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Conserved domains on  [gi|568933200|ref|XP_006535781|]
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WD repeat-containing protein 86 isoform X1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-374 9.24e-71

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 228.26  E-value: 9.24e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200   4 SGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTVDGQCCALLQGHESYVTfchledEAAF--------TCSA 75
Cdd:COG2319   67 AGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVR------SVAFspdgktlaSGSA 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200  76 DCTIRRWDVRTGQCLQVYRGHTSIVNRILVAND--QLFSSSYDRTARVWTVDKGQVSQEFRGHRNCVLTLAYSApedlpq 153
Cdd:COG2319  141 DGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP------ 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200 154 dpcmeaamGGGLLVTGSSDDTAKVWQVASGCCHQTLRGHTGAVLCLVLHVSSHTAFTGSTDATVRAWDILSGEQLRVFRE 233
Cdd:COG2319  215 --------DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200 234 HQGSVICLELT--DRLLYSGSADRTVKCWLADTGERVLTFPAHRHSVSALKYHagtsqdqaqkmmppahemvllhpessa 311
Cdd:COG2319  287 HSGGVNSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS--------------------------- 339

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568933200 312 sgcPD--LVFTGSGDACARAFDAQSGVLQRVFRGHTFVINCLQVH--GQVLYTASHDGALRLWDVRG 374
Cdd:COG2319  340 ---PDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-374 9.24e-71

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 228.26  E-value: 9.24e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200   4 SGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTVDGQCCALLQGHESYVTfchledEAAF--------TCSA 75
Cdd:COG2319   67 AGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVR------SVAFspdgktlaSGSA 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200  76 DCTIRRWDVRTGQCLQVYRGHTSIVNRILVAND--QLFSSSYDRTARVWTVDKGQVSQEFRGHRNCVLTLAYSApedlpq 153
Cdd:COG2319  141 DGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP------ 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200 154 dpcmeaamGGGLLVTGSSDDTAKVWQVASGCCHQTLRGHTGAVLCLVLHVSSHTAFTGSTDATVRAWDILSGEQLRVFRE 233
Cdd:COG2319  215 --------DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200 234 HQGSVICLELT--DRLLYSGSADRTVKCWLADTGERVLTFPAHRHSVSALKYHagtsqdqaqkmmppahemvllhpessa 311
Cdd:COG2319  287 HSGGVNSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS--------------------------- 339

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568933200 312 sgcPD--LVFTGSGDACARAFDAQSGVLQRVFRGHTFVINCLQVH--GQVLYTASHDGALRLWDVRG 374
Cdd:COG2319  340 ---PDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-289 7.59e-62

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 201.41  E-value: 7.59e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200   8 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTVDGQCCALLQGHESYVTFCHL--EDEAAFTCSADCTIRRWDVR 85
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200  86 TGQCLQVYRGHTSIVNRILVANDQ--LFSSSYDRTARVWTVDKGQVSQEFRGHRNCVLTLAYSapedlpqdPCmeaamgG 163
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS--------PD------G 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200 164 GLLVTGSSDDTAKVWQVASGCCHQTLRGHTGAVLCLVLHVSSHTAFTGSTDATVRAWDILSGEQLRVFREHQGSVICL-- 241
Cdd:cd00200  148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVaf 227

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 568933200 242 ELTDRLLYSGSADRTVKCWLADTGERVLTFPAHRHSVSALKYHAGTSQ 289
Cdd:cd00200  228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR 275
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 109-260 4.69e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.09  E-value: 4.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200 109 QLFSSSYDRTARVWTVDKGQVSQEFRGHRNCVLTLAYSApedlpQDPCmeaamgggLLVTGSSDDTAKVWQVASGCCHQT 188
Cdd:PLN00181 547 QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSS-----ADPT--------LLASGSDDGSVKLWSINQGVSIGT 613

