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Conserved domains on  [gi|569007831|ref|XP_006527411|]
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von Willebrand factor C and EGF domain-containing protein isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 493-551 2.65e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 42.41  E-value: 2.65e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 569007831  493 CYFHGRWYTDGAVFSGggDDCTTCVCQNGEVECSFTPCPELECPREEWLLGPGQCCFTC 551
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNPRLEIPPGECCPVC 57
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 707-914 4.05e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 4.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007831  707 PCRPICTDPSCPDSVFPleeKQQPSPH-GELAKAARNARGDTEVPVNCSSCPGPPSASPTRPmvhllqrlLRTNLSNIQS 785
Cdd:PHA03247 2553 PPLPPAAPPAAPDRSVP---PPRPAPRpSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGP--------APPSPLPPDT 2621

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007831  786 ASPSPPIAQTSSSPLLEPEGISLGKPRASQPPEPSAGSPVSPRLSTLPPAIPGTPLSPV---TPESSSSTFGTQTAF--- 859
Cdd:PHA03247 2622 HAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPqrpRRRAARPTVGSLTSLadp 2701

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569007831  860 -----------QWLLSATPLTEAeTPSMTNADLSETLTTSSSSQRLSAALPDTPNPVPQQSTIDTP 914
Cdd:PHA03247 2702 ppppptpepapHALVSATPLPPG-PAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGP 2766
EGF_CA smart00179
Calcium-binding EGF-like domain;
220-262 2.55e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 2.55e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 569007831   220 DVNECrrpQERRVCHH--TCHNTVGSFLCTCRPGFrlrSDRVSCE 262
Cdd:smart00179   1 DIDEC---ASGNPCQNggTCVNTVGSYRCECPPGY---TDGRNCE 39
VWC smart00214
von Willebrand factor (vWF) type C domain;
613-668 3.18e-04

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.42  E-value: 3.18e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569007831   613 CTYTGRIFYNNETFPSvlDPCLSCICLLGS-VACSPVDCP--ITCTYPFH--PDGECCPVC 668
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPppPDCPNPERvkPPGECCPRC 59
EGF_CA smart00179
Calcium-binding EGF-like domain;
142-180 4.74e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 4.74e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 569007831   142 DIDECLSS---SCEGHCVNTEGGFVCECGPGMQlsaDRHSCQ 180
Cdd:smart00179   1 DIDECASGnpcQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 190-218 2.22e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.45  E-value: 2.22e-03
                          10        20
                  ....*....|....*....|....*....
gi 569007831  190 CQQRCKNSIGSYKCSCRAGFHLHGNRHSC 218
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 378-432 2.31e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 37.02  E-value: 2.31e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 569007831  378 CWHLGATYESGSRWNQPGCSQCLCQDGEVTCGGVRC-DATCSHPVP-PRDGGCCPSC 432
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICpPLDCPNPRLeIPPGECCPVC 57
 
Name Accession Description Interval E-value
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 493-551 2.65e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 42.41  E-value: 2.65e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 569007831  493 CYFHGRWYTDGAVFSGggDDCTTCVCQNGEVECSFTPCPELECPREEWLLGPGQCCFTC 551
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNPRLEIPPGECCPVC 57
PHA03247 PHA03247
large tegument protein UL36; Provisional
 707-914 4.05e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 4.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007831  707 PCRPICTDPSCPDSVFPleeKQQPSPH-GELAKAARNARGDTEVPVNCSSCPGPPSASPTRPmvhllqrlLRTNLSNIQS 785
Cdd:PHA03247 2553 PPLPPAAPPAAPDRSVP---PPRPAPRpSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGP--------APPSPLPPDT 2621

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007831  786 ASPSPPIAQTSSSPLLEPEGISLGKPRASQPPEPSAGSPVSPRLSTLPPAIPGTPLSPV---TPESSSSTFGTQTAF--- 859
Cdd:PHA03247 2622 HAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPqrpRRRAARPTVGSLTSLadp 2701

