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Conserved domains on  [gi|568945493|ref|XP_006539913|]
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zinc finger protein 574 isoform X1 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
541-895 1.06e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945493 541 HKCSICGKMFKKKSHVRNHLRTHTGERPFPCPD--CSKPFNSPANLARHRLTHTGERPYRCgdCGKAFTQSSTLRQHRLV 618
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945493 619 HAQHFPYR---CQECGVRFHRPYRLLMHRYHHTGEYPYKCRECPRSFLLR--RLLEVHQLVIHAGR-QPYRCSScgaaFP 692
Cdd:COG5048  112 SSSSNSNDnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqSNSLHPPLPANSLSkDPSSNLS----LL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945493 693 SSLRLREHrcaaaaaqaPRRFECGTCGKKVGSAARLQAHEAAHAAAGPgevlakEPPAPRASRATRTPVAPSPTALSGTT 772
Cdd:COG5048  188 ISSNVSTS---------IPSSSENSPLSSSYSIPSSSSDQNLENSSSS------LPLTTNSQLSPKSLLSQSPSSLSSSD 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945493 773 SAAPAAPARRRGPECSECKKLFSTETSLQVHRRIHTgerPYPCPDCGKAFRQSTHLKDHRR--LHTGE--RPFAC--EVC 846
Cdd:COG5048  253 SSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLC 329

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568945493 847 GKAFAISMRLAEHRRIHTGERPYSCP--DCGKSYRSFSNLWKHRKTHQQQH 895
Cdd:COG5048  330 GKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKD 380
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
541-895 1.06e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945493 541 HKCSICGKMFKKKSHVRNHLRTHTGERPFPCPD--CSKPFNSPANLARHRLTHTGERPYRCgdCGKAFTQSSTLRQHRLV 618
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945493 619 HAQHFPYR---CQECGVRFHRPYRLLMHRYHHTGEYPYKCRECPRSFLLR--RLLEVHQLVIHAGR-QPYRCSScgaaFP 692
Cdd:COG5048  112 SSSSNSNDnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqSNSLHPPLPANSLSkDPSSNLS----LL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945493 693 SSLRLREHrcaaaaaqaPRRFECGTCGKKVGSAARLQAHEAAHAAAGPgevlakEPPAPRASRATRTPVAPSPTALSGTT 772
Cdd:COG5048  188 ISSNVSTS---------IPSSSENSPLSSSYSIPSSSSDQNLENSSSS------LPLTTNSQLSPKSLLSQSPSSLSSSD 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945493 773 SAAPAAPARRRGPECSECKKLFSTETSLQVHRRIHTgerPYPCPDCGKAFRQSTHLKDHRR--LHTGE--RPFAC--EVC 846
Cdd:COG5048  253 SSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLC 329

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568945493 847 GKAFAISMRLAEHRRIHTGERPYSCP--DCGKSYRSFSNLWKHRKTHQQQH 895
Cdd:COG5048  330 GKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKD 380
zf-H2C2_2 pfam13465
Zinc-finger double domain;
799-824 2.53e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 2.53e-05
                          10        20
                  ....*....|....*....|....*.
gi 568945493  799 SLQVHRRIHTGERPYPCPDCGKAFRQ 824
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
541-895 1.06e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 1.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945493 541 HKCSICGKMFKKKSHVRNHLRTHTGERPFPCPD--CSKPFNSPANLARHRLTHTGERPYRCgdCGKAFTQSSTLRQHRLV 618
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945493 619 HAQHFPYR---CQECGVRFHRPYRLLMHRYHHTGEYPYKCRECPRSFLLR--RLLEVHQLVIHAGR-QPYRCSScgaaFP 692
Cdd:COG5048  112 SSSSNSNDnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqSNSLHPPLPANSLSkDPSSNLS----LL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945493 693 SSLRLREHrcaaaaaqaPRRFECGTCGKKVGSAARLQAHEAAHAAAGPgevlakEPPAPRASRATRTPVAPSPTALSGTT 772
Cdd:COG5048  188 ISSNVSTS---------IPSSSENSPLSSSYSIPSSSSDQNLENSSSS------LPLTTNSQLSPKSLLSQSPSSLSSSD 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945493 773 SAAPAAPARRRGPECSECKKLFSTETSLQVHRRIHTgerPYPCPDCGKAFRQSTHLKDHRR--LHTGE--RPFAC--EVC 846
Cdd:COG5048  253 SSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLC 329

