTTRPDKTKPRGTSHKNgvGTGTKQAPKPPSPGRNASVDSHATRKPGSvSG 543
Cdd:PHA03247 2789 ASLSESR-ESLPS-PWDPA-DPPAAVLAPAAALPPAASPAGPLPPP--TSAQPTAPPPPPGPPPPSLPLGGSVAPGG-DV 2862

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  544 TRRPPiphrhSSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGT 623
Cdd:PHA03247 2863 RRRPP-----SRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP 2937

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  624 TTDFSSSPTKETDPLGKPRFIGPHvryiPKPENKPCSITDSVRRFPTEEATEGNATSPPQNPPTNLTVVTVEGCPSFVIL 703
Cdd:PHA03247 2938 RPQPPLAPTTDPAGAGEPSGAVPQ----PWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLAL 3013


                  ...
gi 568995654  704 DWE 706
Cdd:PHA03247 3014 HEE 3016
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 685-765 9.38e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.00  E-value: 9.38e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654   685 PPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV-ISRENGSFSGKNKSIQITNQTFS-TVENLKPDTSYEFQVKPKNPL 762
Cdd:smart00060   3 PPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVgYRVEYREEGSEWKEVNVTPSSTSyTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 568995654   763 GEG 765
Cdd:smart00060  81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
685-768 1.48e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 49.72  E-value: 1.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  685 PPTNLTVVTVEgcPSFVILDWEKP--LNDTVTEYEVISRENGSFSGKNkSIQITNQTFS-TVENLKPDTSYEFQVKPKNP 761
Cdd:pfam00041   2 APSNLTVTDVT--STSLTVSWTPPpdGNGPITGYEVEYRPKNSGEPWN-EITVPGTTTSvTLTGLKPGTEYEVRVQAVNG 78


                  ....*..
gi 568995654  762 LGEGPAS 768
Cdd:pfam00041  79 GGEGPPS 85
PHA03247 PHA03247
large tegument protein UL36; Provisional
 467-694 7.70e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 7.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  467 APHRLHTAPVRPRIPGRPHGRP---ALNKTTTRPDKTKPRGTSHKNGVGTGTKQAPKPPSPgrnASVDSHATRKPGSVSG 543
Cdd:PHA03247 2556 PPAAPPAAPDRSVPPPRPAPRPsepAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSP---LPPDTHAPDPPPPSPS 2632

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  544 TR--RPPIPHRHSSTRPVSPERRPLPP----NNVTGKPGRAGIVSSS--RVTSPPLKATLHPIgTATARPGAEQKEP--- 612
Cdd:PHA03247 2633 PAanEPDPHPPPTVPPPERPRDDPAPGrvsrPRRARRLGRAAQASSPpqRPRRRAARPTVGSL-TSLADPPPPPPTPepa 2711

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  613 ---TAPASEEEFGTTTDFSSSPTKETDPLGKPRFIGPHVRYIPKPENKPCSitdsvrrfPTEEATEGNATSPPQNPPTNL 689
Cdd:PHA03247 2712 phaLVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT--------TAGPPAPAPPAAPAAGPPRRL 2783


                  ....*
gi 568995654  690 TVVTV 694
Cdd:PHA03247 2784 TRPAV 2788
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
569-780 4.69e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.39  E-value: 4.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 569 NNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDFSSSPTKETDPLGKPrfiGPHV 648
Cdd:COG3401  129 TAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEP---GTTY 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 649 RYIPKpenkpcSITDSVRRFPTEEATEGNATSPPqNPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEvISRENGSfSG 728
Cdd:COG3401  206 YYRVA------ATDTGGESAPSNEVSVTTPTTPP-SAPTGLTATADT--PGSVTLSWDPVTESDATGYR-VYRSNSG-DG 274

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568995654 729 KNKSIQITNQTFSTVENLKPDTSYEFQVKPKNPLG-EGPASNTVAFSTESADP 780
Cdd:COG3401  275 PFTKVATVTTTSYTDTGLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDLTPP 327
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 324-633 4.81e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 50.46  E-value: 4.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 324 GQPVTAPrQTTSMPPKlKTPHSRMPAKEpvpKEPLHTTSKPKMPPSPEVADTTSVPKderlslKPDPEVTHSETVLPPVT 403
Cdd:PTZ00449 508 DEPPEGP-EASGLPPK-APGDKEGEEGE---HEDSKESDEPKEGGKPGETKEGEVGK------KPGPAKEHKPSKIPTLS 576

