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Conserved domains on  [gi|568956627|ref|XP_006530978|]
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zinc finger protein 23 isoform X6 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
212-618 4.15e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.20  E-value: 4.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956627 212 KPFKCVECGKCFSYSSHYITHQTIHSGEKPYQCKV--CGKAFSVNGSLVRHQRIHTGEKPYQCKDCGAG--FGCSSAYIT 287
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956627 288 HQRTHTgekPYECSDCGKAFNVNAKLIQHQRIHTGEKPYECdVCGKGFRCSTQLRQHQSIHtgeKPHRCSECGKGFTKNA 367
Cdd:COG5048  112 SSSSNS---NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNN-PLPGNNSSSVNTPQSNSLH---PPLPANSLSKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956627 368 KLIQHQRVHTGEKPYACSDCGKTFSAKGKLIQHQRIHTGERPYECSECGKSFRCNSQLRQHLRIHTGEKPYKCSECGKAF 447
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956627 448 NVNAKLMQHRRTHTGE-------KPFECKECGKCFTSKRNLLDHQRA--HTGE--KPYQCSE--CGKAFSINAKLTRHQQ 514
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956627 515 IHTREKPFKCMEC-------EKAFSCSSDYIVHQRIHTGEKPFQC--GECGKAFHVNAHLIRHQRSHTGEKP--FRCTEC 583
Cdd:COG5048  345 LHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 568956627 584 GKGFSLSSDCIIHQTVHTWKKPYVCNVCGKTFRFS 618
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
KRAB super family cl42959
krueppel associated box;
1-32 1.61e-08

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 51.05  E-value: 1.61e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568956627     1 MLENYRNLASVGFPLLKPAVISQLEERKDLEN 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
212-618 4.15e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.20  E-value: 4.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956627 212 KPFKCVECGKCFSYSSHYITHQTIHSGEKPYQCKV--CGKAFSVNGSLVRHQRIHTGEKPYQCKDCGAG--FGCSSAYIT 287
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956627 288 HQRTHTgekPYECSDCGKAFNVNAKLIQHQRIHTGEKPYECdVCGKGFRCSTQLRQHQSIHtgeKPHRCSECGKGFTKNA 367
Cdd:COG5048  112 SSSSNS---NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNN-PLPGNNSSSVNTPQSNSLH---PPLPANSLSKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956627 368 KLIQHQRVHTGEKPYACSDCGKTFSAKGKLIQHQRIHTGERPYECSECGKSFRCNSQLRQHLRIHTGEKPYKCSECGKAF 447
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956627 448 NVNAKLMQHRRTHTGE-------KPFECKECGKCFTSKRNLLDHQRA--HTGE--KPYQCSE--CGKAFSINAKLTRHQQ 514
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956627 515 IHTREKPFKCMEC-------EKAFSCSSDYIVHQRIHTGEKPFQC--GECGKAFHVNAHLIRHQRSHTGEKP--FRCTEC 583
Cdd:COG5048  345 LHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 568956627 584 GKGFSLSSDCIIHQTVHTWKKPYVCNVCGKTFRFS 618
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
KRAB smart00349
krueppel associated box;
1-32 1.61e-08

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 51.05  E-value: 1.61e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568956627     1 MLENYRNLASVGFPLLKPAVISQLEERKDLEN 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
425-448 3.78e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 3.78e-05
                          10        20
                  ....*....|....*....|....
gi 568956627  425 LRQHLRIHTGEKPYKCSECGKAFN 448
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 548-600 6.29e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 6.29e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568956627 548 KPFqCGECGKAFHVNAHLIRHQRSHTgekpFRCTECGKGFSLSSDCIIH-QTVH 600
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
212-618 4.15e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 78.20  E-value: 4.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956627 212 KPFKCVECGKCFSYSSHYITHQTIHSGEKPYQCKV--CGKAFSVNGSLVRHQRIHTGEKPYQCKDCGAG--FGCSSAYIT 287
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956627 288 HQRTHTgekPYECSDCGKAFNVNAKLIQHQRIHTGEKPYECdVCGKGFRCSTQLRQHQSIHtgeKPHRCSECGKGFTKNA 367
Cdd:COG5048  112 SSSSNS---NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNN-PLPGNNSSSVNTPQSNSLH---PPLPANSLSKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956627 368 KLIQHQRVHTGEKPYACSDCGKTFSAKGKLIQHQRIHTGERPYECSECGKSFRCNSQLRQHLRIHTGEKPYKCSECGKAF 447
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956627 448 NVNAKLMQHRRTHTGE-------KPFECKECGKCFTSKRNLLDHQRA--HTGE--KPYQCSE--CGKAFSINAKLTRHQQ 514
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956627 515 IHTREKPFKCMEC-------EKAFSCSSDYIVHQRIHTGEKPFQC--GECGKAFHVNAHLIRHQRSHTGEKP--FRCTEC 583
Cdd:COG5048  345 LHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 568956627 584 GKGFSLSSDCIIHQTVHTWKKPYVCNVCGKTFRFS 618
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
KRAB smart00349
krueppel associated box;
1-32 1.61e-08

