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Conserved domains on  [gi|569008910|ref|XP_006527766|]
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WD repeat-containing protein 13 isoform X1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
172-483 2.16e-27

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 2.16e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910 172 DEAVPRVRFANDDRhRLACCSLDGSISLCQLvpAPPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRC 251
Cdd:COG2319  120 TGAVRSVAFSPDGK-TLASGSADGTVRLWDL--ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910 252 IREIPDPDGAeLLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVK--GGSsklTGRVLALSFDAPGRLLWAGDDRGSVf 329
Cdd:COG2319  197 LRTLTGHTGA-VRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRtlTGH---SGSVRSVAFSPDGRLLASGSADGTV- 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910 330 sFLFDMATGKLtkaKRLVVHEGSPVTSISArswvsreARDPSLLINACLNKLLlyRVVDNEGALQLKrsfPIEQSSHPVR 409
Cdd:COG2319  271 -RLWDLATGEL---LRTLTGHSGGVNSVAF-------SPDGKLLASGSDDGTV--RLWDLATGKLLR---TLTGHTGAVR 334

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569008910 410 SI-FCPlmsfrQGACVVTGSEDMCVHFFDVerAAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWRRE 483
Cdd:COG2319  335 SVaFSP-----DGKTLASGSDDGTVRLWDL--ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
172-483 2.16e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 2.16e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910 172 DEAVPRVRFANDDRhRLACCSLDGSISLCQLvpAPPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRC 251
Cdd:COG2319  120 TGAVRSVAFSPDGK-TLASGSADGTVRLWDL--ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910 252 IREIPDPDGAeLLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVK--GGSsklTGRVLALSFDAPGRLLWAGDDRGSVf 329
Cdd:COG2319  197 LRTLTGHTGA-VRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRtlTGH---SGSVRSVAFSPDGRLLASGSADGTV- 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910 330 sFLFDMATGKLtkaKRLVVHEGSPVTSISArswvsreARDPSLLINACLNKLLlyRVVDNEGALQLKrsfPIEQSSHPVR 409
Cdd:COG2319  271 -RLWDLATGEL---LRTLTGHSGGVNSVAF-------SPDGKLLASGSDDGTV--RLWDLATGKLLR---TLTGHTGAVR 334

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569008910 410 SI-FCPlmsfrQGACVVTGSEDMCVHFFDVerAAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWRRE 483
Cdd:COG2319  335 SVaFSP-----DGKTLASGSDDGTVRLWDL--ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 175-481 1.40e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.93  E-value: 1.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910 175 VPRVRFaNDDRHRLACCSLDGSISLCQLvpAPPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRCIRE 254
Cdd:cd00200   12 VTCVAF-SPDGKLLATGSGDGTIKVWDL--ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910 255 IPDpDGAELLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVKGGSSKlTGRVLALSFDAPGRLLWAGDDRGSVfsFLFD 334
Cdd:cd00200   89 LTG-HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDGTFVASSSQDGTI--KLWD 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910 335 MATGKLTkaKRLVVHEGsPVTSISARSwvsrearDPSLLINACLNKLLlyRVVDNEGALQLKRsfpIEQSSHPVRSI-FC 413
Cdd:cd00200  164 LRTGKCV--ATLTGHTG-EVNSVAFSP-------DGEKLLSSSSDGTI--KLWDLSTGKCLGT---LRGHENGVNSVaFS 228

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569008910 414 PLMSFrqgacVVTGSEDMCVHFFDVEraAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWR 481
Cdd:cd00200  229 PDGYL-----LASGSEDGTIRVWDLR--TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 206-244 2.28e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.28e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 569008910   206 PPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIW 244
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
208-244 5.53e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 5.53e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 569008910  208 TVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIW 244
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
172-483 2.16e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.47  E-value: 2.16e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910 172 DEAVPRVRFANDDRhRLACCSLDGSISLCQLvpAPPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRC 251
Cdd:COG2319  120 TGAVRSVAFSPDGK-TLASGSADGTVRLWDL--ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910 252 IREIPDPDGAeLLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVK--GGSsklTGRVLALSFDAPGRLLWAGDDRGSVf 329
Cdd:COG2319  197 LRTLTGHTGA-VRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRtlTGH---SGSVRSVAFSPDGRLLASGSADGTV- 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910 330 sFLFDMATGKLtkaKRLVVHEGSPVTSISArswvsreARDPSLLINACLNKLLlyRVVDNEGALQLKrsfPIEQSSHPVR 409
Cdd:COG2319  271 -RLWDLATGEL---LRTLTGHSGGVNSVAF-------SPDGKLLASGSDDGTV--RLWDLATGKLLR---TLTGHTGAVR 334