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568933200 189 LRghTGAVLCLVLHVSS---HTAFtGSTDATVRAWDILSGE-QLRVFREHQGSVICLELTD-RLLYSGSADRTVKCW 260
Cdd:PLN00181 614 IK--TKANICCVQFPSEsgrSLAF-GSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDsSTLVSSSTDNTLKLW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 4-43 5.28e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 5.28e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568933200     4 SGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
5-43 6.16e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 6.16e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568933200    5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
4-374 9.24e-71

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 228.26  E-value: 9.24e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200   4 SGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTVDGQCCALLQGHESYVTfchledEAAF--------TCSA 75
Cdd:COG2319   67 AGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVR------SVAFspdgktlaSGSA 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200  76 DCTIRRWDVRTGQCLQVYRGHTSIVNRILVAND--QLFSSSYDRTARVWTVDKGQVSQEFRGHRNCVLTLAYSApedlpq 153
Cdd:COG2319  141 DGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP------ 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200 154 dpcmeaamGGGLLVTGSSDDTAKVWQVASGCCHQTLRGHTGAVLCLVLHVSSHTAFTGSTDATVRAWDILSGEQLRVFRE 233
Cdd:COG2319  215 --------DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG 286

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200 234 HQGSVICLELT--DRLLYSGSADRTVKCWLADTGERVLTFPAHRHSVSALKYHagtsqdqaqkmmppahemvllhpessa 311
Cdd:COG2319  287 HSGGVNSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS--------------------------- 339

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568933200 312 sgcPD--LVFTGSGDACARAFDAQSGVLQRVFRGHTFVINCLQVH--GQVLYTASHDGALRLWDVRG 374
Cdd:COG2319  340 ---PDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
3-285 3.63e-67

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 218.63  E-value: 3.63e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200   3 SSGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTVDGQCCALLQGHESYVTfchledEAAF--------TCS 74
Cdd:COG2319  108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVT------SVAFspdgkllaSGS 181

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200  75 ADCTIRRWDVRTGQCLQVYRGHTSIVNRILVAND--QLFSSSYDRTARVWTVDKGQVSQEFRGHRNCVLTLAYSApedlp 152
Cdd:COG2319  182 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP----- 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200 153 qdpcmeaamGGGLLVTGSSDDTAKVWQVASGCCHQTLRGHTGAVLCLVLHVSSHTAFTGSTDATVRAWDILSGEQLRVFR 232
Cdd:COG2319  257 ---------DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 327

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568933200 233 EHQGSVICLELT--DRLLYSGSADRTVKCWLADTGERVLTFPAHRHSVSALKYHA 285
Cdd:COG2319  328 GHTGAVRSVAFSpdGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP 382
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-289 7.59e-62

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 201.41  E-value: 7.59e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200   8 LRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTVDGQCCALLQGHESYVTFCHL--EDEAAFTCSADCTIRRWDVR 85
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200  86 TGQCLQVYRGHTSIVNRILVANDQ--LFSSSYDRTARVWTVDKGQVSQEFRGHRNCVLTLAYSapedlpqdPCmeaamgG 163
Cdd:cd00200   82 TGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS--------PD------G 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200 164 GLLVTGSSDDTAKVWQVASGCCHQTLRGHTGAVLCLVLHVSSHTAFTGSTDATVRAWDILSGEQLRVFREHQGSVICL-- 241
Cdd:cd00200  148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVaf 227

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 568933200 242 ELTDRLLYSGSADRTVKCWLADTGERVLTFPAHRHSVSALKYHAGTSQ 289
Cdd:cd00200  228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR 275
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-260 2.21e-60

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 197.56  E-value: 2.21e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200   3 SSGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTVDGQCCALLQGHESYVTFCHL--EDEAAFTCSADCTIR 80
Cdd:cd00200   39 ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFspDGRILSSSSRDKTIK 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200  81 RWDVRTGQCLQVYRGHTSIVN--RILVANDQLFSSSYDRTARVWTVDKGQVSQEFRGHRNCVLTLAYSApedlpqdpcme 158
Cdd:cd00200  119 VWDVETGKCLTTLRGHTDWVNsvAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP----------- 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200 159 aamGGGLLVTGSSDDTAKVWQVASGCCHQTLRGHTGAVLCLVLHVSSHTAFTGSTDATVRAWDILSGEQLRVFREHQGSV 238
Cdd:cd00200  188 ---DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSV 264

