Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974985 354 ILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIE 433
Cdd:cd08721    1 ILYCESALFYFMEYMEQEGARNLLQFWLAADNFQSQLAAKEGQYDGQQAQNDAMIIYDKYFSLQATEPLGFDDKTRLEVE 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568974985 434 SNICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 474
Cdd:cd08721   81 SNICREGGPLPSCFEAPLLQALTTLEQHYLPGFLSSQLYYK 121

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974985 354 ILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIE 433
Cdd:cd08721    1 ILYCESALFYFMEYMEQEGARNLLQFWLAADNFQSQLAAKEGQYDGQQAQNDAMIIYDKYFSLQATEPLGFDDKTRLEVE 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568974985 434 SNICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 474
Cdd:cd08721   81 SNICREGGPLPSCFEAPLLQALTTLEQHYLPGFLSSQLYYK 121

PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of PKA signaling by facilitating the localization of the kinase to subcellular sites through their binding to regulatory (R) subunits of PKA. AKAP-10, also called PRKA10 or Dual-specific AKAP 2 (D-AKAP2), is a multisubunit protein containing two regulator of G protein signaling (RGS)-like domains and a PKA-binding (AKB) domain. The AKB domain of AKAP10 can bind to the dimerization/docking (D/D) domains of both RI and RII regulatory subunits of PKA. This model also includes a C-terminal PDZ-binding motif that binds to PDZK1 and NHERF-1, allowing AKAP10 to link indirectly to membrane proteins. Mutations in AKAP10 can alter its binding to R subunits, which may alter the targeting of PKA; some AKAP10 mutations are associated with abnormalities including hypertension, increased risk of severe arrhythmias during kidney transplantation, and familial breast cancer.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 568974985 589 AMKKWVQGNTDEAQEELAWKIAKMIVSDVMQQAHHDQPLEKSTKL 633
Cdd:cd12804    1 AFKKWVQPEPDEAKEEMAWKIAKMIVNDVEDQAQEEMAWQVAEMI 45

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974985  351 LADILFCESALFYFSEYMEKEDAVNILQFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRL 430
Cdd:pfam00615   2 FDSLLEDQPGRRLFRQFLESEFSEENLEFWLACEEF-------KKADPDEERLKKAKEIYNEFLAPGSPKEINLDSDLRE 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 568974985  431 EIESNICREggPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYKY 475
Cdd:pfam00615  75 EIRENLEKE--PTRDLFDEAQAEVYELMEKDSYPRFLKSPLYLRL 117

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974985 354 ILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIE 433
Cdd:cd08721    1 ILYCESALFYFMEYMEQEGARNLLQFWLAADNFQSQLAAKEGQYDGQQAQNDAMIIYDKYFSLQATEPLGFDDKTRLEVE 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568974985 434 SNICREGGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 474
Cdd:cd08721   81 SNICREGGPLPSCFEAPLLQALTTLEQHYLPGFLSSQLYYK 121

Regulator of G protein signaling (RGS) domain superfamily; The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. While inactive, G-alpha-subunits bind GDP, which is released and replaced by GTP upon agonist activation. GTP binding leads to dissociation of the alpha-subunit and the beta-gamma-dimer, allowing them to interact with effectors molecules and propagate signaling cascades associated with cellular growth, survival, migration, and invasion. Deactivation of the G-protein signaling controlled by the RGS domain accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in the reassociation of the alpha-subunit with the beta-gamma-dimer and thereby inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins are also involved in apoptosis and cell proliferation, as well as modulation of cardiac development. Several RGS proteins can fine-tune immune responses, while others play important roles in neuronal signals modulation. Some RGS proteins are principal elements needed for proper vision.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974985 355 LFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQLAAKKgqydgqEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIES 434
Cdd:cd07440    1 LRDPYGLEYFRQFLKSEHCEENLEFWLAVEKFKKTTSSDE------ELKSKAKEIYDKYISKDAPKEINIPESIREEIEE 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568974985 435 NICREgGPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 474
Cdd:cd07440   75 NLEEP-YPDPDCFDEAQEHILNLLEKDSYPRFLKSDLYLK 113