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568945493 847 GKAFAISMRLAEHRRIHTGERPYSCP--DCGKSYRSFSNLWKHRKTHQQQH 895
Cdd:COG5048  330 GKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKD 380
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
511-631 1.17e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 1.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945493 511 SYRCLLCSREFGKALQLTRHQRFV-HRLE--RRHKC--SICGKMFKKKSHVRNHLRTHTGERPFPC-------------- 571
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRSVnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEkllnssskfsplln 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945493 572 -----------------------PDCSKPFNSPANLARHRLTHTGERP--YRCGDCGKAFTQSSTLRQHRLVHAQHFPYR 626
Cdd:COG5048  369 neppqslqqykdlkndkksetlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448


                 ....*
gi 568945493 627 CQECG 631
Cdd:COG5048  449 CSILK 453
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
811-883 1.91e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 1.91e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568945493 811 RPYPCPDCGKAFRQSTHLKDHRRLHTGERPFACEVCGKAFAISMRLA--EHRRIHTGERPYSCPDCGKSYRSFSN 883
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLElsRHLRTHHNNPSDLNSKSLPLSNSKAS 106
zf-H2C2_2 pfam13465
Zinc-finger double domain;
799-824 2.53e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 2.53e-05
                          10        20
                  ....*....|....*....|....*.
gi 568945493  799 SLQVHRRIHTGERPYPCPDCGKAFRQ 824
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 804-889 3.60e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.41  E-value: 3.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945493 804 RRIHT-GERPYPCP--DCGKAFRQSTHLKDHRrLHTGERPFACEVCGKAfaismrlaEHRRIHTGERPYSCPDCGKSYRS 880
Cdd:COG5189  340 RMLKVkDGKPYKCPveGCNKKYKNQNGLKYHM-LHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKN 410


                 ....*....
gi 568945493 881 FSNLWKHRK 889
Cdd:COG5189  411 LNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
583-608 1.30e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.30e-04
                          10        20
                  ....*....|....*....|....*.
gi 568945493  583 NLARHRLTHTGERPYRCGDCGKAFTQ 608
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
827-851 1.82e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.82e-04
                          10        20
                  ....*....|....*....|....*
gi 568945493  827 HLKDHRRLHTGERPFACEVCGKAFA 851
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 565-648 2.85e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 2.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945493 565 GERPFPCP--DCSKPFNSPANLARHRLThtgerpyrcGDCGKAFTQSSTLRQHRLVHAQHFPYRCQECGVRFHRPYRLLM 642
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 568945493 643 HRYHHT 648
Cdd:COG5189  417 HRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
855-880 4.70e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.70e-04
                          10        20
                  ....*....|....*....|....*.
gi 568945493  855 RLAEHRRIHTGERPYSCPDCGKSYRS 880
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 541-563 5.43e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 5.43e-04
                          10        20
                  ....*....|....*....|...
gi 568945493  541 HKCSICGKMFKKKSHVRNHLRTH 563
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 869-891 6.48e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 6.48e-04
                          10        20
                  ....*....|....*....|...
gi 568945493  869 YSCPDCGKSYRSFSNLWKHRKTH 891
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 813-835 8.44e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 8.44e-04
                          10        20
                  ....*....|....*....|...
gi 568945493  813 YPCPDCGKAFRQSTHLKDHRRLH 835
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
555-580 8.90e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.90e-04
                          10        20
                  ....*....|....*....|....*.
gi 568945493  555 HVRNHLRTHTGERPFPCPDCSKPFNS 580
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 597-619 2.14e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 2.14e-03
                          10        20
                  ....*....|....*....|...
gi 568945493  597 YRCGDCGKAFTQSSTLRQHRLVH 619
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
839-896 2.28e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 2.28e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568945493 839 RPFACEVCGKAFAISMRLAEHRRIHTGERPYSCPD--CGKSYRSFSNLWKHRKTHQQQHQ 896
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPS 91
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 569-591 9.91e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 9.91e-03
                          10        20
                  ....*....|....*....|...
gi 568945493  569 FPCPDCSKPFNSPANLARHRLTH 591
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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