ceramide glucosyltransferase isoform X1 [Mus musculus]
ceramide glucosyltransferase( domain architecture ID 10118552)
ceramide glucosyltransferase catalyzes the first glycosylation step of glycosphingolipid synthesis; its product, glucosylceramide, serves as the core of more than 300 glycosphingolipids (GSLs), a group of membrane components that have the lipid portion embedded in the outer plasma membrane leaflet and the sugar chains extended to the outer environment
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
Glucosylceramide_synthase | cd02520 | Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid ... |
51-284 | 3.04e-90 | ||||
Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; UDP-glucose:N-acylsphingosine D-glucosyltransferase (glucosylceramide synthase or ceramide glucosyltransferase) catalyzes the first glycosylation step of glycosphingolipid synthesis. Its product, glucosylceramide, serves as the core of more than 300 glycosphingolipids (GSL). GSLs are a group of membrane components that have the lipid portion embedded in the outer plasma membrane leaflet and the sugar chains extended to the outer environment. Several lines of evidence suggest the importance of GSLs in various cellular processes such as differentiation, adhesion, proliferation, and cell-cell recognition. In pathogenic fungus Cryptococcus neoformans, glucosylceramide serves as an antigen that elicits an antibody response in patients and it is essential for fungal growth in host extracellular environment. : Pssm-ID: 133012 [Multi-domain] Cd Length: 196 Bit Score: 269.08 E-value: 3.04e-90
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Name | Accession | Description | Interval | E-value | ||||||
Glucosylceramide_synthase | cd02520 | Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid ... |
51-284 | 3.04e-90 | ||||||
Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; UDP-glucose:N-acylsphingosine D-glucosyltransferase (glucosylceramide synthase or ceramide glucosyltransferase) catalyzes the first glycosylation step of glycosphingolipid synthesis. Its product, glucosylceramide, serves as the core of more than 300 glycosphingolipids (GSL). GSLs are a group of membrane components that have the lipid portion embedded in the outer plasma membrane leaflet and the sugar chains extended to the outer environment. Several lines of evidence suggest the importance of GSLs in various cellular processes such as differentiation, adhesion, proliferation, and cell-cell recognition. In pathogenic fungus Cryptococcus neoformans, glucosylceramide serves as an antigen that elicits an antibody response in patients and it is essential for fungal growth in host extracellular environment. Pssm-ID: 133012 [Multi-domain] Cd Length: 196 Bit Score: 269.08 E-value: 3.04e-90
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Glyco_transf_21 | pfam13506 | Glycosyl transferase family 21; This is a family of ceramide beta-glucosyltransferases - EC:2. ... |
106-284 | 2.22e-60 | ||||||
Glycosyl transferase family 21; This is a family of ceramide beta-glucosyltransferases - EC:2.4.1.80. Pssm-ID: 433264 [Multi-domain] Cd Length: 173 Bit Score: 192.11 E-value: 2.22e-60
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HpnI | TIGR03472 | hopanoid biosynthesis associated glycosyl transferase protein HpnI; This family of genes ... |
51-358 | 1.34e-41 | ||||||
hopanoid biosynthesis associated glycosyl transferase protein HpnI; This family of genes include a glycosyl transferase, group 2 domain (pfam00535) which are responsible, generally for the transfer of nucleotide-diphosphate sugars to substrates such as polysaccharides and lipids. The member of this clade from Acidithiobacillus ferrooxidans ATCC 23270 (AFE_0974) is found in the same locus as squalene-hopene cyclase (SHC, TIGR01507) and other genes associated with the biosynthesis of hopanoid natural products. Similarly, in Ralstonia eutropha JMP134 (Reut_B4902) this gene is adjacent to HpnAB, IspH and HpnH (TIGR03470), although SHC itself is elsewhere in the genome. Notably, this gene (here named HpnI) and three others form a conserved set (HpnIJKL) which occur in a subset of all genomes containing the SHC enzyme. This relationship was discerned using the method of partial phylogenetic profiling. This group includes Zymomonas mobilis, the organism where the initial hopanoid biosynthesis locus was described consisting of the genes HpnA-E and SHC (HpnF). Continuing past SHC are found a phosphorylase enzyme (ZMO0873, i.e. HpnG, TIGR03468) and another radical SAM enzyme (ZMO0874), HpnH. Although discontinuous in Z. mobilis, we continue the gene symbol sequence with HpnIJKL. Hopanoids are known to feature polar glycosyl head groups in many organisms. Pssm-ID: 132512 [Multi-domain] Cd Length: 373 Bit Score: 149.45 E-value: 1.34e-41
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BcsA | COG1215 | Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ... |
1-246 | 5.86e-20 | ||||||
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility]; Pssm-ID: 224136 [Multi-domain] Cd Length: 439 Bit Score: 90.38 E-value: 5.86e-20
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Name | Accession | Description | Interval | E-value | ||||||
Glucosylceramide_synthase | cd02520 | Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid ... |
51-284 | 3.04e-90 | ||||||
Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; UDP-glucose:N-acylsphingosine D-glucosyltransferase (glucosylceramide synthase or ceramide glucosyltransferase) catalyzes the first glycosylation step of glycosphingolipid synthesis. Its product, glucosylceramide, serves as the core of more than 300 glycosphingolipids (GSL). GSLs are a group of membrane components that have the lipid portion embedded in the outer plasma membrane leaflet and the sugar chains extended to the outer environment. Several lines of evidence suggest the importance of GSLs in various cellular processes such as differentiation, adhesion, proliferation, and cell-cell recognition. In pathogenic fungus Cryptococcus neoformans, glucosylceramide serves as an antigen that elicits an antibody response in patients and it is essential for fungal growth in host extracellular environment. Pssm-ID: 133012 [Multi-domain] Cd Length: 196 Bit Score: 269.08 E-value: 3.04e-90
