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Conserved domains on  [gi|569010256|ref|XP_006528154|]
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phospholipid-transporting ATPase 11C isoform X1 [Mus musculus]

Protein Classification

phospholipid-transporting P-type ATPase( domain architecture ID 11550343)

phospholipid-transporting P-type ATPase is the catalytic component of a P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, and is distinguished from other transport ATPases (F-, V-, and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle

EC:  7.6.2.1
PubMed:  21768325|15110265
SCOP:  4002228
TCDB:  3.A.3

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
42-974 0e+00

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


:

Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 1303.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   42 DNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQVT-VDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHRADNEV 120
Cdd:cd02073     1 DNRISTTKYTVFTFLPKNLFEQFRRVANLYFLFIAILQQIpGISPTGPYTTLLPLLFVLGVTAIKEGYEDIRRHKSDNEV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  121 NKSAVYIIENAKRVRKESEKIKVGDVVEVQANETFPCDLILLSSCTTDGTCYVTTASLDGESNCKTHYAVRDTIALCTAE 200
Cdd:cd02073    81 NNRPVQVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPADLLLLSSSEPDGLCYVETANLDGETNLKIRQALPETALLLSEE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  201 SIDNLRATIECEQPQPDLYRFVGRISIYSNsieaVARSLGPENLLLKGATLKNTKKIYGVAVYTGMETKMALNYQGKSQK 280
Cdd:cd02073   161 DLARFSGEIECEQPNNDLYTFNGTLELNGG----RELPLSPDNLLLRGCTLRNTEWVYGVVVYTGHETKLMLNSGGTPLK 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  281 CSAVEKSINAFLIVYLFILLTKAAVCTTLKYVWQSSPYNDEPWYNQKTqkerETFQVLKMFTDFLSFMVLFNFIIPVSMY 360
Cdd:cd02073   237 RSSIEKKMNRFIIAIFCILIVMCLISAIGKGIWLSKHGRDLWYLLPKE----ERSPALEFFFDFLTFIILYNNLIPISLY 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  361 VTVEMQKFLGSFFISWDKDFFDEEINEGALVNTSDLNEELGQVDYVFTDKTGTLTENSMEFIECCIDGHKYkgttqevdg 440
Cdd:cd02073   313 VTIEVVKFLQSFFINWDLDMYDEETDTPAEARTSNLNEELGQVEYIFSDKTGTLTENIMEFKKCSINGVDY--------- 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  441 lsqtdgplayfdkadknreaLFLRALCLCHTVEMKTNDDVDGPVegagftYISSSPDEIALVKGAKRFGFTFLGNQNGYI 520
Cdd:cd02073   384 --------------------GFFLALALCHTVVPEKDDHPGQLV------YQASSPDEAALVEAARDLGFVFLSRTPDTV 437
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  521 RVeNQRKEIEEYELLHTLNFDSVRRRMSVIVRTQKGDILLFCKGADSSIFPRVHSHQ---IELTKDHVERNAMDGYRTLC 597
Cdd:cd02073   438 TI-NALGEEEEYEILHILEFNSDRKRMSVIVRDPDGRILLYCKGADSVIFERLSPSSlelVEKTQEHLEDFASEGLRTLC 516
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  598 VAFKEIPPDDFERINAQLVEAKMALQDREEKLEKVFDEIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDK 677
Cdd:cd02073   517 LAYREISEEEYEEWNEKYDEASTALQNREELLDEVAEEIEKDLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDK 596
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  678 METAKSTCYACRLFQTNTEllelttktieeserkedrlhellieyrkkllhefpkstrslkkawtehqEYGLIIDGSTLS 757
Cdd:cd02073   597 QETAINIGYSCRLLSEDME-------------------------------------------------NLALVIDGKTLT 627
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  758 LILNSSQdcssnnyKSIFLQICMKCTAVLCCRMAPLQKAQIVRMVKNLKgSPITLSIGDGANDVSMILESHVGIGIKGKE 837
Cdd:cd02073   628 YALDPEL-------ERLFLELALKCKAVICCRVSPLQKALVVKLVKKSK-KAVTLAIGDGANDVSMIQEAHVGVGISGQE 699
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  838 GRQAARNSDYSVPKFKHLKKLLLVHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNICFTS 917
Cdd:cd02073   700 GMQAARASDYAIAQFRFLRRLLLVHGRWSYQRLAKLILYFFYKNIAFYLTQFWYQFFNGFSGQTLYDSWYLTLYNVLFTS 779
                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 569010256  918 LPILAYSLLEQHINIDTLTADPRLYMKITGNAMLQLGPFLHWTFLAAFEGTVFFFGT 974
Cdd:cd02073   780 LPPLVIGIFDQDVSAETLLRYPELYKPGQLNELFNWKVFLYWILDGIYQSLIIFFVP 836
 
Name Accession Description Interval E-value
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
42-974 0e+00

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 1303.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   42 DNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQVT-VDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHRADNEV 120
Cdd:cd02073     1 DNRISTTKYTVFTFLPKNLFEQFRRVANLYFLFIAILQQIpGISPTGPYTTLLPLLFVLGVTAIKEGYEDIRRHKSDNEV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  121 NKSAVYIIENAKRVRKESEKIKVGDVVEVQANETFPCDLILLSSCTTDGTCYVTTASLDGESNCKTHYAVRDTIALCTAE 200
Cdd:cd02073    81 NNRPVQVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPADLLLLSSSEPDGLCYVETANLDGETNLKIRQALPETALLLSEE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  201 SIDNLRATIECEQPQPDLYRFVGRISIYSNsieaVARSLGPENLLLKGATLKNTKKIYGVAVYTGMETKMALNYQGKSQK 280
Cdd:cd02073   161 DLARFSGEIECEQPNNDLYTFNGTLELNGG----RELPLSPDNLLLRGCTLRNTEWVYGVVVYTGHETKLMLNSGGTPLK 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  281 CSAVEKSINAFLIVYLFILLTKAAVCTTLKYVWQSSPYNDEPWYNQKTqkerETFQVLKMFTDFLSFMVLFNFIIPVSMY 360
Cdd:cd02073   237 RSSIEKKMNRFIIAIFCILIVMCLISAIGKGIWLSKHGRDLWYLLPKE----ERSPALEFFFDFLTFIILYNNLIPISLY 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  361 VTVEMQKFLGSFFISWDKDFFDEEINEGALVNTSDLNEELGQVDYVFTDKTGTLTENSMEFIECCIDGHKYkgttqevdg 440
Cdd:cd02073   313 VTIEVVKFLQSFFINWDLDMYDEETDTPAEARTSNLNEELGQVEYIFSDKTGTLTENIMEFKKCSINGVDY--------- 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  441 lsqtdgplayfdkadknreaLFLRALCLCHTVEMKTNDDVDGPVegagftYISSSPDEIALVKGAKRFGFTFLGNQNGYI 520
Cdd:cd02073   384 --------------------GFFLALALCHTVVPEKDDHPGQLV------YQASSPDEAALVEAARDLGFVFLSRTPDTV 437
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  521 RVeNQRKEIEEYELLHTLNFDSVRRRMSVIVRTQKGDILLFCKGADSSIFPRVHSHQ---IELTKDHVERNAMDGYRTLC 597
Cdd:cd02073   438 TI-NALGEEEEYEILHILEFNSDRKRMSVIVRDPDGRILLYCKGADSVIFERLSPSSlelVEKTQEHLEDFASEGLRTLC 516
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  598 VAFKEIPPDDFERINAQLVEAKMALQDREEKLEKVFDEIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDK 677
Cdd:cd02073   517 LAYREISEEEYEEWNEKYDEASTALQNREELLDEVAEEIEKDLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDK 596
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  678 METAKSTCYACRLFQTNTEllelttktieeserkedrlhellieyrkkllhefpkstrslkkawtehqEYGLIIDGSTLS 757
Cdd:cd02073   597 QETAINIGYSCRLLSEDME-------------------------------------------------NLALVIDGKTLT 627
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  758 LILNSSQdcssnnyKSIFLQICMKCTAVLCCRMAPLQKAQIVRMVKNLKgSPITLSIGDGANDVSMILESHVGIGIKGKE 837
Cdd:cd02073   628 YALDPEL-------ERLFLELALKCKAVICCRVSPLQKALVVKLVKKSK-KAVTLAIGDGANDVSMIQEAHVGVGISGQE 699
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  838 GRQAARNSDYSVPKFKHLKKLLLVHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNICFTS 917
Cdd:cd02073   700 GMQAARASDYAIAQFRFLRRLLLVHGRWSYQRLAKLILYFFYKNIAFYLTQFWYQFFNGFSGQTLYDSWYLTLYNVLFTS 779
                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 569010256  918 LPILAYSLLEQHINIDTLTADPRLYMKITGNAMLQLGPFLHWTFLAAFEGTVFFFGT 974
Cdd:cd02073   780 LPPLVIGIFDQDVSAETLLRYPELYKPGQLNELFNWKVFLYWILDGIYQSLIIFFVP 836
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
40-1088 0e+00

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 940.65  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256    40 FCDNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQVTVD-TPTSPVTSGLPLFFVITVTAIKQGYEDWLRHRADN 118
Cdd:TIGR01652    1 FCSNKISTTKYTVLTFLPKNLFEQFKRFANLYFLVVALLQQVPIlSPTYRGTSIVPLAFVLIVTAIKEAIEDIRRRRRDK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   119 EVNKSAVYIIEN-AKRVRKESEKIKVGDVVEVQANETFPCDLILLSSCTTDGTCYVTTASLDGESNCKTHYAVRDTIALC 197
Cdd:TIGR01652   81 EVNNRLTEVLEGhGQFVEIPWKDLRVGDIVKVKKDERIPADLLLLSSSEPDGVCYVETANLDGETNLKLRQALEETQKML 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   198 TAESIDNLRATIECEQPQPDLYRFVGRISIYSNSIEavarSLGPENLLLKGATLKNTKKIYGVAVYTGMETKMALNYQGK 277
Cdd:TIGR01652  161 DEDDIKNFSGEIECEQPNASLYSFQGNMTINGDRQY----PLSPDNILLRGCTLRNTDWVIGVVVYTGHDTKLMRNATQA 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   278 SQKCSAVEKSINaFLIVYLFILLTKAAVCTTLKYVWQSSPYNDEPWYNQKTQKERETfqVLKMFTDFLSFMVLFNFIIPV 357
Cdd:TIGR01652  237 PSKRSRLEKELN-FLIIILFCLLFVLCLISSVGAGIWNDAHGKDLWYIRLDVSERNA--AANGFFSFLTFLILFSSLIPI 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   358 SMYVTVEMQKFLGSFFISWDKDFFDEEINEGALVNTSDLNEELGQVDYVFTDKTGTLTENSMEFIECCIDGHKY-KGTTQ 436
Cdd:TIGR01652  314 SLYVSLELVKSVQAYFINSDLQMYHEKTDTPASVRTSNLNEELGQVEYIFSDKTGTLTQNIMEFKKCSIAGVSYgDGFTE 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   437 EVDGLSQTDGPLAYFDKADKNREAL------------------------FLRALCLCHTVEMKTNDDVDGPVegagfTYI 492
Cdd:TIGR01652  394 IKDGIRERLGSYVENENSMLVESKGftfvdprlvdllktnkpnakrineFFLALALCHTVVPEFNDDGPEEI-----TYQ 468
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   493 SSSPDEIALVKGAKRFGFTFLGNQNGYIRV-ENQRKEIEEYELLHTLNFDSVRRRMSVIVRTQKGDILLFCKGADSSIFP 571
Cdd:TIGR01652  469 AASPDEAALVKAARDVGFVFFERTPKSISLlIEMHGETKEYEILNVLEFNSDRKRMSVIVRNPDGRIKLLCKGADTVIFK 548
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   572 RVHSHQ---IELTKDHVERNAMDGYRTLCVAFKEIPPDDFERINAQLVEAKMALQDREEKLEKVFDEIETNMNLIGATAV 648
Cdd:TIGR01652  549 RLSSGGnqvNEETKEHLENYASEGLRTLCIAYRELSEEEYEEWNEEYNEASTALTDREEKLDVVAESIEKDLILLGATAI 628
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   649 EDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACRLFQTNTELLELTTKTIEESERKEdrlhELLIEYRKKLLH 728
Cdd:TIGR01652  629 EDKLQEGVPETIELLRQAGIKIWVLTGDKVETAINIGYSCRLLSRNMEQIVITSDSLDATRSVE----AAIKFGLEGTSE 704
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   729 EFPKSTRSLKKAwtehqeygLIIDGSTLSLILnssqdcsSNNYKSIFLQICMKCTAVLCCRMAPLQKAQIVRMVKNLKGS 808
Cdd:TIGR01652  705 EFNNLGDSGNVA--------LVIDGKSLGYAL-------DEELEKEFLQLALKCKAVICCRVSPSQKADVVRLVKKSTGK 769
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   809 pITLSIGDGANDVSMILESHVGIGIKGKEGRQAARNSDYSVPKFKHLKKLLLVHGHLYYVRIAHLVQYFFYKNLCFILPQ 888
Cdd:TIGR01652  770 -TTLAIGDGANDVSMIQEADVGVGISGKEGMQAVMASDFAIGQFRFLTKLLLVHGRWSYKRISKMILYFFYKNLIFAIIQ 848
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   889 FLYQFFCGFSQQPLYDAAYLTMYNICFTSLPILAYSLLEQHINIDTLTADPRLYMKITGNAMLQLGPFLHWTFLAAFEGT 968
Cdd:TIGR01652  849 FWYSFYNGFSGQTLYEGWYMVLYNVFFTALPVISLGVFDQDVSASLSLRYPQLYREGQKGQGFSTKTFWGWMLDGIYQSL 928
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   969 VFFFGTYFLFQTSSLEDNGKIYGNWTFGTIVFTVLVFTVTLKLALDTRFWTWINHFVIWGSLAFYVFFSFFWGGiIWPfl 1048
Cdd:TIGR01652  929 VIFFFPMFAYILGDFVSSGSVDDFSSVGVIVFTALVVIVNLKIALEINRWNWISLITIWGSILVWLIFVIVYSS-IFP-- 1005
                         1050      1060      1070      1080
                   ....*....|....*....|....*....|....*....|
gi 569010256  1049 kQQRMYFVFAQMLCSVSTWLAIILLIFISLFPEILLIVVK 1088
Cdd:TIGR01652 1006 -SPAFYKAAPRVMGTFGFWLVLLVIVLISLLPRFTYKAIQ 1044
PLN03190 PLN03190
aminophospholipid translocase; Provisional
20-1087 0e+00

