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Conserved domains on  [gi|568946241|ref|XP_006540273|]
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zinc finger protein 607A isoform X1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204378)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-75 4.11e-32

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.46  E-value: 4.11e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568946241    14 VTFRDVAVDFSQEEWACLDATQKVLYRDMMLETYSNLVAvVGRCISKPDLIVLLEQEKEPWM 75
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVS-LGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
227-572 7.33e-16

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 80.51  E-value: 7.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 227 RPFECNECGKAFHLPDLLKYHKVIHTDEKPFECEV--CGKSFKRVSHLVEHRTIHAGVKPYECS--ECAKAFKRRSY--- 299
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSksLPLSNSKASSSsls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 300 ----------LMQHQKIHSGERPFQ--------------CKDCGKSFIVLAQ----------------------LTRHQN 333
Cdd:COG5048  112 ssssnsndnnLLSSHSLPPSSRDPQlpdllsisnlrnnpLPGNNSSSVNTPQsnslhpplpanslskdpssnlsLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 334 IHTEDKSFECKHCGKIFSCGSFLLRHQSIHTNEKPFECNVCGKAFRLQVYLSEHRKTHTDERPFECKLCGSAFRRKDQLS 413
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 414 EHQKIHTNV-------KPYQCKECGNLFRRKSSFIEHQ--SIHSEK--KPFNC--KDCGKVFRLNTHLMRHQKSHSGERP 480
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 481 FECKEC-------GKAFHLPSQLTYHKTVHTNQKPFACE--ECGKSFKHVSSLIEHRVIHAGLKPYEC--GECGKAFNHR 549
Cdd:COG5048  352 AKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRH 431

                        410       420
                 ....*....|....*....|...
gi 568946241 550 SNLKQHQKIHSDERPFECKDCGK 572
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
635-658 3.70e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.70e-03
                          10        20
                  ....*....|....*....|....
gi 568946241  635 ALRIHQRIHTGEKPFQCNKCGEAF 658
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
608-632 6.67e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.67e-03
                          10        20
                  ....*....|....*....|....*
gi 568946241  608 LNQHQRIHTDVKPYQCKECGKGFVR 632
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-75 4.11e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.46  E-value: 4.11e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568946241    14 VTFRDVAVDFSQEEWACLDATQKVLYRDMMLETYSNLVAvVGRCISKPDLIVLLEQEKEPWM 75
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVS-LGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 4.02e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 4.02e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568946241   13 SVTFRDVAVDFSQEEWACLDATQKVLYRDMMLETYSNLVAV 53
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-51 5.57e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.59  E-value: 5.57e-18
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 568946241  14 VTFRDVAVDFSQEEWACLDATQKVLYRDMMLETYSNLV 51
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
227-572 7.33e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 80.51  E-value: 7.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 227 RPFECNECGKAFHLPDLLKYHKVIHTDEKPFECEV--CGKSFKRVSHLVEHRTIHAGVKPYECS--ECAKAFKRRSY--- 299
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSksLPLSNSKASSSsls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 300 ----------LMQHQKIHSGERPFQ--------------CKDCGKSFIVLAQ----------------------LTRHQN 333
Cdd:COG5048  112 ssssnsndnnLLSSHSLPPSSRDPQlpdllsisnlrnnpLPGNNSSSVNTPQsnslhpplpanslskdpssnlsLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 334 IHTEDKSFECKHCGKIFSCGSFLLRHQSIHTNEKPFECNVCGKAFRLQVYLSEHRKTHTDERPFECKLCGSAFRRKDQLS 413
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 414 EHQKIHTNV-------KPYQCKECGNLFRRKSSFIEHQ--SIHSEK--KPFNC--KDCGKVFRLNTHLMRHQKSHSGERP 480
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 481 FECKEC-------GKAFHLPSQLTYHKTVHTNQKPFACE--ECGKSFKHVSSLIEHRVIHAGLKPYEC--GECGKAFNHR 549
Cdd:COG5048  352 AKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRH 431

                        410       420
                 ....*....|....*....|...
gi 568946241 550 SNLKQHQKIHSDERPFECKDCGK 572
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
467-490 6.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.44e-04
                          10        20
                  ....*....|....*....|....
gi 568946241  467 HLMRHQKSHSGERPFECKECGKAF 490
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 174-332 3.33e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 40.63  E-value: 3.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 174 ECKECGKCFGCRSTL------TQHQSV--HAGekpyeceeCGKAFRlpqqlTRHQKSHsgerpFECNECGKAFHLPDLLK 245
Cdd:PLN03086 409 ECRNCKHYIPSRSIAlheaycSRHNVVcpHDG--------CGIVLR-----VEEAKNH-----VHCEKCGQAFQQGEMEK 470

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 246 YHKVIHtdeKPFECEvCGKSFKRvSHLVEHR----------------TIHAGvkpyecSECAKAFKRRSYLMQHQKIhSG 309
Cdd:PLN03086 471 HMKVFH---EPLQCP-CGVVLEK-EQMVQHQastcplrlitcrfcgdMVQAG------GSAMDVRDRLRGMSEHESI-CG 538