PKA-binding (AKB) domain of A Kinase Anchor Protein 10; AKAPs coordinate the specificity of PKA signaling by facilitating the localization of the kinase to subcellular sites through their binding to regulatory (R) subunits of PKA. AKAP-10, also called PRKA10 or Dual-specific AKAP 2 (D-AKAP2), is a multisubunit protein containing two regulator of G protein signaling (RGS)-like domains and a PKA-binding (AKB) domain. The AKB domain of AKAP10 can bind to the dimerization/docking (D/D) domains of both RI and RII regulatory subunits of PKA. This model also includes a C-terminal PDZ-binding motif that binds to PDZK1 and NHERF-1, allowing AKAP10 to link indirectly to membrane proteins. Mutations in AKAP10 can alter its binding to R subunits, which may alter the targeting of PKA; some AKAP10 mutations are associated with abnormalities including hypertension, increased risk of severe arrhythmias during kidney transplantation, and familial breast cancer.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 568974985 589 AMKKWVQGNTDEAQEELAWKIAKMIVSDVMQQAHHDQPLEKSTKL 633
Cdd:cd12804    1 AFKKWVQPEPDEAKEEMAWKIAKMIVNDVEDQAQEEMAWQVAEMI 45

Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the first RGS domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974985 351 LADILFCESALFYFSEYMEKEDAVNILQFWLAADNFQS--------------------QLAAKKGQYDGQEAQN------ 404
Cdd:cd08735    5 LEQILHDNSALPYFIQFMETRRAEHLIKFWLEAESFKSaawsrirahslntvkhssleEPVSPSLDRKVLESKStdslsq 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974985 405 ----------------DAMILYDKYFSLQATHPLGFDDVVRLEIESNICREGGPL-PNCFTTPLRQAWTTMEKVFLPGFL 467
Cdd:cd08735   85 rltddddeksmksierDAVSIYTKYISPDAAKPIPITEEIRNDIVAKICGEDGQVdPNCFVEAQSFVFSAMEQDHFTEFL 164

                 ....*..
gi 568974985 468 SSNLYYK 474
Cdd:cd08735  165 RSHFFCK 171

Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2; The RGS (Regulator of G-protein Signaling) domain is an essential part of the D-AKAP2 (A-kinase anchoring protein), a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. D-AKAP2 contains two RGS domains which play an important role in spatiotemporal localization of cAMP-dependent PKA (cyclic AMP-dependent protein kinase) that regulates many different signaling pathways by phosphorylation of target proteins. This cd contains the second RGS domain.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568974985 268 DAVNTFTKYISPDAAKPIPITEAMRNDIIAKICGEDGQVdPNCFVLAQAVVFSAMEQEHFSEFLRSHHFCK 338
Cdd:cd08721   52 DAMIIYDKYFSLQATEPLGFDDKTRLEVESNICREGGPL-PSCFEAPLLQALTTLEQHYLPGFLSSQLYYK 121

Regulator of G protein signaling domain; RGS family members are GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568974985  260 KLMKSIE---QDAVNTFTKYISPDAAKPIPITEAMRNDIIAKICGEdgqVDPNCFVLAQAVVFSAMEQEHFSEFLRS 333
Cdd:pfam00615  38 KKADPDEerlKKAKEIYNEFLAPGSPKEINLDSDLREEIRENLEKE---PTRDLFDEAQAEVYELMEKDSYPRFLKS 111

Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the SNX14 (Sorting Nexin14) protein, a member of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. SNX14 is believed to regulates membrane trafficking in motor neurons.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974985 354 ILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQ-LAAKKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEI 432
Cdd:cd08722    1 ILDDQRLLFPFMQFLKEEGAVHLLQFCLTVEDFNRRiLNPDLTDEEKQSLHKEAQEIYKTYFLPEAPDRIHFPPDIVEEI 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 568974985 433 ESNIcrEGGPLPNCF---TTPLRQAW----TTMEKVFLPGFLSSNLYY 473
Cdd:cd08722   81 KQIL--EGGPEKIVKlrtSRPLFEAYehvySLLESVFCPLFCHSDEYF 126

Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS13 protein. RGS13 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS13 is predominantly expressed in T and B lymphocytes and in mast cells, and plays a role in adaptive immune responses. RGS13 also found in Rgs13, which is also expressed in dendritic cells and in neuroendocrine cells of the thymus, gastrointestinal, and respiratory tracts. Outside of the GPCR pathway, RGS5 interacts with the PIP3 protein.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568974985 269 AVNTFTKYISPDAAKPIPITEAMRNDIIAKIcgedGQVDPNCFVLAQAVVFSAMEQEHFSEFLRS 333
Cdd:cd08716   49 ARKLFASYIQPQAPREINIDSPTRKAIIRNI----QEPTQSCFDEAQRIVYMHMERDSYPRFLES 109