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569007831  860 -----------QWLLSATPLTEAeTPSMTNADLSETLTTSSSSQRLSAALPDTPNPVPQQSTIDTP 914
Cdd:PHA03247 2702 ppppptpepapHALVSATPLPPG-PAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGP 2766
EGF_CA smart00179
Calcium-binding EGF-like domain;
220-262 2.55e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 2.55e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 569007831   220 DVNECrrpQERRVCHH--TCHNTVGSFLCTCRPGFrlrSDRVSCE 262
Cdd:smart00179   1 DIDEC---ASGNPCQNggTCVNTVGSYRCECPPGY---TDGRNCE 39
VWC smart00214
von Willebrand factor (vWF) type C domain;
613-668 3.18e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.42  E-value: 3.18e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569007831   613 CTYTGRIFYNNETFPSvlDPCLSCICLLGS-VACSPVDCP--ITCTYPFH--PDGECCPVC 668
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPppPDCPNPERvkPPGECCPRC 59
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 220-256 4.27e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 4.27e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 569007831 220 DVNECrrpQERRVC--HHTCHNTVGSFLCTCRPGFRLRS 256
Cdd:cd00054    1 DIDEC---ASGNPCqnGGTCVNTVGSYRCSCPPGYTGRN 36
VWC smart00214
von Willebrand factor (vWF) type C domain;
493-551 4.32e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.04  E-value: 4.32e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569007831   493 CYFHGRWYTDGAVFSGggDDCTTCVCQNGE-VECSFTPCPE-LECPREEWLLGPGQCCFTC 551
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKPPGECCPRC 59
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 233-261 4.37e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 38.38  E-value: 4.37e-04
                          10        20
                  ....*....|....*....|....*....
gi 569007831  233 CHHTCHNTVGSFLCTCRPGFRLRSDRVSC 261
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
142-180 4.74e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 4.74e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 569007831   142 DIDECLSS---SCEGHCVNTEGGFVCECGPGMQlsaDRHSCQ 180
Cdd:smart00179   1 DIDECASGnpcQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 720-867 2.00e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 41.76  E-value: 2.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007831 720 SVFPLEEKQQPSPHGELAKAARNARGDTEVPVNCSSCPGPPSAS----PTRPMVHLLQRLLRTNLSNIQSASPSPPIAQT 795
Cdd:COG3266  219 AVAAAAELAALALLAAGAAEVLTARLVLLLLIIGSALKAPSQASsasaPATTSLGEQQEVSLPPAVAAQPAAAAAAQPSA 298

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569007831 796 SSSPLLEPEGISLGKPRASQPPEPSAGSPVS-PRLSTLPPAiPGTPLSPVTPESSSSTFGTQTAFQWLLSATP 867
Cdd:COG3266  299 VALPAAPAAAAAAAAPAEAAAPQPTAAKPVVtETAAPAAPA-PEAAAAAAAPAAPAVAKKLAADEQWLASQPA 370
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 190-218 2.22e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.45  E-value: 2.22e-03
                          10        20
                  ....*....|....*....|....*....
gi 569007831  190 CQQRCKNSIGSYKCSCRAGFHLHGNRHSC 218
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 378-432 2.31e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.02  E-value: 2.31e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 569007831  378 CWHLGATYESGSRWNQPGCSQCLCQDGEVTCGGVRC-DATCSHPVP-PRDGGCCPSC 432
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICpPLDCPNPRLeIPPGECCPVC 57
EGF_CA smart00179
Calcium-binding EGF-like domain;
181-214 2.48e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 2.48e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 569007831   181 DTDECL-GTPCQQ--RCKNSIGSYKCSCRAGFHLHGN 214
Cdd:smart00179   1 DIDECAsGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 613-668 2.78e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.02  E-value: 2.78e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 569007831  613 CTYTGRIFYNNETFpsVLDPCLSCICLLGSVACSPVDCPI-TCTYPFH--PDGECCPVC 668
Cdd:pfam00093   1 CVQNGVVYENGETW--KPDLCTICTCDDGKVLCDKIICPPlDCPNPRLeiPPGECCPVC 57
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 181-212 3.06e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 3.06e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 569007831 181 DTDECL-GTPCQ--QRCKNSIGSYKCSCRAGFHLH 212
Cdd:cd00054    1 DIDECAsGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 747-903 3.74e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.06  E-value: 3.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007831  747 TEVPVNCSScpgPPSASPTrpmvhllqrllrtnLSNIQSASPSPPIAQTSSSPLLEPEgislgKPR--ASQPPEPSAGSP 824
Cdd:pfam05109 452 THVPTNLTA---PASTGPT--------------VSTADVTSPTPAGTTSGASPVTPSP-----SPRdnGTESKAPDMTSP 509

