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Conserved domains on  [gi|568932084|ref|XP_006539330|]
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MORN repeat-containing protein 1 isoform X12 [Mus musculus]

Protein Classification

MORN repeat-containing protein( domain architecture ID 11468649)

membrane-occupation-and-recognition-nexus (MORN) repeat-containing protein may be involved in protein-protein interactions

PubMed:  33296386|35568981

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-110 3.39e-31

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 119.29  E-value: 3.39e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932084   2 KYKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKGQ 81
Cdd:COG4642  143 TFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGE 222

                         90       100
                 ....*....|....*....|....*....
gi 568932084  82 WHSDVFSGLGSLVHCSGVTYCGMFINGHP 110
Cdd:COG4642  223 FKNGKRHGQGTLTYADGDRYEGEFKNGKR 251
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-110 3.39e-31

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 119.29  E-value: 3.39e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932084   2 KYKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKGQ 81
Cdd:COG4642  143 TFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGE 222

                         90       100
                 ....*....|....*....|....*....
gi 568932084  82 WHSDVFSGLGSLVHCSGVTYCGMFINGHP 110
Cdd:COG4642  223 FKNGKRHGQGTLTYADGDRYEGEFKNGKR 251
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 1-108 9.56e-17

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 81.80  E-value: 9.56e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932084   1 MKYKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKG 80
Cdd:PLN03185  49 ISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLG 128

                         90       100
                 ....*....|....*....|....*...
gi 568932084  81 QWHSDVFSGLGSLVHCSGVTYCGMFING 108
Cdd:PLN03185 129 DMKGGKMSGKGTLTWVSGDSYEGQWLDG 156
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
31-51 5.10e-05

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 39.63  E-value: 5.10e-05
                           10        20
                   ....*....|....*....|.
gi 568932084    31 VYQGSFHDNKRHGRGQMIFKN 51
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 55-77 2.17e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 37.77  E-value: 2.17e-04
                          10        20
                  ....*....|....*....|...
gi 568932084   55 YEGDWVRDQRQGHGVLCCADGST 77
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-110 3.39e-31

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 119.29  E-value: 3.39e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932084   2 KYKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKGQ 81
Cdd:COG4642  143 TFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGE 222

                         90       100
                 ....*....|....*....|....*....
gi 568932084  82 WHSDVFSGLGSLVHCSGVTYCGMFINGHP 110
Cdd:COG4642  223 FKNGKRHGQGTLTYADGDRYEGEFKNGKR 251
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
1-107 9.29e-31

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 118.14  E-value: 9.29e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932084   1 MKYKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKG 80
Cdd:COG4642  165 LTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEG 244

                         90       100
                 ....*....|....*....|....*..
gi 568932084  81 QWHSDVFSGLGSLVHCSGVTYCGMFIN 107
Cdd:COG4642  245 EFKNGKRHGQGTMTYADGSVYEGEWKN 271
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
1-108 2.08e-26

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 106.58  E-value: 2.08e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932084   1 MKYKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKG 80
Cdd:COG4642  119 LEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEG 198

                         90       100
                 ....*....|....*....|....*...
gi 568932084  81 QWHSDVFSGLGSLVHCSGVTYCGMFING 108
Cdd:COG4642  199 EFKNGQRHGQGTYTYADGDRYEGEFKNG 226
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
1-110 3.12e-18

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 83.47  E-value: 3.12e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932084   1 MKYKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKG 80
Cdd:COG4642   96 GGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEG 175

                         90       100       110
                 ....*....|....*....|....*....|
gi 568932084  81 QWHSDVFSGLGSLVHCSGVTYCGMFINGHP 110
Cdd:COG4642  176 EFKNGKRHGQGTLTYANGDVYEGEFKNGQR 205
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 1-108 9.56e-17

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 81.80  E-value: 9.56e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932084   1 MKYKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKG 80
Cdd:PLN03185  49 ISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGNVYLG 128

                         90       100
                 ....*....|....*....|....*...
gi 568932084  81 QWHSDVFSGLGSLVHCSGVTYCGMFING 108
Cdd:PLN03185 129 DMKGGKMSGKGTLTWVSGDSYEGQWLDG 156
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 6-110 1.47e-12

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 69.09  E-value: 1.47e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932084   6 GGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKGQWHSD 85
Cdd:PLN03185   8 GDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLN 87

                         90       100
                 ....*....|....*....|....*
gi 568932084  86 VFSGLGSLVHCSGVTYCGMFINGHP 110
Cdd:PLN03185  88 LKHGLGYQRYPNGDVFEGSWIQGLQ 112
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 3-92 2.32e-12

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 68.32  E-value: 2.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932084   3 YKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKGQW 82
Cdd:PLN03185  97 YPNGDVFEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTW 176

                         90
                 ....*....|
gi 568932084  83 HSDVFSGLGS 92
Cdd:PLN03185 177 TRGLKDGKGV 186
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
3-110 8.54e-11

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 61.90  E-value: 8.54e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932084   3 YKAGGRYEGELSQGLREGQGFLEDQDGQVYQGSFH-DNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKGQ 81
Cdd:COG4642   74 AAGGGGGGGGGKGDGGDGGGGEGGFGGGGGGGGGKkGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGE 153

                         90       100
                 ....*....|....*....|....*....
gi 568932084  82 WHSDVFSGLGSLVHCSGVTYCGMFINGHP 110
Cdd:COG4642  154 FKNGKPHGQGTLTYADGDRYEGEFKNGKR 182
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 22-103 1.96e-07

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 52.91  E-value: 1.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932084  22 GFLEDQDGQVYQGSFHDNKRHGRGQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKGQWHSDVFSGLGSLVHCSGVTY 101
Cdd:PLN03185   1 GELVLSNGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTY 80


                 ..
gi 568932084 102 CG 103
Cdd:PLN03185  81 KG 82
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 45-109 1.08e-05

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 47.52  E-value: 1.08e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568932084  45 GQMIFKNGDKYEGDWVRDQRQGHGVLCCADGSTYKGQWHSDVFSGLGSLVHCSGVTYCGMFINGH 109
Cdd:PLN03185   1 GELVLSNGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGY 65
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
31-51 5.10e-05

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 39.63  E-value: 5.10e-05
                           10        20
                   ....*....|....*....|.
gi 568932084    31 VYQGSFHDNKRHGRGQMIFKN 51
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 55-77 2.17e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 37.77  E-value: 2.17e-04
                          10        20
                  ....*....|....*....|...
gi 568932084   55 YEGDWVRDQRQGHGVLCCADGST 77
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 32-54 5.30e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 37.00  E-value: 5.30e-04
                          10        20
                  ....*....|....*....|...
gi 568932084   32 YQGSFHDNKRHGRGQMIFKNGDK 54
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
53-74 3.48e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 34.62  E-value: 3.48e-03
                           10        20
                   ....*....|....*....|..
gi 568932084    53 DKYEGDWVRDQRQGHGVLCCAD 74
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYAN 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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