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 617.68  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   20 RTVFVgNHPISGTEPYiaqRFCDNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIF----LVQVTVDTPTSPVtsgLPL 95
Cdd:PLN03190   71 RLVYL-NDPEKSNERF---EFAGNSIRTAKYSVFSFLPRNLFEQFHRVAYIYFLVIAvlnqLPQLAVFGRGASI---LPL 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   96 FFVITVTAIKQGYEDWLRHRADNEVNKSAVYIIENAKRVRKESEKIKVGDVVEVQANETFPCDLILLSSCTTDGTCYVTT 175
Cdd:PLN03190  144 AFVLLVTAVKDAYEDWRRHRSDRIENNRLAWVLVDDQFQEKKWKDIRVGEIIKIQANDTLPCDMVLLSTSDPTGVAYVQT 223
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  176 ASLDGESNCKTHYAVRDTIA-LCTAESIDNLratIECEQPQPDLYRFVGRISIYSNSIeavarSLGPENLLLKGATLKNT 254
Cdd:PLN03190  224 INLDGESNLKTRYAKQETLSkIPEKEKINGL---IKCEKPNRNIYGFQANMEVDGKRL-----SLGPSNIILRGCELKNT 295
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  255 KKIYGVAVYTGMETKMALNYQGKSQKCSAVEKSINA---FLIVYLFILLTKAAVCTTlkyVWQSSpYNDE----PWYNQK 327
Cdd:PLN03190  296 AWAIGVAVYCGRETKAMLNNSGAPSKRSRLETRMNLeiiILSLFLIALCTIVSVCAA---VWLRR-HRDEldtiPFYRRK 371
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  328 --TQKERETFQ----VLKMFTDFLSFMVLFNFIIPVSMYVTVEMQKFLGSFFISWDKDFFDEEINEGALVNTSDLNEELG 401
Cdd:PLN03190  372 dfSEGGPKNYNyygwGWEIFFTFLMSVIVFQIMIPISLYISMELVRVGQAYFMIRDDQMYDEASNSRFQCRALNINEDLG 451
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  402 QVDYVFTDKTGTLTENSMEFIECCIDGHKYKGTTQ-----------EVDGLS-------QTDGPLAYFDKADKNREAL-- 461
Cdd:PLN03190  452 QIKYVFSDKTGTLTENKMEFQCASIWGVDYSDGRTptqndhagysvEVDGKIlrpkmkvKVDPQLLELSKSGKDTEEAkh 531
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  462 ---FLRALCLCHTVEMKTNDDVDGPVEGAgFTYISSSPDEIALVKGAKRFGFTFLGNQNGYIrVENQRKEIEEYELLHTL 538
Cdd:PLN03190  532 vhdFFLALAACNTIVPIVVDDTSDPTVKL-MDYQGESPDEQALVYAAAAYGFMLIERTSGHI-VIDIHGERQRFNVLGLH 609
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  539 NFDSVRRRMSVIVRTQKGDILLFCKGADSSIFPRV----HSHQIELTKDHVERNAMDGYRTLCVAFKEIPPDDFERINAQ 614
Cdd:PLN03190  610 EFDSDRKRMSVILGCPDKTVKVFVKGADTSMFSVIdrslNMNVIRATEAHLHTYSSLGLRTLVVGMRELNDSEFEQWHFS 689
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  615 LVEAKMALQDREEKLEKVFDEIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACRLFQTN 694
Cdd:PLN03190  690 FEAASTALIGRAALLRKVASNVENNLTILGASAIEDKLQQGVPEAIESLRTAGIKVWVLTGDKQETAISIGYSSKLLTNK 769
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  695 TELLELTTKTIEESERKedrLHELLIeYRKKLLHEFPKSTRSLKKAWTEHQEYGLIIDGSTLSLILNssqdcssNNYKSI 774
Cdd:PLN03190  770 MTQIIINSNSKESCRKS---LEDALV-MSKKLTTVSGISQNTGGSSAAASDPVALIIDGTSLVYVLD-------SELEEQ 838
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  775 FLQICMKCTAVLCCRMAPLQKAQIVRMVKNlKGSPITLSIGDGANDVSMILESHVGIGIKGKEGRQAARNSDYSVPKFKH 854
Cdd:PLN03190  839 LFQLASKCSVVLCCRVAPLQKAGIVALVKN-RTSDMTLAIGDGANDVSMIQMADVGVGISGQEGRQAVMASDFAMGQFRF 917
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  855 LKKLLLVHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNICFTSLPILAYSLLEQHINIDT 934
Cdd:PLN03190  918 LVPLLLVHGHWNYQRMGYMILYNFYRNAVFVLVLFWYVLFTCFTLTTAINEWSSVLYSVIYTALPTIVVGILDKDLSRRT 997
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  935 LTADPRLYMkiTGNAMLQLGPFLHWTFL--AAFEGTVFFFGTYFLFQTSSLeDNGKIYGNWTFGTIVFtvlvftVTLKLA 1012
Cdd:PLN03190  998 LLKYPQLYG--AGQRQEAYNSKLFWLTMidTLWQSAVVFFVPLFAYWASTI-DGSSIGDLWTLAVVIL------VNLHLA 1068
                        1050      1060      1070      1080      1090      1100      1110
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569010256 1013 LDTRFWTWINHFVIWGSLAfyvffSFFWGGIIWPFLKQQRMYFVFAQMLCSVSTWLAIILLIFISLFPEILLIVV 1087
Cdd:PLN03190 1069 MDIIRWNWITHAAIWGSIV-----ATFICVIVIDAIPTLPGYWAIFHIAKTGSFWLCLLAIVVAALLPRFVVKVL 1138
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
43-1097 2.51e-123

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 223550 [Multi-domain]  Cd Length: 917  Bit Score: 401.33  E-value: 2.51e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   43 NRIVssKYTLWNFLPKNLFEQFRRIANFYF---LIIFLVQVTVDTPTSPVTSgLPLFFVITVTAIKQGYEDWLRHRADNE 119
Cdd:COG0474    60 NELP--EEKKRSLLKKFLRQFKDPFIILLLvaaLLSAFVGDWVDAGVDAIVI-LLVVVINALLGFVQEYRAEKALEALKK 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  120 VNKSAVYIIENAKRVRKESEKIKVGDVVEVQANETFPCDLILLSScttdgTC-YVTTASLDGESNCKthyaVRDTIALCT 198
Cdd:COG0474   137 MSSPKAKVLRDGKFVEIPASELVPGDIVLLEAGDVVPADLRLLES-----SDlEVDESALTGESLPV----EKQALPLTK 207
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  199 AESIDNLRATieceqpqpdlyrfvgrisiysnsieavarslgpeNLLLKGATLKNTKkIYGVAVYTGMETKM---ALNYQ 275
Cdd:COG0474   208 SDAPLGLDRD----------------------------------NMLFSGTTVVSGR-AKGIVVATGFETEFgkiARLLP 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  276 GKSQKCSAVEKSINaFLIVYLFILLTKAAVCTTLKYVWQSSPyndePWYNQktqkeretfqvlkmftdFLSFMVLFNFII 355
Cdd:COG0474   253 TKKEVKTPLQRKLN-KLGKFLLVLALVLGALVFVVGLFRGGN----GLLES-----------------FLTALALAVAAV 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  356 PVSMYVTVEMQKFLGSFFISWDKdffdeeinegALVNTSDLNEELGQVDYVFTDKTGTLTENSMEFiECCIDGhkykgtt 435
Cdd:COG0474   311 PEGLPAVVTIALALGAQRMAKDN----------AIVRSLNAIETLGSVDVICSDKTGTLTQNKMTV-KKIYIN------- 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  436 qevDGLSQTDGPLAYFDKADKNrealFLRALCLCHTVEMKTNDDvdgpvegagftYISSSPDEIALVKGAKRFGFTFlgn 515
Cdd:COG0474   373 ---GGGKDIDDKDLKDSPALLR----FLLAAALCNSVTPEKNGW-----------YQAGDPTEGALVEFAEKLGFSL--- 431
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  516 qngyirveNQRKEIEEYELLHTLNFDSVRRRMSVIVRTQKGDILLFCKGADSSIFPRVHS--HQIELTKDHVER--NAMD 591
Cdd:COG0474   432 --------DLSGLEVEYPILAEIPFDSERKRMSVIVKTDEGKYILFVKGAPEVILERCKSigELEPLTEEGLRTleEAVK 503
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  592 -----GYRTLCVAFKEIPpddferinaqlveakmalqdrEEKLEKVFDEIETNMNLIGATAVEDKLQDQAAETIEALHAA 666
Cdd:COG0474   504 elaseGLRVLAVAYKKLD---------------------RAEKDDEVDEIESDLVFLGLTGIEDPPREDVKEAIEELREA 562
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  667 GLKVWVLTGDKMETAKSTCYACRLfqtntellelttktieESERKEDrlhellieyrkkllhefpkstrslkkawtehqe 746
Cdd:COG0474   563 GIKVWMITGDHVETAIAIAKECGI----------------EAEAESA--------------------------------- 593
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  747 ygLIIDGSTLSLILNSSqdcssnnyksiFLQICMKCTavLCCRMAPLQKAQIVRMVKNlKGSpITLSIGDGANDVSMILE 826
Cdd:COG0474   594 --LVIDGAELDALSDEE-----------LAELVEELS--VFARVSPEQKARIVEALQK-SGH-VVAMTGDGVNDAPALKA 656
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  827 SHVGIGIkGKEGRQAARNSD--YSVPKFKHLKKLLLVHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFsqQPLYD 904
Cdd:COG0474   657 ADVGIAM-GGEGTDAAKEAAdiVLLDDNFATIVLAVVEGRRVYVNIKKFILYLLSKNVGEVLTLLIYSLFNLF--FLPLT 733
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  905 AAYLTMYNICFTSLPILAYSLLEqhINIDTLTADPRLymkiTGNAMLQLGPFLHWTFLAAFEGTVFFFGTYFLFQTSSLE 984
Cdd:COG0474   734 PLQLLWINLLTDSLPALALGVED--PESDVMKRPPRG----PEEGLFNRKIFWRFILIIGLLSAILFILTFLLYLLGFIA 807
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  985 DN---GKIYGNWTfgTIVFTVLVFTVTLkLALDTRFwtwinHFVIWGSLAFYVFFSFFWGGIIWPFLKQQRMYFVFAQML 1061
Cdd:COG0474   808 NTlglDLFQALLQ--TTAFTVLVLIQLL-LTLAVRS-----RGRPFLSSLLFSNKYLWLALLVIIILQLLIIFLPPLNLK 879
                        1050      1060      1070
                  ....*....|....*....|....*....|....*.
gi 569010256 1062 CSVSTWLAIILLIFISLFPEILLIVVKNVRRRSARR 1097
Cdd:COG0474   880 IFQPTPLSLFEWLIAIAVALLLLYIVVSELYKLKSR 915
PhoLip_ATPase_C pfam16212
Phospholipid-translocating P-type ATPase C-terminal; PhoLip_ATPase_C is found at the ...
842-1089 4.79e-78

Phospholipid-translocating P-type ATPase C-terminal; PhoLip_ATPase_C is found at the C-terminus of a number of phospholipid-translocating ATPases. It is found in higher eukaryotes.


Pssm-ID: 435220 [Multi-domain]  Cd Length: 250  Bit Score: 256.67  E-value: 4.79e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   842 ARNSDYSVPKFKHLKKLLLVHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNICFTSLPIL 921
Cdd:pfam16212    1 ARASDYAIAQFRFLKRLLLVHGRWSYRRTSKLILYFFYKNIVFTLTQFWYQFYNGFSGQSLYESWYLTLYNLLFTSLPVI 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   922 AYSLLEQHINIDTLTADPRLYMKITGNAMLQLGPFLHWTFLAAFEGTVFFFGTYFLFQTSSLeDNGKIYGNWTFGTIVFT 1001
Cdd:pfam16212   81 VLGIFDQDVSAETLLAYPELYKLGQKNKLFNLKTFLGWMLDGIYQSLIIFFIPYLAYGDSAF-SGGKDADLWAFGTTVFT 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  1002 VLVFTVTLKLALDTRFWTWINHFVIWGSLAFYVFFSFFWGGIIWPFLKQqrMYFVFAQMLCSVSTWLAIILLIFISLFPE 1081
Cdd:pfam16212  160 ALVLVVNLKLALETHYWTWITHLAIWGSILLYFLFTLIYSSIYPSSYYV--FYGVASRLFGSPSFWLTLLLVVVVCLLPD 237

                   ....*...
gi 569010256  1082 ILLIVVKN 1089
Cdd:pfam16212  238 FAYKALKR 245
 
Name Accession Description Interval E-value
P-type_ATPase_APLT_Dnf-like cd02073
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
42-974 0e+00

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, and human ATP8A2, -10D, -11B, -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. This subfamily includes mammalian flippases such as ATP11C which may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319770 [Multi-domain]  Cd Length: 836  Bit Score: 1303.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   42 DNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQVT-VDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHRADNEV 120
Cdd:cd02073     1 DNRISTTKYTVFTFLPKNLFEQFRRVANLYFLFIAILQQIpGISPTGPYTTLLPLLFVLGVTAIKEGYEDIRRHKSDNEV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  121 NKSAVYIIENAKRVRKESEKIKVGDVVEVQANETFPCDLILLSSCTTDGTCYVTTASLDGESNCKTHYAVRDTIALCTAE 200
Cdd:cd02073    81 NNRPVQVLRGGKFVKKKWKDIRVGDIVRVKNDEFVPADLLLLSSSEPDGLCYVETANLDGETNLKIRQALPETALLLSEE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  201 SIDNLRATIECEQPQPDLYRFVGRISIYSNsieaVARSLGPENLLLKGATLKNTKKIYGVAVYTGMETKMALNYQGKSQK 280
Cdd:cd02073   161 DLARFSGEIECEQPNNDLYTFNGTLELNGG----RELPLSPDNLLLRGCTLRNTEWVYGVVVYTGHETKLMLNSGGTPLK 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  281 CSAVEKSINAFLIVYLFILLTKAAVCTTLKYVWQSSPYNDEPWYNQKTqkerETFQVLKMFTDFLSFMVLFNFIIPVSMY 360
Cdd:cd02073   237 RSSIEKKMNRFIIAIFCILIVMCLISAIGKGIWLSKHGRDLWYLLPKE----ERSPALEFFFDFLTFIILYNNLIPISLY 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  361 VTVEMQKFLGSFFISWDKDFFDEEINEGALVNTSDLNEELGQVDYVFTDKTGTLTENSMEFIECCIDGHKYkgttqevdg 440
Cdd:cd02073   313 VTIEVVKFLQSFFINWDLDMYDEETDTPAEARTSNLNEELGQVEYIFSDKTGTLTENIMEFKKCSINGVDY--------- 383
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  441 lsqtdgplayfdkadknreaLFLRALCLCHTVEMKTNDDVDGPVegagftYISSSPDEIALVKGAKRFGFTFLGNQNGYI 520
Cdd:cd02073   384 --------------------GFFLALALCHTVVPEKDDHPGQLV------YQASSPDEAALVEAARDLGFVFLSRTPDTV 437
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  521 RVeNQRKEIEEYELLHTLNFDSVRRRMSVIVRTQKGDILLFCKGADSSIFPRVHSHQ---IELTKDHVERNAMDGYRTLC 597
Cdd:cd02073   438 TI-NALGEEEEYEILHILEFNSDRKRMSVIVRDPDGRILLYCKGADSVIFERLSPSSlelVEKTQEHLEDFASEGLRTLC 516
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  598 VAFKEIPPDDFERINAQLVEAKMALQDREEKLEKVFDEIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDK 677
Cdd:cd02073   517 LAYREISEEEYEEWNEKYDEASTALQNREELLDEVAEEIEKDLILLGATAIEDKLQDGVPETIEALQRAGIKIWVLTGDK 596
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  678 METAKSTCYACRLFQTNTEllelttktieeserkedrlhellieyrkkllhefpkstrslkkawtehqEYGLIIDGSTLS 757
Cdd:cd02073   597 QETAINIGYSCRLLSEDME-------------------------------------------------NLALVIDGKTLT 627
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  758 LILNSSQdcssnnyKSIFLQICMKCTAVLCCRMAPLQKAQIVRMVKNLKgSPITLSIGDGANDVSMILESHVGIGIKGKE 837
Cdd:cd02073   628 YALDPEL-------ERLFLELALKCKAVICCRVSPLQKALVVKLVKKSK-KAVTLAIGDGANDVSMIQEAHVGVGISGQE 699
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  838 GRQAARNSDYSVPKFKHLKKLLLVHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNICFTS 917
Cdd:cd02073   700 GMQAARASDYAIAQFRFLRRLLLVHGRWSYQRLAKLILYFFYKNIAFYLTQFWYQFFNGFSGQTLYDSWYLTLYNVLFTS 779
                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 569010256  918 LPILAYSLLEQHINIDTLTADPRLYMKITGNAMLQLGPFLHWTFLAAFEGTVFFFGT 974
Cdd:cd02073   780 LPPLVIGIFDQDVSAETLLRYPELYKPGQLNELFNWKVFLYWILDGIYQSLIIFFVP 836
ATPase-Plipid TIGR01652
phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase ...
40-1088 0e+00

phospholipid-translocating P-type ATPase, flippase; This model describes the P-type ATPase responsible for transporting phospholipids from one leaflet of bilayer membranes to the other. These ATPases are found only in eukaryotes.


