CAP-Gly domain-containing linker protein 4 isoform X8 [Mus musculus]
CAP-Gly domain-containing linker protein; CAP-Gly domain-containing protein( domain architecture ID 12790878)
CAP-Gly domain-containing linker protein functions as a cytoplasmic linker protein; CAP-Gly domain-containing protein similar to human dynactin-1 and Saccharomyces cerevisiae nuclear fusion protein BIK1; CAP-Gly domains serve as recognition domains for EEY/F-COO(-) motifs
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
CAP_GLY | pfam01302 | CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of ... |
439-503 | 1.05e-32 | ||||
CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove. : Pssm-ID: 460154 [Multi-domain] Cd Length: 65 Bit Score: 119.43 E-value: 1.05e-32
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CAP_GLY | pfam01302 | CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of ... |
285-342 | 4.64e-28 | ||||
CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove. : Pssm-ID: 460154 [Multi-domain] Cd Length: 65 Bit Score: 106.33 E-value: 4.64e-28
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ANKYR | COG0666 | Ankyrin repeat [Signal transduction mechanisms]; |
84-254 | 6.18e-17 | ||||
Ankyrin repeat [Signal transduction mechanisms]; : Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 81.54 E-value: 6.18e-17
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Name | Accession | Description | Interval | E-value | ||||
CAP_GLY | pfam01302 | CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of ... |
439-503 | 1.05e-32 | ||||
CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove. Pssm-ID: 460154 [Multi-domain] Cd Length: 65 Bit Score: 119.43 E-value: 1.05e-32
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CAP_GLY | pfam01302 | CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of ... |
285-342 | 4.64e-28 | ||||
CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove. Pssm-ID: 460154 [Multi-domain] Cd Length: 65 Bit Score: 106.33 E-value: 4.64e-28
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CAP_GLY | smart01052 | Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and ... |
439-504 | 1.21e-26 | ||||
Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network; A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove. Pssm-ID: 214997 [Multi-domain] Cd Length: 68 Bit Score: 102.66 E-value: 1.21e-26
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CAP_GLY | smart01052 | Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and ... |
285-342 | 3.03e-24 | ||||
Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network; A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove. Pssm-ID: 214997 [Multi-domain] Cd Length: 68 Bit Score: 95.73 E-value: 3.03e-24
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NIP100 | COG5244 | Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle ... |
437-500 | 3.89e-17 | ||||
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 227569 [Multi-domain] Cd Length: 669 Bit Score: 84.74 E-value: 3.89e-17
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ANKYR | COG0666 | Ankyrin repeat [Signal transduction mechanisms]; |
84-254 | 6.18e-17 | ||||
Ankyrin repeat [Signal transduction mechanisms]; Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 81.54 E-value: 6.18e-17
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NIP100 | COG5244 | Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle ... |
283-342 | 1.21e-13 | ||||
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 227569 [Multi-domain] Cd Length: 669 Bit Score: 73.57 E-value: 1.21e-13
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Ank_2 | pfam12796 | Ankyrin repeats (3 copies); |
111-217 | 1.64e-09 | ||||
Ankyrin repeats (3 copies); Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 54.74 E-value: 1.64e-09
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PHA03095 | PHA03095 | ankyrin-like protein; Provisional |
92-226 | 5.87e-07 | ||||
ankyrin-like protein; Provisional Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 51.95 E-value: 5.87e-07
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trp | TIGR00870 | transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
152-212 | 5.91e-03 | ||||
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds] Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 39.68 E-value: 5.91e-03
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Name | Accession | Description | Interval | E-value | ||||
CAP_GLY | pfam01302 | CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of ... |
439-503 | 1.05e-32 | ||||
CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove. Pssm-ID: 460154 [Multi-domain] Cd Length: 65 Bit Score: 119.43 E-value: 1.05e-32
|
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CAP_GLY | pfam01302 | CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of ... |
285-342 | 4.64e-28 | ||||