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007831  825 VSPRLSTLPPAIPGTP-LSPVTPESSSSTFGTQTAFQWLLSATPLTEAETPSMTNADLSETLTTSSSSQRLSAALPDTPN 903
Cdd:pfam05109 510 TSAVTTPTPNATSPTPaVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPN 589
KLF8_12_N cd21093
N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins; Kruppel-like ...
 780-852 4.24e-03

N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins; Kruppel-like transcription factors (also known as Krueppel-like transcription factors, KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Although these factors bind to similar elements in vitro, they have distinct activities in vivo depending on their expression profile and the sequence of the N-terminal activation/repression domain, which differ between members. This model represents the related N-terminal activation/repression domains of KLF8 and KLF12.


Pssm-ID: 410606 [Multi-domain]  Cd Length: 172  Bit Score: 38.99  E-value: 4.24e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569007831 780 LSNIQSASPSPPIAQTSSSPLLEPEGISLGKPRASQPPEPSAGSPVSPRLSTLPPAIPGTPLSPVTPESSSST 852
Cdd:cd21093   16 LNNIKTEPPEELLSSDHSQPQTEPVDLSINKARTSPTAVSSSPVSMSSSISSSSSSSPRPASSPTVITSVSSA 88
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 142-172 4.91e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 4.91e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 569007831 142 DIDECLSSS---CEGHCVNTEGGFVCECGPGMQL 172
Cdd:cd00054    1 DIDECASGNpcqNGGTCVNTVGSYRCSCPPGYTG 34
VWC smart00214
von Willebrand factor (vWF) type C domain;
378-432 9.52e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 35.57  E-value: 9.52e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 569007831   378 CWHLGATYESGSRWNQPGCSQCLCQDGE-VTCGGVRCDA--TCSHPV-PPRDGGCCPSC 432
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPppDCPNPErVKPPGECCPRC 59
 
Name Accession Description Interval E-value
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 493-551 2.65e-05

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 42.41  E-value: 2.65e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 569007831  493 CYFHGRWYTDGAVFSGggDDCTTCVCQNGEVECSFTPCPELECPREEWLLGPGQCCFTC 551
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNPRLEIPPGECCPVC 57
PHA03247 PHA03247
large tegument protein UL36; Provisional
 707-914 4.05e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 4.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007831  707 PCRPICTDPSCPDSVFPleeKQQPSPH-GELAKAARNARGDTEVPVNCSSCPGPPSASPTRPmvhllqrlLRTNLSNIQS 785
Cdd:PHA03247 2553 PPLPPAAPPAAPDRSVP---PPRPAPRpSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGP--------APPSPLPPDT 2621

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007831  786 ASPSPPIAQTSSSPLLEPEGISLGKPRASQPPEPSAGSPVSPRLSTLPPAIPGTPLSPV---TPESSSSTFGTQTAF--- 859
Cdd:PHA03247 2622 HAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPqrpRRRAARPTVGSLTSLadp 2701