                        170       180
                 ....*....|....*....|...
gi 568946241 310 ERPFQCKDCGKSfIVLAQLTRHQ 332
Cdd:PLN03086 539 SRTAPCDSCGRS-VMLKEMDIHQ 560
zf-H2C2_2 pfam13465
Zinc-finger double domain;
635-658 3.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.70e-03
                          10        20
                  ....*....|....*....|....
gi 568946241  635 ALRIHQRIHTGEKPFQCNKCGEAF 658
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
608-632 6.67e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.67e-03
                          10        20
                  ....*....|....*....|....*
gi 568946241  608 LNQHQRIHTDVKPYQCKECGKGFVR 632
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
14-75 4.11e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 118.46  E-value: 4.11e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568946241    14 VTFRDVAVDFSQEEWACLDATQKVLYRDMMLETYSNLVAvVGRCISKPDLIVLLEQEKEPWM 75
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVS-LGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 4.02e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 89.45  E-value: 4.02e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 568946241   13 SVTFRDVAVDFSQEEWACLDATQKVLYRDMMLETYSNLVAV 53
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-51 5.57e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.59  E-value: 5.57e-18
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 568946241  14 VTFRDVAVDFSQEEWACLDATQKVLYRDMMLETYSNLV 51
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
227-572 7.33e-16

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 80.51  E-value: 7.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 227 RPFECNECGKAFHLPDLLKYHKVIHTDEKPFECEV--CGKSFKRVSHLVEHRTIHAGVKPYECS--ECAKAFKRRSY--- 299
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSksLPLSNSKASSSsls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 300 ----------LMQHQKIHSGERPFQ--------------CKDCGKSFIVLAQ----------------------LTRHQN 333
Cdd:COG5048  112 ssssnsndnnLLSSHSLPPSSRDPQlpdllsisnlrnnpLPGNNSSSVNTPQsnslhpplpanslskdpssnlsLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 334 IHTEDKSFECKHCGKIFSCGSFLLRHQSIHTNEKPFECNVCGKAFRLQVYLSEHRKTHTDERPFECKLCGSAFRRKDQLS 413
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 414 EHQKIHTNV-------KPYQCKECGNLFRRKSSFIEHQ--SIHSEK--KPFNC--KDCGKVFRLNTHLMRHQKSHSGERP 480
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 481 FECKEC-------GKAFHLPSQLTYHKTVHTNQKPFACE--ECGKSFKHVSSLIEHRVIHAGLKPYEC--GECGKAFNHR 549
Cdd:COG5048  352 AKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRH 431

                        410       420
                 ....*....|....*....|...
gi 568946241 550 SNLKQHQKIHSDERPFECKDCGK 572
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
283-680 4.94e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 4.94e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 283 KPYECSECAKAFKRRSYLMQHQKIHSGERPFQCKD--CGKSFIVLAQLTRHQNIHTEDKSFECKHCGKI--FSCGSFLLR 358
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 359 HQSIHTNekpFECNVCGKAFRLQVYLSEHRKTHTDERPFECKL--CGSAFRRKDQLSEHQKIHTNVKPYQCKECGNLFRR 436
Cdd:COG5048  112 SSSSNSN---DNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLpgNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 437 KSSFIEHQSIHSEKKPFNCKDcgKVFRLNTHLMRHQKShsGERPFECKECGKAFHLPSQLTYHKTVHTNQKPfaCEECGK 516
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSY--SIPSSSSDQNLENSS--SSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSS--ASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 517 SFKHVSSLIEHRVIH-------AGLKPYECGECGKAFNHRSNLKQHQ--KIHSDE--RPFEC--KDCGKGFTVLAQLTRH 583
Cdd:COG5048  263 SSLPTASSQSSSPNEsdsssekGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 584 QSIHTGEKSFEC--EQCGSSFR-----LKSQLNQHQRIHTDVKPYQC--KECGKGFVR--GTALRIHQRIHTGEKPFQCN 652
Cdd:COG5048  343 ILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRdsNLSLHIITHLSFRPYNCKNP 422

                        410       420
                 ....*....|....*....|....*...
gi 568946241 653 KCGEAFQYHYQFLAHFRTHTGKKPSECE 680
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
326-651 6.65e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.10  E-value: 6.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 326 AQLTRHQNIHTEDKSFECKHCGKIFSCGSFLLRHQSIHTNEKPFECNVCGKA---FRLQVYLSEHRKTHTDERPFECKLC 402
Cdd:COG5048   19 TPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksfSRPLELSRHLRTHHNNPSDLNSKSL 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 403 GSAFRRKDQLSEHQKIHTNVKPYQCKECGNLFRRKSSFieHQSIHSEKKPFNCKDcGKVFRLNTHLMRHQKSHSgerPFE 482
Cdd:COG5048   99 PLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQ--LPDLLSISNLRNNPL-PGNNSSSVNTPQSNSLHP---PLP 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 483 CKECGKAFHLPSQLTYHKTVHTNQKPFACEECGKSFKHVSSLIEHRVIHAGLKPYECGECGKAFNHRSNLKQHQKIHSDE 562
Cdd:COG5048  173 ANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSD 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 563 RPFECKDCGKGFTVLAQLTRHQSIHTGE-------KSFECEQCGSSFRLKSQLNQHQR--IHT--DVKPYQCKE--CGKG 629
Cdd:COG5048  253 SSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSgeSLKPFSCPYslCGKL 332

