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Conserved domains on  [gi|568952466|ref|XP_006536303|]
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leucine-rich repeat-containing protein 56 isoform X1 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
90-203 1.20e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.04  E-value: 1.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952466  90 NSLGNfglyLPNLIQLKLNHSYLGSLRDLGTSLGHLQVLWLARCGLTDLDGIGSFLELKELYVSYNNISDLSPLCLLEQL 169
Cdd:COG4886  199 EPLGN----LTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNL 274

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568952466 170 EVLDLEGNNVEDLgQMRYLQLCPRLAMLTLEGNL 203
Cdd:COG4886  275 KTLDLSNNQLTDL-KLKELELLLGLNSLLLLLLL 307
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
90-203 1.20e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.04  E-value: 1.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952466  90 NSLGNfglyLPNLIQLKLNHSYLGSLRDLGTSLGHLQVLWLARCGLTDLDGIGSFLELKELYVSYNNISDLSPLCLLEQL 169
Cdd:COG4886  199 EPLGN----LTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNL 274

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568952466 170 EVLDLEGNNVEDLgQMRYLQLCPRLAMLTLEGNL 203
Cdd:COG4886  275 KTLDLSNNQLTDL-KLKELELLLGLNSLLLLLLL 307
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 99-240 1.01e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.50  E-value: 1.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952466  99 LPNLIQLKLNHSYLGSLRDLGtSLGHLQVLWLAR------CGLTDLDgigsflELKELYVSY------------------ 154
Cdd:cd21340   45 LTNLTHLYLQNNQIEKIENLE-NLVNLKKLYLGGnrisvvEGLENLT------NLEELHIENqrlppgekltfdprslaa 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952466 155 ------------NNISDLSPLCLLEQLEVLDLEGNNVEDLGQM-RYLQLCPRLAMLTLEGNLVCLKPdpgpsnkapqgyN 221
Cdd:cd21340  118 lsnslrvlnisgNNIDSLEPLAPLRNLEQLDASNNQISDLEELlDLLSSWPSLRELDLTGNPVCKKP------------K 185

                        170
                 ....*....|....*....
gi 568952466 222 YRAEVKKLIPQLHVLDEVP 240
Cdd:cd21340  186 YRDKIILASKSLEVLDGKE 204
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 147-178 2.62e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 44.16  E-value: 2.62e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 568952466  147 LKELYVSYNNISDLSPLCLLEQLEVLDLEGNN 178
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNN 34
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
90-203 1.20e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.04  E-value: 1.20e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952466  90 NSLGNfglyLPNLIQLKLNHSYLGSLRDLGTSLGHLQVLWLARCGLTDLDGIGSFLELKELYVSYNNISDLSPLCLLEQL 169
Cdd:COG4886  199 EPLGN----LTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNL 274

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568952466 170 EVLDLEGNNVEDLgQMRYLQLCPRLAMLTLEGNL 203
Cdd:COG4886  275 KTLDLSNNQLTDL-KLKELELLLGLNSLLLLLLL 307
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
91-202 2.90e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.89  E-value: 2.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952466  91 SLGNFGLYLPNLIQLKLNHSylgSLRDLGTSLGH---LQVLWLARCGLTDL-DGIGSFLELKELYVSYNNISDLSPLCLL 166
Cdd:COG4886  173 DLPEELGNLTNLKELDLSNN---QITDLPEPLGNltnLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNL 249

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568952466 167 EQLEVLDLEGNNVEDLGQMRYLQlcpRLAMLTLEGN 202
Cdd:COG4886  250 TNLEELDLSNNQLTDLPPLANLT---NLKTLDLSNN 282
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
99-202 3.49e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.50  E-value: 3.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952466  99 LPNLIQLKLNHSYLGSLRDLGTSLGHLQVLWLARCGLTDL-DGIGSFLELKELYVSYNNISDLS-PLCLLEQLEVLDLEG 176
Cdd:COG4886  135 LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPePLGNLTNLEELDLSG 214

                         90       100
                 ....*....|....*....|....*.
gi 568952466 177 NNVEDLGQmrYLQLCPRLAMLTLEGN 202
Cdd:COG4886  215 NQLTDLPE--PLANLTNLETLDLSNN 238
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 99-240 1.01e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 67.50  E-value: 1.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952466  99 LPNLIQLKLNHSYLGSLRDLGtSLGHLQVLWLAR------CGLTDLDgigsflELKELYVSY------------------ 154
Cdd:cd21340   45 LTNLTHLYLQNNQIEKIENLE-NLVNLKKLYLGGnrisvvEGLENLT------NLEELHIENqrlppgekltfdprslaa 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952466 155 ------------NNISDLSPLCLLEQLEVLDLEGNNVEDLGQM-RYLQLCPRLAMLTLEGNLVCLKPdpgpsnkapqgyN 221
Cdd:cd21340  118 lsnslrvlnisgNNIDSLEPLAPLRNLEQLDASNNQISDLEELlDLLSSWPSLRELDLTGNPVCKKP------------K 185

                        170
                 ....*....|....*....
gi 568952466 222 YRAEVKKLIPQLHVLDEVP 240
Cdd:cd21340  186 YRDKIILASKSLEVLDGKE 204
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-202 1.01e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.80  E-value: 1.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952466  73 DDLQLVRVLEMCVDTRKNSLGNFGLYLPNLIQLK-LNHSYLGSLRDLGtSLGHLQVLWLARCGLTDL-DGIGSFLELKEL 150
Cdd:COG4886   63 SSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTnLTELDLSGNEELS-NLTNLESLDLSGNQLTDLpEELANLTNLKEL 141

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568952466 151 YVSYNNISDL-SPLCLLEQLEVLDLEGNNVEDLGqmRYLQLCPRLAMLTLEGN 202
Cdd:COG4886  142 DLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLP--EELGNLTNLKELDLSNN 192
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 147-178 2.62e-06

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 44.16  E-value: 2.62e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 568952466  147 LKELYVSYNNISDLSPLCLLEQLEVLDLEGNN 178
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNN 34
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
99-194 4.38e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 4.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952466  99 LPNLIQLKLNHSYLGSLRDLGtSLGHLQVLWLARCGLTDLDGIGSFLELKELYVSYNNISDLSplclLEQLEVLDLEGNN 178
Cdd:COG4886  227 LTNLETLDLSNNQLTDLPELG-NLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK----LKELELLLGLNSL 301

                         90
                 ....*....|....*.
gi 568952466 179 VEDLGQMRYLQLCPRL 194
Cdd:COG4886  302 LLLLLLLNLLELLILL 317
LRR_8 pfam13855
Leucine rich repeat;
124-179 8.38e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 8.38e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568952466  124 HLQVLWLARCGLTDLDGiGSFL---ELKELYVSYNNISDLSPLCL--LEQLEVLDLEGNNV 179
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDD-GAFKglsNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 124-163 2.04e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.85  E-value: 2.04e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568952466  124 HLQVLWLARCGLTDLDGIGSFLELKELYVSYNN-ISDLSPL 163
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNkITDLSDL 42
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 105-189 1.12e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568952466 105 LKLNHSYLGSLRDLGtSLGHLQVLWLARCGLTDLDGIGSFLELKELYVSYNNISDLSPLCLLEQLEVLDLEGNN---VED 181
Cdd:cd21340    7 LYLNDKNITKIDNLS-LCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRisvVEG 85


                 ....*...
gi 568952466 182 LGQMRYLQ 189
Cdd:cd21340   86 LENLTNLE 93
LRR_8 pfam13855
Leucine rich repeat;
146-204 1.89e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 1.89e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568952466  146 ELKELYVSYNNISDLSPLCL--LEQLEVLDLEGNNVEDLGqMRYLQLCPRLAMLTLEGNLV 204
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFkgLSNLKVLDLSNNLLTTLS-PGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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