CAP-Gly domain; Cytoskeleton-associated proteins (CAPs) are involved in the organization of microtubules and transportation of vesicles and organelles along the cytoskeletal network. A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove. Pssm-ID: 460154 [Multi-domain] Cd Length: 65 Bit Score: 106.33 E-value: 4.64e-28
|
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CAP_GLY | smart01052 | Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and ... |
439-504 | 1.21e-26 | ||||
Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network; A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove. Pssm-ID: 214997 [Multi-domain] Cd Length: 68 Bit Score: 102.66 E-value: 1.21e-26
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CAP_GLY | smart01052 | Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and ... |
285-342 | 3.03e-24 | ||||
Cytoskeleton-associated proteins (CAPs) are involved in the organisation of microtubules and transportation of vesicles and organelles along the cytoskeletal network; A conserved motif, CAP-Gly, has been identified in a number of CAPs, including CLIP-170 and dynactins. The crystal structure of Caenorhabditis elegans F53F4.3 protein CAP-Gly domain was recently solved. The domain contains three beta-strands. The most conserved sequence, GKNDG, is located in two consecutive sharp turns on the surface, forming the entrance to a groove. Pssm-ID: 214997 [Multi-domain] Cd Length: 68 Bit Score: 95.73 E-value: 3.03e-24
|
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NIP100 | COG5244 | Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle ... |
437-500 | 3.89e-17 | ||||
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 227569 [Multi-domain] Cd Length: 669 Bit Score: 84.74 E-value: 3.89e-17
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ANKYR | COG0666 | Ankyrin repeat [Signal transduction mechanisms]; |
84-254 | 6.18e-17 | ||||
Ankyrin repeat [Signal transduction mechanisms]; Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 81.54 E-value: 6.18e-17
|
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NIP100 | COG5244 | Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle ... |
283-342 | 1.21e-13 | ||||
Dynactin complex subunit involved in mitotic spindle partitioning in anaphase B [Cell cycle control, cell division, chromosome partitioning]; Pssm-ID: 227569 [Multi-domain] Cd Length: 669 Bit Score: 73.57 E-value: 1.21e-13
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ANKYR | COG0666 | Ankyrin repeat [Signal transduction mechanisms]; |
84-254 | 9.51e-13 | ||||
Ankyrin repeat [Signal transduction mechanisms]; Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 68.83 E-value: 9.51e-13
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Ank_2 | pfam12796 | Ankyrin repeats (3 copies); |
111-217 | 1.64e-09 | ||||
Ankyrin repeats (3 copies); Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 54.74 E-value: 1.64e-09
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PHA03095 | PHA03095 | ankyrin-like protein; Provisional |
92-226 | 5.87e-07 | ||||
ankyrin-like protein; Provisional Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 51.95 E-value: 5.87e-07
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PHA03100 | PHA03100 | ankyrin repeat protein; Provisional |
92-225 | 2.81e-05 | ||||
ankyrin repeat protein; Provisional Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 46.58 E-value: 2.81e-05
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Ank_4 | pfam13637 | Ankyrin repeats (many copies); |
150-207 | 5.26e-04 | ||||
Ankyrin repeats (many copies); Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 38.02 E-value: 5.26e-04
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ANKYR | COG0666 | Ankyrin repeat [Signal transduction mechanisms]; |
132-254 | 1.31e-03 | ||||
Ankyrin repeat [Signal transduction mechanisms]; Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 41.09 E-value: 1.31e-03
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PTZ00322 | PTZ00322 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
166-226 | 3.79e-03 | ||||
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 40.27 E-value: 3.79e-03
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trp | TIGR00870 | transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
152-212 | 5.91e-03 | ||||
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds] Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 39.68 E-value: 5.91e-03
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Ank | pfam00023 | Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
189-218 | 9.77e-03 | ||||
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity. Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 33.80 E-value: 9.77e-03
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Blast search parameters | ||||
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