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 404 FRVEPPKTTIAPLETRgiplipviSPRPSQEELQTAMEETDQSTQELFTTKIPRTTELAKTTQAPHRlHTAPVRPRIPGR 483
Cdd:PTZ00449 577 KKPEFPKDPKHPKDPE--------EPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKR-PPPPQRPSSPER 647

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 484 PHGrPALNKTTTRPDKTKP----------RGTSHKNGVGTGTKQAPKPPSPGRNASVDSHATRKPGSVSGTRRPPIPHR- 552
Cdd:PTZ00449 648 PEG-PKIIKSPKPPKSPKPpfdpkfkekfYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLp 726

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 553 HSSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGT----------ATARPGAEQKEPTAPaSEEEFG 622
Cdd:PTZ00449 727 RDEEFPFEPIGDPDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILAeefkeedihaETGEPDEAMKRPDSP-SEHEDK 805

                        330
                 ....*....|.
gi 568995654 623 TTTDFSSSPTK 633
Cdd:PTZ00449 806 PPGDHPSLPKK 816
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 312-641 5.58e-06

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 50.55  E-value: 5.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  312 AESKTPEVEKLAGQPVTAPRQTTSMPPKLKTPHSRMPAKEPVPKEPLHTTSKPKMPPSPEVADTTSVPKDE--------- 382
Cdd:PHA03307   86 STPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGaspaavasd 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  383 --------RLSLKPDPEVTHSETVLPPVTFRVEPPKTTIAPLETRGIPLIPVISPRPS---QEELQTAMEETDQSTQELF 451
Cdd:PHA03307  166 aassrqaaLPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPApgrSAADDAGASSSDSSSSESS 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  452 TTKIPRTTELAKTTQAPHRLHTAPVRPRIPGRPHGRPALNKTTTRPDKTKPRGTSHKNGVGTGTKQAPKPPSPGRNASVD 531
Cdd:PHA03307  246 GCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESS 325

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  532 SHATRKPGSVS---GTRRPPIPHRH-SSTRPVSPERRPLPPNNVTGKP-GRAGIVSSSRVTSPPLKATLHPIGTATARPG 606
Cdd:PHA03307  326 SSSTSSSSESSrgaAVSPGPSPSRSpSPSRPPPPADPSSPRKRPRPSRaPSSPAASAGRPTRRRARAAVAGRARRRDATG 405

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 568995654  607 AEQKEPTAPASEEEFGTTTDFSSSPtKETDPLGKP 641
Cdd:PHA03307  406 RFPAGRPRPSPLDAGAASGAFYARY-PLLTPSGEP 439
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
669-820 6.44e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 50.00  E-value: 6.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 669 PTEEATEGNATSPPQnPPTNLTVVTVEgcPSFVILDWEKPLNDTVTEYEV--ISRENGSFSGKNKSIqitNQTFSTVENL 746
Cdd:COG3401  314 PSNVVSVTTDLTPPA-APSGLTATAVG--SSSITLSWTASSDADVTGYNVyrSTSGGGTYTKIAETV---TTTSYTDTGL 387

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 747 KPDTSYEFQVKPKNPLG-EGPASNTVAFSTESADPRVS----------EPISAGRDAIWTERPFNSDSYSECKGKQYVKR 815
Cdd:COG3401  388 TPGTTYYYKVTAVDAAGnESAPSEEVSATTASAASGESltasvdavplTDVAGATAAASAASNPGVSAAVLADGGDTGNA 467


                 ....*
gi 568995654 816 TWYKK 820
Cdd:COG3401  468 VPFTT 472
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 311-575 9.91e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 49.69  E-value: 9.91e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 311 PAESKTPEVEKLAG-----QPVTAPRQTT--SMPPKLKTPhsRMPAKEPVPKEPLhTTSKPKMPPSPEVADTTSVPKDER 383
Cdd:PTZ00449 549 PGETKEGEVGKKPGpakehKPSKIPTLSKkpEFPKDPKHP--KDPEEPKKPKRPR-SAQRPTRPKSPKLPELLDIPKSPK 625

