NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568947861|ref|XP_006540944|]
View 

zinc finger protein 473 homolog isoform X1 [Mus musculus]

Protein Classification

KRAB_A-box and COG5048 domain-containing protein( domain architecture ID 11577774)

protein containing domains KRAB_A-box, zf-H2C2_2, and COG5048

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 23-63 3.01e-09

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


:

Pssm-ID: 143639  Cd Length: 40  Bit Score: 52.94  E-value: 3.01e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568947861  23 ETLKDLAMDFTVEDWKDLESEwdQRDLFWDVTLNHYQDMFS 63
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPA--QRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
485-888 1.62e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 1.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947861 485 QKPHKCSECGKAFCRRTDLTEHQRVHSGFRPHQCPV--CARTFNRPSHLVRHRLRHAEERHFGCAKCketFIYKEQLERH 562
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKS---LPLSNSKASS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947861 563 NKIHTieglyeckqCGEHFICRSTLNCHLSIHIRENTSEKVVGQNSQHTEKCFKNTKcRKAPNHSRYLGQHEKIHAQVTs 642
Cdd:COG5048  108 SSLSS---------SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNN-SSSVNTPQSNSLHPPLPANSL- 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947861 643 gecdpCGETYDQSVQPICHQSICAGVKPSECAEPEKCTRNT-SASEHHPSQREPSFKCDIYNRAFKQRAHLSKHQLIHIT 721
Cdd:COG5048  177 -----SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPsSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSS 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947861 722 EKPFKCNECDRAFKQSNYLIQHQKTHTAE-------KHFECSECGKTFHQRSCLSKHQ--KIHSGE--KPFKCG--DCGK 788
Cdd:COG5048  252 DSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPysLCGK 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947861 789 AFISGAQLIRHQRIHTGEKPYVC--QECGKTFSQSS------CLTLHLRIHTGEKPYTCG-TCGKAFAQRANQRKHERIH 859
Cdd:COG5048  332 LFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppqSLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITH 411

                        410       420       430
                 ....*....|....*....|....*....|.
gi 568947861 860 TGEKPYAC--GLCGKAFGLRTHLQQHQRIHT 888
Cdd:COG5048  412 LSFRPYNCknPPCSKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
446-471 1.24e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.24e-03
                          10        20
                  ....*....|....*....|....*.
gi 568947861  446 SLIKHQAIHKGEKPYKCDECGKAFNH 471
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 23-63 3.01e-09

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 52.94  E-value: 3.01e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568947861  23 ETLKDLAMDFTVEDWKDLESEwdQRDLFWDVTLNHYQDMFS 63
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPA--QRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
485-888 1.62e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 1.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947861 485 QKPHKCSECGKAFCRRTDLTEHQRVHSGFRPHQCPV--CARTFNRPSHLVRHRLRHAEERHFGCAKCketFIYKEQLERH 562
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKS---LPLSNSKASS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947861 563 NKIHTieglyeckqCGEHFICRSTLNCHLSIHIRENTSEKVVGQNSQHTEKCFKNTKcRKAPNHSRYLGQHEKIHAQVTs 642
Cdd:COG5048  108 SSLSS---------SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNN-SSSVNTPQSNSLHPPLPANSL- 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947861 643 gecdpCGETYDQSVQPICHQSICAGVKPSECAEPEKCTRNT-SASEHHPSQREPSFKCDIYNRAFKQRAHLSKHQLIHIT 721
Cdd:COG5048  177 -----SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPsSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSS 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947861 722 EKPFKCNECDRAFKQSNYLIQHQKTHTAE-------KHFECSECGKTFHQRSCLSKHQ--KIHSGE--KPFKCG--DCGK 788
Cdd:COG5048  252 DSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPysLCGK 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947861 789 AFISGAQLIRHQRIHTGEKPYVC--QECGKTFSQSS------CLTLHLRIHTGEKPYTCG-TCGKAFAQRANQRKHERIH 859
Cdd:COG5048  332 LFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppqSLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITH 411

                        410       420       430
                 ....*....|....*....|....*....|.
gi 568947861 860 TGEKPYAC--GLCGKAFGLRTHLQQHQRIHT 888
Cdd:COG5048  412 LSFRPYNCknPPCSKSFNRHYNLIPHKKIHT 442
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 24-63 4.85e-07

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 47.08  E-value: 4.85e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 568947861   24 TLKDLAMDFTVEDWKDLESewDQRDLFWDVTLNHYQDMFS 63
Cdd:pfam01352   3 TFEDVAVDFTQEEWALLDP--AQRNLYRDVMLENYRNLVS 40
KRAB smart00349
krueppel associated box;
24-83 2.04e-06

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 45.66  E-value: 2.04e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568947861    24 TLKDLAMDFTVEDWKDLESewDQRDLFWDVTLNHYQDMFSF-TDTSQPSLTSQPDVREELE 83
Cdd:smart00349   2 TFEDVAVYFTQEEWEQLDP--AQKNLYRDVMLENYSNLVSLgFQVPKPDLISQLEQGEEPW 60
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 723-775 2.41e-06

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 46.01  E-value: 2.41e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568947861 723 KPFkCNECDRAFKQSNYLIQHQKthtaEKHFECSECGKTFHQRSCLSKH-QKIH 775
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
796-820 3.42e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.42e-04
                          10        20
                  ....*....|....*....|....*
gi 568947861  796 LIRHQRIHTGEKPYVCQECGKTFSQ 820
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
446-471 1.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.24e-03
                          10        20
                  ....*....|....*....|....*.
gi 568947861  446 SLIKHQAIHKGEKPYKCDECGKAFNH 471
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 23-63 3.01e-09