Pssm-ID: 273734 [Multi-domain]  Cd Length: 1057  Bit Score: 940.65  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256    40 FCDNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQVTVD-TPTSPVTSGLPLFFVITVTAIKQGYEDWLRHRADN 118
Cdd:TIGR01652    1 FCSNKISTTKYTVLTFLPKNLFEQFKRFANLYFLVVALLQQVPIlSPTYRGTSIVPLAFVLIVTAIKEAIEDIRRRRRDK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   119 EVNKSAVYIIEN-AKRVRKESEKIKVGDVVEVQANETFPCDLILLSSCTTDGTCYVTTASLDGESNCKTHYAVRDTIALC 197
Cdd:TIGR01652   81 EVNNRLTEVLEGhGQFVEIPWKDLRVGDIVKVKKDERIPADLLLLSSSEPDGVCYVETANLDGETNLKLRQALEETQKML 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   198 TAESIDNLRATIECEQPQPDLYRFVGRISIYSNSIEavarSLGPENLLLKGATLKNTKKIYGVAVYTGMETKMALNYQGK 277
Cdd:TIGR01652  161 DEDDIKNFSGEIECEQPNASLYSFQGNMTINGDRQY----PLSPDNILLRGCTLRNTDWVIGVVVYTGHDTKLMRNATQA 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   278 SQKCSAVEKSINaFLIVYLFILLTKAAVCTTLKYVWQSSPYNDEPWYNQKTQKERETfqVLKMFTDFLSFMVLFNFIIPV 357
Cdd:TIGR01652  237 PSKRSRLEKELN-FLIIILFCLLFVLCLISSVGAGIWNDAHGKDLWYIRLDVSERNA--AANGFFSFLTFLILFSSLIPI 313
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   358 SMYVTVEMQKFLGSFFISWDKDFFDEEINEGALVNTSDLNEELGQVDYVFTDKTGTLTENSMEFIECCIDGHKY-KGTTQ 436
Cdd:TIGR01652  314 SLYVSLELVKSVQAYFINSDLQMYHEKTDTPASVRTSNLNEELGQVEYIFSDKTGTLTQNIMEFKKCSIAGVSYgDGFTE 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   437 EVDGLSQTDGPLAYFDKADKNREAL------------------------FLRALCLCHTVEMKTNDDVDGPVegagfTYI 492
Cdd:TIGR01652  394 IKDGIRERLGSYVENENSMLVESKGftfvdprlvdllktnkpnakrineFFLALALCHTVVPEFNDDGPEEI-----TYQ 468
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   493 SSSPDEIALVKGAKRFGFTFLGNQNGYIRV-ENQRKEIEEYELLHTLNFDSVRRRMSVIVRTQKGDILLFCKGADSSIFP 571
Cdd:TIGR01652  469 AASPDEAALVKAARDVGFVFFERTPKSISLlIEMHGETKEYEILNVLEFNSDRKRMSVIVRNPDGRIKLLCKGADTVIFK 548
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   572 RVHSHQ---IELTKDHVERNAMDGYRTLCVAFKEIPPDDFERINAQLVEAKMALQDREEKLEKVFDEIETNMNLIGATAV 648
Cdd:TIGR01652  549 RLSSGGnqvNEETKEHLENYASEGLRTLCIAYRELSEEEYEEWNEEYNEASTALTDREEKLDVVAESIEKDLILLGATAI 628
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   649 EDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACRLFQTNTELLELTTKTIEESERKEdrlhELLIEYRKKLLH 728
Cdd:TIGR01652  629 EDKLQEGVPETIELLRQAGIKIWVLTGDKVETAINIGYSCRLLSRNMEQIVITSDSLDATRSVE----AAIKFGLEGTSE 704
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   729 EFPKSTRSLKKAwtehqeygLIIDGSTLSLILnssqdcsSNNYKSIFLQICMKCTAVLCCRMAPLQKAQIVRMVKNLKGS 808
Cdd:TIGR01652  705 EFNNLGDSGNVA--------LVIDGKSLGYAL-------DEELEKEFLQLALKCKAVICCRVSPSQKADVVRLVKKSTGK 769
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   809 pITLSIGDGANDVSMILESHVGIGIKGKEGRQAARNSDYSVPKFKHLKKLLLVHGHLYYVRIAHLVQYFFYKNLCFILPQ 888
Cdd:TIGR01652  770 -TTLAIGDGANDVSMIQEADVGVGISGKEGMQAVMASDFAIGQFRFLTKLLLVHGRWSYKRISKMILYFFYKNLIFAIIQ 848
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   889 FLYQFFCGFSQQPLYDAAYLTMYNICFTSLPILAYSLLEQHINIDTLTADPRLYMKITGNAMLQLGPFLHWTFLAAFEGT 968
Cdd:TIGR01652  849 FWYSFYNGFSGQTLYEGWYMVLYNVFFTALPVISLGVFDQDVSASLSLRYPQLYREGQKGQGFSTKTFWGWMLDGIYQSL 928
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   969 VFFFGTYFLFQTSSLEDNGKIYGNWTFGTIVFTVLVFTVTLKLALDTRFWTWINHFVIWGSLAFYVFFSFFWGGiIWPfl 1048
Cdd:TIGR01652  929 VIFFFPMFAYILGDFVSSGSVDDFSSVGVIVFTALVVIVNLKIALEINRWNWISLITIWGSILVWLIFVIVYSS-IFP-- 1005
                         1050      1060      1070      1080
                   ....*....|....*....|....*....|....*....|
gi 569010256  1049 kQQRMYFVFAQMLCSVSTWLAIILLIFISLFPEILLIVVK 1088
Cdd:TIGR01652 1006 -SPAFYKAAPRVMGTFGFWLVLLVIVLISLLPRFTYKAIQ 1044
P-type_ATPase_APLT cd07536
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, ...
42-972 0e+00

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Dnf1-3p, Drs2p, Neo1p, and human ATP8A2, -9B, -10D, -11B, and -11C; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. Yeast Dnf1 and Dnf2 mediate the transport of phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine from the outer to the inner leaflet of the plasma membrane. Mammalian ATP11C may selectively transports PS and PE from the outer leaflet of the plasma membrane to the inner leaflet. The yeast Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Human putative ATPase phospholipid transporting 9B, ATP9B, localizes to the trans-golgi network in a CDC50 protein-independent manner. It also includes Arabidopsis phospholipid flippases including ALA1, and Caenorhabditis elegans flippases, including TAT-1, the latter has been shown to facilitate the inward transport of phosphatidylserine. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319838 [Multi-domain]  Cd Length: 805  Bit Score: 624.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   42 DNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQVTVD-TPTSPVTSGLPLFFVITVTAIKQGYEDWLRHRADNEV 120
Cdd:cd07536     1 DNSISNQKYNVFTFLPGVLYEQFKRFLNLYFLVIACLQFVPAlKPGYLYTTWAPLIFILAVTMTKEAIDDFRRFQRDKEV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  121 NKSAVYIIENAKRVRKESEKIKVGDVVEVQANETFPCDLILLSSCTTDGTCYVTTASLDGESNCKTHYAVRDTIALCTAE 200
Cdd:cd07536    81 NKKQLYSKLTGRKVQIKSSDIQVGDIVIVEKNQRIPSDMVLLRTSEPQGSCYVETAQLDGETDLKLRVAVSCTQQLPALG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  201 SIDNLRATIECEQPQPDLYRFVGRISIYSNSIEAVArSLGPENLLLKGATLKNTKKIYGVAVYTGMETKMALNYQGKSQK 280
Cdd:cd07536   161 DLMKISAYVECQKPQMDIHSFEGNFTLEDSDPPIHE-SLSIENTLLRASTLRNTGWVIGVVVYTGKETKLVMNTSNAKNK 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  281 CSAVEKSINAFLIVYLFILLTKAAVCTTLKYVWQSSpYNDEPWYNQKTQKERETFQVlkmftDFLSFMVLFNFIIPVSMY 360
Cdd:cd07536   240 VGLLDLELNRLTKALFLALVVLSLVMVTLQGFWGPW-YGEKNWYIKKMDTTSDNFGR-----NLLRFLLLFSYIIPISLR 313
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  361 VTVEMQKFLGSFFISWDKDFFDEEINEGALVNTSDLNEELGQVDYVFTDKTGTLTENSMEFIECCIDGHKYKGTTQEvdg 440
Cdd:cd07536   314 VNLDMVKAVYAWFIMWDENMYYIGNDTGTVARTSTIPEELGQVVYLLTDKTGTLTQNEMIFKRCHIGGVSYGGQVLS--- 390
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  441 lsqtdgplayfdkadknrealflralclchtvemktnddvdgpvegagftyissspdeialvkgakrfgftflgnqngyi 520
Cdd:cd07536       --------------------------------------------------------------------------------
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  521 rvenqrkeieeYELLHTLNFDSVRRRMSVIVRT-QKGDILLFCKGADSSIFPRVHS-HQIELTKDHVERNAMDGYRTLCV 598
Cdd:cd07536   391 -----------FCILQLLEFTSDRKRMSVIVRDeSTGEITLYMKGADVAISPIVSKdSYMEQYNDWLEEECGEGLRTLCV 459
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  599 AFKEIPPDDFERINAQLVEAKMALQDREEKLEKVFDEIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKM 678
Cdd:cd07536   460 AKKALTENEYQEWESRYTEASLSLHDRSLRVAEVVESLERELELLGLTAIEDRLQAGVPETIETLRKAGIKIWMLTGDKQ 539
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  679 ETAKSTCYACRLFQTNTE--LLELTTKTiEESERKEDRLHELLIEYRKKllhefpkstrslkkawtehQEYGLIIDGSTL 756
Cdd:cd07536   540 ETAICIAKSCHLVSRTQDihLLRQDTSR-GERAAITQHAHLELNAFRRK-------------------HDVALVIDGDSL 599
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  757 SLILNssqdcssnNYKSIFLQICMKCTAVLCCRMAPLQKAQIVRMVKNLKGSpITLSIGDGANDVSMILESHVGIGIKGK 836
Cdd:cd07536   600 EVALK--------YYRHEFVELACQCPAVICCRVSPTQKARIVTLLKQHTGR-RTLAIGDGGNDVSMIQAADCGVGISGK 670
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  837 EGRQAARNSDYSVPKFKHLKKLLLVHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNICFT 916
Cdd:cd07536   671 EGKQASLAADYSITQFRHLGRLLLVHGRNSYNRSAALGQYVFYKGLIISTIQAVFSFVFGFSGVPLFQGFLMVGYNVIYT 750
                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 569010256  917 SLPILAySLLEQHINIDTLTADPRLYMKITGNAMLQLGPFLHWTFLAAFEGTVFFF 972
Cdd:cd07536   751 MFPVFS-LVIDQDVKPESAMLYPQLYKDLQKGRSLNFKTFLGWVLISLYHGGILFY 805
PLN03190 PLN03190
aminophospholipid translocase; Provisional
20-1087 0e+00

