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Conserved domains on  [gi|568974935|ref|XP_006533852|]
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protein AATF isoform X1 [Mus musculus]

Protein Classification

AATF family protein( domain architecture ID 10595130)

apoptosis-antagonizing transcription factor (AATF) family protein, such as AATF, also called Che-1, which has been shown to play a crucial role in cell cycle control, apoptosis, and chromatin remodeling due to its interaction with various important components of cell survival machinery including Retinoblastoma(Rb), DAP like kinases(DLK) and histone deacetylases (HDACs)

Gene Ontology:  GO:0043522|GO:0019901|GO:0042254|GO:0006974
PubMed:  33145763

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AATF-Che1 pfam13339
Apoptosis antagonizing transcription factor; The N-terminal and leucine-zipper region of the ...
 155-307 7.61e-44

Apoptosis antagonizing transcription factor; The N-terminal and leucine-zipper region of the apoptosis antagonizing transcription factor-Che1.


:

Pssm-ID: 463850  Cd Length: 136  Bit Score: 150.99  E-value: 7.61e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974935  155 EVEKGRAVKNQIALWDQLLEGRIKLQKALLTTNQLPQPDVFPVFKdKGGPEFASALKNSHKALKALLRSLVDLQEELlfq 234
Cdd:pfam13339   1 DAEKGKAVKNQRKLWDSLLELRIKLQKALTAANQLPQPEARSEFL-KSDEEFSEALEEAEKALKKLLDTLLELREEL--- 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568974935  235 ypdtrhivngakpNTESEEISSEDDELVGEKKKQRKAPPKRKLEMEDYPSFMAKRFADFTIYRNHTLQKWHDK 307
Cdd:pfam13339  77 -------------QQNPANASSSEDEEKSGKKRKRKRKDDSDTSLDDLWEELEKLEARLLPYRNAVLDKWSRK 136
TRAUB pfam08164
Apoptosis-antagonizing transcription factor, C-terminal; This C terminal domain is found in ...
 398-482 1.33e-33

Apoptosis-antagonizing transcription factor, C-terminal; This C terminal domain is found in traube proteins. This is the domain of the AATF proteins that interacts with BLOS2 or Ceap, that functions as an adaptor in processes such as protein and vesicle processing and transport, and perhaps transcription.


:

Pssm-ID: 462388  Cd Length: 81  Bit Score: 121.91  E-value: 1.33e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974935  398 YHQLLRELIERKTSSLDPNDQvamgrQWLAIQKLRSKI-RKKVDRKASKGRKLRFHVLSKLLSFMAPIDHTAMSDDARTE 476
Cdd:pfam08164   1 YQQLLKELIESKTADSSAGSG-----DPLALQALRKKKkKKKVDTKASKGRKLRYTVHEKLQNFMAPIPRGTWPDEQIDE 75


                  ....*.
gi 568974935  477 LFRSLF 482
Cdd:pfam08164  76 LFASLF 81
 
Name Accession Description Interval E-value
AATF-Che1 pfam13339
Apoptosis antagonizing transcription factor; The N-terminal and leucine-zipper region of the ...
 155-307 7.61e-44

Apoptosis antagonizing transcription factor; The N-terminal and leucine-zipper region of the apoptosis antagonizing transcription factor-Che1.


Pssm-ID: 463850  Cd Length: 136  Bit Score: 150.99  E-value: 7.61e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974935  155 EVEKGRAVKNQIALWDQLLEGRIKLQKALLTTNQLPQPDVFPVFKdKGGPEFASALKNSHKALKALLRSLVDLQEELlfq 234
Cdd:pfam13339   1 DAEKGKAVKNQRKLWDSLLELRIKLQKALTAANQLPQPEARSEFL-KSDEEFSEALEEAEKALKKLLDTLLELREEL--- 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568974935  235 ypdtrhivngakpNTESEEISSEDDELVGEKKKQRKAPPKRKLEMEDYPSFMAKRFADFTIYRNHTLQKWHDK 307
Cdd:pfam13339  77 -------------QQNPANASSSEDEEKSGKKRKRKRKDDSDTSLDDLWEELEKLEARLLPYRNAVLDKWSRK 136
TRAUB pfam08164
Apoptosis-antagonizing transcription factor, C-terminal; This C terminal domain is found in ...
 398-482 1.33e-33

Apoptosis-antagonizing transcription factor, C-terminal; This C terminal domain is found in traube proteins. This is the domain of the AATF proteins that interacts with BLOS2 or Ceap, that functions as an adaptor in processes such as protein and vesicle processing and transport, and perhaps transcription.


Pssm-ID: 462388  Cd Length: 81  Bit Score: 121.91  E-value: 1.33e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974935  398 YHQLLRELIERKTSSLDPNDQvamgrQWLAIQKLRSKI-RKKVDRKASKGRKLRFHVLSKLLSFMAPIDHTAMSDDARTE 476
Cdd:pfam08164   1 YQQLLKELIESKTADSSAGSG-----DPLALQALRKKKkKKKVDTKASKGRKLRYTVHEKLQNFMAPIPRGTWPDEQIDE 75


                  ....*.
gi 568974935  477 LFRSLF 482
Cdd:pfam08164  76 LFASLF 81
 
Name Accession Description Interval E-value
AATF-Che1 pfam13339
Apoptosis antagonizing transcription factor; The N-terminal and leucine-zipper region of the ...
 155-307 7.61e-44

Apoptosis antagonizing transcription factor; The N-terminal and leucine-zipper region of the apoptosis antagonizing transcription factor-Che1.


Pssm-ID: 463850  Cd Length: 136  Bit Score: 150.99  E-value: 7.61e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974935  155 EVEKGRAVKNQIALWDQLLEGRIKLQKALLTTNQLPQPDVFPVFKdKGGPEFASALKNSHKALKALLRSLVDLQEELlfq 234
Cdd:pfam13339   1 DAEKGKAVKNQRKLWDSLLELRIKLQKALTAANQLPQPEARSEFL-KSDEEFSEALEEAEKALKKLLDTLLELREEL--- 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568974935  235 ypdtrhivngakpNTESEEISSEDDELVGEKKKQRKAPPKRKLEMEDYPSFMAKRFADFTIYRNHTLQKWHDK 307
Cdd:pfam13339  77 -------------QQNPANASSSEDEEKSGKKRKRKRKDDSDTSLDDLWEELEKLEARLLPYRNAVLDKWSRK 136
TRAUB pfam08164
Apoptosis-antagonizing transcription factor, C-terminal; This C terminal domain is found in ...
 398-482 1.33e-33

Apoptosis-antagonizing transcription factor, C-terminal; This C terminal domain is found in traube proteins. This is the domain of the AATF proteins that interacts with BLOS2 or Ceap, that functions as an adaptor in processes such as protein and vesicle processing and transport, and perhaps transcription.


Pssm-ID: 462388  Cd Length: 81  Bit Score: 121.91  E-value: 1.33e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974935  398 YHQLLRELIERKTSSLDPNDQvamgrQWLAIQKLRSKI-RKKVDRKASKGRKLRFHVLSKLLSFMAPIDHTAMSDDARTE 476
Cdd:pfam08164   1 YQQLLKELIESKTADSSAGSG-----DPLALQALRKKKkKKKVDTKASKGRKLRYTVHEKLQNFMAPIPRGTWPDEQIDE 75


                  ....*.
gi 568974935  477 LFRSLF 482
Cdd:pfam08164  76 LFASLF 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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