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569007831  860 -----------QWLLSATPLTEAeTPSMTNADLSETLTTSSSSQRLSAALPDTPNPVPQQSTIDTP 914
Cdd:PHA03247 2702 ppppptpepapHALVSATPLPPG-PAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGP 2766
EGF_CA smart00179
Calcium-binding EGF-like domain;
220-262 2.55e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 2.55e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 569007831   220 DVNECrrpQERRVCHH--TCHNTVGSFLCTCRPGFrlrSDRVSCE 262
Cdd:smart00179   1 DIDEC---ASGNPCQNggTCVNTVGSYRCECPPGY---TDGRNCE 39
VWC smart00214
von Willebrand factor (vWF) type C domain;
613-668 3.18e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.42  E-value: 3.18e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569007831   613 CTYTGRIFYNNETFPSvlDPCLSCICLLGS-VACSPVDCP--ITCTYPFH--PDGECCPVC 668
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPppPDCPNPERvkPPGECCPRC 59
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 220-256 4.27e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 4.27e-04
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 569007831 220 DVNECrrpQERRVC--HHTCHNTVGSFLCTCRPGFRLRS 256
Cdd:cd00054    1 DIDEC---ASGNPCqnGGTCVNTVGSYRCSCPPGYTGRN 36
VWC smart00214
von Willebrand factor (vWF) type C domain;
493-551 4.32e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 39.04  E-value: 4.32e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569007831   493 CYFHGRWYTDGAVFSGggDDCTTCVCQNGE-VECSFTPCPE-LECPREEWLLGPGQCCFTC 551
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKPPGECCPRC 59
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 233-261 4.37e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 38.38  E-value: 4.37e-04
                          10        20
                  ....*....|....*....|....*....
gi 569007831  233 CHHTCHNTVGSFLCTCRPGFRLRSDRVSC 261
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
142-180 4.74e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 4.74e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 569007831   142 DIDECLSS---SCEGHCVNTEGGFVCECGPGMQlsaDRHSCQ 180
Cdd:smart00179   1 DIDECASGnpcQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 705-907 1.16e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.00  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007831  705 TVPCRPICTDPSCPDSVFP---LEEKQQPSPHGELAKAARNARGDTEVPVncsscpGPPSASPTRPMVHLLQRllRTNLS 781
Cdd:PHA03247 2715 LVSATPLPPGPAAARQASPalpAAPAPPAVPAGPATPGGPARPARPPTTA------GPPAPAPPAAPAAGPPR--RLTRP 2786

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007831  782 NIQSASPSPPIAQTSSSPLLEPEGISLGKPRASQPPEPSAGSPVSPRLSTLPPAIPGTPLSPVTPESSSSTFGTQTAFQW 861
Cdd:PHA03247 2787 AVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRP 2866

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 569007831  862 LLSATPLTEAeTPSMTNADLSETLTTSSSSQRLsAALPDTPNPVPQ 907
Cdd:PHA03247 2867 PSRSPAAKPA-APARPPVRRLARPAVSRSTESF-ALPPDQPERPPQ 2910
DamX COG3266
Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell ...
 720-867 2.00e-03

Cell division protein DamX, binds to the septal ring, contains C-terminal SPOR domain [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442497 [Multi-domain]  Cd Length: 455  Bit Score: 41.76  E-value: 2.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007831 720 SVFPLEEKQQPSPHGELAKAARNARGDTEVPVNCSSCPGPPSAS----PTRPMVHLLQRLLRTNLSNIQSASPSPPIAQT 795
Cdd:COG3266  219 AVAAAAELAALALLAAGAAEVLTARLVLLLLIIGSALKAPSQASsasaPATTSLGEQQEVSLPPAVAAQPAAAAAAQPSA 298

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569007831 796 SSSPLLEPEGISLGKPRASQPPEPSAGSPVS-PRLSTLPPAiPGTPLSPVTPESSSSTFGTQTAFQWLLSATP 867
Cdd:COG3266  299 VALPAAPAAAAAAAAPAEAAAPQPTAAKPVVtETAAPAAPA-PEAAAAAAAPAAPAVAKKLAADEQWLASQPA 370
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 190-218 2.22e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 36.45  E-value: 2.22e-03
                          10        20
                  ....*....|....*....|....*....
gi 569007831  190 CQQRCKNSIGSYKCSCRAGFHLHGNRHSC 218
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 378-432 2.31e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.02  E-value: 2.31e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 569007831  378 CWHLGATYESGSRWNQPGCSQCLCQDGEVTCGGVRC-DATCSHPVP-PRDGGCCPSC 432
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICpPLDCPNPRLeIPPGECCPVC 57
EGF_CA pfam07645
Calcium-binding EGF domain;
220-251 2.40e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 2.40e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 569007831  220 DVNECRrpQERRVCHH--TCHNTVGSFLCTCRPG 251
Cdd:pfam07645   1 DVDECA--TGTHNCPAntVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
181-214 2.48e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 2.48e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 569007831   181 DTDECL-GTPCQQ--RCKNSIGSYKCSCRAGFHLHGN 214
Cdd:smart00179   1 DIDECAsGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 613-668 2.78e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.02  E-value: 2.78e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 569007831  613 CTYTGRIFYNNETFpsVLDPCLSCICLLGSVACSPVDCPI-TCTYPFH--PDGECCPVC 668
Cdd:pfam00093   1 CVQNGVVYENGETW--KPDLCTICTCDDGKVLCDKIICPPlDCPNPRLeiPPGECCPVC 57
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 181-212 3.06e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 3.06e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 569007831 181 DTDECL-GTPCQ--QRCKNSIGSYKCSCRAGFHLH 212
Cdd:cd00054    1 DIDECAsGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 747-903 3.74e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.06  E-value: 3.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007831  747 TEVPVNCSScpgPPSASPTrpmvhllqrllrtnLSNIQSASPSPPIAQTSSSPLLEPEgislgKPR--ASQPPEPSAGSP 824
Cdd:pfam05109 452 THVPTNLTA---PASTGPT--------------VSTADVTSPTPAGTTSGASPVTPSP-----SPRdnGTESKAPDMTSP 509