aminophospholipid translocase; Provisional


Pssm-ID: 215623 [Multi-domain]  Cd Length: 1178  Bit Score: 617.68  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   20 RTVFVgNHPISGTEPYiaqRFCDNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIF----LVQVTVDTPTSPVtsgLPL 95
Cdd:PLN03190   71 RLVYL-NDPEKSNERF---EFAGNSIRTAKYSVFSFLPRNLFEQFHRVAYIYFLVIAvlnqLPQLAVFGRGASI---LPL 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   96 FFVITVTAIKQGYEDWLRHRADNEVNKSAVYIIENAKRVRKESEKIKVGDVVEVQANETFPCDLILLSSCTTDGTCYVTT 175
Cdd:PLN03190  144 AFVLLVTAVKDAYEDWRRHRSDRIENNRLAWVLVDDQFQEKKWKDIRVGEIIKIQANDTLPCDMVLLSTSDPTGVAYVQT 223
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  176 ASLDGESNCKTHYAVRDTIA-LCTAESIDNLratIECEQPQPDLYRFVGRISIYSNSIeavarSLGPENLLLKGATLKNT 254
Cdd:PLN03190  224 INLDGESNLKTRYAKQETLSkIPEKEKINGL---IKCEKPNRNIYGFQANMEVDGKRL-----SLGPSNIILRGCELKNT 295
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  255 KKIYGVAVYTGMETKMALNYQGKSQKCSAVEKSINA---FLIVYLFILLTKAAVCTTlkyVWQSSpYNDE----PWYNQK 327
Cdd:PLN03190  296 AWAIGVAVYCGRETKAMLNNSGAPSKRSRLETRMNLeiiILSLFLIALCTIVSVCAA---VWLRR-HRDEldtiPFYRRK 371
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  328 --TQKERETFQ----VLKMFTDFLSFMVLFNFIIPVSMYVTVEMQKFLGSFFISWDKDFFDEEINEGALVNTSDLNEELG 401
Cdd:PLN03190  372 dfSEGGPKNYNyygwGWEIFFTFLMSVIVFQIMIPISLYISMELVRVGQAYFMIRDDQMYDEASNSRFQCRALNINEDLG 451
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  402 QVDYVFTDKTGTLTENSMEFIECCIDGHKYKGTTQ-----------EVDGLS-------QTDGPLAYFDKADKNREAL-- 461
Cdd:PLN03190  452 QIKYVFSDKTGTLTENKMEFQCASIWGVDYSDGRTptqndhagysvEVDGKIlrpkmkvKVDPQLLELSKSGKDTEEAkh 531
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  462 ---FLRALCLCHTVEMKTNDDVDGPVEGAgFTYISSSPDEIALVKGAKRFGFTFLGNQNGYIrVENQRKEIEEYELLHTL 538
Cdd:PLN03190  532 vhdFFLALAACNTIVPIVVDDTSDPTVKL-MDYQGESPDEQALVYAAAAYGFMLIERTSGHI-VIDIHGERQRFNVLGLH 609
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  539 NFDSVRRRMSVIVRTQKGDILLFCKGADSSIFPRV----HSHQIELTKDHVERNAMDGYRTLCVAFKEIPPDDFERINAQ 614
Cdd:PLN03190  610 EFDSDRKRMSVILGCPDKTVKVFVKGADTSMFSVIdrslNMNVIRATEAHLHTYSSLGLRTLVVGMRELNDSEFEQWHFS 689
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  615 LVEAKMALQDREEKLEKVFDEIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACRLFQTN 694
Cdd:PLN03190  690 FEAASTALIGRAALLRKVASNVENNLTILGASAIEDKLQQGVPEAIESLRTAGIKVWVLTGDKQETAISIGYSSKLLTNK 769
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  695 TELLELTTKTIEESERKedrLHELLIeYRKKLLHEFPKSTRSLKKAWTEHQEYGLIIDGSTLSLILNssqdcssNNYKSI 774
Cdd:PLN03190  770 MTQIIINSNSKESCRKS---LEDALV-MSKKLTTVSGISQNTGGSSAAASDPVALIIDGTSLVYVLD-------SELEEQ 838
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  775 FLQICMKCTAVLCCRMAPLQKAQIVRMVKNlKGSPITLSIGDGANDVSMILESHVGIGIKGKEGRQAARNSDYSVPKFKH 854
Cdd:PLN03190  839 LFQLASKCSVVLCCRVAPLQKAGIVALVKN-RTSDMTLAIGDGANDVSMIQMADVGVGISGQEGRQAVMASDFAMGQFRF 917
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  855 LKKLLLVHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNICFTSLPILAYSLLEQHINIDT 934
Cdd:PLN03190  918 LVPLLLVHGHWNYQRMGYMILYNFYRNAVFVLVLFWYVLFTCFTLTTAINEWSSVLYSVIYTALPTIVVGILDKDLSRRT 997
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  935 LTADPRLYMkiTGNAMLQLGPFLHWTFL--AAFEGTVFFFGTYFLFQTSSLeDNGKIYGNWTFGTIVFtvlvftVTLKLA 1012
Cdd:PLN03190  998 LLKYPQLYG--AGQRQEAYNSKLFWLTMidTLWQSAVVFFVPLFAYWASTI-DGSSIGDLWTLAVVIL------VNLHLA 1068
                        1050      1060      1070      1080      1090      1100      1110
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569010256 1013 LDTRFWTWINHFVIWGSLAfyvffSFFWGGIIWPFLKQQRMYFVFAQMLCSVSTWLAIILLIFISLFPEILLIVV 1087
Cdd:PLN03190 1069 MDIIRWNWITHAAIWGSIV-----ATFICVIVIDAIPTLPGYWAIFHIAKTGSFWLCLLAIVVAALLPRFVVKVL 1138
P-type_ATPase_APLT_Neo1-like cd07541
Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human ...
43-1006 4.25e-139

Aminophospholipid translocases (APLTs), similar to Saccharomyces cerevisiae Neo1p and human putative APLT, ATP9B; Aminophospholipid translocases (APLTs), also known as type 4 P-type ATPases, act as a flippases, and translocate specific phospholipids from the exoplasmic leaflet to the cytoplasmic leaflet of biological membranes. The yeast Neo1 gene is an essential gene; Neo1p localizes to the endoplasmic reticulum and the Golgi complex and plays a role in membrane trafficking within the endomembrane system. Also included in this sub family is human putative ATPase phospholipid transporting 9B, ATP9B, which localizes to the trans-golgi network in a CDC50 protein-independent manner. Levels of ATP9B, along with levels of other ATPase genes, may contribute to expressivity of and atypical presentations of Hailey-Hailey disease (HHD), and the ATP9B gene has recently been identified as a putative Alzheimer's disease loci. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319841 [Multi-domain]  Cd Length: 792  Bit Score: 439.54  E-value: 4.25e-139
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   43 NRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQVTVDTPTS-PVTSGLPLFFVITVTAIKQGYEDWLRHRADNEVN 121
Cdd:cd07541     2 NEVRNQKYNIFTFLPKVLYEQFKFFYNLYFLVVALSQFVPALKIGyLYTYWAPLGFVLAVTMAKEAVDDIRRRRRDKEQN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  122 KSAVYIIENAKRVRkeSEKIKVGDVVEVQANETFPCDLILLSSCTTDGTCYVTTASLDGESNCKTHYAVRDTIALCTAES 201
Cdd:cd07541    82 YEKLTVRGETVEIP--SSDIKVGDLIIVEKNQRIPADMVLLRTSEKSGSCFIRTDQLDGETDWKLRIAVPCTQKLPEEGI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  202 IDNLRAtIECEQPQPDLYRFVGRISIYSNSIEavaRSLGPENLLLkGATLKNTKKIYGVAVYTGMETKMALNYQGKSQKC 281
Cdd:cd07541   160 LNSISA-VYAEAPQKDIHSFYGTFTINDDPTS---ESLSVENTLW-ANTVVASGTVIGVVVYTGKETRSVMNTSQPKNKV 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  282 SAVEKSINaFLIVYLFILLTKAAVCTTLKYVWQSspyndePWYnqktqkeretfqvlkmfTDFLSFMVLFNFIIPVSMYV 361
Cdd:cd07541   235 GLLDLEIN-FLTKILFCAVLALSIVMVALQGFQG------PWY-----------------IYLFRFLILFSSIIPISLRV 290
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  362 TVEMQKFLGSFFISWDKDFfdeeinEGALVNTSDLNEELGQVDYVFTDKTGTLTENSMEFIECCIdghkykGTtqevdgL 441
Cdd:cd07541   291 NLDMAKIVYSWQIEHDKNI------PGTVVRTSTIPEELGRIEYLLSDKTGTLTQNEMVFKKLHL------GT------V 352
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  442 SQTDGPLayfdkadknrealflralclchtvemktnddvdgpvegagftyissspdeialvkgakrfgftflgnqngyir 521
Cdd:cd07541   353 SYGGQNL------------------------------------------------------------------------- 359
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  522 venqrkeieEYELLHTLNFDSVRRRMSVIVRTQK-GDILLFCKGADSSIFPRVHSHqiELTKDHVERNAMDGYRTLCVAF 600
Cdd:cd07541   360 ---------NYEILQIFPFTSESKRMGIIVREEKtGEITFYMKGADVVMSKIVQYN--DWLEEECGNMAREGLRTLVVAK 428
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  601 KEIPPDDFERINAQLVEAKMALQDREEKLEKVFDEIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMET 680
Cdd:cd07541   429 KKLSEEEYQAFEKRYNAAKLSIHDRDLKVAEVVESLERELELLCLTGVEDKLQEDVKPTLELLRNAGIKIWMLTGDKLET 508
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  681 AKSTCYACRLFQTNTELLELTTKTieeseRKEDRLHELLIEYRKkllhefpkstrslkkawtehQEYGLIIDGSTLSLIL 760
Cdd:cd07541   509 ATCIAKSSKLVSRGQYIHVFRKVT-----TREEAHLELNNLRRK--------------------HDCALVIDGESLEVCL 563
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  761 NssqdcssnNYKSIFLQICMKCTAVLCCRMAPLQKAQIVRMVKNLKGSpITLSIGDGANDVSMILESHVGIGIKGKEGRQ 840
Cdd:cd07541   564 K--------YYEHEFIELACQLPAVVCCRCSPTQKAQIVRLIQKHTGK-RTCAIGDGGNDVSMIQAADVGVGIEGKEGKQ 634
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  841 AARNSDYSVPKFKHLKKLLLVHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNICFTSLPI 920
Cdd:cd07541   635 ASLAADFSITQFSHIGRLLLWHGRNSYKRSAKLAQFVMHRGLIISIMQAVFSSVFYFAPIALYQGFLMVGYSTIYTMAPV 714
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  921 laYSL-LEQHINIDTLTADPRLYMKITGNAMLQLGPFLHWTFLAAFEGTVFFFGTYFLFQTSsledngkiygnwtFGTIV 999
Cdd:cd07541   715 --FSLvLDQDVSEELAMLYPELYKELTKGRSLSYKTFFIWVLISIYQGGIIMYGALLLFDSE-------------FVHIV 779
                         970
                  ....*....|
gi 569010256 1000 ---FTVLVFT 1006
Cdd:cd07541   780 aisFTALILT 789
MgtA COG0474
Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];
43-1097 2.51e-123

Magnesium-transporting ATPase (P-type) [Inorganic ion transport and metabolism];


Pssm-ID: 223550 [Multi-domain]  Cd Length: 917  Bit Score: 401.33  E-value: 2.51e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   43 NRIVssKYTLWNFLPKNLFEQFRRIANFYF---LIIFLVQVTVDTPTSPVTSgLPLFFVITVTAIKQGYEDWLRHRADNE 119
Cdd:COG0474    60 NELP--EEKKRSLLKKFLRQFKDPFIILLLvaaLLSAFVGDWVDAGVDAIVI-LLVVVINALLGFVQEYRAEKALEALKK 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  120 VNKSAVYIIENAKRVRKESEKIKVGDVVEVQANETFPCDLILLSScttdgTC-YVTTASLDGESNCKthyaVRDTIALCT 198
Cdd:COG0474   137 MSSPKAKVLRDGKFVEIPASELVPGDIVLLEAGDVVPADLRLLES-----SDlEVDESALTGESLPV----EKQALPLTK 207
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  199 AESIDNLRATieceqpqpdlyrfvgrisiysnsieavarslgpeNLLLKGATLKNTKkIYGVAVYTGMETKM---ALNYQ 275
Cdd:COG0474   208 SDAPLGLDRD----------------------------------NMLFSGTTVVSGR-AKGIVVATGFETEFgkiARLLP 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  276 GKSQKCSAVEKSINaFLIVYLFILLTKAAVCTTLKYVWQSSPyndePWYNQktqkeretfqvlkmftdFLSFMVLFNFII 355
Cdd:COG0474   253 TKKEVKTPLQRKLN-KLGKFLLVLALVLGALVFVVGLFRGGN----GLLES-----------------FLTALALAVAAV 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  356 PVSMYVTVEMQKFLGSFFISWDKdffdeeinegALVNTSDLNEELGQVDYVFTDKTGTLTENSMEFiECCIDGhkykgtt 435
Cdd:COG0474   311 PEGLPAVVTIALALGAQRMAKDN----------AIVRSLNAIETLGSVDVICSDKTGTLTQNKMTV-KKIYIN------- 372
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  436 qevDGLSQTDGPLAYFDKADKNrealFLRALCLCHTVEMKTNDDvdgpvegagftYISSSPDEIALVKGAKRFGFTFlgn 515
Cdd:COG0474   373 ---GGGKDIDDKDLKDSPALLR----FLLAAALCNSVTPEKNGW-----------YQAGDPTEGALVEFAEKLGFSL--- 431
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  516 qngyirveNQRKEIEEYELLHTLNFDSVRRRMSVIVRTQKGDILLFCKGADSSIFPRVHS--HQIELTKDHVER--NAMD 591
Cdd:COG0474   432 --------DLSGLEVEYPILAEIPFDSERKRMSVIVKTDEGKYILFVKGAPEVILERCKSigELEPLTEEGLRTleEAVK 503
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  592 -----GYRTLCVAFKEIPpddferinaqlveakmalqdrEEKLEKVFDEIETNMNLIGATAVEDKLQDQAAETIEALHAA 666
Cdd:COG0474   504 elaseGLRVLAVAYKKLD---------------------RAEKDDEVDEIESDLVFLGLTGIEDPPREDVKEAIEELREA 562
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  667 GLKVWVLTGDKMETAKSTCYACRLfqtntellelttktieESERKEDrlhellieyrkkllhefpkstrslkkawtehqe 746
Cdd:COG0474   563 GIKVWMITGDHVETAIAIAKECGI----------------EAEAESA--------------------------------- 593
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  747 ygLIIDGSTLSLILNSSqdcssnnyksiFLQICMKCTavLCCRMAPLQKAQIVRMVKNlKGSpITLSIGDGANDVSMILE 826
Cdd:COG0474   594 --LVIDGAELDALSDEE-----------LAELVEELS--VFARVSPEQKARIVEALQK-SGH-VVAMTGDGVNDAPALKA 656
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  827 SHVGIGIkGKEGRQAARNSD--YSVPKFKHLKKLLLVHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFsqQPLYD 904
Cdd:COG0474   657 ADVGIAM-GGEGTDAAKEAAdiVLLDDNFATIVLAVVEGRRVYVNIKKFILYLLSKNVGEVLTLLIYSLFNLF--FLPLT 733
                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  905 AAYLTMYNICFTSLPILAYSLLEqhINIDTLTADPRLymkiTGNAMLQLGPFLHWTFLAAFEGTVFFFGTYFLFQTSSLE 984
Cdd:COG0474   734 PLQLLWINLLTDSLPALALGVED--PESDVMKRPPRG----PEEGLFNRKIFWRFILIIGLLSAILFILTFLLYLLGFIA 807
                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  985 DN---GKIYGNWTfgTIVFTVLVFTVTLkLALDTRFwtwinHFVIWGSLAFYVFFSFFWGGIIWPFLKQQRMYFVFAQML 1061
Cdd:COG0474   808 NTlglDLFQALLQ--TTAFTVLVLIQLL-LTLAVRS-----RGRPFLSSLLFSNKYLWLALLVIIILQLLIIFLPPLNLK 879
                        1050      1060      1070
                  ....*....|....*....|....*....|....*.
gi 569010256 1062 CSVSTWLAIILLIFISLFPEILLIVVKNVRRRSARR 1097
Cdd:COG0474   880 IFQPTPLSLFEWLIAIAVALLLLYIVVSELYKLKSR 915
ATPase_P-type TIGR01494
ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large ...
89-891 6.00e-119

ATPase, P-type (transporting), HAD superfamily, subfamily IC; The P-type ATPases are a large family of trans-membrane transporters acting on charged substances. The distinguishing feature of the family is the formation of a phosphorylated intermediate (aspartyl-phosphate) during the course of the reaction. Another common name for these enzymes is the E1-E2 ATPases based on the two isolable conformations: E1 (unphosphorylated) and E2 (phosphorylated). Generally, P-type ATPases consist of only a single subunit encompassing the ATPase and ion translocation pathway, however, in the case of the potassium (TIGR01497) and sodium/potassium (TIGR01106) varieties, these functions are split between two subunits. Additional small regulatory or stabilizing subunits may also exist in some forms. P-type ATPases are nearly ubiquitous in life and are found in numerous copies in higher organisms (at least 45 in Arabidopsis thaliana, for instance). Phylogenetic analyses have revealed that the P-type ATPase subfamily is divided up into groups based on substrate specificities and this is represented in the various subfamily and equivalog models that have been made: IA (K+) TIGR01497, IB (heavy metals) TIGR01525, IIA1 (SERCA-type Ca++) TIGR01116, IIA2 (PMR1-type Ca++) TIGR01522, IIB (PMCA-type Ca++) TIGR01517, IIC (Na+/K+, H+/K+ antiporters) TIGR01106, IID (fungal-type Na+ and K+) TIGR01523, IIIA (H+) TIGR01647, IIIB (Mg++) TIGR01524, IV (phospholipid, flippase) TIGR01652 and V (unknown specificity) TIGR01657. The crystal structure of one calcium-pumping ATPase and an analysis of the fold of the catalytic domain of the P-type ATPases have been published. These reveal that the catalytic core of these enzymes is a haloacid dehalogenase(HAD)-type aspartate-nucleophile hydrolase. The location of the ATP-binding loop in between the first and second HAD conserved catalytic motifs defines these enzymes as members of subfamily I of the HAD superfamily (see also TIGR01493, TIGR01509, TIGR01549, TIGR01544 and TIGR01545). Based on these classifications, the P-type ATPase _superfamily_ corresponds to the IC subfamily of the HAD superfamily.