                        330       340
                 ....*....|....*....|..
gi 568946241 630 FVRGTALRIHQRIHTGEKPFQC 651
Cdd:COG5048  333 FSRNDALKRHILLHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
126-361 6.62e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 6.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 126 SFTSGPNYNTSKGLQSSQEGDDNQKITNKEEIPTHTCQTLAHNtekayECKECGKCFGCRSTLTQHQSVHAGE------- 198
Cdd:COG5048  213 SSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS-----SASESPRSSLPTASSQSSSPNESDSssekgfs 287

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 199 KPYECEECGKAFRLPQQLTRHQKS--HSGE--RPFECNE--CGKAFHLPDLLKYHKVIHTDEKPFEC--EVCGKSF---- 266
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFspll 367

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 267 --KRVSHLVEHRTIHAGvKPYEC--SECAKAFKRRSYLMQHQKIHSGERP--FQCKDCGKSFIVLAQLTRHQNIHTEDKS 340
Cdd:COG5048  368 nnEPPQSLQQYKDLKND-KKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAP 446

                        250       260
                 ....*....|....*....|.
gi 568946241 341 FECKHCGKIFSCGSFLLRHQS 361
Cdd:COG5048  447 LLCSILKSFRRDLDLSNHGKD 467
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 197-277 5.11e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 5.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 197 GEKPYECE--ECGKAFRLPQQLTRHQKsHSGERPfecnecgKAFHLPDLLKyHKVIHTDEKPFECEVCGKSFKRVSHLVE 274
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQ-------KLHENPSPEK-MNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 568946241 275 HRT 277
Cdd:COG5189  417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
467-490 6.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.44e-04
                          10        20
                  ....*....|....*....|....
gi 568946241  467 HLMRHQKSHSGERPFECKECGKAF 490
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 477-560 7.68e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 7.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 477 GERPFECK--ECGKAFHLPSQLTYHKtVHTNQKPFACEEcgksfkhvSSLIEHRVIHAGLKPYECGECGKAFNHRSNLKQ 554
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM-LHGHQNQKLHEN--------PSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 568946241 555 HQKiHS 560
Cdd:COG5189  417 HRK-HS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
299-322 2.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.09e-03
                          10        20
                  ....*....|....*....|....
gi 568946241  299 YLMQHQKIHSGERPFQCKDCGKSF 322
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 174-332 3.33e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 40.63  E-value: 3.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 174 ECKECGKCFGCRSTL------TQHQSV--HAGekpyeceeCGKAFRlpqqlTRHQKSHsgerpFECNECGKAFHLPDLLK 245
Cdd:PLN03086 409 ECRNCKHYIPSRSIAlheaycSRHNVVcpHDG--------CGIVLR-----VEEAKNH-----VHCEKCGQAFQQGEMEK 470

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946241 246 YHKVIHtdeKPFECEvCGKSFKRvSHLVEHR----------------TIHAGvkpyecSECAKAFKRRSYLMQHQKIhSG 309
Cdd:PLN03086 471 HMKVFH---EPLQCP-CGVVLEK-EQMVQHQastcplrlitcrfcgdMVQAG------GSAMDVRDRLRGMSEHESI-CG 538

                        170       180
                 ....*....|....*....|...
gi 568946241 310 ERPFQCKDCGKSfIVLAQLTRHQ 332
Cdd:PLN03086 539 SRTAPCDSCGRS-VMLKEMDIHQ 560
zf-H2C2_2 pfam13465
Zinc-finger double domain;
635-658 3.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.70e-03
                          10        20
                  ....*....|....*....|....
gi 568946241  635 ALRIHQRIHTGEKPFQCNKCGEAF 658
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
244-268 4.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.20e-03
                          10        20
                  ....*....|....*....|....*
gi 568946241  244 LKYHKVIHTDEKPFECEVCGKSFKR 268
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
216-238 5.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.32e-03
                          10        20
                  ....*....|....*....|...
gi 568946241  216 LTRHQKSHSGERPFECNECGKAF 238
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
608-632 6.67e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.67e-03
                          10        20
                  ....*....|....*....|....*
gi 568946241  608 LNQHQRIHTDVKPYQCKECGKGFVR 632
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
551-575 9.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.32e-03
                          10        20
                  ....*....|....*....|....*
gi 568946241  551 NLKQHQKIHSDERPFECKDCGKGFT 575
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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