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Conserved domains on  [gi|568946377|ref|XP_006540337|]
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phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_PINLYP_rpt1 cd23571
first extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 26-112 2.77e-29

first extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


:

Pssm-ID: 467101  Cd Length: 89  Bit Score: 104.42  E-value: 2.77e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946377  26 PLTCEVCKGSGHTCSGKMKTCEDGKDACVVLVSESSTKGRKSVNTFKACMKYKDCYSGFVSTTMTPSDYMVSNAHCCQSD 105
Cdd:cd23571    3 PLSCEVCKSKGSLCSGPLQTCAPGEDACLTLTGETTLGGNGLVRTFKGCLKPSDCPSGPFSFTFFPKIRMRRNSKCCQTD 82


                 ....*..
gi 568946377 106 GCNSGSV 112
Cdd:cd23571   83 GCNSGAV 89
TFP_LU_ECD_PINLYP_rpt2 cd23572
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 122-201 1.86e-17

second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


:

Pssm-ID: 467102  Cd Length: 80  Bit Score: 73.62  E-value: 1.86e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946377 122 NGLMCPSCIAPFQETCPGTQAARCVGRETHCIYFAGNVQAGIIHTKFATRGCATESACHTKAGAEvPSAFYLYFLRRADC 201
Cdd:cd23572    1 NGLQCPACYSEGSDSCKSEETVNCTGEETQCIEFSGTISGGGSSVKFAMKGCATESACDLGKGSL-PFGGTSVNITTATC 79
 
Name Accession Description Interval E-value
TFP_LU_ECD_PINLYP_rpt1 cd23571
first extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 26-112 2.77e-29

first extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467101  Cd Length: 89  Bit Score: 104.42  E-value: 2.77e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946377  26 PLTCEVCKGSGHTCSGKMKTCEDGKDACVVLVSESSTKGRKSVNTFKACMKYKDCYSGFVSTTMTPSDYMVSNAHCCQSD 105
Cdd:cd23571    3 PLSCEVCKSKGSLCSGPLQTCAPGEDACLTLTGETTLGGNGLVRTFKGCLKPSDCPSGPFSFTFFPKIRMRRNSKCCQTD 82


                 ....*..
gi 568946377 106 GCNSGSV 112
Cdd:cd23571   83 GCNSGAV 89
TFP_LU_ECD_PINLYP_rpt2 cd23572
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 122-201 1.86e-17

second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467102  Cd Length: 80  Bit Score: 73.62  E-value: 1.86e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946377 122 NGLMCPSCIAPFQETCPGTQAARCVGRETHCIYFAGNVQAGIIHTKFATRGCATESACHTKAGAEvPSAFYLYFLRRADC 201
Cdd:cd23572    1 NGLQCPACYSEGSDSCKSEETVNCTGEETQCIEFSGTISGGGSSVKFAMKGCATESACDLGKGSL-PFGGTSVNITTATC 79
PLA2_inh pfam02988
Phospholipase A2 inhibitor;
27-107 6.91e-04

Phospholipase A2 inhibitor;


Pssm-ID: 190495  Cd Length: 83  Bit Score: 37.47  E-value: 6.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946377   27 LTCEVCKGSGHTCSGKMKTCEDGKDACVVLVSESSTKGRKSVNTFKACMKYKDCYSGFVSTTMTPSDYMVSNAHCCQSDG 106
Cdd:pfam02988   1 RSCEICHNLGKDCNGWTEECDSPEDQCGTVLTEVSSAPLSIRTIHKNCFSSSTCKLEYFDVNPGHELYLRGRIHCCTGEE 80


                  .
gi 568946377  107 C 107
Cdd:pfam02988  81 C 81
 
Name Accession Description Interval E-value
TFP_LU_ECD_PINLYP_rpt1 cd23571
first extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 26-112 2.77e-29

first extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467101  Cd Length: 89  Bit Score: 104.42  E-value: 2.77e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946377  26 PLTCEVCKGSGHTCSGKMKTCEDGKDACVVLVSESSTKGRKSVNTFKACMKYKDCYSGFVSTTMTPSDYMVSNAHCCQSD 105
Cdd:cd23571    3 PLSCEVCKSKGSLCSGPLQTCAPGEDACLTLTGETTLGGNGLVRTFKGCLKPSDCPSGPFSFTFFPKIRMRRNSKCCQTD 82


                 ....*..
gi 568946377 106 GCNSGSV 112
Cdd:cd23571   83 GCNSGAV 89
TFP_LU_ECD_PLIG cd23588
extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma ...
 27-108 2.30e-19

extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma subunit (gamma-PLI) family; The gamma-PLI family includes gamma-PLI A and gamma-PLI B. Gamma-PLI inhibits the enzymatic activity of all phospholipase A2 (PA2) groups. Gamma-PLI A and gamma-PLI B form a heterodimer. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467117  Cd Length: 82  Bit Score: 78.51  E-value: 2.30e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946377  27 LTCEVCKGSGHTCSGKMKTCEDGKDACVVLVSESSTKGRKSVNTFKACMKYKDCYSGFVSTTMTPSDYMVSNAHCCQSDG 106
Cdd:cd23588    1 LECEVCSGTGTNCTGPMETCSPGEDTCGIILTESTLGGKKTQTVEKGCVSSSVCTLGPVSFNFGKGRTIRTSVSCCTGDA 80