Pssm-ID: 273656 [Multi-domain]  Cd Length: 545  Bit Score: 378.20  E-value: 6.00e-119
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256    89 VTSGLPLFFVITVTAIKQGYEDWLRHRADNEVNKSAVYIIENAKrVRKESEKIKVGDVVEVQANETFPCDLILLSscttd 168
Cdd:TIGR01494    1 FILFLVLLFVLLEVKQKLKAEDALRSLKDSLVNTATVLVLRNGW-KEISSKDLVPGDVVLVKSGDTVPADGVLLS----- 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   169 GTCYVTTASLDGESNCKTHYAVRdtialctaesidnlratiECEQPQPDLYRFVGRISIysnsieavarSLGPENLLlkg 248
Cdd:TIGR01494   75 GSAFVDESSLTGESLPVLKTALP------------------DGDAVFAGTINFGGTLIV----------KVTATGIL--- 123
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   249 atlkNTKKIYGVAVYTGMETKMALnyqgkSQKCSAVEKsinaFLIVYLFILLTKAAVCTTLKYVWQSSPyndepwynqkt 328
Cdd:TIGR01494  124 ----TTVGKIAVVVYTGFSTKTPL-----QSKADKFEN----FIFILFLLLLALAVFLLLPIGGWDGNS----------- 179
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   329 qkeretfqvlkMFTDFLSFMVLFNFIIPVSMYVTVEMQKFLGsffiswDKDFFDEeineGALVNTSDLNEELGQVDYVFT 408
Cdd:TIGR01494  180 -----------IYKAILRALAVLVIAIPCALPLAVSVALAVG------DARMAKK----GILVKNLNALEELGKVDVICF 238
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   409 DKTGTLTENSMEFIECCIDGhkykgttqevdglsqtdgplayfdKADKNREALFLRALCLchtvemktnddvdgpvegag 488
Cdd:TIGR01494  239 DKTGTLTTNKMTLQKVIIIG------------------------GVEEASLALALLAASL-------------------- 274
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   489 fTYISSSPDEIALVKGAKRFGFTFLGNQngyirvenqrkeieEYELLHTLNFDSVRRRMSVIVRTQKGDILLFCKGADSS 568
Cdd:TIGR01494  275 -EYLSGHPLERAIVKSAEGVIKSDEINV--------------EYKILDVFPFSSVLKRMGVIVEGANGSDLLFVKGAPEF 339
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   569 IFPRVHSHQIelTKDHVERNAMDGYRTLCVAFKEIPPddferinaqlveakmalqdreeklekvfdeietNMNLIGATAV 648
Cdd:TIGR01494  340 VLERCNNEND--YDEKVDEYARQGLRVLAFASKKLPD---------------------------------DLEFLGLLTF 384
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   649 EDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACRLFqtntellelttktieeserkedrlhellieyrkkllh 728
Cdd:TIGR01494  385 EDPLRPDAKETIEALRKAGIKVVMLTGDNVLTAKAIAKELGID------------------------------------- 427
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   729 efpkstrslkkawtehqeygliidgstlslilnssqdcssnnyksiflqicmkctavLCCRMAPLQKAQIVRMVKNlKGs 808
Cdd:TIGR01494  428 ---------------------------------------------------------VFARVKPEEKAAIVEALQE-KG- 448
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   809 PITLSIGDGANDVSMILESHVGIGIKGKEGRQAArnSDYSVPKFKHLKKLLLV-HGHLYYVRIAHLVQYFFYKNLCFILP 887
Cdd:TIGR01494  449 RTVAMTGDGVNDAPALKKADVGIAMGSGDVAKAA--ADIVLLDDDLSTIVEAVkEGRKTFSNIKKNIFWAIAYNLILIPL 526

                   ....
gi 569010256   888 QFLY 891
Cdd:TIGR01494  527 ALLL 530
PhoLip_ATPase_C pfam16212
Phospholipid-translocating P-type ATPase C-terminal; PhoLip_ATPase_C is found at the ...
842-1089 4.79e-78

Phospholipid-translocating P-type ATPase C-terminal; PhoLip_ATPase_C is found at the C-terminus of a number of phospholipid-translocating ATPases. It is found in higher eukaryotes.


Pssm-ID: 435220 [Multi-domain]  Cd Length: 250  Bit Score: 256.67  E-value: 4.79e-78
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   842 ARNSDYSVPKFKHLKKLLLVHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNICFTSLPIL 921
Cdd:pfam16212    1 ARASDYAIAQFRFLKRLLLVHGRWSYRRTSKLILYFFYKNIVFTLTQFWYQFYNGFSGQSLYESWYLTLYNLLFTSLPVI 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   922 AYSLLEQHINIDTLTADPRLYMKITGNAMLQLGPFLHWTFLAAFEGTVFFFGTYFLFQTSSLeDNGKIYGNWTFGTIVFT 1001
Cdd:pfam16212   81 VLGIFDQDVSAETLLAYPELYKLGQKNKLFNLKTFLGWMLDGIYQSLIIFFIPYLAYGDSAF-SGGKDADLWAFGTTVFT 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  1002 VLVFTVTLKLALDTRFWTWINHFVIWGSLAFYVFFSFFWGGIIWPFLKQqrMYFVFAQMLCSVSTWLAIILLIFISLFPE 1081
Cdd:pfam16212  160 ALVLVVNLKLALETHYWTWITHLAIWGSILLYFLFTLIYSSIYPSSYYV--FYGVASRLFGSPSFWLTLLLVVVVCLLPD 237

                   ....*...
gi 569010256  1082 ILLIVVKN 1089
Cdd:pfam16212  238 FAYKALKR 245
P-ATPase-V TIGR01657
P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade ...
401-842 9.99e-31

P-type ATPase of unknown pump specificity (type V); These P-type ATPases form a distinct clade but the substrate of their pumping activity has yet to be determined. This clade has been designated type V in.


Pssm-ID: 273738 [Multi-domain]  Cd Length: 1054  Bit Score: 131.33  E-value: 9.99e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   401 GQVDYVFTDKTGTLTENSMEFIEccidghkykgttqeVDGLSQTDGPLAYFDKADKNREALFLRALCLCHTVeMKTNDDV 480
Cdd:TIGR01657  446 GKIDVCCFDKTGTLTEDGLDLRG--------------VQGLSGNQEFLKIVTEDSSLKPSITHKALATCHSL-TKLEGKL 510
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   481 DG-PVEGAGFTYISSSPDEIalvkGAKRFGftflgnqNGYIRVENQRKEIEEYELLHTLNFDSVRRRMSVIVRTQKGDIL 559
Cdd:TIGR01657  511 VGdPLDKKMFEATGWTLEED----DESAEP-------TSILAVVRTDDPPQELSIIRRFQFSSALQRMSVIVSTNDERSP 579
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   560 -LFCKGADSSIFPRVHSHQIELTKDHV-ERNAMDGYRTLCVAFKEIPpddferinaqlveaKMALQdreeKLEKVF-DEI 636
Cdd:TIGR01657  580 dAFVKGAPETIQSLCSPETVPSDYQEVlKSYTREGYRVLALAYKELP--------------KLTLQ----KAQDLSrDAV 641
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   637 ETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACRLFQTntellELTTKTIEESERKEDRLH 716
Cdd:TIGR01657  642 ESNLTFLGFIVFENPLKPDTKEVIKELKRASIRTVMITGDNPLTAVHVARECGIVNP-----SNTLILAEAEPPESGKPN 716
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   717 ELLIEY-------RKKLLHEFPKSTRSLKKAWTEhqEYGLIIDGSTLSLILNSSQDcssnnyksiFLQICMKCTAVLcCR 789
Cdd:TIGR01657  717 QIKFEVidsipfaSTQVEIPYPLGQDSVEDLLAS--RYHLAMSGKAFAVLQAHSPE---------LLLRLLSHTTVF-AR 784
                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|...
gi 569010256   790 MAPLQKAQIVRMVKNLkgSPITLSIGDGANDVSMILESHVGIGIKGKEGRQAA 842
Cdd:TIGR01657  785 MAPDQKETLVELLQKL--DYTVGMCGDGANDCGALKQADVGISLSEAEASVAA 835
P-type_ATPases cd01431
ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, ...
535-845 8.90e-24

ATP-dependent membrane-bound cation and aminophospholipid transporters; The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd(2+), and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319764 [Multi-domain]  Cd Length: 319  Bit Score: 103.30  E-value: 8.90e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  535 LHTLNFDSVRRRMSVIVRTqKGDILLFCKGADSSIFPRVHSHQIELTKDHVER----NAMDGYRTLCVAFKEIPPDDFEr 610
Cdd:cd01431    22 IEEIPFNSTRKRMSVVVRL-PGRYRAIVKGAPETILSRCSHALTEEDRNKIEKaqeeSAREGLRVLALAYREFDPETSK- 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  611 inaqlveakmalqdreeklekvfDEIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACRL 690
Cdd:cd01431   100 -----------------------EAVELNLVFLGLIGLQDPPRPEVKEAIAKCRTAGIKVVMITGDNPLTAIAIAREIGI 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  691 FQTNTELLELttktiEESERKEDRLHELLIeyrkkllhefpkstrslkkawtehqeygliidgstlslilnssqdcssnn 770
Cdd:cd01431   157 DTKASGVILG-----EEADEMSEEELLDLI-------------------------------------------------- 181
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 569010256  771 yksiflqicmkCTAVLCCRMAPLQKAQIVRMVKNLKGspITLSIGDGANDVSMILESHVGIGIkGKEGRQAARNS 845
Cdd:cd01431   182 -----------AKVAVFARVTPEQKLRIVKALQARGE--VVAMTGDGVNDAPALKQADVGIAM-GSTGTDVAKEA 242
P-type_ATPase_Ca_PMCA-like cd02081
animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related ...
495-712 1.32e-22

animal plasma membrane Ca2(+)-ATPases (PMCA), similar to human ATP2B1-4/PMCA1-4, and related Ca2(+)-ATPases including Saccharomyces cerevisiae vacuolar PMC1; Animal PMCAs function to export Ca(2+) from cells and play a role in regulating Ca(2+) signals following stimulus induction and in preventing calcium toxicity. Many PMCA pump variants exist due to alternative splicing of transcripts. PMCAs are regulated by the binding of calmodulin or by kinase-mediated phosphorylation. Saccharomyces cerevisiae vacuolar transporter Pmc1p facilitates the accumulation of Ca2+ into vacuoles. Pmc1p is not regulated by direct calmodulin binding but responds to the calmodulin/calcineurin-signaling pathway and is controlled by the transcription factor complex Tcn1p/Crz1p. Similarly, the expression of the gene for Dictyostelium discoideum Ca(2+)-ATPase PAT1, patA, is under the control of a calcineurin-dependent transcription factor. Plant vacuolar Ca(2+)-ATPases, are regulated by direct-calmodulin binding. Plant Ca(2+)-ATPases are present at various cellular locations including the plasma membrane, endoplasmic reticulum, chloroplast and vacuole. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319776 [Multi-domain]  Cd Length: 721  Bit Score: 104.21  E-value: 1.32e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  495 SPDEIALVKGAKRFGFTFlgnqngyirveNQRKEIEEYELLHTLNFDSVRRRMSVIVRTQKGDILLFCKGA--------- 565
Cdd:cd02081   340 NKTECALLGFVLELGGDY-----------RYREKRPEEKVLKVYPFNSARKRMSTVVRLKDGGYRLYVKGAseivlkkcs 408
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  566 ----DSSIFPRVHSHQIELTKDHVERNAMDGYRTLCVAFKEIPPDDferinaqlveakmalQDREEKLEKVFDEIETNMN 641
Cdd:cd02081   409 yilnSDGEVVFLTSEKKEEIKRVIEPMASDSLRTIGLAYRDFSPDE---------------EPTAERDWDDEEDIESDLT 473
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 569010256  642 LIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACRLFQTNTELLELTTKTIEESERKE 712
Cdd:cd02081   474 FIGIVGIKDPLRPEVPEAVAKCQRAGITVRMVTGDNINTARAIARECGILTEGEDGLVLEGKEFRELIDEE 544
PhoLip_ATPase_N pfam16209
Phospholipid-translocating ATPase N-terminal; PhoLip_ATPase_N is found at the N-terminus of a ...
37-91 7.55e-22

Phospholipid-translocating ATPase N-terminal; PhoLip_ATPase_N is found at the N-terminus of a number of phospholipid-translocating ATPases. It is found in higher eukaryotes.