Regulator of G protein signaling (RGS) domain found in the RGS13 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS13 protein. RGS13 is member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS13 is predominantly expressed in T and B lymphocytes and in mast cells, and plays a role in adaptive immune responses. RGS13 also found in Rgs13, which is also expressed in dendritic cells and in neuroendocrine cells of the thymus, gastrointestinal, and respiratory tracts. Outside of the GPCR pathway, RGS5 interacts with the PIP3 protein.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974985 364 FSEYMEKEDAVNILQFWLAADNFQSQLAAKKGQYDGQEaqndamiLYDKYFSLQATHPLGFDDVVRLEIESNICReggPL 443
Cdd:cd08716   14 YATYLKTEHSDENIEFWLACETYKKIASQRKRISMARK-------LFASYIQPQAPREINIDSPTRKAIIRNIQE---PT 83

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568974985 444 PNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 474
Cdd:cd08716   84 QSCFDEAQRIVYMHMERDSYPRFLESKFYQK 114

Regulator of G protein signaling (RGS) domain found in the RGS21 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part RGS21 protein, a member of RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, apoptosis, and cell proliferation, as well as modulation of cardiac development. RGS21 is a member of the R4/RGS subfamily and its mRNA was detected only in sensory taste cells that express sweet taste receptors and the taste G-alpha subunit, gustducin, suggesting a potential role in regulating taste transduction.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974985 354 ILFCESALFYFSEYMEKEDAVNILQFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIE 433
Cdd:cd08723    1 LLANQAGLDAFRTFLKSEFSEENVEFWLACEDF-------KKTKSSTEIALKAQMIYSEFIQADAPKEINIDFHTRDLIS 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568974985 434 SNICReggPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLYYK 474
Cdd:cd08723   74 QNISE---PTLKCFDEAQSLIYCLMAKDSFPRFLKSEVYKK 111

Regulator of G protein signaling (RGS) domain found in the RGS4 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS4 protein. RGS4 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. RGS4 is expressed widely in brain including prefrontal cortex, striatum, locus coeruleus (LC), and hippocampus and has been implicated in regulation of opioid, cholinergic, and serotonergic signaling. Dysfunctions in RGS4 proteins are involved in etiology of Parkinson's disease, addiction, and schizophrenia. RGS4 also is up-regulated in the failing human heart. RGS4 interacts with many binding partners outside of GPCR pathways, including calmodulin, COP, Kir3, PIP, calcium/CaM, PA, ErbB3, and 14-3-3.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974985 362 FYFSEYMEKedavNIlQFWLAADNFQSQLAAKKGQydgQEAQNdamiLYDKYFSLQATHPLGFDDVVRLEIESNICRegg 441
Cdd:cd08714   17 FLKSEYSEE----NI-DFWVSCEDYKKTKSPSKLS---PKARK----IYEEFISVQATKEVNLDSCTREETSRNMLE--- 81

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568974985 442 PLPNCFTTPLRQAWTTMEKVFLPGFLSSNLY 472
Cdd:cd08714   82 PTISCFDEAQKKIFTLMEKDSYRRFLKSRFY 112

Regulator of G protein signaling (RGS) domain found in the RGS17 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS17 protein, a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of the G-protein signaling controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. The RZ subfamily of RGS proteins includes RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS. RGS17 is a relatively non-selective GAP for G-alpha-z and other G-alpha-i/o proteins. RGS17 blocks dopamine receptor-mediated inhibition of cAMP accumulation; it also blocks thyrotropin releasing hormone-stimulated Ca++ mobilization. RGS17, like other members of RZ subfamily, can act either as a GAP or as G-protein effector antogonist.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974985 364 FSEYMEKEDAVNILQFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICregGPL 443
Cdd:cd08744   18 FREFLRTEYSEENLLFWLACEDL-------KKEQNKKVIEEKARLIYEDYISILSPKEVSLDSRVREVINRNLL---DPN 87

                         90       100
                 ....*....|....*....|....*....
gi 568974985 444 PNCFTTPLRQAWTTMEKVFLPGFLSSNLY 472
Cdd:cd08744   88 PHMYEDAQLQIYTLMHRDSFPRFLNSQIY 116

