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Conserved domains on  [gi|569001553|ref|XP_006524950|]
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lymphocyte antigen 6G6e isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_Ly6G6e cd23548
extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G6e (Ly6G6e) ...
 26-136 2.51e-46

extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G6e (Ly6G6e) and similar proteins; Ly6G6e (also called lymphocyte antigen 6G6e) is a glycosylated, GPI-anchored, cell surface molecule, located on filopodia, which could act as cell receptor with potential roles in signaling or cell-cell interactions. It may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it potentiates alpha-3:beta-4-containing nAChRs maximum response by increasing peak current and slowing down receptor desensitization; the activity is dependent on its cell surface localization. Ly6G6e contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467078  Cd Length: 78  Bit Score: 145.92  E-value: 2.51e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001553  26 GRLRCYTCSFAKPCDPVPRECREDEVCGVSVGTSGRTlvrwpfsrwllsflpmaaaatsaflfcpteqkeEEVIERKGCL 105
Cdd:cd23548    1 GRLRCYTCSFAKPCYPVPTECREDEVCGVSVGTSEQS---------------------------------EEVIERKGCL 47

                         90       100       110
                 ....*....|....*....|....*....|.
gi 569001553 106 PRAQCPLLGHATYWSRSYSLRHQCCEQDLCN 136
Cdd:cd23548   48 PRAQCPLLGHATYWSRSYTLRHQCCEQDLCN 78
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6G6e cd23548
extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G6e (Ly6G6e) ...
 26-136 2.51e-46

extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G6e (Ly6G6e) and similar proteins; Ly6G6e (also called lymphocyte antigen 6G6e) is a glycosylated, GPI-anchored, cell surface molecule, located on filopodia, which could act as cell receptor with potential roles in signaling or cell-cell interactions. It may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it potentiates alpha-3:beta-4-containing nAChRs maximum response by increasing peak current and slowing down receptor desensitization; the activity is dependent on its cell surface localization. Ly6G6e contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467078  Cd Length: 78  Bit Score: 145.92  E-value: 2.51e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001553  26 GRLRCYTCSFAKPCDPVPRECREDEVCGVSVGTSGRTlvrwpfsrwllsflpmaaaatsaflfcpteqkeEEVIERKGCL 105
Cdd:cd23548    1 GRLRCYTCSFAKPCYPVPTECREDEVCGVSVGTSEQS---------------------------------EEVIERKGCL 47

                         90       100       110
                 ....*....|....*....|....*....|.
gi 569001553 106 PRAQCPLLGHATYWSRSYSLRHQCCEQDLCN 136
Cdd:cd23548   48 PRAQCPLLGHATYWSRSYTLRHQCCEQDLCN 78
Activin_recp pfam01064
Activin types I and II receptor domain; This Pfam entry consists of both TGF-beta receptor ...
 28-137 5.68e-10

Activin types I and II receptor domain; This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box.


Pssm-ID: 460048  Cd Length: 78  Bit Score: 52.89  E-value: 5.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001553   28 LRCYtcsfakpCDPVprECREDEVCGVSVGTsgrtlvRWPFSRWLLSflpmaaaatsaflfCPTEQKeeevIERKGCLPR 107
Cdd:pfam01064   1 LKCY-------CNPL--KCNDDNVNFTCETD------GQCFSSWELD--------------TDGFIE----CVKKGCLSP 47

                          90       100       110
                  ....*....|....*....|....*....|
gi 569001553  108 AQCPLLGHATYWSRSYSlRHQCCEQDLCNA 137
Cdd:pfam01064  48 EDDPFECKTSNKPHSLY-RIECCKTDFCNK 76
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6G6e cd23548
extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G6e (Ly6G6e) ...
 26-136 2.51e-46

extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G6e (Ly6G6e) and similar proteins; Ly6G6e (also called lymphocyte antigen 6G6e) is a glycosylated, GPI-anchored, cell surface molecule, located on filopodia, which could act as cell receptor with potential roles in signaling or cell-cell interactions. It may act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it potentiates alpha-3:beta-4-containing nAChRs maximum response by increasing peak current and slowing down receptor desensitization; the activity is dependent on its cell surface localization. Ly6G6e contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467078  Cd Length: 78  Bit Score: 145.92  E-value: 2.51e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001553  26 GRLRCYTCSFAKPCDPVPRECREDEVCGVSVGTSGRTlvrwpfsrwllsflpmaaaatsaflfcpteqkeEEVIERKGCL 105
Cdd:cd23548    1 GRLRCYTCSFAKPCYPVPTECREDEVCGVSVGTSEQS---------------------------------EEVIERKGCL 47