Pssm-ID: 435218 [Multi-domain]  Cd Length: 67  Bit Score: 89.83  E-value: 7.55e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 569010256    37 AQRFCDNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQVTVD-TPTSPVTS 91
Cdd:pfam16209   11 KFKYPSNKISTSKYTLLTFLPKNLFEQFRRVANLYFLLIAILQLIPGiSPTGPYTT 66
P-type_ATPase_cation cd07542
P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and ...
401-831 3.03e-19

P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. This subfamily also includes zebrafish ATP13A2 a lysosome-specific transmembrane ATPase protein of unknown function which plays a crucial role during embryonic development, its deletion is lethal. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319842 [Multi-domain]  Cd Length: 760  Bit Score: 93.47  E-value: 3.03e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  401 GQVDYVFTDKTGTLTENSMEFIeCCIDGHKYKGTTQEVDGLSQtdgplayfDKADKNREALFLRALCLCHTVEMktnddV 480
Cdd:cd07542   303 GKINLVCFDKTGTLTEDGLDLW-GVRPVSGNNFGDLEVFSLDL--------DLDSSLPNGPLLRAMATCHSLTL-----I 368
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  481 DGPVEGagftyissSPDEIalvkgaKRFGFTflgnqnGYIrvenqrkeieeYELLHTLNFDSVRRRMSVIVRTQKGDIL- 559
Cdd:cd07542   369 DGELVG--------DPLDL------KMFEFT------GWS-----------LEILRQFPFSSALQRMSVIVKTPGDDSMm 417
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  560 LFCKGADSSI--------FPRVHSHQI-ELTKdhvernamDGYRTLCVAFKEIPPDDFERInaqlveakmalqdreeKLE 630
Cdd:cd07542   418 AFTKGAPEMIaslckpetVPSNFQEVLnEYTK--------QGFRVIALAYKALESKTWLLQ----------------KLS 473
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  631 KvfDEIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACRLFQTNtellelttktieeser 710
Cdd:cd07542   474 R--EEVESDLEFLGLIVMENRLKPETAPVINELNRANIRTVMVTGDNLLTAISVARECGMISPS---------------- 535
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  711 kedrlhellieyRKKLLHEFPKSTRSlkkawtehqeygliidgstlslilnssqDCSSNNYKsiflqICMKCTaVLcCRM 790
Cdd:cd07542   536 ------------KKVILIEAVKPEDD----------------------------DSASLTWT-----LLLKGT-VF-ARM 568
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|..
gi 569010256  791 APLQKAQIVRMVKNLkgsPITLSI-GDGANDVSMILESHVGI 831
Cdd:cd07542   569 SPDQKSELVEELQKL---DYTVGMcGDGANDCGALKAADVGI 607
P-type_ATPase_cation cd07543
P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 ...
125-831 1.15e-18

P-type cation-transporting ATPases, similar to human cation-transporting ATPase type 13A1 (ATP13A1) and Saccharomyces manganese-transporting ATPase 1 Spf1p; Saccharomyces Spf1p may mediate manganese transport into the endoplasmic reticulum (ER); one consequence of deletion of SPF1 is severe ER stress. This subfamily also includes Arabidopsis thaliana MIA (Male Gametogenesis Impaired Anthers) protein which is highly abundant in the endoplasmic reticulum and small vesicles of developing pollen grains and tapetum cells. The MIA gene functionally complements a mutant in the SPF1 from Saccharomyces cerevisiae. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319843 [Multi-domain]  Cd Length: 804  Bit Score: 91.68  E-value: 1.15e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  125 VYIIENAKRVRKESEKIKVGDVVEV---QANETFPCDLILLsscttDGTCYVTTASLDGESNCKThyavRDTIALCTAES 201
Cdd:cd07543    88 IQVYRDGKWVPISSDELLPGDLVSIgrsAEDNLVPCDLLLL-----RGSCIVNEAMLTGESVPLM----KEPIEDRDPED 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  202 IDNLRAtieceqpqpdlyrfVGRISIYSNSIEAVARSlGPENLLLK---GATLkntkkiyGVAVYTGMETKmalnyQGKS 278
Cdd:cd07543   159 VLDDDG--------------DDKLHVLFGGTKVVQHT-PPGKGGLKppdGGCL-------AYVLRTGFETS-----QGKL 211
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  279 QK---CSAVEKSIN---AFL-IVYLFILLTKAAVcttlkYVWQsspyndepwynQKTQKERETFQVlkmftdFLSFMVLF 351
Cdd:cd07543   212 LRtilFSTERVTANnleTFIfILFLLVFAIAAAA-----YVWI-----------EGTKDGRSRYKL------FLECTLIL 269
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  352 NFIIP------VSMYVT---VEMQKF----LGSFFISWdkdffdeeinegalvntsdlneeLGQVDYVFTDKTGTLTENS 418
Cdd:cd07543   270 TSVVPpelpmeLSLAVNtslIALAKLyifcTEPFRIPF-----------------------AGKVDICCFDKTGTLTSDD 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  419 MEFieccidghkykgttQEVDGLSqtDGPLAYFDKADKNREALflRALCLCHT-VEMKTNDDVDGPVEGAGFTYISSSpd 497
Cdd:cd07543   327 LVV--------------EGVAGLN--DGKEVIPVSSIEPVETI--LVLASCHSlVKLDDGKLVGDPLEKATLEAVDWT-- 386
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  498 eiaLVKGAKrfgftflgnqngyirVENQRKEIEEYELLHTLNFDSVRRRMSVIVR-----TQKGDILLFCKGADSSIfpr 572
Cdd:cd07543   387 ---LTKDEK---------------VFPRSKKTKGLKIIQRFHFSSALKRMSVVASykdpgSTDLKYIVAVKGAPETL--- 445
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  573 vHSHQIELTKDHVE---RNAMDGYRTLCVAFKEIPPddferinaqlveakmalQDREEKLEKVFDEIETNMNLIGATAVE 649
Cdd:cd07543   446 -KSMLSDVPADYDEvykEYTRQGSRVLALGYKELGH-----------------LTKQQARDYKREDVESDLTFAGFIVFS 507
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  650 DKLQDQAAETIEALHAAGLKVWVLTGDKMETAkstCYACRlfqtntellELTtktieeserkedrlhellieyrkkllhe 729
Cdd:cd07543   508 CPLKPDSKETIKELNNSSHRVVMITGDNPLTA---CHVAK---------ELG---------------------------- 547
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  730 fpkstrslkkawtehqeyglIIDGSTLSLILnsSQDCSSNNYKSIFlqicmkcTAVLCCRMAPLQKAQIVRMVKNLkgSP 809
Cdd:cd07543   548 --------------------IVDKPVLILIL--SEEGKSNEWKLIP-------HVKVFARVAPKQKEFIITTLKEL--GY 596
                         730       740
                  ....*....|....*....|..
gi 569010256  810 ITLSIGDGANDVSMILESHVGI 831
Cdd:cd07543   597 VTLMCGDGTNDVGALKHAHVGV 618
P-type_ATPase_Na_ENA cd02086
fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces ...
398-683 3.02e-18

fungal-type Na(+)-ATPase, similar to the plasma membrane sodium transporters Saccharomyces cerevisiae Ena1p, Ena2p and Ustilago maydis Ena1, and the endoplasmic reticulum sodium transporter Ustilago maydis Ena2; Fungal-type Na(+)-ATPase (also called ENA ATPases). This subfamily includes the Saccharomyces cerevisiae plasma membrane transporters: Na(+)/Li(+)-exporting ATPase Ena1p which may also extrudes K(+), and Na(+)-exporting P-type ATPase Ena2p. It also includes Ustilago maydis plasma membrane Ena1, an K(+)/Na(+)-ATPase whose chief role is to pump Na(+) and K(+) out of the cytoplasm, especially at high pH values, and endoplasmic reticulum Ena2 ATPase which mediates Na(+) or K(+) fluxes in the ER or in other endomembranes. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319780 [Multi-domain]  Cd Length: 920  Bit Score: 90.59  E-value: 3.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  398 EELGQVDYVFTDKTGTLTENSMefieccidghkykgttqevdglsqtdgplayfdkadKNREALFLRALCLCHTVEmKTN 477
Cdd:cd02086   323 EALGAVTDICSDKTGTLTQGKM------------------------------------VVRQVWIPAALCNIATVF-KDE 365
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  478 DDVDGPVEGagftyissSPDEIALVKGAKRFGFtflGNQNGYIRVENQRKEIEEYEllhtlnFDSVRRRMSVI-VRTQKG 556
Cdd:cd02086   366 ETDCWKAHG--------DPTEIALQVFATKFDM---GKNALTKGGSAQFQHVAEFP------FDSTVKRMSVVyYNNQAG 428
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  557 DILLFCKGADSSIFPRVHSHQ------------IELTKDHVERNAMDGYRTLCVAFKEIPPDDFErinaqlveakmALQD 624
Cdd:cd02086   429 DYYAYMKGAVERVLECCSSMYgkdgiiplddefRKTIIKNVESLASQGLRVLAFASRSFTKAQFN-----------DDQL 497
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 569010256  625 REEKLEKvfDEIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKS 683
Cdd:cd02086   498 KNITLSR--ADAESDLTFLGLVGIYDPPRNESAGAVEKCHQAGITVHMLTGDHPGTAKA 554
P-type_ATPase_cation cd02082
P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins ...
138-842 3.03e-18

P-type cation-transporting ATPases, similar to human ATPase type 13A1-A4 (ATP13A1-A4) proteins and Saccharomyces cerevisiae Ypk9p and Spf1p; Saccharomyces cerevisiae Yph9p localizes to the yeast vacuole and may play a role in sequestering heavy metal ions, its deletion confers sensitivity for growth for cadmium, manganese, nickel or selenium. Saccharomyces 1 Spf1p may mediate manganese transport into the endoplasmic reticulum. Human ATP13A2 (PARK9/CLN12) is a lysosomal transporter with zinc as the possible substrate. Mutation in the ATP13A2 gene has been linked to Parkinson's disease and Kufor-Rakeb syndrome, and to neuronal ceroid lipofuscinoses. ATP13A3/AFURS1 is a candidate gene for oculo auriculo vertebral spectrum (OAVS), being one of nine genes included in a 3q29 microduplication in a patient with OAVS. Mutation in the human ATP13A4 may be involved in a speech-language disorder. The expression of ATP13A1 has been followed during mouse development, ATP13A1 transcript expression showed an increase as development progressed, with the highest expression at the peak of neurogenesis. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319777 [Multi-domain]  Cd Length: 786  Bit Score: 90.34  E-value: 3.03e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  138 SEKIKVGDVVEVQANET-FPCDLILLsscttDGTCYVTTASLdgesnckthyavrdtialcTAESIDNLRATIECEQPQP 216
Cdd:cd02082   102 SNMIVPGDIVLIKRREVtLPCDCVLL-----EGSCIVTEAML-------------------TGESVPIGKCQIPTDSHDD 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  217 DLYRFVG--RISIYSNSieAVARSLGPENLLLKGatlkntkkiygVAVYTGMETkmalnYQGKSQKCSAVEKSINA--FL 292
Cdd:cd02082   158 VLFKYESskSHTLFQGT--QVMQIIPPEDDILKA-----------IVVRTGFGT-----SKGQLIRAILYPKPFNKkfQQ 219
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  293 IVYLFILLTKAAVCTTLKYVWQSSPYNDEPwynqktqkeretfqVLKMFTDFLSFMVlfnFIIPVSMYVTVEMQKFLGSF 372
Cdd:cd02082   220 QAVKFTLLLATLALIGFLYTLIRLLDIELP--------------PLFIAFEFLDILT---YSVPPGLPMLIAITNFVGLK 282
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  373 FISwdkdffdeeiNEGALVNTSDLNEELGQVDYVFTDKTGTLTENSMEFIeccidGHKYKGTTQEVDGLSQTdgplayfd 452
Cdd:cd02082   283 RLK----------KNQILCQDPNRISQAGRIQTLCFDKTGTLTEDKLDLI-----GYQLKGQNQTFDPIQCQ-------- 339
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  453 kaDKNREALFLRALCLCHTVeMKTNDDVDG-PVEGAGFTYISSSPDEIALVKGAkrfgFTFLGNQNGYIRVENQrkeiee 531
Cdd:cd02082   340 --DPNNISIEHKLFAICHSL-TKINGKLLGdPLDVKMAEASTWDLDYDHEAKQH----YSKSGTKRFYIIQVFQ------ 406
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  532 yellhtlnFDSVRRRMSVIVRTQKGDILLFC-----KGADSSIfPRVHSHQIELTKDHVERNAMDGYRTLCVAFKEIPPd 606
Cdd:cd02082   407 --------FHSALQRMSVVAKEVDMITKDFKhyafiKGAPEKI-QSLFSHVPSDEKAQLSTLINEGYRVLALGYKELPQ- 476
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  607 dferinaqlveakmalQDREEKLEKVFDEIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCY 686
Cdd:cd02082   477 ----------------SEIDAFLDLSREAQEANVQFLGFIIYKNNLKPDTQAVIKEFKEACYRIVMITGDNPLTALKVAQ 540
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  687 ACrlfqtntELLELTTKTIeeserkedrLHELLIeyrkkllhefPKSTRSLKKAWTehqeygLIIDGSTLSlilnssqdc 766
Cdd:cd02082   541 EL-------EIINRKNPTI---------IIHLLI----------PEIQKDNSTQWI------LIIHTNVFA--------- 579
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 569010256  767 ssnnyksiflqicmkctavlccRMAPLQKAQIVRMVKNLkgSPITLSIGDGANDVSMILESHVGIGIKGKEGRQAA 842
Cdd:cd02082   580 ----------------------RTAPEQKQTIIRLLKES--DYIVCMCGDGANDCGALKEADVGISLAEADASFAS 631
P-type_ATPase_SERCA cd02083
sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; ...
398-697 4.81e-16

sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3; SERCA is a transmembrane (Ca2+)-ATPase and a major regulator of Ca(2+) homeostasis and contractility in cardiac and skeletal muscle. It re-sequesters cytoplasmic Ca(2+) to the sarco/endoplasmic reticulum store, thereby also terminating Ca(2+)-induced signaling such as in muscle contraction. Three genes (ATP2A1-3/SERCA1-3) encode SERCA pumps in mammals, further isoforms exist due to alternative splicing of transcripts. The activity of SERCA is regulated by two small membrane proteins called phospholamban and sarcolipin. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319778 [Multi-domain]  Cd Length: 979  Bit Score: 83.49  E-value: 4.81e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  398 EELGQVDYVFTDKTGTLTENSMEFIECCI-DGHKYKGTTQEVDGLSQTDGPLAYFDKADKNREALFLRALclchtVEMKT 476
Cdd:cd02083   335 ETLGCTSVICSDKTGTLTTNQMSVSRMFIlDKVEDDSSLNEFEVTGSTYAPEGEVFKNGKKVKAGQYDGL-----VELAT 409
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  477 -----ND---DVDgpvEGAGFTYISSSPDEIALVKGAKRFGFtFLGNQNGYIRVENQ---RKEIE-EYELLHTLNFDSVR 544
Cdd:cd02083   410 icalcNDsslDYN---ESKGVYEKVGEATETALTVLVEKMNV-FNTDKSGLSKRERAnacNDVIEqLWKKEFTLEFSRDR 485
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  545 RRMSVIVRTQKGDI--LLFCKGADSSIFPRVhSH---------------QIELTKDHVERNAmDGYRTLCVAFKEIPPDD 607
Cdd:cd02083   486 KSMSVYCSPTKASGgnKLFVKGAPEGVLERC-THvrvgggkvvpltaaiKILILKKVWGYGT-DTLRCLALATKDTPPKP 563
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  608 ferinaqlveAKMALQDREEklekvFDEIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYA 687
Cdd:cd02083   564 ----------EDMDLEDSTK-----FYKYETDLTFVGVVGMLDPPRPEVRDSIEKCRDAGIRVIVITGDNKGTAEAICRR 628
                         330
                  ....*....|
gi 569010256  688 CRLFQTNTEL 697
Cdd:cd02083   629 IGIFGEDEDT 638
P-type_ATPase_Ca_prok cd02089
prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL ...
398-683 5.35e-15