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 384 LSLKPDPEVTHSETVLPPVTFRVEPPKT--TIAPLETRGIPLIPVISPRPSQEELQTA--MEET------DQSTQELFTT 453
Cdd:PTZ00449 626 RPESPKSPKRPPPPQRPSSPERPEGPKIikSPKPPKSPKPPFDPKFKEKFYDDYLDAAakSKETkttvvlDESFESILKE 705

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 454 KIPRTTELAKTTQAPhrlhTAPVRPRIPGRPHGRPAlnktttRPDKTKPRGTSHKNGVGTGTKQAPKPPSPGRNASVDSH 533
Cdd:PTZ00449 706 TLPETPGTPFTTPRP----LPPKLPRDEEFPFEPIG------DPDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILAE 775

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 568995654 534 ATRKPGSVSGTRRPPIPHRhsstRPVSP-ERRPLPPNNVTGKP 575
Cdd:PTZ00449 776 EFKEEDIHAETGEPDEAMK----RPDSPsEHEDKPPGDHPSLP 814
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 114-195 2.20e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 2.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 114 PRKPLQLVVGTLTPSSVFLSWgfliNPHHDWTLPSHcpsdrFYTIRYREKDKE--KKWIFQLCPATETIVENLKPNTVYE 191
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSW----TPPEDDGGPIT-----GYVVEYREKGSGdwKEVEVTPGSETSYTLTGLKPGTEYE 71


                 ....
gi 568995654 192 FGVK 195
Cdd:cd00063   72 FRVR 75
fn3 pfam00041
Fibronectin type III domain;
116-195 2.80e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.17  E-value: 2.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  116 KPLQLVVGTLTPSSVFLSWgflinphhdwTLPSHCPSD-RFYTIRYREKDKEKKWIFQLCPATET--IVENLKPNTVYEF 192
Cdd:pfam00041   2 APSNLTVTDVTSTSLTVSW----------TPPPDGNGPiTGYEVEYRPKNSGEPWNEITVPGTTTsvTLTGLKPGTEYEV 71


                  ...
gi 568995654  193 GVK 195
Cdd:pfam00041  72 RVQ 74
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 291-686 3.60e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.86  E-value: 3.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  291 MLEISDALKAQLAKNETLAlpAESKTPEVEKLAGQPVTAPRQTTSMPPKLKTPHSRMPAKEPVPKEPLHTTSKPKMPPSP 370
Cdd:PHA03307   42 QLVSDSAELAAVTVVAGAA--ACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPP 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  371 evadtTSVPkderLSLKPDPEVTHSEtVLPPVTFRVEPPKTTiapletrgiPLIPVISPRPSQEELQTAMEETD--QSTQ 448
Cdd:PHA03307  120 -----TPPP----ASPPPSPAPDLSE-MLRPVGSPGPPPAAS---------PPAAGASPAAVASDAASSRQAALplSSPE 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  449 ELFTTKIPRTTELAKTTQAPHRLHTAPVR--PRIPGRPHGRPALNKTTTRPDKTKPRGTSHKNGVGTG---TKQAPKP-- 521
Cdd:PHA03307  181 ETARAPSSPPAEPPPSTPPAAASPRPPRRssPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGwgpENECPLPrp 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  522 -----PSPGRNASVDSHATRKPGSVSGTRRPPIPH-RHSSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPLKATL 595
Cdd:PHA03307  261 apitlPTRIWEASGWNGPSSRPGPASSSSSPRERSpSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAA 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  596 HPIGTATARPGAEQ--KEPTAPASEEEFGTTTDFSSSPTKEtdplgKPRFIGPHVRYIPKPENKP---CSITDSVRRFPT 670
Cdd:PHA03307  341 VSPGPSPSRSPSPSrpPPPADPSSPRKRPRPSRAPSSPAAS-----AGRPTRRRARAAVAGRARRrdaTGRFPAGRPRPS 415