                 ..
gi 568946377 107 CN 108
Cdd:cd23588   81 CK 82
TFP_LU_ECD_PINLYP_rpt2 cd23572
second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR ...
 122-201 1.86e-17

second extracellular domain (ECD) found in phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein (PINLYP) and similar proteins; PINLYP is a cytotoxic necrotizing factor (CNF)-like-inhibitor family protein which is the paralog of Ly6/PLAUR domain-containing protein 8 (LYPD8), a highly glycosylated glycosylphosphatidylinositol-anchored secreted protein that mediates segregation of intestinal bacteria and epithelial cells in the colon to preserve intestinal homeostasis. PINLYP contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467102  Cd Length: 80  Bit Score: 73.62  E-value: 1.86e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946377 122 NGLMCPSCIAPFQETCPGTQAARCVGRETHCIYFAGNVQAGIIHTKFATRGCATESACHTKAGAEvPSAFYLYFLRRADC 201
Cdd:cd23572    1 NGLQCPACYSEGSDSCKSEETVNCTGEETQCIEFSGTISGGGSSVKFAMKGCATESACDLGKGSL-PFGGTSVNITTATC 79
TFP_LU_ECD_PLIGB cd23630
extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma ...
 27-107 8.72e-07

extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma subunit B (gamma-PLI B) and similar proteins; Gamma-PLI inhibits the enzymatic activity of all phospholipase A2 (PA2) groups. There are two gamma-PLI subunits, subunit A and subunit B, which form a heterodimer. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467150  Cd Length: 82  Bit Score: 45.22  E-value: 8.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946377  27 LTCEVCKGSGHTCSGKMKTCEDGKDACVVLVSESSTKGRKSVNTFKACMKYKDCYSGFVSTTMTPSDYMVSNAHCCQSDG 106
Cdd:cd23630    1 LECEVCIGLGKKCNGWTKTCKANEDTCVTFQTEVIRAPVSLTFTAKHCGTSDTCHLDYLETTLHDELTVRLKRTCCTGEE 80


                 .
gi 568946377 107 C 107
Cdd:cd23630   81 C 81
PLA2_inh pfam02988
Phospholipase A2 inhibitor;
27-107 6.91e-04

Phospholipase A2 inhibitor;


Pssm-ID: 190495  Cd Length: 83  Bit Score: 37.47  E-value: 6.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946377   27 LTCEVCKGSGHTCSGKMKTCEDGKDACVVLVSESSTKGRKSVNTFKACMKYKDCYSGFVSTTMTPSDYMVSNAHCCQSDG 106
Cdd:pfam02988   1 RSCEICHNLGKDCNGWTEECDSPEDQCGTVLTEVSSAPLSIRTIHKNCFSSSTCKLEYFDVNPGHELYLRGRIHCCTGEE 80


                  .
gi 568946377  107 C 107
Cdd:pfam02988  81 C 81
TFP_LU_ECD_CD59 cd23554
extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called ...
 27-108 1.96e-03

extracellular domain (ECD) found in CD59 glycoprotein and similar proteins; CD59 (also called 1F5 antigen, or 20 kDa homologous restriction factor, or HRF-20, or MAC-inhibitory protein (MAC-IP), or MEM43 antigen, or membrane attack complex inhibition factor (MACIF), or membrane inhibitor of reactive lysis (MIRL), or protectin) is an LY-6-like protein expressed in human lymphoid cells and inhibits the action of the complement membrane attack complex (MAC) on homologous cells. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is also involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. CD59 contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467084  Cd Length: 70  Bit Score: 35.76  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946377  27 LTCEVCKGSGHTCSGKMkTCEDGKDACVVLVSESstkgrksvNTFKACMKYKDCYSGFVSTtmtpsDYMVSNAH--CCQS 104
Cdd:cd23554    1 LKCYNCPNPTSNCNTNV-TCSSNLDACLIVKAGN--------RIYRQCWKYSDCNFDFISE-----RFGESNFKyrCCQK 66


                 ....
gi 568946377 105 DGCN 108
Cdd:cd23554   67 DLCN 70
TFP_LU_ECD_LYPD3_rpt2 cd23563
second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and ...
 122-187 5.92e-03

second extracellular domain (ECD) found in Ly6/PLAUR domain-containing protein 3 (LYPD3) and similar proteins; LYPD3 (also called GPI-anchored metastasis-associated protein C4.4A homolog, or matrigel-induced gene C4 protein (MIG-C4)) supports cell migration. It may be involved in urothelial cell-matrix interactions as well as in tumor progression. LYPD3 contains two extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the second ECD.


Pssm-ID: 467093  Cd Length: 88  Bit Score: 34.74  E-value: 5.92e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568946377 122 NGLMCPSCIAPFQETCPGTQAA--RCVGRETHCiyFAGNV--QAGIIHTKFATRGCATESAC--HTKAGAEV 187
Cdd:cd23563    2 NGVECYSCVGNSRGACSPSNAPvvRCYGAYSGC--FDGNVtlTIGNVTLSLPVKGCVQDGDCtrESKGGASV 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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