prokaryotic P-type Ca(2+)-ATPase similar to Synechococcus elongatus sp. strain PCC 7942 PacL and Listeria monocytogenes LMCA1; Ca(2+) transport ATPase is a plasma membrane protein which pumps Ca(2+) ion out of the cytoplasm. This prokaryotic subfamily includes the Ca(2+)-ATPase Synechococcus elongatus PacL, Listeria monocytogenes Ca(2+)-ATPase 1 (LMCA1) which has a low Ca(2+) affinity and a high pH optimum (pH about 9) and may remove Ca(2+) from the microorganism in environmental conditions when e.g. stressed by high Ca(2+) and alkaline pH, and the Bacillus subtilis putative P-type Ca(2+)-transport ATPase encoded by the yloB gene, which is expressed during sporulation. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319781 [Multi-domain]  Cd Length: 674  Bit Score: 79.58  E-value: 5.35e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  398 EELGQVDYVFTDKTGTLTENSMefieccidghkykgTTQEVdglsqtdgplayfdkadknrealflralclchtvemktn 477
Cdd:cd02089   294 ETLGSVSVICSDKTGTLTQNKM--------------TVEKI--------------------------------------- 320
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  478 ddvdgpvegagftYISSSPDEIALVKGAKRFGFTFLGNQNGYIRVEnqrkEIEeyellhtlnFDSVRRRMSVIVRTqKGD 557
Cdd:cd02089   321 -------------YTIGDPTETALIRAARKAGLDKEELEKKYPRIA----EIP---------FDSERKLMTTVHKD-AGK 373
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  558 ILLFCKGADSSIFPR----VHSHQI----ELTKDHVER--NAM--DGYRTLCVAFKEIPPDDFErinaqlveakmalqdr 625
Cdd:cd02089   374 YIVFTKGAPDVLLPRctyiYINGQVrpltEEDRAKILAvnEEFseEALRVLAVAYKPLDEDPTE---------------- 437
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 569010256  626 eeklekVFDEIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKS 683
Cdd:cd02089   438 ------SSEDLENDLIFLGLVGMIDPPRPEVKDAVAECKKAGIKTVMITGDHKLTARA 489
P-type_ATPase_Mg cd02077
magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella ...
400-685 5.63e-15

magnesium transporting ATPase (MgtA), similar to Escherichia coli MgtA and Salmonella typhimurium MgtA; MgtA is a membrane protein which actively transports Mg(2+) into the cytosol with its electro-chemical gradient rather than against the gradient as other cation transporters do. It may act both as a transporter and as a sensor for Mg(2+). In Salmonella typhimurium and Escherichia coli, the two-component system PhoQ/PhoP regulates the transcription of the mgtA gene by sensing Mg(2+) concentrations in the periplasm. MgtA is activated by cardiolipin and it highly sensitive to free magnesium in vitro. It consists of a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319772 [Multi-domain]  Cd Length: 768  Bit Score: 79.98  E-value: 5.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  400 LGQVDYVFTDKTGTLTENSMEFIEccidghkykgttqevdglsqtdgplaYFDkadknrealflralclchtVEMKTNDD 479
Cdd:cd02077   304 FGAMDILCTDKTGTLTQDKIVLER--------------------------HLD-------------------VNGKESER 338
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  480 VdgpvegAGFTYISSS-------PDEIALVKGAkrfgftflgNQNGYIRVENQRKEIEEyellhtLNFDSVRRRMSVIVR 552
Cdd:cd02077   339 V------LRLAYLNSYfqtglknLLDKAIIDHA---------EEANANGLIQDYTKIDE------IPFDFERRRMSVVVK 397
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  553 TQKGDILLFCKGA-------------DSSIFPRVHSHQIELTKDHVERNAmDGYRTLCVAFKEIPPDDFErinaqlveak 619
Cdd:cd02077   398 DNDGKHLLITKGAveeilnvcthvevNGEVVPLTDTLREKILAQVEELNR-EGLRVLAIAYKKLPAPEGE---------- 466
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 569010256  620 malqdreeklekvFDEI-ETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTC 685
Cdd:cd02077   467 -------------YSVKdEKELILIGFLAFLDPPKESAAQAIKALKKNGVNVKILTGDNEIVTKAIC 520
Cation_ATPase pfam13246
Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including ...
467-572 2.39e-14

Cation transport ATPase (P-type); This domain is found in cation transport ATPases, including phospholipid-transporting ATPases, calcium-transporting ATPases, and sodium-potassium ATPases.


Pssm-ID: 433060 [Multi-domain]  Cd Length: 91  Bit Score: 69.55  E-value: 2.39e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   467 CLCHTVEMKTNDDVdgpvegaGFTYISSSPDEIALVKGAKRFGftflgnqngyIRVENQRKEieeYELLHTLNFDSVRRR 546
Cdd:pfam13246    1 ALCNSAAFDENEEK-------GKWEIVGDPTESALLVFAEKMG----------IDVEELRKD---YPKVAEIPFNSDRKR 60
                           90       100
                   ....*....|....*....|....*..
gi 569010256   547 MSVIVRTQK-GDILLFCKGADSSIFPR 572
Cdd:pfam13246   61 MSTVHKLPDdGKYRLFVKGAPEIILDR 87
P-type_ATPase_cation cd02080
P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, ...
398-683 7.78e-13

P-type cation-transporting ATPase similar to Exiguobacterium aurantiacum Mna, an Na(+)-ATPase, and Synechocystis sp. PCC 6803 PMA1, a putative Ca(2+)-ATPase; This subfamily includes the P-type Na(+)-ATPase of an alkaliphilic bacterium Exiguobacterium aurantiacum Mna and cyanobacterium Synechocystis sp. PCC 6803 PMA1, a cation-transporting ATPase which may translocate calcium. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319775 [Multi-domain]  Cd Length: 819  Bit Score: 73.07  E-value: 7.78e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  398 EELGQVDYVFTDKTGTLTENSMefieccidghkykgTTQEVdglsqtdgplayfdkadknrealflraLCLCHTVEMKTN 477
Cdd:cd02080   294 ETLGSVTVICSDKTGTLTRNEM--------------TVQAI---------------------------VTLCNDAQLHQE 332
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  478 DDVDGpvegagftyISSSPDEIALVKGAKRFGFtflgnqngyirveNQRKEIEEYELLHTLNFDSVRRRMSVIVRtQKGD 557
Cdd:cd02080   333 DGHWK---------ITGDPTEGALLVLAAKAGL-------------DPDRLASSYPRVDKIPFDSAYRYMATLHR-DDGQ 389
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  558 ILLFCKGADSSIFPR---------VHSHQIELTKDHVERNAMDGYRTLCVAFKEIPPddferinaqlveakmalqdreEK 628
Cdd:cd02080   390 RVIYVKGAPERLLDMcdqelldggVSPLDRAYWEAEAEDLAKQGLRVLAFAYREVDS---------------------EV 448
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 569010256  629 LEKVFDEIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKS 683
Cdd:cd02080   449 EEIDHADLEGGLTFLGLQGMIDPPRPEAIAAVAECQSAGIRVKMITGDHAETARA 503
PRK15122 PRK15122
magnesium-transporting ATPase; Provisional
514-689 1.11e-12

magnesium-transporting ATPase; Provisional


Pssm-ID: 237914 [Multi-domain]  Cd Length: 903  Bit Score: 72.37  E-value: 1.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  514 GNQNGYIRVENQRKEIEEyellhtLNFDSVRRRMSVIVRTQKGDILLFCKGADS---SIFPRVHSHQIELTKDHVERNAM 590
Cdd:PRK15122  427 AEGNPEIVKPAGYRKVDE------LPFDFVRRRLSVVVEDAQGQHLLICKGAVEemlAVATHVRDGDTVRPLDEARRERL 500
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  591 ---------DGYRTLCVAFKEIPPDDferINAQLVEAKmalqdreeklekvfdeiETNMNLIGATAVEDKLQDQAAETIE 661
Cdd:PRK15122  501 lalaeaynaDGFRVLLVATREIPGGE---SRAQYSTAD-----------------ERDLVIRGFLTFLDPPKESAAPAIA 560
                         170       180
                  ....*....|....*....|....*...
gi 569010256  662 ALHAAGLKVWVLTGDkmeTAKSTCYACR 689
Cdd:PRK15122  561 ALRENGVAVKVLTGD---NPIVTAKICR 585
P-type_ATPase cd07539
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
535-844 3.82e-12

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319840 [Multi-domain]  Cd Length: 634  Bit Score: 70.52  E-value: 3.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  535 LHTLNFDSVRRRMSVIVRTQKGDILLFCKGADSSIFPR-----VHSHQIELTKDH-------VERNAMDGYRTLCVAFKE 602
Cdd:cd07539   324 LAELPFESSRGYAAAIGRTGGGIPLLAVKGAPEVVLPRcdrrmTGGQVVPLTEADrqaieevNELLAGQGLRVLAVAYRT 403
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  603 IppDDFERinaqlveakmalqdreEKLEKVFDEIEtnmnLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAK 682
Cdd:cd07539   404 L--DAGTT----------------HAVEAVVDDLE----LLGLLGLADTARPGAAALIAALHDAGIDVVMITGDHPITAR 461
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  683 StcYACRLfqtntellelttktieeserkedrlhellieyrkkllhefpkstrslkkAWTEHQEyglIIDGSTLSlilns 762
Cdd:cd07539   462 A--IAKEL-------------------------------------------------GLPRDAE---VVTGAELD----- 482
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  763 sqDCSSNNYKSIFLQIcmkctaVLCCRMAPLQKAQIVRMVKnlKGSPITLSIGDGANDVSMILESHVGIGIkGKEGRQAA 842
Cdd:cd07539   483 --ALDEEALTGLVADI------DVFARVSPEQKLQIVQALQ--AAGRVVAMTGDGANDAAAIRAADVGIGV-GARGSDAA 551

                  ..
gi 569010256  843 RN 844
Cdd:cd07539   552 RE 553
PRK10517 PRK10517
magnesium-transporting P-type ATPase MgtA;
522-686 5.06e-12

magnesium-transporting P-type ATPase MgtA;


Pssm-ID: 236705 [Multi-domain]  Cd Length: 902  Bit Score: 70.48  E-value: 5.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  522 VENQRKEIEEYELLHTLNFDSVRRRMSVIVRTQKGDILLFCKGADSSIFP-----RVHSHQIELTKDHVER--------N 588
Cdd:PRK10517  431 EESARSLASRWQKIDEIPFDFERRRMSVVVAENTEHHQLICKGALEEILNvcsqvRHNGEIVPLDDIMLRRikrvtdtlN 510
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  589 AmDGYRTLCVAFKEIPPD--DFERINaqlveakmalqdreeklekvfdeiETNMNLIGATAVEDKLQDQAAETIEALHAA 666
Cdd:PRK10517  511 R-QGLRVVAVATKYLPARegDYQRAD------------------------ESDLILEGYIAFLDPPKETTAPALKALKAS 565
                         170       180
                  ....*....|....*....|
gi 569010256  667 GLKVWVLTGDKMETAKSTCY 686
Cdd:PRK10517  566 GVTVKILTGDSELVAAKVCH 585
ATPase-IID_K-Na TIGR01523
potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium ...
354-683 9.09e-12

potassium and/or sodium efflux P-type ATPase, fungal-type; Initially described as a calcium efflux ATPase, more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump. This model describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.


Pssm-ID: 130586 [Multi-domain]  Cd Length: 1053  Bit Score: 69.66  E-value: 9.09e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   354 IIPVSMYVTVEMQKFLGSFFISwdkdffdeeiNEGALVNTSDLNEELGQVDYVFTDKTGTLTENSMEFIECCIDGHKYKG 433
Cdd:TIGR01523  320 IIPESLIAVLSITMAMGAANMS----------KRNVIVRKLDALEALGAVNDICSDKTGTITQGKMIARQIWIPRFGTIS 389
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   434 TTQEVDGLSQTDG---------PLAYFDKADKNREAL-----------------------FLRALCLCHTVEMKTNDDVD 481
Cdd:TIGR01523  390 IDNSDDAFNPNEGnvsgiprfsPYEYSHNEAADQDILkefkdelkeidlpedidmdlfikLLETAALANIATVFKDDATD 469
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   482 GPVegagftyISSSPDEIALVKGAKRFGFTFLG------------NQNGYIRVENQRKEIEEYELLHTLNFDSVRRRMSV 549
Cdd:TIGR01523  470 CWK-------AHGDPTEIAIHVFAKKFDLPHNAltgeedllksneNDQSSLSQHNEKPGSAQFEFIAEFPFDSEIKRMAS 542
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   550 IVRTQKGDIL-LFCKGADSSIFPRVHSH--------------QIELTKDHVERNAMDGYRTLCVAFKEIPPDDferinaq 614
Cdd:TIGR01523  543 IYEDNHGETYnIYAKGAFERIIECCSSSngkdgvkispledcDRELIIANMESLAAEGLRVLAFASKSFDKAD------- 615
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 569010256   615 lveaKMALQDREEKLEKvfDEIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKS 683
Cdd:TIGR01523  616 ----NNDDQLKNETLNR--ATAESDLEFLGLIGIYDPPRNESAGAVEKCHQAGINVHMLTGDFPETAKA 678
P-type_ATPase_H cd02076
plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+) ...
345-685 1.48e-08

plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases; This subfamily includes eukaryotic plasma membrane H(+)-ATPase which transports H(+) from the cytosol to the extracellular space, thus energizing the plasma membrane for the uptake of ions and nutrients, and is expressed in plants and fungi. This H(+)-ATPase consists of four domains: a transmembrane domain and three cytosolic domains: nucleotide-binding domain, phosphorylation domain and actuator domain, and belongs to the P-type ATPase type III subfamily. This subfamily also includes the putative P-type H(+)-ATPase, MJ1226p of the anaerobic hyperthermophilic archaea Methanococcus jannaschii. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319771 [Multi-domain]  Cd Length: 781  Bit Score: 58.78  E-value: 1.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  345 LSF-MVLFNFIIPVSMYVTVEMQKFLGSFFISwdkdffdeeiNEGALVntSDLN--EELGQVDYVFTDKTGTLTENSMEF 421
Cdd:cd02076   235 LQFvLVLLIASIPVAMPAVLTVTMAVGALELA----------KKKAIV--SRLSaiEELAGVDILCSDKTGTLTLNKLSL 302
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  422 IECCidghkykgttqevdglsqtdgPLAYFDKADknrealFLRALCLCHTVEmkTNDDVDgpvegagftyissspdeIAL 501
Cdd:cd02076   303 DEPY---------------------SLEGDGKDE------LLLLAALASDTE--NPDAID-----------------TAI 336
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  502 VKGAKRFGftflgnqngyirvenqrKEIEEYELLHTLNFDSVRRRMSVIVRTQKGDILLFCKGADSSIFPRVHsHQIELT 581
Cdd:cd02076   337 LNALDDYK-----------------PDLAGYKQLKFTPFDPVDKRTEATVEDPDGERFKVTKGAPQVILELVG-NDEAIR 398
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  582 K---DHVERNAMDGYRTLCVAFKEIPPddferinaqlveakmalqdreeklekvfdeietNMNLIGATAVEDKLQDQAAE 658
Cdd:cd02076   399 QaveEKIDELASRGYRSLGVARKEDGG---------------------------------RWELLGLLPLFDPPRPDSKA 445
                         330       340
                  ....*....|....*....|....*..
gi 569010256  659 TIEALHAAGLKVWVLTGDKMETAKSTC 685
Cdd:cd02076   446 TIARAKELGVRVKMITGDQLAIAKETA 472
P-type_ATPase_Cu-like cd02094
P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A ...
642-683 3.36e-07