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 52.94  E-value: 3.01e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 568947861  23 ETLKDLAMDFTVEDWKDLESEwdQRDLFWDVTLNHYQDMFS 63
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPA--QRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
485-888 1.62e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 1.62e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947861 485 QKPHKCSECGKAFCRRTDLTEHQRVHSGFRPHQCPV--CARTFNRPSHLVRHRLRHAEERHFGCAKCketFIYKEQLERH 562
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKS---LPLSNSKASS 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947861 563 NKIHTieglyeckqCGEHFICRSTLNCHLSIHIRENTSEKVVGQNSQHTEKCFKNTKcRKAPNHSRYLGQHEKIHAQVTs 642
Cdd:COG5048  108 SSLSS---------SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNN-SSSVNTPQSNSLHPPLPANSL- 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947861 643 gecdpCGETYDQSVQPICHQSICAGVKPSECAEPEKCTRNT-SASEHHPSQREPSFKCDIYNRAFKQRAHLSKHQLIHIT 721
Cdd:COG5048  177 -----SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPsSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSS 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947861 722 EKPFKCNECDRAFKQSNYLIQHQKTHTAE-------KHFECSECGKTFHQRSCLSKHQ--KIHSGE--KPFKCG--DCGK 788
Cdd:COG5048  252 DSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPysLCGK 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947861 789 AFISGAQLIRHQRIHTGEKPYVC--QECGKTFSQSS------CLTLHLRIHTGEKPYTCG-TCGKAFAQRANQRKHERIH 859
Cdd:COG5048  332 LFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppqSLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITH 411

                        410       420       430
                 ....*....|....*....|....*....|.
gi 568947861 860 TGEKPYAC--GLCGKAFGLRTHLQQHQRIHT 888
Cdd:COG5048  412 LSFRPYNCknPPCSKSFNRHYNLIPHKKIHT 442
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 24-63 4.85e-07

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 47.08  E-value: 4.85e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 568947861   24 TLKDLAMDFTVEDWKDLESewDQRDLFWDVTLNHYQDMFS 63
Cdd:pfam01352   3 TFEDVAVDFTQEEWALLDP--AQRNLYRDVMLENYRNLVS 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
458-823 2.03e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 2.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947861 458 KPYKCDECGKAFNHSSTLKIHQRIHSGQKPHKCS--ECGKAFCRRTDLTEHQRVHSGFRPHQC----------------P 519
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNskslplsnskasssslS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947861 520 VCARTFNRPSHLVRHRLRHAE----------ERHFGCAKCK-ETFIYKEQLERHNKIHTIEGLYECKqcgEHFICRSTLN 588
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSrdpqlpdllsISNLRNNPLPgNNSSSVNTPQSNSLHPPLPANSLSK---DPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947861 589 CHLSIHIRENTSEK------------VVGQNSQHTEKCFKNTKCRKAPNHSRYLGQHEKIHAQVTSGECDPCGETYDQSV 656
Cdd:COG5048  189 SSNVSTSIPSSSENsplsssysipssSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947861 657 QPICHQSICAG-VKPSECAEPEKCTRNTSA------------SEHHPSQREPSFKCDI--YNRAFKQRAHLSKHQLIHIT 721
Cdd:COG5048  269 SSQSSSPNESDsSSEKGFSLPIKSKQCNISfsrsspltrhlrSVNHSGESLKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947861 722 EKPFKCNECDRAFKQSNYL-------IQHQKTHTAEKHFEC--SECGKTFHQRSCLSKH--QKIHSGEKPFKCGDCGKAF 790
Cdd:COG5048  349 ISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHiiTHLSFRPYNCKNPPCSKSF 428

                        410       420       430
                 ....*....|....*....|....*....|...
gi 568947861 791 ISGAQLIRHQRIHTGEKPYVCQECGKTFSQSSC 823
Cdd:COG5048  429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
KRAB smart00349
krueppel associated box;
24-83 2.04e-06

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 45.66  E-value: 2.04e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568947861    24 TLKDLAMDFTVEDWKDLESewDQRDLFWDVTLNHYQDMFSF-TDTSQPSLTSQPDVREELE 83
Cdd:smart00349   2 TFEDVAVYFTQEEWEQLDP--AQKNLYRDVMLENYSNLVSLgFQVPKPDLISQLEQGEEPW 60
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 723-775 2.41e-06

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 46.01  E-value: 2.41e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568947861 723 KPFkCNECDRAFKQSNYLIQHQKthtaEKHFECSECGKTFHQRSCLSKH-QKIH 775
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
796-820 3.42e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.42e-04
                          10        20
                  ....*....|....*....|....*
gi 568947861  796 LIRHQRIHTGEKPYVCQECGKTFSQ 820
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
446-471 1.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.24e-03
                          10        20
                  ....*....|....*....|....*.
gi 568947861  446 SLIKHQAIHKGEKPYKCDECGKAFNH 471
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
475-497 1.98e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.98e-03
                          10        20
                  ....*....|....*....|...
gi 568947861  475 LKIHQRIHSGQKPHKCSECGKAF 497
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 460-482 4.15e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 4.15e-03
                          10        20
                  ....*....|....*....|...
gi 568947861  460 YKCDECGKAFNHSSTLKIHQRIH 482
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
824-848 4.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.70e-03
                          10        20
                  ....*....|....*....|....*
gi 568947861  824 LTLHLRIHTGEKPYTCGTCGKAFAQ 848
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
768-792 5.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.04e-03
                          10        20
                  ....*....|....*....|....*
gi 568947861  768 LSKHQKIHSGEKPFKCGDCGKAFIS 792
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
853-874 7.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.24e-03
                          10        20
                  ....*....|....*....|..
gi 568947861  853 RKHERIHTGEKPYACGLCGKAF 874
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH