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Conserved domains on  [gi|568932073|ref|XP_006539325|]
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MORN repeat-containing protein 1 isoform X7 [Mus musculus]

Protein Classification

MORN repeat-containing protein( domain architecture ID 11468649)

membrane-occupation-and-recognition-nexus (MORN) repeat-containing protein may be involved in protein-protein interactions

PubMed:  33296386|35568981

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
24-207 2.14e-41

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 148.18  E-value: 2.14e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932073  24 RNGYGVYVYPNSFFRYEGEWKGGKKHGHGKLLFKDGSYYEGEFVDGEITGEGCQHWAwSGNTYSGQFVLGEPQGHGVMKY 103
Cdd:COG4642   89 GDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFP-NGDVYEGEFKNGKPHGQGTLTY 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932073 104 KAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKGQWH 183
Cdd:COG4642  168 ADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFK 247

                        170       180
                 ....*....|....*....|....
gi 568932073 184 SDVFSGLGSLVHCSGVTYCGMFIN 207
Cdd:COG4642  248 NGKRHGQGTMTYADGSVYEGEWKN 271
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
24-207 2.14e-41

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 148.18  E-value: 2.14e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932073  24 RNGYGVYVYPNSFFRYEGEWKGGKKHGHGKLLFKDGSYYEGEFVDGEITGEGCQHWAwSGNTYSGQFVLGEPQGHGVMKY 103
Cdd:COG4642   89 GDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFP-NGDVYEGEFKNGKPHGQGTLTY 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932073 104 KAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKGQWH 183
Cdd:COG4642  168 ADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFK 247

                        170       180
                 ....*....|....*....|....
gi 568932073 184 SDVFSGLGSLVHCSGVTYCGMFIN 207
Cdd:COG4642  248 NGKRHGQGTMTYADGSVYEGEWKN 271
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 5-192 1.55e-22

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 100.68  E-value: 1.55e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932073   5 GDPYQASLQPRrhsprLPprNGYGVYVYPNSFFrYEGEWKGGKKHGHGKLLFKDGSYYEGEFVDGEITGEGcQHWAWSGN 84
Cdd:PLN03185   8 GDFYSGSLLGN-----VP--EGPGKYLWSDGCM-YEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSG-TYTGTDGT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932073  85 TYSGQFVLGEPQGHGVMKYKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQR 164
Cdd:PLN03185  79 TYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMM 158

                        170       180
                 ....*....|....*....|....*...
gi 568932073 165 QGHGVLCCADGSTYKGQWHSDVFSGLGS 192
Cdd:PLN03185 159 HGFGVYTWSDGGCYVGTWTRGLKDGKGV 186
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
131-151 2.62e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 37.71  E-value: 2.62e-04
                           10        20
                   ....*....|....*....|.
gi 568932073   131 VYQGSFHDNKRHGRGQMIFKN 151
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 155-177 1.10e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 36.23  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|...
gi 568932073  155 YEGDWVRDQRQGHGVLCCADGST 177
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
24-207 2.14e-41

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 148.18  E-value: 2.14e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932073  24 RNGYGVYVYPNSFFRYEGEWKGGKKHGHGKLLFKDGSYYEGEFVDGEITGEGCQHWAwSGNTYSGQFVLGEPQGHGVMKY 103
Cdd:COG4642   89 GDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFP-NGDVYEGEFKNGKPHGQGTLTY 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932073 104 KAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKGQWH 183
Cdd:COG4642  168 ADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFK 247

                        170       180
                 ....*....|....*....|....
gi 568932073 184 SDVFSGLGSLVHCSGVTYCGMFIN 207
Cdd:COG4642  248 NGKRHGQGTMTYADGSVYEGEWKN 271
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
5-213 3.29e-34

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 128.92  E-value: 3.29e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932073   5 GDPYQASLQPRRHSPRLPPRNGYGVYVYPNSFFRYEGEWKGGKKHGHGKLLFKDGSYYEGEFVDGEITGEGCQHWAWSGN 84
Cdd:COG4642   47 GGGADGGGGGGGGTGVAGGGGGEGGVTAAGGGGGGGGGKGDGGDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGG 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932073  85 tYSGQFVLGEPQGHGVMKYKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQR 164
Cdd:COG4642  127 -YGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQR 205

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 568932073 165 QGHGVLCCADGSTYKGQWHSDVFSGLGSLVHCSGVTYCGMFINGHPAGE 213
Cdd:COG4642  206 HGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQ 254
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
22-213 4.90e-28

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 111.97  E-value: 4.90e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932073  22 PPRNGYGVYVYPNSFFRYEGEWKGGKKHGHGKLLFKDGSYYEGEFVDGEITGEGCQHWAWS-----------GNTYSGQF 90
Cdd:COG4642   29 AGGEGGGGLGTLPGGGGYGGGADGGGGGGGGTGVAGGGGGEGGVTAAGGGGGGGGGKGDGGdggggeggfggGGGGGGGK 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932073  91 VLGEPQGHGVMKYKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVL 170
Cdd:COG4642  109 KGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTL 188

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 568932073 171 CCADGSTYKGQWHSDVFSGLGSLVHCSGVTYCGMFINGHPAGE 213
Cdd:COG4642  189 TYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQ 231
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 5-192 1.55e-22

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 100.68  E-value: 1.55e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932073   5 GDPYQASLQPRrhsprLPprNGYGVYVYPNSFFrYEGEWKGGKKHGHGKLLFKDGSYYEGEFVDGEITGEGcQHWAWSGN 84
Cdd:PLN03185   8 GDFYSGSLLGN-----VP--EGPGKYLWSDGCM-YEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSG-TYTGTDGT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932073  85 TYSGQFVLGEPQGHGVMKYKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQR 164
Cdd:PLN03185  79 TYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMM 158

                        170       180
                 ....*....|....*....|....*...
gi 568932073 165 QGHGVLCCADGSTYKGQWHSDVFSGLGS 192
Cdd:PLN03185 159 HGFGVYTWSDGGCYVGTWTRGLKDGKGV 186
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 58-208 9.54e-22

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 97.98  E-value: 9.54e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932073  58 DGSYYEGEFVDGeiTGEGCQHWAWS-GNTYSGQFVLGEPQGHGVMKYKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSF 136
Cdd:PLN03185   7 NGDFYSGSLLGN--VPEGPGKYLWSdGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRW 84

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568932073 137 HDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKGQWHSDVFSGLGSLVHCSGVTYCGMFING 208
Cdd:PLN03185  85 RLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDG 156
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 106-212 1.23e-12

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 69.86  E-value: 1.23e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932073 106 GGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKGQWHSD 185
Cdd:PLN03185   8 GDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLN 87

                         90       100
                 ....*....|....*....|....*..
gi 568932073 186 VFSGLGSLVHCSGVTYCGMFINGHPAG 212
Cdd:PLN03185  88 LKHGLGYQRYPNGDVFEGSWIQGLQEG 114
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 145-213 1.35e-05

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 47.52  E-value: 1.35e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568932073 145 GQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKGQWHSDVFSGLGSLVHCSGVTYCGMFINGHPAGE 213
Cdd:PLN03185   1 GELVLSNGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGS 69
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
25-164 5.76e-05

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 43.52  E-value: 5.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932073  25 NGYGVYVYPNSFFRYEGEWKGGKKHGHGKLLFKDGSYYEGEFVDGEITGEgCQHWAWSGNTYS-GQFVLGEPQGHGVMKY 103
Cdd:COG2849   20 YELGDTLLEKNGYKSGVKEKTEDSYNEGGKLIKKKLGKGLGKYKKGKLGE-WKTYYPNGQLKSeGTYKNGKLEGEWKEYY 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568932073 104 KAGG-RYEGELSQGLREGQGFLEDQDGQV-YQGSFHDNKRHGRGQMIFKNGD-KYEGDWVRDQR 164
Cdd:COG2849   99 ENGKlKSEGNYKNGKLHGEWKEYYENGKLkEEGNYKNGKKDGVWKYYDENGKlVKEEEYKNGKK 162
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
131-151 2.62e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 37.71  E-value: 2.62e-04
                           10        20
                   ....*....|....*....|.
gi 568932073   131 VYQGSFHDNKRHGRGQMIFKN 151
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 155-177 1.10e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 36.23  E-value: 1.10e-03
                          10        20
                  ....*....|....*....|...
gi 568932073  155 YEGDWVRDQRQGHGVLCCADGST 177
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 132-154 2.50e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 35.08  E-value: 2.50e-03
                          10        20
                  ....*....|....*....|...
gi 568932073  132 YQGSFHDNKRHGRGQMIFKNGDK 154
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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