                         410
                  ....*....|....*.
gi 568995654  671 EEATEGNATSPPQNPP 686
Cdd:PHA03307  416 PLDAGAASGAFYARYP 431
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 114-195 3.71e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 3.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654   114 PRKPLQLVVGTLTPSSVFLSWgflinphhdwtLPSHCPSDRFYTIRYREKDKEKKWIFQLCPA----TETIVENLKPNTV 189
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSW-----------EPPPDDGITGYIVGYRVEYREEGSEWKEVNVtpssTSYTLTGLKPGTE 69


                   ....*.
gi 568995654   190 YEFGVK 195
Cdd:smart00060  70 YEFRVR 75
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 329-680 2.38e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 44.91  E-value: 2.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  329 APRQTTSMPPKLKTPHSrmpAKEPVPKEPLHTTSKPKmppSPEVADTTSvpKDERLSLKPDPEVTHSETVLPPVTfrvEP 408
Cdd:pfam05109 441 APNTTTGLPSSTHVPTN---LTAPASTGPTVSTADVT---SPTPAGTTS--GASPVTPSPSPRDNGTESKAPDMT---SP 509

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  409 PKTTIAPLETRGIPLIPVISPRPSQeelqTAMEETDQSTQELFTTKIPRTTELAKTTQAPHRLHTAPVRPRI-PGRPHGR 487
Cdd:pfam05109 510 TSAVTTPTPNATSPTPAVTTPTPNA----TSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTsPTSAVTT 585

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  488 PALNKTTTRPDKTKPRGTSHKNGVGtGTKQAPKPPSPGRNA-------------SVDSHATRKPGSVSGTRRPPIPHRHS 554
Cdd:pfam05109 586 PTPNATSPTVGETSPQANTTNHTLG-GTSSTPVVTSPPKNAtsavttgqhnitsSSTSSMSLRPSSISETLSPSTSDNST 664

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  555 STRPVSPERRPLPPNNVTgkpgragivsssRVTspPLKATLHPIGTAT--ARPGAeqkepTAPASEEEFGTTtdfSSSPT 632
Cdd:pfam05109 665 SHMPLLTSAHPTGGENIT------------QVT--PASTSTHHVSTSSpaPRPGT-----TSQASGPGNSST---STKPG 722

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 568995654  633 KETDPLGKPrfigphvryiPKPENKPCSITDSVRRFPTEEATEGNATS 680
Cdd:pfam05109 723 EVNVTKGTP----------PKNATSPQAPSGQKTAVPTVTSTGGKANS 760
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
311-431 3.77e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 3.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 311 PAESKTPEVEKLAGQPVTAPRQTTSMPPklktPHSRMPAKEPVPKEPLHTTSKPKMPPSPEVADTTSVPKDERLSLKPDP 390
Cdd:PRK12323 454 PAAAPAAAARPAAAGPRPVAAAAAAAPA----RAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDP 529

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568995654 391 EvthseTVLPPVTFRVEPPKTTIAPLETRGIPLIPVISPRP 431
Cdd:PRK12323 530 A-----TADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRP 565
PHA03247 PHA03247
large tegument protein UL36; Provisional
 307-489 3.95e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 3.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  307 TLALPAESKTPEVEKLAGQPVTAPRQTTSMPP----KLKTPHS----RMPAKEPVPKEPLHTTSKPKMPPSPEVADTTSV 378
Cdd:PHA03247 2871 PAAKPAAPARPPVRRLARPAVSRSTESFALPPdqpeRPPQPQAppppQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPA 2950

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  379 PKDERLSLKPDPEVTHSETVLPPVT-FRVEPPKTTIAPLETRGIPLIPVISPRPSQEELQTAM-EETDQSTQELFTT-KI 455
Cdd:PHA03247 2951 GAGEPSGAVPQPWLGALVPGRVAVPrFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALhEETDPPPVSLKQTlWP 3030

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 568995654  456 PRTTELAKTTQA----PHRLHTAPVRPrIPGRPHGRPA 489
Cdd:PHA03247 3031 PDDTEDSDADSLfdsdSERSDLEALDP-LPPEPHDPFA 3067
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 317-643 4.29e-04

