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Conserved domains on  [gi|569008591|ref|XP_006527612|]
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protein Shroom4 isoform X1 [Mus musculus]

Protein Classification

PDZ and ASD2 domain-containing protein( domain architecture ID 10643681)

PDZ and ASD2 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ASD2 pfam08687
Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which ...
1173-1417 3.47e-112

Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.


:

Pssm-ID: 430155 [Multi-domain]  Cd Length: 287  Bit Score: 355.02  E-value: 3.47e-112
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008591  1173 WRTTEQEATVTPKQEFQHFSPPKGASGIPTSYSAYYNISVAKAELLNKLK--QQPEMAEA-GLGEEGVDYELAQKKIQLI 1249
Cdd:pfam08687   39 LRAMKPDLGEAYRPEEEGSEEEKSGTSSLSSCSAYYTTSAPKAELLTKMKdlTLPEPDQPeEQSEEELDHDLQQKKVELI 118
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008591  1250 ESISRKLSVLREAQRGLLDDINANAALGEEVEANLKAVCKSNEFEKYHLFIGDLDKVVNLLLSLSGRLARVENALNSIDS 1329
Cdd:pfam08687  119 ESLQRKLQVLREEQEALQEEIQANAALGEEVEALVQQVCKPNELEKYRMFIGDLEKVVSLLLSLSGRLARVENALSSLDS 198
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008591  1330 ESNQ-EKLVLIEKKQQLTNQLADAKELKEHVDGREKLVFGMVSRYLPQDQLQDYQHFVKMKSALIIEQRELEEKIKLGEE 1408
Cdd:pfam08687  199 DADAeERKSLEEKRRLLLRQLEDAKELKENLDRRERVVSGILARYLTAEQLQDYQHFVKMKAALLIEQRELEDKIKLGEE 278

                   ....*....
gi 569008591  1409 QLKCLKESL 1417
Cdd:pfam08687  279 QLKALKESL 287
PDZ smart00228
Domain present in PSD-95, Dlg, and ZO-1/2; Also called DHR (Dlg homologous region) or GLGF ...
1-41 4.94e-04

Domain present in PSD-95, Dlg, and ZO-1/2; Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides; others appear to bind internal (non-C-terminal) polypeptides. Different PDZs possess different binding specificities.


:

Pssm-ID: 214570 [Multi-domain]  Cd Length: 85  Bit Score: 40.44  E-value: 4.94e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 569008591      1 MRTGDELVNINGTPLYG-SRQEALILIKGSFRILKLIVRRRN 41
Cdd:smart00228   44 LRVGDVILEVNGTSVEGlTHLEAVDLLKKAGGKVTLTVLRGG 85
 
Name Accession Description Interval E-value
ASD2 pfam08687
Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which ...
1173-1417 3.47e-112

Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.


Pssm-ID: 430155 [Multi-domain]  Cd Length: 287  Bit Score: 355.02  E-value: 3.47e-112
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008591  1173 WRTTEQEATVTPKQEFQHFSPPKGASGIPTSYSAYYNISVAKAELLNKLK--QQPEMAEA-GLGEEGVDYELAQKKIQLI 1249
Cdd:pfam08687   39 LRAMKPDLGEAYRPEEEGSEEEKSGTSSLSSCSAYYTTSAPKAELLTKMKdlTLPEPDQPeEQSEEELDHDLQQKKVELI 118
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008591  1250 ESISRKLSVLREAQRGLLDDINANAALGEEVEANLKAVCKSNEFEKYHLFIGDLDKVVNLLLSLSGRLARVENALNSIDS 1329
Cdd:pfam08687  119 ESLQRKLQVLREEQEALQEEIQANAALGEEVEALVQQVCKPNELEKYRMFIGDLEKVVSLLLSLSGRLARVENALSSLDS 198
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008591  1330 ESNQ-EKLVLIEKKQQLTNQLADAKELKEHVDGREKLVFGMVSRYLPQDQLQDYQHFVKMKSALIIEQRELEEKIKLGEE 1408
Cdd:pfam08687  199 DADAeERKSLEEKRRLLLRQLEDAKELKENLDRRERVVSGILARYLTAEQLQDYQHFVKMKAALLIEQRELEDKIKLGEE 278

                   ....*....
gi 569008591  1409 QLKCLKESL 1417
Cdd:pfam08687  279 QLKALKESL 287
Smc COG1196
Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];
1198-1417 2.49e-04

Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 224117 [Multi-domain]  Cd Length: 1163  Bit Score: 45.86  E-value: 2.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008591 1198 SGIPTSYSAYYNISVAKAELLNKLKQQPEMAEAGLGEEGVDYELAQKKIQLIESISRKLSVLREAQRGLLDDINANAALG 1277
Cdd:COG1196   649 SGSITGGSRNKRSSLAQKRELKELEEELAELEAQLEKLEEELKSLKNELRSLEDLLEELRRQLEELERQLEELKRELAAL 728
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008591 1278 EEVEANLKAVCKSNEFEkyhlfigdLDKVVNLLLSLSGRLARVENALNSIDSESNQEKLV---LIEKKQQLTNQLADAKE 1354
Cdd:COG1196   729 EEELEQLQSRLEELEEE--------LEELEEELEELQERLEELEEELESLEEALAKLKEEieeLEEKRQALQEELEELEE 800
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569008591 1355 LKEHVDGREKLVfgmvsRYLPQDQLQDYQHFVKMKSALIIEQRELEEKIKLGEEQLKCLKESL 1417
Cdd:COG1196   801 ELEEAERRLDAL-----ERELESLEQRRERLEQEIEELEEEIEELEEKLDELEEELEELEKEL 858
PDZ smart00228
Domain present in PSD-95, Dlg, and ZO-1/2; Also called DHR (Dlg homologous region) or GLGF ...
1-41 4.94e-04

Domain present in PSD-95, Dlg, and ZO-1/2; Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides; others appear to bind internal (non-C-terminal) polypeptides. Different PDZs possess different binding specificities.