P-type heavy metal-transporting ATPase, similar to human copper-transporting ATPases, ATP7A and ATP7B; The mammalian copper-transporting P-type ATPases, ATP7A and ATP7B are key molecules required for the regulation and maintenance of copper homeostasis. Menkes and Wilson diseases are caused by mutation in ATP7A and ATP7B respectively. This subfamily includes other copper-transporting ATPases such as: Bacillus subtilis CopA , Archeaoglobus fulgidus CopA, and Saccharomyces cerevisiae Ccc2p. This subclass of P-type ATPase is also referred to as CPx-type ATPases because their amino acid sequences contain a characteristic CPC or CPH motif associated with a stretch of hydrophobic amino acids and N-terminal ion-binding sequences. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319783 [Multi-domain]  Cd Length: 647  Bit Score: 54.41  E-value: 3.36e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 569010256  642 LIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKS 683
Cdd:cd02094   459 LAGLIAVADPLKPDAAEAIEALKKMGIKVVMLTGDNRRTARA 500
ATPase-IIIB_Mg TIGR01524
magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ...
538-685 7.76e-07

magnesium-translocating P-type ATPase; This model describes the magnesium translocating P-type ATPase found in a limited number of bacterial species and best described in Salmonella typhimurium, which contains two isoforms. These transporters are active in low external Mg2+ concentrations and pump the ion into the cytoplasm. The magnesium ATPases have been classified as type IIIB by a phylogenetic analysis. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 130587 [Multi-domain]  Cd Length: 867  Bit Score: 53.33  E-value: 7.76e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   538 LNFDSVRRRMSVIVRTQKGDILLFCKGAdssifprvhSHQIELTKDHVERNamDGYRTLCVAFKEIPPDDFERINAQ--- 614
Cdd:TIGR01524  412 IPFDFDRRRLSVVVENRAEVTRLICKGA---------VEEMLTVCTHKRFG--GAVVTLSESEKSELQDMTAEMNRQgir 480
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 569010256   615 -LVEAKMALQDREEKLEKvfdEIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTC 685
Cdd:TIGR01524  481 vIAVATKTLKVGEADFTK---TDEEQLIIEGFLGFLDPPKESTKEAIAALFKNGINVKVLTGDNEIVTARIC 549
ZntA COG2217
Cation transport ATPase [Inorganic ion transport and metabolism];
642-683 2.26e-06

Cation transport ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 225127 [Multi-domain]  Cd Length: 713  Bit Score: 51.83  E-value: 2.26e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 569010256  642 LIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKS 683
Cdd:COG2217   528 LVGVIALADELRPDAKEAIAALKALGIKVVMLTGDNRRTAEA 569
E1-E2_ATPase pfam00122
E1-E2 ATPase;
119-182 1.01e-05

E1-E2 ATPase;


Pssm-ID: 425475 [Multi-domain]  Cd Length: 181  Bit Score: 47.18  E-value: 1.01e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 569010256   119 EVNKSAVYIIENAKRVRKESEKIKVGDVVEVQANETFPCDLILLSscttdGTCYVTTASLDGES 182
Cdd:pfam00122    1 SLLPPTATVLRDGTEEEVPADELVPGDIVLLKPGERVPADGRIVE-----GSASVDESLLTGES 59
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
642-684 6.08e-05

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 47.21  E-value: 6.08e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 569010256  642 LIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKST 684
Cdd:cd02079   439 LVGLFALEDQLRPEAKEVIAELKSGGIKVVMLTGDNEAAAQAV 481
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
60-182 2.19e-04

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 45.28  E-value: 2.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   60 LFEQFRRIANFYF----LIIFLVQVTVDTPTSPVTSGLPLFF-----VITVTAIKQGYEDWLRHRADNEVNKSAVYIIEN 130
Cdd:cd02079    47 LRGAWRSLRRGRLnmdvLVSLAAIGAFVASLLTPLLGGIGYFeeaamLLFLFLLGRYLEERARSRARSALKALLSLAPET 126
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 569010256  131 AKRVRKESEK------IKVGDVVEVQANETFPCDLILLSscttdGTCYVTTASLDGES 182
Cdd:cd02079   127 ATVLEDGSTEevpvddLKVGDVVLVKPGERIPVDGVVVS-----GESSVDESSLTGES 179
P-type_ATPase cd07538
uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase ...
523-683 2.47e-04

uncharacterized subfamily of P-type ATPase transporters; This subfamily contains P-type ATPase transporters of unknown function. The P-type ATPases, are a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids. They are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle. A general characteristic of P-type ATPases is a bundle of transmembrane helices which make up the transport path, and three domains on the cytoplasmic side of the membrane. Members include pumps that transport various light metal ions, such as H(+), Na(+), K(+), Ca(2+), and Mg(2+), pumps that transport indispensable trace elements, such as Zn(2+) and Cu(2+), pumps that remove toxic heavy metal ions, such as Cd2+, and pumps such as aminophospholipid translocases which transport phosphatidylserine and phosphatidylethanolamine.


Pssm-ID: 319839 [Multi-domain]  Cd Length: 653  Bit Score: 45.13  E-value: 2.47e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  523 ENQRKEIEEYELLHTLNFDSVRRRMSVIVRTQKGdILLFCKGADSSIFP--RVHSHQIELTKDHVERNAMDGYRTLCVAF 600
Cdd:cd07538   311 KNQMEVVELTSLVREYPLRPELRMMGQVWKRPEG-AFAAAKGSPEAIIRlcRLNPDEKAAIEDAVSEMAGEGLRVLAVAA 389
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  601 KEIppdDFERINAQLVEAKMalqdreeklekvfdeietnmNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMET 680
Cdd:cd07538   390 CRI---DESFLPDDLEDAVF--------------------IFVGLIGLADPLREDVPEAVRICCEAGIRVVMITGDNPAT 446

                  ...
gi 569010256  681 AKS 683
Cdd:cd07538   447 AKA 449
P-type_ATPase_Na-K_like cd02608
alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+) ...
92-683 9.57e-04

alpha-subunit of Na(+)/K(+)-ATPases and of gastric H(+)/K(+)-ATPase, similar to the human Na(+)/K(+)-ATPase alpha subunits 1-4; This subfamily includes the alpha subunit of Na(+)/K(+)-ATPase a heteromeric transmembrane protein composed of an alpha- and beta-subunit and an optional third subunit belonging to the FXYD proteins which are more tissue specific regulatory subunits of the enzyme. The alpha-subunit is the catalytic subunit responsible for transport activities of the enzyme. This subfamily includes all four isotopes of the human alpha subunit: (alpha1-alpha4, encoded by the ATP1A1- ATP1A4 genes). Na(+)/K(+)-ATPase functions chiefly as an ion pump, hydrolyzing one molecule of ATP to pump three Na(+) out of the cell in exchange for two K(+)entering the cell per pump cycle. In addition Na(+)/K(+)-ATPase acts as a signal transducer. This subfamily also includes Oreochromis mossambicus (tilapia) Na(+)/K(+)-ATPase alpha 1 and alpha 3 subunits, and gastric H(+)/K(+)-ATPase which exchanges hydronium ion with potassium and is responsible for gastric acid secretion. Gastric H(+)/K(+)-ATPase is an alpha,beta-heterodimeric enzyme. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319794 [Multi-domain]  Cd Length: 905  Bit Score: 43.49  E-value: 9.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   92 GLPLFFVITVTAIKQGYEDwlrHRAD-------NEVNKSAVyIIENAKRVRKESEKIKVGDVVEVQANETFPCDLILLSS 164
Cdd:cd02608    72 GIVLAAVVIVTGCFSYYQE---AKSSkimdsfkNMVPQQAL-VIRDGEKMQINAEELVVGDLVEVKGGDRIPADIRIISA 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  165 cttdGTCYVTTASLDGESNCKThyavrdtialctaesidnlRATiECEQPQPDLYRfvgRISIYS-NSIEAVARslgpen 243
Cdd:cd02608   148 ----HGCKVDNSSLTGESEPQT-------------------RSP-EFTHENPLETK---NIAFFStNCVEGTAR------ 194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  244 lllkgatlkntkkiyGVAVYTGMETKM----ALNYQ---GKSQKCSAVEKSINAFLIVYLFILLTKAAVCTTLKYVWqss 316
Cdd:cd02608   195 ---------------GIVINTGDRTVMgriaTLASGlevGKTPIAREIEHFIHIITGVAVFLGVSFFILSLILGYTW--- 256
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  317 pyndepwynqktqkeretfqvlkmftdfLSFMVLFNFII----PVSMYVTV---------EMQKflgsffiswdkdffde 383
Cdd:cd02608   257 ----------------------------LEAVIFLIGIIvanvPEGLLATVtvcltltakRMAR---------------- 292
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  384 einEGALVNTSDLNEELGQVDYVFTDKTGTLTENSMEFIECCIDGHKYKGTTQEvdglSQTDgplAYFDKADKNREALFl 463
Cdd:cd02608   293 ---KNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTE----DQSG---ASFDKSSATWLALS- 361
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  464 RALCLCHTVEMKTNDDvDGPV---EGAGftyissSPDEIALVKgakrFGFTFLGNQNGYiRVENqrKEIEEyellhtLNF 540
Cdd:cd02608   362 RIAGLCNRAEFKAGQE-NVPIlkrDVNG------DASESALLK----CIELSCGSVMEM-RERN--PKVAE------IPF 421
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  541 DSVRR-RMSVIVRTQKGD--ILLFCKGADSSIFPR-----VHSHQIELTKDHVER--NA-MD----GYRTLCVAFKEIPP 605
Cdd:cd02608   422 NSTNKyQLSIHENEDPGDprYLLVMKGAPERILDRcstilINGKEQPLDEEMKEAfqNAyLElgglGERVLGFCHLYLPD 501
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  606 DDFERINAqlveakmalqdreeklekvFDEIE-----TNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMET 680
Cdd:cd02608   502 DKFPEGFK-------------------FDTDEvnfptENLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPIT 562

                  ...
gi 569010256  681 AKS 683
Cdd:cd02608   563 AKA 565
P-type_ATPase_HM cd02079
P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) ...
388-424 1.14e-03

P-type heavy metal-transporting ATPase; Heavy metal-transporting ATPases (Type IB ATPases) transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. These ATPases include mammalian copper-transporting ATPases, ATP7A and ATP7B, Bacillus subtilis CadA which transports cadmium, zinc and cobalt out of the cell, Bacillus subtilis ZosA/PfeT which transports copper, and perhaps also zinc and ferrous iron, Archaeoglobus fulgidus CopA and CopB, Staphylococcus aureus plasmid pI258 CadA, a cadmium-efflux ATPase, and Escherichia coli ZntA which is selective for Pb(2+), Zn(2+), and Cd(2+). The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This family belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319774 [Multi-domain]  Cd Length: 617  Bit Score: 42.97  E-value: 1.14e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 569010256  388 GALVNTSDLNEELGQVDYVFTDKTGTLTENSMEFIEC 424
Cdd:cd02079   302 GILIKGGDVLETLAKVDTVAFDKTGTLTEGKPEVTEI 338
P-type_ATPase_HM cd07550
P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily ...
642-698 1.42e-03

P-type heavy metal-transporting ATPase; uncharacterized subfamily; Uncharacterized subfamily of the heavy metal-transporting ATPases (Type IB ATPases) which transport heavy metal ions (Cu(+), Cu(2+), Zn(2+), Cd(2+), Co(2+), etc.) across biological membranes. The characteristic N-terminal heavy metal associated (HMA) domain of this group is essential for the binding of metal ions. This subfamily belongs to the P-type ATPases, a large family of integral membrane transporters that are of critical importance in all kingdoms of life. They generate and maintain (electro-) chemical gradients across cellular membranes, by translocating cations, heavy metals and lipids, and are distinguished from other main classes of transport ATPases (F- , V- , and ABC- type) by the formation of a phosphorylated (P-) intermediate state in the catalytic cycle.


Pssm-ID: 319848 [Multi-domain]  Cd Length: 592  Bit Score: 42.65  E-value: 1.42e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 569010256  642 LIGATAVEDKLQDQAAETIEALHAAG-LKVWVLTGDKMETAKSTCYACRLFQTNTELL 698
Cdd:cd07550   412 LIGVIGLSDPLRPEAAEVIARLRALGgKRIIMLTGDHEQRARALAEQLGIDRYHAEAL 469
ZntA COG2217
Cation transport ATPase [Inorganic ion transport and metabolism];
109-182 1.96e-03

Cation transport ATPase [Inorganic ion transport and metabolism];


Pssm-ID: 225127 [Multi-domain]  Cd Length: 713  Bit Score: 42.20  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256  109 EDWLRHRADNEVN-------KSAVYIIENAKRVRKESEKIKVGDVVEVQANETFPCDLILLSscttdGTCYVTTASLDGE 181
Cdd:COG2217   191 EARAKGRARRAIRalldlapKTATVVRGDGEEEEVPVEEVQVGDIVLVRPGERIPVDGVVVS-----GSSSVDESMLTGE 265

                  .
gi 569010256  182 S 182
Cdd:COG2217   266 S 266
Hydrolase pfam00702
haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha ...
602-682 2.43e-03

haloacid dehalogenase-like hydrolase; This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Pseudomonas sp. (S)-2-haloacid dehalogenase 1. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteristic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.


Pssm-ID: 395571 [Multi-domain]  Cd Length: 191  Bit Score: 40.26  E-value: 2.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 569010256   602 EIPPDDFERI----NAQLVEAKMALQDREEKLEKVFDEIETNmNLIGATAVEDKLQ--DQAAETIEALHAAGLKVWVLTG 675
Cdd:pfam00702   44 PIPVEDFTARlllgKRDWLEELDILRGLVETLEAEGLTVVLV-ELLGVIALADELKlyPGAAEALKALKERGIKVAILTG 122

                   ....*..
gi 569010256   676 DKMETAK 682
Cdd:pfam00702  123 DNPEAAE 129
serB TIGR00338
phosphoserine phosphatase SerB; Phosphoserine phosphatase catalyzes the reaction ...
811-840 9.79e-03

phosphoserine phosphatase SerB; Phosphoserine phosphatase catalyzes the reaction 3-phospho-serine + H2O = L-serine + phosphate. It catalyzes the last of three steps in the biosynthesis of serine from D-3-phosphoglycerate. Note that this enzyme acts on free phosphoserine, not on phosphoserine residues of phosphoproteins. [Amino acid biosynthesis, Serine family]


Pssm-ID: 273022 [Multi-domain]  Cd Length: 219  Bit Score: 38.88  E-value: 9.79e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 569010256   811 TLSIGDGANDVSMILESHVGIGIKGKEGRQ 840
Cdd:TIGR00338  171 TVAVGDGANDLSMIKAAGLGIAFNAKPKLQ 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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