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 43.90  E-value: 4.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 317 PEVEKLAGQPVTAPRQTTSMPPKLktphSRMPAKEPVPKEPLHTTSKPKMPPSPEVADTTSVPKDERLSLKPDPEVTHSE 396
Cdd:COG5180  127 AAAAALPKAKVTREATSASAGVAL----AAALLQRSDPILAKDPDGDSASTLPPPAEKLDKVLTEPRDALKDSPEKLDRP 202

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 397 TVLPPVTFRVEPPKTTIAPLETRGIPLIPVISPRPSQEELQTAMEETDQStqelfttkiPRTTELAKTTQAPHRLHTAPV 476
Cdd:COG5180  203 KVEVKDEAQEEPPDLTGGADHPRPEAASSPKVDPPSTSEARSRPATVDAQ---------PEMRPPADAKERRRAAIGDTP 273

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 477 RPRIPGRPHGRPALNKTTTRPDKTKPRGTSHKngvgtGTKQAPKPPSPGR-NASVDSHATRKPGSVsgTRRPPIPHRHSS 555
Cdd:COG5180  274 AAEPPGLPVLEAGSEPQSDAPEAETARPIDVK-----GVASAPPATRPVRpPGGARDPGTPRPGQP--TERPAGVPEAAS 346

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 556 TRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSPPLKATLHPIGTATARPGAEQKePTAPASEEEFGTTTDfssSPTKET 635
Cdd:COG5180  347 DAGQPPSAYPPAEEAVPGKPLEQGAPRPGSSGGDGAPFQPPNGAPQPGLGRRGAP-GPPMGAGDLVQAALD---GGGRET 422


                 ....*...
gi 568995654 636 DPLGKPRF 643
Cdd:COG5180  423 ASLGGAAG 430
PHA03247 PHA03247
large tegument protein UL36; Provisional
 309-631 5.18e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 5.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  309 ALPAESKTPEVEKLAGQPVTAPRQTTSMPPKLKTPHSRMPAKEPVPKEPLHTTSKP-----------KMPPSPEVADTTS 377
Cdd:PHA03247 2797 SLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLggsvapggdvrRRPPSRSPAAKPA 2876

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  378 VPKDERLSLKPDPEVTHSETVLPPVTFRVEPPKTTIAPLEtrgiplipvisPRPSQEELQTAMEETDQSTQELFTTKIPR 457
Cdd:PHA03247 2877 APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPP-----------PQPQPQPPPPPQPQPPPPPPPRPQPPLAP 2945

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  458 TTELAKTTQAPHRLHTAPVRPRIPGRPhgrPALNKTTTRPDKTKPrgtshkngvgtgtkqAPKPPSPGRNASVDSHATRK 537
Cdd:PHA03247 2946 TTDPAGAGEPSGAVPQPWLGALVPGRV---AVPRFRVPQPAPSRE---------------APASSTPPLTGHSLSRVSSW 3007

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  538 PGSVSgtrrppiPHRHSSTRPVSPERRPLPPNNVTGKPGRAGIVSSSRVTSpplKATLHPIGTATARPGAEQKEPTAPAS 617
Cdd:PHA03247 3008 ASSLA-------LHEETDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSD---LEALDPLPPEPHDPFAHEPDPATPEA 3077

                         330
                  ....*....|....
gi 568995654  618 EEEFGTTTDFSSSP 631
Cdd:PHA03247 3078 GARESPSSQFGPPP 3091
COG3979 COG3979
Chitodextrinase [Carbohydrate transport and metabolism];
681-780 1.02e-03

Chitodextrinase [Carbohydrate transport and metabolism];


Pssm-ID: 443178 [Multi-domain]  Cd Length: 369  Bit Score: 42.45  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 681 PPQNPpTNLTVVTVEgcPSFVILDWEK-PLNDTVTEYEVisrengsFSGKNKSIQITNQTFSTVENLKPDTSYEFQVKPK 759
Cdd:COG3979    2 APTAP-TGLTASNVT--SSSVSLSWDAsTDNVGVTGYDV-------YRGGDQVATVTGLTAWTVTGLTPGTEYTFTVGAC 71

                         90       100
                 ....*....|....*....|.
gi 568995654 760 nplgeGPASNTVAFSTESADP 780
Cdd:COG3979   72 -----DAAGNVSAASGTSTAM 87
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
295-477 4.30e-03