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Glyco_transf_21 | pfam13506 | Glycosyl transferase family 21; This is a family of ceramide beta-glucosyltransferases - EC:2. ... |
106-284 | 2.22e-60 | ||||||
Glycosyl transferase family 21; This is a family of ceramide beta-glucosyltransferases - EC:2.4.1.80. Pssm-ID: 433264 [Multi-domain] Cd Length: 173 Bit Score: 192.11 E-value: 2.22e-60
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HpnI | TIGR03472 | hopanoid biosynthesis associated glycosyl transferase protein HpnI; This family of genes ... |
51-358 | 1.34e-41 | ||||||
hopanoid biosynthesis associated glycosyl transferase protein HpnI; This family of genes include a glycosyl transferase, group 2 domain (pfam00535) which are responsible, generally for the transfer of nucleotide-diphosphate sugars to substrates such as polysaccharides and lipids. The member of this clade from Acidithiobacillus ferrooxidans ATCC 23270 (AFE_0974) is found in the same locus as squalene-hopene cyclase (SHC, TIGR01507) and other genes associated with the biosynthesis of hopanoid natural products. Similarly, in Ralstonia eutropha JMP134 (Reut_B4902) this gene is adjacent to HpnAB, IspH and HpnH (TIGR03470), although SHC itself is elsewhere in the genome. Notably, this gene (here named HpnI) and three others form a conserved set (HpnIJKL) which occur in a subset of all genomes containing the SHC enzyme. This relationship was discerned using the method of partial phylogenetic profiling. This group includes Zymomonas mobilis, the organism where the initial hopanoid biosynthesis locus was described consisting of the genes HpnA-E and SHC (HpnF). Continuing past SHC are found a phosphorylase enzyme (ZMO0873, i.e. HpnG, TIGR03468) and another radical SAM enzyme (ZMO0874), HpnH. Although discontinuous in Z. mobilis, we continue the gene symbol sequence with HpnIJKL. Hopanoids are known to feature polar glycosyl head groups in many organisms. Pssm-ID: 132512 [Multi-domain] Cd Length: 373 Bit Score: 149.45 E-value: 1.34e-41
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BcsA | COG1215 | Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ... |
1-246 | 5.86e-20 | ||||||
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility]; Pssm-ID: 224136 [Multi-domain] Cd Length: 439 Bit Score: 90.38 E-value: 5.86e-20
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Glyco_tranf_2_3 | pfam13641 | Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ... |
51-239 | 8.78e-15 | ||||||
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis. Pssm-ID: 433372 [Multi-domain] Cd Length: 230 Bit Score: 72.79 E-value: 8.78e-15
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CESA_like | cd06423 | CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ... |
75-236 | 4.77e-08 | ||||||
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan. Pssm-ID: 133045 [Multi-domain] Cd Length: 180 Bit Score: 52.23 E-value: 4.77e-08
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Glyco_tranf_GTA_type | cd00761 | Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ... |
58-252 | 1.07e-06 | ||||||
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities. Pssm-ID: 132997 [Multi-domain] Cd Length: 156 Bit Score: 47.89 E-value: 1.07e-06
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Glycos_transf_2 | pfam00535 | Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ... |
64-222 | 4.73e-05 | ||||||
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids. Pssm-ID: 425738 [Multi-domain] Cd Length: 166 Bit Score: 43.15 E-value: 4.73e-05
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GT_2_like_e | cd04192 | Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ... |
65-260 | 8.56e-05 | ||||||
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families. Pssm-ID: 133035 [Multi-domain] Cd Length: 229 Bit Score: 43.43 E-value: 8.56e-05
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CESA_NdvC_like | cd06435 | NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; ... |
66-225 | 1.68e-04 | ||||||
NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase. Bradyrhizobium japonicum synthesizes periplasmic cyclic beta-(1,3),beta-(1,6)-D-glucans during growth under hypoosmotic conditions. Two genes (ndvB, ndvC) are involved in the beta-(1, 3), beta-(1,6)-glucan synthesis. The ndvC mutant strain resulted in synthesis of altered cyclic beta-glucans composed almost entirely of beta-(1, 3)-glycosyl linkages. The periplasmic cyclic beta-(1,3),beta-(1,6)-D-glucans function for osmoregulation. The ndvC mutation also affects the ability of the bacteria to establish a successful symbiotic interaction with host plant. Thus, the beta-glucans may function as suppressors of a host defense response. Pssm-ID: 133057 [Multi-domain] Cd Length: 236 Bit Score: 42.39 E-value: 1.68e-04
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CESA_CelA_like | cd06421 | CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Family of ... |
76-237 | 7.28e-04 | ||||||
CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Family of proteins related to Agrobacterium tumefaciens CelA and Gluconacetobacter xylinus BscA. These proteins are involved in the elongation of the glucan chain of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues. They are putative catalytic subunit of cellulose synthase, which is a glycosyltransferase using UDP-glucose as the substrate. The catalytic subunit is an integral membrane protein with 6 transmembrane segments and it is postulated that the protein is anchored in the membrane at the N-terminal end. Pssm-ID: 133043 [Multi-domain] Cd Length: 234 Bit Score: 40.63 E-value: 7.28e-04
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Blast search parameters | ||||
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