                        250       260
                 ....*....|....*....|....
gi 568933200 239 ICLELTD--RLLYSGSADRTVKCW 260
Cdd:cd00200  265 TSLAWSPdgKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
22-396 1.24e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 183.19  E-value: 1.24e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200  22 SLSPDGQRLLTGSEDGTARLWSTVDGQCCALLQGHESYVT--FCHLEDEAAFTCSADCTIRRWDVRTGQCLQVYRGHTSI 99
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVAslAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200 100 VNRILVAND--QLFSSSYDRTARVWTVDKGQVSQEFRGHRNCVLTLAYSApedlpqdpcmeaamGGGLLVTGSSDDTAKV 177
Cdd:COG2319   81 VLSVAFSPDgrLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP--------------DGKTLASGSADGTVRL 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200 178 WQVASGCCHQTLRGHTGAVLCLVLHVSSHTAFTGSTDATVRAWDILSGEQLRVFREHQGSVICLELT--DRLLYSGSADR 255
Cdd:COG2319  147 WDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSADG 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200 256 TVKCWLADTGERVLTFPAHRHSVSALKYHagtsqdqaqkmmppahemvllhpessasgcPD--LVFTGSGDACARAFDAQ 333
Cdd:COG2319  227 TVRLWDLATGKLLRTLTGHSGSVRSVAFS------------------------------PDgrLLASGSADGTVRLWDLA 276

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568933200 334 SGVLQRVFRGHTFVINCLQVH--GQVLYTASHDGALRLWDVRGLQSVPPLPRRPAAKRSLSrlFS 396
Cdd:COG2319  277 TGELLRTLTGHSGGVNSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA--FS 339
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-221 1.15e-47

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 164.43  E-value: 1.15e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200   3 SSGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTVDGQCCALLQGHESYVTFC--HLEDEAAFTCSADCTIR 80
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVafSPDGTFVASSSQDGTIK 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200  81 RWDVRTGQCLQVYRGHTSIVNRILVAND--QLFSSSYDRTARVWTVDKGQVSQEFRGHRNCVLTLAYSApedlpqdpcme 158
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP----------- 229

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568933200 159 aamGGGLLVTGSSDDTAKVWQVASGCCHQTLRGHTGAVLCLVLHVSSHTAFTGSTDATVRAWD 221
Cdd:cd00200  230 ---DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 130-403 5.12e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 146.71  E-value: 5.12e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200 130 SQEFRGHRNCVLTLAYSApedlpqdpcmeaamGGGLLVTGSSDDTAKVWQVASGCCHQTLRGHTGAVLCLVLHVSSHTAF 209
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSP--------------DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLA 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200 210 TGSTDATVRAWDILSGEQLRVFREHQGSVICLELT--DRLLYSGSADRTVKCWLADTGERVLTFPAHRHSVSALKYHagt 287
Cdd:cd00200   68 SGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSpdGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFS--- 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200 288 sqdqaqkmmppahemvllhpessasGCPDLVFTGSGDACARAFDAQSGVLQRVFRGHTFVINCLQVH--GQVLYTASHDG 365
Cdd:cd00200  145 -------------------------PDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSpdGEKLLSSSSDG 199

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 568933200 366 ALRLWDVRGLQSVPPLPRRPAAKRSLSRLFSNKVACAA 403
Cdd:cd00200  200 TIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASG 237
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-122 3.57e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.04  E-value: 3.57e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200   2 GSSGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTVDGQCCALLQGHESYVTFC--HLEDEAAFTCSADCTI 79
Cdd:cd00200  164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVafSPDGYLLASGSEDGTI 243

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 568933200  80 RRWDVRTGQCLQVYRGHTSIVNRILVAND--QLFSSSYDRTARVW 122
Cdd:cd00200  244 RVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTIRIW 288
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 109-260 4.69e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 55.09  E-value: 4.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200 109 QLFSSSYDRTARVWTVDKGQVSQEFRGHRNCVLTLAYSApedlpQDPCmeaamgggLLVTGSSDDTAKVWQVASGCCHQT 188
Cdd:PLN00181 547 QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSS-----ADPT--------LLASGSDDGSVKLWSINQGVSIGT 613

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568933200 189 LRghTGAVLCLVLHVSS---HTAFtGSTDATVRAWDILSGE-QLRVFREHQGSVICLELTD-RLLYSGSADRTVKCW 260
Cdd:PLN00181 614 IK--TKANICCVQFPSEsgrSLAF-GSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDsSTLVSSSTDNTLKLW 687
WD40 COG2319
WD40 repeat [General function prediction only];
3-44 3.65e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.84  E-value: 3.65e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 568933200   3 SSGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWST 44
Cdd:COG2319  360 ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 4-43 5.28e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 5.28e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568933200     4 SGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
5-43 6.16e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 6.16e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568933200    5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 182-221 7.24e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 7.24e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568933200   182 SGCCHQTLRGHTGAVLCLVLHVSSHTAFTGSTDATVRAWD 221
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
183-221 8.86e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 8.86e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568933200  183 GCCHQTLRGHTGAVLCLVLHVSSHTAFTGSTDATVRAWD 221
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 334-371 2.92e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 2.92e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568933200   334 SGVLQRVFRGHTFVINCLQVH--GQVLYTASHDGALRLWD 371
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
335-371 1.06e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.06e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568933200  335 GVLQRVFRGHTFVINCLQVH--GQVLYTASHDGALRLWD 371
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSpdGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 86-122 1.97e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 1.97e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 568933200    86 TGQCLQVYRGHTSIVNRILVAND--QLFSSSYDRTARVW 122
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDgkYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 224-260 2.67e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 2.67e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 568933200   224 SGEQLRVFREHQGSVICLEL--TDRLLYSGSADRTVKCW 260
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
225-260 8.39e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 8.39e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568933200  225 GEQLRVFREHQGSVICLEL--TDRLLYSGSADRTVKCW 260
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVW 38
PTZ00421 PTZ00421
coronin; Provisional
 5-282 9.26e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.42  E-value: 9.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200   5 GSALRVCADHRGGINWLSLSpdgqrlltgsedGTARLWSTVDGQCCA---LLQGHESY---VTFCHLEDEAAFTCSADCT 78
Cdd:PTZ00421  32 CSNTIACNDRFIAVPWQQLG------------STAVLKHTDYGKLASnppILLGQEGPiidVAFNPFDPQKLFTASEDGT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200  79 IRRWDVR----TGQC------LQVYRGHTSIVNRILVANDQLFSSSYDRTARVWTVDKGQVSQEFRGHRNCVLTLAYSap 148
Cdd:PTZ00421 100 IMGWGIPeeglTQNIsdpivhLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWN-- 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568933200 149 edlpqdpcmeaaMGGGLLVTGSSDDTAKVWQ------VASGCCHQTLRGHTgAVLCLVLHVSSHTAFTGSTDATVRAWDI 222
Cdd:PTZ00421 178 ------------LDGSLLCTTSKDKKLNIIDprdgtiVSSVEAHASAKSQR-CLWAKRKDLIITLGCSKSQQRQIMLWDT 244

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568933200 223 LSGEQ-LRVFREHQGSVICLELTDR---LLYSGS-ADRTVKCW-LADTGervLTFPAHRHSVSALK 282
Cdd:PTZ00421 245 RKMASpYSTVDLDQSSALFIPFFDEdtnLLYIGSkGEGNIRCFeLMNER---LTFCSSYSSVEPHK 307
WD40 pfam00400
WD domain, G-beta repeat;
87-122 1.11e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.11e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568933200   87 GQCLQVYRGHTSIVNRILVANDQ--LFSSSYDRTARVW 122
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGklLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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