Pssm-ID: 214570 [Multi-domain]  Cd Length: 85  Bit Score: 40.44  E-value: 4.94e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 569008591      1 MRTGDELVNINGTPLYG-SRQEALILIKGSFRILKLIVRRRN 41
Cdd:smart00228   44 LRVGDVILEVNGTSVEGlTHLEAVDLLKKAGGKVTLTVLRGG 85
PDZ_signaling cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. ...
1-38 9.46e-04

PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this subfamily of PDZ domains an N-terminal beta-strand forms the peptide-binding groove base, a circular permutation with respect to PDZ domains found in proteases.


Pssm-ID: 238492 [Multi-domain]  Cd Length: 82  Bit Score: 39.47  E-value: 9.46e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 569008591    1 MRTGDELVNINGTPLYG-SRQEALILIKGSFRILKLIVR 38
Cdd:cd00992    44 LRVGDRILEVNGVSVEGlTHEEAVELLKNSGDEVTLTVR 82
 
Name Accession Description Interval E-value
ASD2 pfam08687
Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which ...
1173-1417 3.47e-112

Apx/Shroom domain ASD2; This region is found in the actin binding protein Shroom which mediates apical contriction in epithelial cells and is required for neural tube closure.


Pssm-ID: 430155 [Multi-domain]  Cd Length: 287  Bit Score: 355.02  E-value: 3.47e-112
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008591  1173 WRTTEQEATVTPKQEFQHFSPPKGASGIPTSYSAYYNISVAKAELLNKLK--QQPEMAEA-GLGEEGVDYELAQKKIQLI 1249
Cdd:pfam08687   39 LRAMKPDLGEAYRPEEEGSEEEKSGTSSLSSCSAYYTTSAPKAELLTKMKdlTLPEPDQPeEQSEEELDHDLQQKKVELI 118
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008591  1250 ESISRKLSVLREAQRGLLDDINANAALGEEVEANLKAVCKSNEFEKYHLFIGDLDKVVNLLLSLSGRLARVENALNSIDS 1329
Cdd:pfam08687  119 ESLQRKLQVLREEQEALQEEIQANAALGEEVEALVQQVCKPNELEKYRMFIGDLEKVVSLLLSLSGRLARVENALSSLDS 198
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008591  1330 ESNQ-EKLVLIEKKQQLTNQLADAKELKEHVDGREKLVFGMVSRYLPQDQLQDYQHFVKMKSALIIEQRELEEKIKLGEE 1408
Cdd:pfam08687  199 DADAeERKSLEEKRRLLLRQLEDAKELKENLDRRERVVSGILARYLTAEQLQDYQHFVKMKAALLIEQRELEDKIKLGEE 278

                   ....*....
gi 569008591  1409 QLKCLKESL 1417
Cdd:pfam08687  279 QLKALKESL 287
Smc COG1196
Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];
1198-1417 2.49e-04

Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 224117 [Multi-domain]  Cd Length: 1163  Bit Score: 45.86  E-value: 2.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008591 1198 SGIPTSYSAYYNISVAKAELLNKLKQQPEMAEAGLGEEGVDYELAQKKIQLIESISRKLSVLREAQRGLLDDINANAALG 1277
Cdd:COG1196   649 SGSITGGSRNKRSSLAQKRELKELEEELAELEAQLEKLEEELKSLKNELRSLEDLLEELRRQLEELERQLEELKRELAAL 728
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008591 1278 EEVEANLKAVCKSNEFEkyhlfigdLDKVVNLLLSLSGRLARVENALNSIDSESNQEKLV---LIEKKQQLTNQLADAKE 1354
Cdd:COG1196   729 EEELEQLQSRLEELEEE--------LEELEEELEELQERLEELEEELESLEEALAKLKEEieeLEEKRQALQEELEELEE 800
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569008591 1355 LKEHVDGREKLVfgmvsRYLPQDQLQDYQHFVKMKSALIIEQRELEEKIKLGEEQLKCLKESL 1417
Cdd:COG1196   801 ELEEAERRLDAL-----ERELESLEQRRERLEQEIEELEEEIEELEEKLDELEEELEELEKEL 858
PDZ smart00228
Domain present in PSD-95, Dlg, and ZO-1/2; Also called DHR (Dlg homologous region) or GLGF ...
1-41 4.94e-04

Domain present in PSD-95, Dlg, and ZO-1/2; Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides; others appear to bind internal (non-C-terminal) polypeptides. Different PDZs possess different binding specificities.


Pssm-ID: 214570 [Multi-domain]  Cd Length: 85  Bit Score: 40.44  E-value: 4.94e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 569008591      1 MRTGDELVNINGTPLYG-SRQEALILIKGSFRILKLIVRRRN 41
Cdd:smart00228   44 LRVGDVILEVNGTSVEGlTHLEAVDLLKKAGGKVTLTVLRGG 85
PDZ_signaling cd00992
PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. ...
1-38 9.46e-04

PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this subfamily of PDZ domains an N-terminal beta-strand forms the peptide-binding groove base, a circular permutation with respect to PDZ domains found in proteases.


Pssm-ID: 238492 [Multi-domain]  Cd Length: 82  Bit Score: 39.47  E-value: 9.46e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 569008591    1 MRTGDELVNINGTPLYG-SRQEALILIKGSFRILKLIVR 38
Cdd:cd00992    44 LRVGDRILEVNGVSVEGlTHEEAVELLKNSGDEVTLTVR 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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