                         90       100       110
                 ....*....|....*....|....*....|.
gi 569001553 106 PRAQCPLLGHATYWSRSYSLRHQCCEQDLCN 136
Cdd:cd23548   48 PRAQCPLLGHATYWSRSYTLRHQCCEQDLCN 78
Activin_recp pfam01064
Activin types I and II receptor domain; This Pfam entry consists of both TGF-beta receptor ...
 28-137 5.68e-10

Activin types I and II receptor domain; This Pfam entry consists of both TGF-beta receptor types. This is an alignment of the hydrophilic cysteine-rich ligand-binding domains, Both receptor types, (type I and II) posses a 9 amino acid cysteine box, with the the consensus CCX{4-5}CN. The type I receptors also possess 7 extracellular residues preceding the cysteine box.


Pssm-ID: 460048  Cd Length: 78  Bit Score: 52.89  E-value: 5.68e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001553   28 LRCYtcsfakpCDPVprECREDEVCGVSVGTsgrtlvRWPFSRWLLSflpmaaaatsaflfCPTEQKeeevIERKGCLPR 107
Cdd:pfam01064   1 LKCY-------CNPL--KCNDDNVNFTCETD------GQCFSSWELD--------------TDGFIE----CVKKGCLSP 47

                          90       100       110
                  ....*....|....*....|....*....|
gi 569001553  108 AQCPLLGHATYWSRSYSlRHQCCEQDLCNA 137
Cdd:pfam01064  48 EDDPFECKTSNKPHSLY-RIECCKTDFCNK 76
TFP_LU_ECD_Bncr cd23597
extracellular domain (ECD) found in Danio rerio protein Bouncer and similar proteins; Bouncer ...
 28-136 9.36e-06

extracellular domain (ECD) found in Danio rerio protein Bouncer and similar proteins; Bouncer (bncr) is an oocyte-expressed fertilization factor that mediates sperm-egg binding and is essential for sperm entry into the egg. It is necessary and sufficient to mediate species-specific gamete recognition and fertilization, which is essential for vertebrate species performing external fertilization. Bouncer contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467126  Cd Length: 78  Bit Score: 41.87  E-value: 9.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001553  28 LRCYTC---SFAKPCDPVPRECREDEVCGVSVGTSGRTlvrwpfsrwllsflpmaaaatsaflfcpteqkeeEVIERKGC 104
Cdd:cd23597    1 LLCLYCplqEKEKTCTNVTTECPPQERCFSARGRYGGY----------------------------------HVLSAQGC 46

                         90       100       110
                 ....*....|....*....|....*....|..
gi 569001553 105 LPRAQCPLLGHATYWSRSYSLRHQCCEQDLCN 136
Cdd:cd23597   47 MARELCGSVHSVSYRGINYNVTYSCCCWDYCN 78
TFP_LU_ECD_SPACA4 cd23574
extracellular domain (ECD) found in sperm acrosome membrane-associated protein 4 (SPACA4); ...
 28-136 2.77e-03

extracellular domain (ECD) found in sperm acrosome membrane-associated protein 4 (SPACA4); SPACA4 (also called SAMP14) is a sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. SPACA4 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467104  Cd Length: 79  Bit Score: 35.04  E-value: 2.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569001553  28 LRCYTCSFAKP--CDPVPRECREDEVCGVSVGTSgrtlvrwpfsrWLLSflpmaaaatsaflfcpteqkeeeVIERKGCL 105
Cdd:cd23574    3 KTCYYCDLTNSsdCPGIPMICADEEDCYTGRGAA-----------LGFP-----------------------LIINKGCI 48

                         90       100       110
                 ....*....|....*....|....*....|.
gi 569001553 106 PRAQCPLLGHATYWSRSYSLRHQCCEQDLCN 136
Cdd:cd23574   49 EATRCGKEESVTYMGVTYNLTTYCCEGELCN 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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