NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568998288|ref|XP_006523411|]
View 

1-acyl-sn-glycerol-3-phosphate acyltransferase delta isoform X2 [Mus musculus]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10870651)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0008654|GO:0016020
PubMed:  18287005|18931347|18718904

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 11-150 8.09e-55

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


:

Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 175.50  E-value: 8.09e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998288  11 NSKVLAKKELAYVPIIGWMWYFVEMIFCTRKWEQDRQTVAKSLLHLRDYPEKYLFLIHCEGTRFTEKKHQISMQVAQAKG 90
Cdd:cd07990   53 RLKIVLKDSLKYPPLGGWGWQLGEFIFLKRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNG 132

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568998288  91 LPSLKHHLLPRTKGFAITVKCLRDVVPAVYDCTLNFRNNENPTLL-GVLNGKKYHADCYVR 150
Cdd:cd07990  133 LPPLKHVLLPRTKGFVAILETLRDAVDAVYDVTIAYPDGKPPSEQrLLLGGKPREVHVHVR 193
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 136-208 7.33e-31

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


:

Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 109.97  E-value: 7.33e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568998288  136 GVLNGKKYHADCYVRRIPMEDIPEDEDKCSAWLHKLYQEKDAFQEEYYRTGVFPETPW-VPPRRPWSLVNWLFW 208
Cdd:pfam16076   1 SLLNGKPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYETGTFFPGKEhIIPRRLKSLLVFIFW 74
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 11-150 8.09e-55

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 175.50  E-value: 8.09e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998288  11 NSKVLAKKELAYVPIIGWMWYFVEMIFCTRKWEQDRQTVAKSLLHLRDYPEKYLFLIHCEGTRFTEKKHQISMQVAQAKG 90
Cdd:cd07990   53 RLKIVLKDSLKYPPLGGWGWQLGEFIFLKRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNG 132

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568998288  91 LPSLKHHLLPRTKGFAITVKCLRDVVPAVYDCTLNFRNNENPTLL-GVLNGKKYHADCYVR 150
Cdd:cd07990  133 LPPLKHVLLPRTKGFVAILETLRDAVDAVYDVTIAYPDGKPPSEQrLLLGGKPREVHVHVR 193
PLN02380 PLN02380
1-acyl-sn-glycerol-3-phosphate acyltransferase
 17-220 5.88e-49

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178006 [Multi-domain]  Cd Length: 376  Bit Score: 166.07  E-value: 5.88e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998288  17 KKELAYVPIIGWMWYFVEMIFCTRKWEQDRQTVAKSLLHLRDYPEKYLFLIHCEGTRFTEKKHQISMQVAQAKGLPSLKH 96
Cdd:PLN02380 119 KKSSKFLPVIGWSMWFSEYVFLERSWAKDENTLKSGFQRLKDFPRPFWLALFVEGTRFTQAKLLAAQEYAASRGLPVPRN 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998288  97 HLLPRTKGFAITVKCLRDVVPAVYDCTLNF-RNNENPTLLGVLNGKKYHADCYVRRIPMEDIPEDEDKCSAWLHKLYQEK 175
Cdd:PLN02380 199 VLIPRTKGFVSAVSNMRSFVPAIYDVTVAVpKGQPAPTMLRIFRGQSSVVHVHIKRHSMKELPETDDGIAQWCKDVFVAK 278

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 568998288 176 DAFQEEYYRTGVFPETPWVPPRRPW-SLVNWLFWASLLLYPFFQFL 220
Cdd:PLN02380 279 DALLDKHFAEDTFGDQEYQDIGRPKkSLIVVISWACLLILGAIKFL 324
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 136-208 7.33e-31

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 109.97  E-value: 7.33e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568998288  136 GVLNGKKYHADCYVRRIPMEDIPEDEDKCSAWLHKLYQEKDAFQEEYYRTGVFPETPW-VPPRRPWSLVNWLFW 208
Cdd:pfam16076   1 SLLNGKPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYETGTFFPGKEhIIPRRLKSLLVFIFW 74
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 11-106 3.74e-15

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 70.08  E-value: 3.74e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998288    11 NSKVLAKKELAYVPIIGWMWYFVEMIFCTRKWE-QDRQTVAKSLLHLRDypeKYLFLIHCEGTRFTEKKHQ-----ISMQ 84
Cdd:smart00563  26 RVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGrKARAALREAVELLKE---GEWLLIFPEGTRSRPGKLLpfkkgAARL 102

                           90       100
                   ....*....|....*....|..
gi 568998288    85 VAQAkglpslKHHLLPRTKGFA 106
Cdd:smart00563 103 ALEA------GVPIVPVAIRGT 118
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 13-120 1.21e-05

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 43.81  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998288   13 KVLAKKELAYVPIIGWMWYFVEMIFCTRKWEQDRQTVAKSLLHLRDypEKYLFLIHCEGTRFTEKKhqismqvaqakglp 92
Cdd:pfam01553  43 VFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTLEYLVELLR--EGKLVVIFPEGTRSREGE-------------- 106