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569008910 410 SI-FCPlmsfrQGACVVTGSEDMCVHFFDVerAAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWRRE 483
Cdd:COG2319  335 SVaFSP-----DGKTLASGSDDGTVRLWDL--ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
95-483 2.41e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.83  E-value: 2.41e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910  95 DFEDDPRALGARGHRRSVSRGSYQLQAQMNRAVYEDRPPGSVVPTSVAEASRAMAGDTSLSENYAFAGMYHVFDQHVDEA 174
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910 175 VPRVRFANDDRhRLACCSLDGSISLCQLvpAPPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRCIRE 254
Cdd:COG2319   81 VLSVAFSPDGR-LLASASADGTVRLWDL--ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910 255 IPDPDGAeLLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVKggssKLTG---RVLALSFDAPGRLLWAGDDRGSVfsF 331
Cdd:COG2319  158 LTGHSGA-VTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLR----TLTGhtgAVRSVAFSPDGKLLASGSADGTV--R 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910 332 LFDMATGKLTkakRLVVHEGSPVTSISarswVSreaRDPSLLINACLNKLLlyRVVDNEGALQLKRsfpIEQSSHPVRSI 411
Cdd:COG2319  230 LWDLATGKLL---RTLTGHSGSVRSVA----FS---PDGRLLASGSADGTV--RLWDLATGELLRT---LTGHSGGVNSV 294

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 569008910 412 -FCPlmsfrQGACVVTGSEDMCVHFFDVerAAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWRRE 483
Cdd:COG2319  295 aFSP-----DGKLLASGSDDGTVRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 175-481 1.40e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 88.93  E-value: 1.40e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910 175 VPRVRFaNDDRHRLACCSLDGSISLCQLvpAPPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRCIRE 254
Cdd:cd00200   12 VTCVAF-SPDGKLLATGSGDGTIKVWDL--ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910 255 IPDpDGAELLCCTFQPvNNNLTVVGNAKHNVHVMNISTGKKVKGGSSKlTGRVLALSFDAPGRLLWAGDDRGSVfsFLFD 334
Cdd:cd00200   89 LTG-HTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSPDGTFVASSSQDGTI--KLWD 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910 335 MATGKLTkaKRLVVHEGsPVTSISARSwvsrearDPSLLINACLNKLLlyRVVDNEGALQLKRsfpIEQSSHPVRSI-FC 413
Cdd:cd00200  164 LRTGKCV--ATLTGHTG-EVNSVAFSP-------DGEKLLSSSSDGTI--KLWDLSTGKCLGT---LRGHENGVNSVaFS 228

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 569008910 414 PLMSFrqgacVVTGSEDMCVHFFDVEraAKAAVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWR 481
Cdd:cd00200  229 PDGYL-----LASGSEDGTIRVWDLR--TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 210-481 7.51e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 86.62  E-value: 7.51e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910 210 LHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIWASEDGRCIREIPDPDGaELLCCTFQPVNNNLTVVGNAKhNVHVMN 289
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG-PVRDVAASADGTYLASGSSDK-TIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910 290 ISTGKKVkggsSKLTG---RVLALSFDAPGRLL-WAGDDrGSVfsFLFDMATGKLTKAkrLVVHEGsPVTSISARSwvsr 365
Cdd:cd00200   80 LETGECV----RTLTGhtsYVSSVAFSPDGRILsSSSRD-KTI--KVWDVETGKCLTT--LRGHTD-WVNSVAFSP---- 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910 366 earDPSLLINACLNKLLlyRVVDNEgALQLKRSFPIEQSshPVRSI-FCPlmsfrQGACVVTGSEDMCVHFFDVerAAKA 444
Cdd:cd00200  146 ---DGTFVASSSQDGTI--KLWDLR-TGKCVATLTGHTG--EVNSVaFSP-----DGEKLLSSSSDGTIKLWDL--STGK 210

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 569008910 445 AVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWR 481
Cdd:cd00200  211 CLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 206-244 2.28e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.28e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 569008910   206 PPTVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIW 244
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
208-244 5.53e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 5.53e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 569008910  208 TVLHVLRGHTRGVSDFAWSLSNDILVSTSLDATMRIW 244
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 446-480 1.70e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.70e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 569008910   446 VNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVW 480
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
446-480 1.32e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.32e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 569008910  446 VNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVW 480
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
166-342 1.58e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 43.14  E-value: 1.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910 166 VFDQHVDEAVPRVRFANDDRHRLACCSLDGSISLCQLVPAPPTVLHVLRGHTRGVSDFAWSLSNDIL-VSTSLDATMRIW 244
Cdd:COG3391   16 LALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLyVANSGSGRVSVI 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569008910 245 ASEDGRCIREIPDPDGAELLCctFQPVNNNLTVVGNAKHNVHVMNISTGKKVKggSSKLTGRVLALSFDAPGRLLW---A 321
Cdd:COG3391   96 DLATGKVVATIPVGGGPRGLA--VDPDGGRLYVADSGNGRVSVIDTATGKVVA--TIPVGAGPHGIAVDPDGKRLYvanS 171

                        170       180
                 ....*....|....*....|.
gi 569008910 322 GDDRGSVFSFLFDMATGKLTK 342
Cdd:COG3391  172 GSNTVSVIVSVIDTATGKVVA 192
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 424-484 3.86e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.24  E-value: 3.86e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569008910 424 VVTGSEDMCVHFFDVERAAKaaVNKLQGHSAPVLDVSFNCDESLLASSDASGMVIVWRREQ 484
Cdd:cd00200   24 LATGSGDGTIKVWDLETGEL--LRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLET 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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