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 40.74  E-value: 4.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 295 SDALKAQLAKNETLALPAESKTPEVEKLAGQPV-------------TAPRQTTSMPPKLKTPHSRMPAKEPVPKEPLHTT 361
Cdd:PRK12727 105 AEDMIAAMALRQPVSVPRQAPAAAPVRAASIPSpaaqalahaaavrTAPRQEHALSAVPEQLFADFLTTAPVPRAPVQAP 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 362 SKPKMPPSPEVADTTSVPKD--ERLSLKPDPEVTHSETVLPPVTFRVEPPKTTIAPLETRGIPLIPVISPRPSQEelqta 439
Cdd:PRK12727 185 VVAAPAPVPAIAAALAAHAAyaQDDDEQLDDDGFDLDDALPQILPPAALPPIVVAPAAPAALAAVAAAAPAPQND----- 259

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 568995654 440 mEETDQSTQELFTTKIPRTTELAKTTQapHRLHTAPVR 477
Cdd:PRK12727 260 -EELKQLRGELALMRQMIEREMNRLTD--ERLRGSPVR 294
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 472-758 5.71e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.44  E-value: 5.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 472 HTAPVRPRIPGRPHGRPALNKTTTRPDKTKPRGTSHKNGVGTGTKQAP---KPPSPGRNASVDShaTRKPGSVSGTRRPP 548
Cdd:PTZ00449 533 EHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSKIPTLSKKPEfpkDPKHPKDPEEPKK--PKRPRSAQRPTRPK 610

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 549 IPHR-HSSTRPVSPERRPLPPNnvtgkPGRAgiVSSSRVTSPplKATLHPIGTATARPGAEQKEPTAPASEEEFGTTTDF 627
Cdd:PTZ00449 611 SPKLpELLDIPKSPKRPESPKS-----PKRP--PPPQRPSSP--ERPEGPKIIKSPKPPKSPKPPFDPKFKEKFYDDYLD 681

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654 628 SSSPTKETDPLGKPRFIGPHVRYIPKPENKPCSITDSVRRFPTEEATEGNATSPPQNP------PTNLTVVTVEGCPSFV 701
Cdd:PTZ00449 682 AAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLPRDEEFPFEPIGDPdaeqpdDIEFFTPPEEERTFFH 761

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568995654 702 ILDWEKPLNDTVTEyevisrengsfsgKNKSIQITNQTFSTVENLK-PDTSYEFQVKP 758
Cdd:PTZ00449 762 ETPADTPLPDILAE-------------EFKEEDIHAETGEPDEAMKrPDSPSEHEDKP 806
PHA03247 PHA03247
large tegument protein UL36; Provisional
 312-550 8.61e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 8.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  312 AESKTPEVEKLAGQPVTAPRQTTSMPPKLKTPHSRMPAKEP--VPKEPLHTTSkPKMPPSPEVADTTSVPKDErlslKPD 389
Cdd:PHA03247  254 APAPPPVVGEGADRAPETARGATGPPPPPEAAAPNGAAAPPdgVWGAALAGAP-LALPAPPDPPPPAPAGDAE----EED 328

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  390 PEVTHSETVLPPVTFRVEPPktTIAPLETRgipliPVISPRPSQEELqTAMEETDQSTQELFTTKipRTTELAKT----- 464
Cdd:PHA03247  329 DEDGAMEVVSPLPRPRQHYP--LGFPKRRR-----PTWTPPSSLEDL-SAGRHHPKRASLPTRKR--RSARHAATpfarg 398

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568995654  465 ---TQAPHRLHTAPVRPRIPGRPHGRPALNKTTTRPDKTKPRGTSHkngvGTGTKQAPKPPSPGRNASVDS--HATRKPG 539
Cdd:PHA03247  399 pggDDQTRPAAPVPASVPTPAPTPVPASAPPPPATPLPSAEPGSDD----GPAPPPERQPPAPATEPAPDDpdDATRKAL 474

                         250
                  ....*....|.
gi 568995654  540 SVSGTRRPPIP 550
Cdd:PHA03247  475 DALRERRPPEP 485
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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