Regulator of G protein signaling (RGS) domain found in the RGS1 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS1 protein. RGS1 is a member of the R4/RGS subfamily of the RGS family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha subunits. The RGS domain controls G-protein signaling by accelerating the GTPase activity of the G-alpha subunit which leads to G protein deactivation and promotes desensitization. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. RGS 1 is expressed predominantly in hematopoietic compartments, including T and B lymphocytes, and may play a major role in chemokine-mediated homing of lymphocytes to secondary lymphoid organs. In addition, RGS1 interacts with calmodulin and 14-3-3 protein outside of the GPCR pathway.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568974985 273 FTKYISPDAAKPIPITEAMRNDIIAKIcgedGQVDPNCFVLAQAVVFSAMEQEHFSEFLRSHHF 336
Cdd:cd08715   52 YKEFVQSDAAKQINIDFRTRESTAKKI----KAPTPTCFDEAQKVIYILMERDSYPRFLKSDIY 111

Regulator of G protein signaling (RGS) domain found in the RGS20 protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RGS20 protein (also known as RGSZ1), a member of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by the RGS domain, which accelerates GTPase activity of the alpha subunit by hydrolysis of GTP to GDP resulting in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, the RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins include RGS17, RGS19 (former GAIP), and the splice variant of RGS20, Ret-RGS. RGS20 is expressed exclusively in brain, with the highest concentrations in the temporal lobe and the caudate nucleus and may play a role in signaling regulation in these brain regions. RGS20 acts as a GAP of both G-alpha-z and G-alpha-I and controls signaling in the mu opioid receptor pathway.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974985 354 ILFCESALFYFSEYMEKEDAVNILQFWLAADNFQSQlaAKKGQydgqeAQNDAMILYDKYFSLQATHPLGFDDVVRLEIE 433
Cdd:cd08746   57 LMLTPAGRNAFREFLRTEFSEENMLFWMACEELKKE--ANKSV-----IEEKARIIYEDYISILSPKEVSLDSRVREVIN 129

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 568974985 434 SNICReggPLPNCFTTPLRQAWTTMEKVFLPGFLSSNLY 472
Cdd:cd08746  130 RNMLE---PSQHTFDDAQLQIYTLMHRDSYPRFMNSAIY 165

Regulator of G protein signaling domain; These uncharacterized RGS-like domains are found in proteins that also contain one or more PX domains. The RGS domain is an essential part of the Regulator of G-protein Signaling (RGS) protein family, a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. As a major G-protein regulator, the RGS domain containing proteins that are involves in many crucial cellular processes. RGS proteins regulate intracellular trafficking and provide vital support for signal transduction. RGS proteins play critical regulatory role as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. RGS proteins regulate many aspects of embryonic development such as glial differentiation, embryonic axis formation, skeletal and muscle development, cell migration during early embryogenesis, as well as apoptosis, cell proliferation, and modulation of cardiac development. Several RGS proteins can fine-tune immune responses, others RGS proteins play important role in neuronal signals modulation. Some RGS proteins are the principal elements needed for proper vision.

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gi 568974985 101 LRDTVVLPYFLQFMELRRMEHLVKFWLEAESF 132
Cdd:cd08729    1 LRDPSSLSYFMEFMDRRNRSQLVQFWLVVEGF 32

Regulator of G protein signaling (RGS) domain found in the RZ protein; The RGS (Regulator of G-protein Signaling) domain is an essential part of the RZ subfamily of the RGS protein family. They are a diverse group of multifunctional proteins that regulate cellular signaling events downstream of G-protein coupled receptors (GPCRs). RGS proteins play critical regulatory roles as GTPase activating proteins (GAPs) of the heterotrimeric G-protein G-alpha-subunits. Deactivation of G-protein signaling is controlled by RGS domains, which accelerate GTPase activity of the alpha subunit by hydrolysis of GTP to GDP, which results in reassociation of the alpha-subunit with the beta-gamma-dimer and inhibition of downstream activity. As a major G-protein regulator, RGS domain containing proteins are involved in many crucial cellular processes such as regulation of intracellular trafficking, glial differentiation, embryonic axis formation, skeletal and muscle development, and cell migration during early embryogenesis. The RZ subfamily of RGS proteins includes RGS17, RGS19 (former GAIP), RGS20, and its splice variant Ret-RGS.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568974985 363 YFSEYMEKEDAVNILQFWLAADNFqsqlaakKGQYDGQEAQNDAMILYDKYFSLQATHPLGFDDVVRLEIESNICReggP 442
Cdd:cd08718   17 VFREFLRTEYSEENMLFWLACEEL-------KKEANKHVIEEKARLIYEDYISILSPKEVSLDSRVREVINRNMLE---P 86

                         90       100       110
                 ....*....|....*....|....*....|
gi 568974985 443 LPNCFTTPLRQAWTTMEKVFLPGFLSSNLY 472
Cdd:cd08718   87 SPHTFDDAQLQIYTLMHRDSYPRFLNSAIY 116