MAP3K TRAFs-binding domain; This entry corresponds to the TNF receptor-associated factors ...
130-508
0e+00
MAP3K TRAFs-binding domain; This entry corresponds to the TNF receptor-associated factors (TRAFs)-binding domain found at the N-terminus of some MAP3Ks, like Apoptosis signal-regulating kinases (ASK). This domain is flanked by a thioredoxin-binding domain and a PH-like domain. It includes seven tetratricopeptide repeats (TPRs) and, together with the PH-like domain, constitutes the central regulatory domain of ASK1.
:
Pssm-ID: 463827 Cd Length: 370 Bit Score: 617.74 E-value: 0e+00
ASK kinase PH domain; This PH-like domain is found in the regulatory region of ASK1 and ...
524-618
6.58e-26
ASK kinase PH domain; This PH-like domain is found in the regulatory region of ASK1 and related kinase proteins. This domain is found adjacent to the kinase domain.
:
Pssm-ID: 465956 Cd Length: 101 Bit Score: 101.91 E-value: 6.58e-26
Deoxyribohydrolase (DRHyd) domain of the ASK signalosome; This is an uncharacterized DRHyd ...
75-115
7.15e-10
Deoxyribohydrolase (DRHyd) domain of the ASK signalosome; This is an uncharacterized DRHyd domain observed in ASK signalosome proteins ASK1, ASK2, and ASK3. Potentially generates nucleotide-derived signal recognized by the TPR-S domain found in the same proteins.
:
Pssm-ID: 466459 Cd Length: 36 Bit Score: 54.41 E-value: 7.15e-10
MAP3K TRAFs-binding domain; This entry corresponds to the TNF receptor-associated factors ...
130-508
0e+00
MAP3K TRAFs-binding domain; This entry corresponds to the TNF receptor-associated factors (TRAFs)-binding domain found at the N-terminus of some MAP3Ks, like Apoptosis signal-regulating kinases (ASK). This domain is flanked by a thioredoxin-binding domain and a PH-like domain. It includes seven tetratricopeptide repeats (TPRs) and, together with the PH-like domain, constitutes the central regulatory domain of ASK1.
Pssm-ID: 463827 Cd Length: 370 Bit Score: 617.74 E-value: 0e+00
ASK kinase PH domain; This PH-like domain is found in the regulatory region of ASK1 and ...
524-618
6.58e-26
ASK kinase PH domain; This PH-like domain is found in the regulatory region of ASK1 and related kinase proteins. This domain is found adjacent to the kinase domain.
Pssm-ID: 465956 Cd Length: 101 Bit Score: 101.91 E-value: 6.58e-26
Deoxyribohydrolase (DRHyd) domain of the ASK signalosome; This is an uncharacterized DRHyd ...
75-115
7.15e-10
Deoxyribohydrolase (DRHyd) domain of the ASK signalosome; This is an uncharacterized DRHyd domain observed in ASK signalosome proteins ASK1, ASK2, and ASK3. Potentially generates nucleotide-derived signal recognized by the TPR-S domain found in the same proteins.
Pssm-ID: 466459 Cd Length: 36 Bit Score: 54.41 E-value: 7.15e-10
MAP3K TRAFs-binding domain; This entry corresponds to the TNF receptor-associated factors ...
130-508
0e+00
MAP3K TRAFs-binding domain; This entry corresponds to the TNF receptor-associated factors (TRAFs)-binding domain found at the N-terminus of some MAP3Ks, like Apoptosis signal-regulating kinases (ASK). This domain is flanked by a thioredoxin-binding domain and a PH-like domain. It includes seven tetratricopeptide repeats (TPRs) and, together with the PH-like domain, constitutes the central regulatory domain of ASK1.
Pssm-ID: 463827 Cd Length: 370 Bit Score: 617.74 E-value: 0e+00
Tetratricopeptide Repeats-Sensor; This entry represents a sensor domain consisting of 7 TPR ...
290-403
6.64e-32
Tetratricopeptide Repeats-Sensor; This entry represents a sensor domain consisting of 7 TPR repeats forming a tightly-wound solenoid structure harbouring a deep central pocket. The TPR-S binding pocket is lined with several conserved aromatic and polar residues predicted to bind a NAD+-derived nucleotide in prokaryotic NAD+-derived nucleotide-activated effector conflict systems. It has been acquired at the base of the choanoflagellate-animal lineage as a core component of the ASK signalosome.
Pssm-ID: 466458 [Multi-domain] Cd Length: 105 Bit Score: 119.30 E-value: 6.64e-32
ASK kinase PH domain; This PH-like domain is found in the regulatory region of ASK1 and ...
524-618
6.58e-26
ASK kinase PH domain; This PH-like domain is found in the regulatory region of ASK1 and related kinase proteins. This domain is found adjacent to the kinase domain.
Pssm-ID: 465956 Cd Length: 101 Bit Score: 101.91 E-value: 6.58e-26
Deoxyribohydrolase (DRHyd) domain of the ASK signalosome; This is an uncharacterized DRHyd ...
75-115
7.15e-10
Deoxyribohydrolase (DRHyd) domain of the ASK signalosome; This is an uncharacterized DRHyd domain observed in ASK signalosome proteins ASK1, ASK2, and ASK3. Potentially generates nucleotide-derived signal recognized by the TPR-S domain found in the same proteins.
Pssm-ID: 466459 Cd Length: 36 Bit Score: 54.41 E-value: 7.15e-10
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
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specific hits meet or exceed a domain-specific e-value threshold
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and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
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the domain superfamily to which the specific and non-specific hits belong
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Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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