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007831  825 VSPRLSTLPPAIPGTP-LSPVTPESSSSTFGTQTAFQWLLSATPLTEAETPSMTNADLSETLTTSSSSQRLSAALPDTPN 903
Cdd:pfam05109 510 TSAVTTPTPNATSPTPaVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPN 589
KLF8_12_N cd21093
N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins; Kruppel-like ...
 780-852 4.24e-03

N-terminal domain of Kruppel-like factor (KLF) 8, KLF12, and similar proteins; Kruppel-like transcription factors (also known as Krueppel-like transcription factors, KLFs) belong to a family of proteins called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Although these factors bind to similar elements in vitro, they have distinct activities in vivo depending on their expression profile and the sequence of the N-terminal activation/repression domain, which differ between members. This model represents the related N-terminal activation/repression domains of KLF8 and KLF12.


Pssm-ID: 410606 [Multi-domain]  Cd Length: 172  Bit Score: 38.99  E-value: 4.24e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569007831 780 LSNIQSASPSPPIAQTSSSPLLEPEGISLGKPRASQPPEPSAGSPVSPRLSTLPPAIPGTPLSPVTPESSSST 852
Cdd:cd21093   16 LNNIKTEPPEELLSSDHSQPQTEPVDLSINKARTSPTAVSSSPVSMSSSISSSSSSSPRPASSPTVITSVSSA 88
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 142-172 4.91e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 4.91e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 569007831 142 DIDECLSSS---CEGHCVNTEGGFVCECGPGMQL 172
Cdd:cd00054    1 DIDECASGNpcqNGGTCVNTVGSYRCSCPPGYTG 34
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 718-920 5.91e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.44  E-value: 5.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007831 718 PDSVFPLEEKQQPSPHGElakaarnaRGDTEVPVNCSSCPGPP-SASPTRPMVHLLQRLLRTnlSNIQSASPSPPIAQTS 796
Cdd:PTZ00449 549 PGETKEGEVGKKPGPAKE--------HKPSKIPTLSKKPEFPKdPKHPKDPEEPKKPKRPRS--AQRPTRPKSPKLPELL 618

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569007831 797 SSPLLEPEGISLGKPRasQPPEPSagSPVSPRL--STLPPAIPGTPLSPVTP--------------ESSSSTFGTQT--- 857
Cdd:PTZ00449 619 DIPKSPKRPESPKSPK--RPPPPQ--RPSSPERpeGPKIIKSPKPPKSPKPPfdpkfkekfyddylDAAAKSKETKTtvv 694

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569007831 858 ---AFQWLLSATPLTEAETPSMTNADLSETLTTSSSSQRLSAALPDTPNPVPqqSTIDTPKKENST 920
Cdd:PTZ00449 695 ldeSFESILKETLPETPGTPFTTPRPLPPKLPRDEEFPFEPIGDPDAEQPDD--IEFFTPPEEERT 758
VWC smart00214
von Willebrand factor (vWF) type C domain;
378-432 9.52e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 35.57  E-value: 9.52e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 569007831   378 CWHLGATYESGSRWNQPGCSQCLCQDGE-VTCGGVRCDA--TCSHPV-PPRDGGCCPSC 432
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPppDCPNPErVKPPGECCPRC 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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