                          90       100
                  ....*....|....*....|....*....
gi 568998288   93 slkhhLLPRTKGFA-ITVKCLRDVVPAVY 120
Cdd:pfam01553 107 -----LLPFKKGAFrLAIEAGVPIVPVAI 130
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 5-123 2.14e-03

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 38.45  E-value: 2.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998288   5 ATASPANSKVLAKKELAYVPIIGWMWYFVEMIFCTR-KWEQDRQTVAKSLLHLRdypEKYLFLIHCEGTRftekkhqism 83
Cdd:COG0204   61 LAALPRPVRFVAKKELFKIPLLGWLLRALGAIPVDRsKRRAALRALRQAVEALK---AGESLVIFPEGTR---------- 127

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568998288  84 qvaqakglpSLKHHLLP-RTKGFAITVKCLRDVVPAVYDCT 123
Cdd:COG0204  128 ---------SPDGRLLPfKTGAARLALEAGVPIVPVAIDGT 159
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 9-92 5.30e-03

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 36.17  E-value: 5.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998288    9 PANSKVLAKKELAYVPIIGWMWYFVEMIFCTRKWEQDRQTVAKSLLHLRDypEKYLFLIHCEGTRFTEKK----HQISMQ 84
Cdd:TIGR00530  38 PPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENIRAIATALKAAIEVLK--QGRSIGVFPEGTRSRGRDilpfKKGAFH 115


                  ....*...
gi 568998288   85 VAQAKGLP 92
Cdd:TIGR00530 116 IAIKAGVP 123
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 11-150 8.09e-55

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 175.50  E-value: 8.09e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998288  11 NSKVLAKKELAYVPIIGWMWYFVEMIFCTRKWEQDRQTVAKSLLHLRDYPEKYLFLIHCEGTRFTEKKHQISMQVAQAKG 90
Cdd:cd07990   53 RLKIVLKDSLKYPPLGGWGWQLGEFIFLKRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKERSQEFAEKNG 132

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568998288  91 LPSLKHHLLPRTKGFAITVKCLRDVVPAVYDCTLNFRNNENPTLL-GVLNGKKYHADCYVR 150
Cdd:cd07990  133 LPPLKHVLLPRTKGFVAILETLRDAVDAVYDVTIAYPDGKPPSEQrLLLGGKPREVHVHVR 193
PLN02380 PLN02380
1-acyl-sn-glycerol-3-phosphate acyltransferase
 17-220 5.88e-49

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178006 [Multi-domain]  Cd Length: 376  Bit Score: 166.07  E-value: 5.88e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998288  17 KKELAYVPIIGWMWYFVEMIFCTRKWEQDRQTVAKSLLHLRDYPEKYLFLIHCEGTRFTEKKHQISMQVAQAKGLPSLKH 96
Cdd:PLN02380 119 KKSSKFLPVIGWSMWFSEYVFLERSWAKDENTLKSGFQRLKDFPRPFWLALFVEGTRFTQAKLLAAQEYAASRGLPVPRN 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998288  97 HLLPRTKGFAITVKCLRDVVPAVYDCTLNF-RNNENPTLLGVLNGKKYHADCYVRRIPMEDIPEDEDKCSAWLHKLYQEK 175
Cdd:PLN02380 199 VLIPRTKGFVSAVSNMRSFVPAIYDVTVAVpKGQPAPTMLRIFRGQSSVVHVHIKRHSMKELPETDDGIAQWCKDVFVAK 278

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 568998288 176 DAFQEEYYRTGVFPETPWVPPRRPW-SLVNWLFWASLLLYPFFQFL 220
Cdd:PLN02380 279 DALLDKHFAEDTFGDQEYQDIGRPKkSLIVVISWACLLILGAIKFL 324
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 13-189 2.37e-34

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 127.51  E-value: 2.37e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998288  13 KVLAKKELAYVPIIGWMWYFVEMIFCTRKWEQDRQTVAKSLLHLRDyPEKYLFLI-HCEGTRFTEKKHQISMQVAQAKGL 91
Cdd:PLN02510 123 KYVLKSSLMKLPVFGWAFHIFEFIPVERKWEVDEPNIRQMLSSFKD-PRDPLWLAlFPEGTDYTEAKCQRSQKFAAEHGL 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998288  92 PSLKHHLLPRTKGFAITVKCLRDVVPAVYDCTLNFRnNENPTLLGVLNG---KKYHadCYVRRIPMEDIPEDEDKCSAWL 168
Cdd:PLN02510 202 PILNNVLLPKTKGFVSCLQELRCSLDAVYDVTIGYK-HRCPSFLDNVFGidpSEVH--IHIRRIPLKQIPTSEDEVSAWL 278

                        170       180
                 ....*....|....*....|.
gi 568998288 169 HKLYQEKDAFQEEYYRTGVFP 189
Cdd:PLN02510 279 MDRFQLKDQLLSDFYAQGHFP 299
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 136-208 7.33e-31

