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Conserved domains on  [gi|568930383|ref|XP_006538514|]
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telomere zinc finger-associated protein isoform X4 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473500)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11179890|12665246|10940247|11361095|22803940

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
121-182 3.34e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 3.34e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568930383 121 RPYVCEFCSHAFTQKANLNMHLRTHTGEKPFQCHL--CGKTFRTQASLDKHNRTHTGERPFSCE 182
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNS 95
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 32-117 5.53e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.79  E-value: 5.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930383  32 GEMPYKCS--SCSQQFMQKKDLQSHMIKLHGAPKPHACPTCAKcflsrtelqlHEAFKHRgEKLFVCEECGHRASSRNGL 109
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHGHQNQKLHENPSPEK----------MNIFSAK-DKPYRCEVCDKRYKNLNGL 414


                 ....*...
gi 568930383 110 QMHIKAKH 117
Cdd:COG5189  415 KYHRKHSH 422
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 236-258 2.72e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 2.72e-03
                          10        20
                  ....*....|....*....|...
gi 568930383  236 FECTECGYKFTRQAHLRRHMEIH 258
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
223-247 3.04e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.04e-03
                          10        20
                  ....*....|....*....|....*
gi 568930383  223 LRVHVRRHKGVRKFECTECGYKFTR 247
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
121-182 3.34e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 3.34e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568930383 121 RPYVCEFCSHAFTQKANLNMHLRTHTGEKPFQCHL--CGKTFRTQASLDKHNRTHTGERPFSCE 182
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNS 95
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 32-117 5.53e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.79  E-value: 5.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930383  32 GEMPYKCS--SCSQQFMQKKDLQSHMIKLHGAPKPHACPTCAKcflsrtelqlHEAFKHRgEKLFVCEECGHRASSRNGL 109
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHGHQNQKLHENPSPEK----------MNIFSAK-DKPYRCEVCDKRYKNLNGL 414


                 ....*...
gi 568930383 110 QMHIKAKH 117
Cdd:COG5189  415 KYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
137-162 9.51e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 9.51e-05
                          10        20
                  ....*....|....*....|....*.
gi 568930383  137 NLNMHLRTHTGEKPFQCHLCGKTFRT 162
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 236-258 2.72e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 2.72e-03
                          10        20
                  ....*....|....*....|...
gi 568930383  236 FECTECGYKFTRQAHLRRHMEIH 258
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
223-247 3.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.04e-03
                          10        20
                  ....*....|....*....|....*
gi 568930383  223 LRVHVRRHKGVRKFECTECGYKFTR 247
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 122-170 5.19e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 5.19e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568930383 122 PYVCEFCSHAFTQKANLNMHLRTHTGEKpfQCHLCGKTFR-TQASLD----KHN 170
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRnTDSTLDhvckKHN 124
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
121-182 3.34e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 3.34e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568930383 121 RPYVCEFCSHAFTQKANLNMHLRTHTGEKPFQCHL--CGKTFRTQASLDKHNRTHTGERPFSCE 182
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNS 95
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 32-117 5.53e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.79  E-value: 5.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930383  32 GEMPYKCS--SCSQQFMQKKDLQSHMIKLHGAPKPHACPTCAKcflsrtelqlHEAFKHRgEKLFVCEECGHRASSRNGL 109
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHGHQNQKLHENPSPEK----------MNIFSAK-DKPYRCEVCDKRYKNLNGL 414


                 ....*...
gi 568930383 110 QMHIKAKH 117
Cdd:COG5189  415 KYHRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
122-270 2.47e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 2.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930383 122 PYVCEFCSHAFTQKANLNMHLRT--HTGE--KPFQC--HLCGKTFRTQASLDKHNRTHTGERPFSCEFCEQRFTEKGPLL 195
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLN 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930383 196 -RHVASRHQEGRPH----FC---QICGKTFKAVEQLRVHVRRHKGVR--KFECTECGYKFTRQAHLRRHMEIHDRVENYN 265
Cdd:COG5048  369 nEPPQSLQQYKDLKndkkSEtlsNSCIRNFKRDSNLSLHIITHLSFRpyNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448


                 ....*
gi 568930383 266 PRQRK 270
Cdd:COG5048  449 CSILK 453
zf-H2C2_2 pfam13465
Zinc-finger double domain;
137-162 9.51e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 9.51e-05
                          10        20
                  ....*....|....*....|....*.
gi 568930383  137 NLNMHLRTHTGEKPFQCHLCGKTFRT 162
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 236-258 2.72e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 2.72e-03
                          10        20
                  ....*....|....*....|...
gi 568930383  236 FECTECGYKFTRQAHLRRHMEIH 258
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
2-163 2.90e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 2.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930383   2 NRSEQVFTCSVCQETFRRRMELRLHM--VSHTGE--MPYKCSS--CSQQFMQKKDLQSHmIKLHGAPKPHACPTCA---- 71
Cdd:COG5048  284 KGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRH-ILLHTSISPAKEKLLNsssk 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930383  72 --KCFLSRTELQLHEAFKHRGEKLFVCE--ECGHRASSRNGLQMHIKaKHRNERPYVCEF--CSHAFTQKANLNMHLRTH 145
Cdd:COG5048  363 fsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHII-THLSFRPYNCKNppCSKSFNRHYNLIPHKKIH 441

                        170
                 ....*....|....*...
gi 568930383 146 TGEKPFQCHLCGKTFRTQ 163
Cdd:COG5048  442 TNHAPLLCSILKSFRRDL 459
zf-H2C2_2 pfam13465
Zinc-finger double domain;
223-247 3.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.04e-03
                          10        20
                  ....*....|....*....|....*
gi 568930383  223 LRVHVRRHKGVRKFECTECGYKFTR 247
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
39-122 3.20e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 3.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930383  39 SSCSQQFMQKKdlQSHMIKLHGAPKPHACPTCAKCFlSRTELQLHEAFKHRGEKLFVCEECGHRASSRNGLQMHIKAKHR 118
Cdd:COG5048   10 SSNNSVLSSTP--KSTLKSLSNAPRPDSCPNCTDSF-SRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTH 86


                 ....
gi 568930383 119 NERP 122
Cdd:COG5048   87 HNNP 90
PHA00733 PHA00733
hypothetical protein
 122-170 5.19e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 36.78  E-value: 5.19e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568930383 122 PYVCEFCSHAFTQKANLNMHLRTHTGEKpfQCHLCGKTFR-TQASLD----KHN 170
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRnTDSTLDhvckKHN 124
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
94-255 5.51e-03

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 38.46  E-value: 5.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930383  94 FVCEE--CGHRASSRNGLQMHIKAKHRNerpYVCEFCShaftqkanlnmhlrthTGEKPFQCHLcgkTFRTQASLDKHNR 171
Cdd:COG5236  152 FKCPKskCHRRCGSLKELKKHYKAQHGF---VLCSECI----------------GNKKDFWNEI---RLFRSSTLRDHKN 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568930383 172 THTGERPFS----CEFCEQRFTEKGPLLRHVASRHQEgrphfCQICGKT-------FKAVEQLRVHVRRHKGVRKFECTE 240
Cdd:COG5236  210 GGLEEEGFKghplCIFCKIYFYDDDELRRHCRLRHEA-----CHICDMVgpiryqyFKSYEDLEAHFRNAHYCCTFQTCR 284

                        170
                 ....*....|....*..
gi 568930383 241 CG--YKFTRQAHLRRHM 255
Cdd:COG5236  285 VGkcYVFPYHTELLEHL 301
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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