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 51.05  E-value: 1.61e-08
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568956627     1 MLENYRNLASVGFPLLKPAVISQLEERKDLEN 32
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
268-423 7.53e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 7.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956627 268 KPYQCKDCGAGFGCSSAYITHQRT--HTGE--KPYEC--SDCGKAFNVNAKLIQHQRIHTGEKPYEC--DVCGKGFR--- 336
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpll 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956627 337 --CSTQLRQHQSIHTGEKPHRC--SECGKGFTKNAKLIQHQRVHTGEKPYAC--SDCGKTFSAKGKLIQHQRIHTGERPY 410
Cdd:COG5048  368 nnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|...
gi 568956627 411 ECSECGKSFRCNS 423
Cdd:COG5048  448 LCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
324-633 7.03e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 7.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956627 324 KPYECDVCGKGFRCSTQLRQHQSIHTGEKPHRCS--ECGKGFTKNAKLIQHQRVHTGEKPYACSDCGKT----------- 390
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnskassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956627 391 ----FSAKGKLIQHQRIHTGERPYE-CSECGKSFRCNSQLRQHLRIHTGEKPYKCS-------ECGKAFNVNAKLMQHRR 458
Cdd:COG5048  112 ssssNSNDNNLLSSHSLPPSSRDPQlPDLLSISNLRNNPLPGNNSSSVNTPQSNSLhpplpanSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956627 459 THTGEKPFECKECGKCFTSKRNLLDHQRAHTGEKPYQCSECGKAFSINAKLTRHQQIHTREKPFKCMECEKAFSCSSDYI 538
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568956627 539 VHQRIHTGE-------KPFQCGECGKAFHVNAHLIRHQRS--HTGE--KPFRCTE--CGKGFSLSSDCIIHQTVHTWKKP 605
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 568956627 606 YVC--NVCGKTFRFSF------QLSQHQDVHNEDKS 633
Cdd:COG5048  352 AKEklLNSSSKFSPLLnneppqSLQQYKDLKNDKKS 387
zf-H2C2_2 pfam13465
Zinc-finger double domain;
425-448 3.78e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 3.78e-05
                          10        20
                  ....*....|....*....|....
gi 568956627  425 LRQHLRIHTGEKPYKCSECGKAFN 448
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
453-477 1.05e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.05e-04
                          10        20
                  ....*....|....*....|....*
gi 568956627  453 LMQHRRTHTGEKPFECKECGKCFTS 477
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
564-588 3.18e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.18e-04
                          10        20
                  ....*....|....*....|....*
gi 568956627  564 HLIRHQRSHTGEKPFRCTECGKGFS 588
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
397-421 4.66e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.66e-04
                          10        20
                  ....*....|....*....|....*
gi 568956627  397 LIQHQRIHTGERPYECSECGKSFRC 421
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-337 6.13e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.13e-04
                          10        20
                  ....*....|....*....|....*
gi 568956627  313 LIQHQRIHTGEKPYECDVCGKGFRC 337
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-279 1.77e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.77e-03
                          10        20
                  ....*....|....*....|....
gi 568956627  256 SLVRHQRIHTGEKPYQCKDCGAGF 279
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
288-308 1.90e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.90e-03
                          10        20
                  ....*....|....*....|.
gi 568956627  288 HQRTHTGEKPYECSDCGKAFN 308
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-365 2.40e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.40e-03
                          10        20
                  ....*....|....*....|....*
gi 568956627  341 LRQHQSIHTGEKPHRCSECGKGFTK 365
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
369-392 3.77e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.77e-03
                          10        20
                  ....*....|....*....|....
gi 568956627  369 LIQHQRVHTGEKPYACSDCGKTFS 392
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
480-504 4.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.08e-03
                          10        20
                  ....*....|....*....|....*
gi 568956627  480 NLLDHQRAHTGEKPYQCSECGKAFS 504
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
540-559 4.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.73e-03
                          10        20
                  ....*....|....*....|
gi 568956627  540 HQRIHTGEKPFQCGECGKAF 559
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 548-600 6.29e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 6.29e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568956627 548 KPFqCGECGKAFHVNAHLIRHQRSHTgekpFRCTECGKGFSLSSDCIIH-QTVH 600
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 466-488 8.56e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.56e-03
                          10        20
                  ....*....|....*....|...
gi 568956627  466 FECKECGKCFTSKRNLLDHQRAH 488
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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