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 109.97  E-value: 7.33e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568998288  136 GVLNGKKYHADCYVRRIPMEDIPEDEDKCSAWLHKLYQEKDAFQEEYYRTGVFPETPW-VPPRRPWSLVNWLFW 208
Cdd:pfam16076   1 SLLNGKPSEVHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYETGTFFPGKEhIIPRRLKSLLVFIFW 74
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 11-106 3.74e-15

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 70.08  E-value: 3.74e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998288    11 NSKVLAKKELAYVPIIGWMWYFVEMIFCTRKWE-QDRQTVAKSLLHLRDypeKYLFLIHCEGTRFTEKKHQ-----ISMQ 84
Cdd:smart00563  26 RVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGrKARAALREAVELLKE---GEWLLIFPEGTRSRPGKLLpfkkgAARL 102

                           90       100
                   ....*....|....*....|..
gi 568998288    85 VAQAkglpslKHHLLPRTKGFA 106
Cdd:smart00563 103 ALEA------GVPIVPVAIRGT 118
PRK14014 PRK14014
putative acyltransferase; Provisional
 13-177 5.97e-13

putative acyltransferase; Provisional


Pssm-ID: 237584 [Multi-domain]  Cd Length: 301  Bit Score: 67.18  E-value: 5.97e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998288  13 KVLAKKELAYVPIIGWMWYFVEMIFCTR-----------KWEQDRQTVAKSLLHLRDYPEKYL-FLihcEGTRFTEKKHQ 80
Cdd:PRK14014 116 KFFLKQELIWVPFLGLAWWALDFPFMKRyskaylaknpeLKGKDLETTRRACEKFKRMPTTIVnFV---EGTRFTPEKHQ 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998288  81 ismqvAQAkglpSLKHHLL-PRTKGFAITVKCLRDVVPAVYDCTLNFRnNENPTLLGVLNGK--KYHADCYVRRIPMEDI 157
Cdd:PRK14014 193 -----QQQ----SPYQHLLkPKAGGIAFALNAMGEQFDGLLDVTIVYP-DGRPSFWDLLSGRvkKIVVHVRLLPIPEELI 262

                        170       180
                 ....*....|....*....|....*.
gi 568998288 158 ------PEDEDKCSAWLHKLYQEKDA 177
Cdd:PRK14014 263 gdyfndKEFRRRFQQWLNQLWQEKDQ 288
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 13-120 1.21e-05

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 43.81  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998288   13 KVLAKKELAYVPIIGWMWYFVEMIFCTRKWEQDRQTVAKSLLHLRDypEKYLFLIHCEGTRFTEKKhqismqvaqakglp 92
Cdd:pfam01553  43 VFVAKKELFDIPLVGWLMRLLGCIFIDRKNRKDAAGTLEYLVELLR--EGKLVVIFPEGTRSREGE-------------- 106

                          90       100
                  ....*....|....*....|....*....
gi 568998288   93 slkhhLLPRTKGFA-ITVKCLRDVVPAVY 120
Cdd:pfam01553 107 -----LLPFKKGAFrLAIEAGVPIVPVAI 130
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 5-73 2.39e-04

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 41.10  E-value: 2.39e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998288   5 ATASPANSKVLAKKELAYVPIIGWMWYFVEMIFCTR-KWEQDRQTVAKSLLHLRdypEKYLFLIHCEGTR 73
Cdd:cd07989   42 GAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRgNGRSAREALREAIEALK---EGESVVIFPEGTR 108
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 5-123 2.14e-03

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 38.45  E-value: 2.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998288   5 ATASPANSKVLAKKELAYVPIIGWMWYFVEMIFCTR-KWEQDRQTVAKSLLHLRdypEKYLFLIHCEGTRftekkhqism 83
Cdd:COG0204   61 LAALPRPVRFVAKKELFKIPLLGWLLRALGAIPVDRsKRRAALRALRQAVEALK---AGESLVIFPEGTR---------- 127

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568998288  84 qvaqakglpSLKHHLLP-RTKGFAITVKCLRDVVPAVYDCT 123
Cdd:COG0204  128 ---------SPDGRLLPfKTGAARLALEAGVPIVPVAIDGT 159
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 9-92 5.30e-03

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 36.17  E-value: 5.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568998288    9 PANSKVLAKKELAYVPIIGWMWYFVEMIFCTRKWEQDRQTVAKSLLHLRDypEKYLFLIHCEGTRFTEKK----HQISMQ 84
Cdd:TIGR00530  38 PPPIVFIAKKELKWIPFFGIMLWLTGAIFIDRENIRAIATALKAAIEVLK--QGRSIGVFPEGTRSRGRDilpfKKGAFH 115


                  ....*...
gi 568998288   85 VAQAKGLP 92
Cdd:TIGR00530 116 IAIKAGVP 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH