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Conserved domains on  [gi|578804722|ref|XP_006712743|]
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sodium channel protein type 7 subunit alpha isoform X1 [Homo sapiens]

Protein Classification

sodium channel protein subunit alpha( domain architecture ID 11999110)

sodium channel protein subunit alpha mediates the voltage-dependent sodium ion permeability of excitable membranes

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
933-1198 2.16e-46

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 167.06  E-value: 2.16e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   933 NNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILlEYADMIFTYIFILEMLLKWMAYGF-KAYFSNGWYRLDFVVVIVF 1011
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVL-EILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722  1012 CLSLIGKTREE---LKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECI 1088
Cdd:pfam00520   80 LISLVLSSVGSlsgLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722  1089 DPtsgerfpssevmnksrcesllfnesmlwENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSvavniqphfEVNIY 1168
Cdd:pfam00520  160 NP----------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDG---------KGEFW 202
                          250       260       270
                   ....*....|....*....|....*....|
gi 578804722  1169 MYCYFINFIIFGVFLPLSMLITVIIDNFNK 1198
Cdd:pfam00520  203 AYIYFVSFIILGGFLLLNLFIAVIIDNFQE 232
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
504-717 1.50e-44

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 161.67  E-value: 1.50e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   504 APFTDLFLIICIILNVCFLTLEHYPMSKQ-TNTLLNIGNLVFIGIFTAEMIFKIIAMHP-YGYFQVGWNIFDSMIVFHGL 581
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   582 IELCLA---NVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYeefvc 658
Cdd:pfam00520   81 ISLVLSsvgSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   659 HIDKDCQLPRWHMHDFFHSFLNVFRILCGE-WVETLWDCMEVAGQSWCIPFYLMVILIGN 717
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
117-403 1.95e-34

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 132.78  E-value: 1.95e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   117 HPFFQLFILISVLIDCVFMSL-------TNLPKWRPVLENTLLGIYTFEILVKLFARGVWagsFSFLGDPWNWLDFSVTV 189
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALetyfqpeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   190 FEVII----RYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKH 265
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   266 kcfrwpqenenetlhnrtgnpyyiretenfyylegeryallcgnrtdagqcpegyvcvkaGINPDQGFTNFDSFGWALFA 345
Cdd:pfam00520  158 ------------------------------------------------------------WENPDNGRTNFDNFPNAFLW 177
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 578804722   346 LFRLMAQD-YPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQR 403
Cdd:pfam00520  178 LFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1250-1497 6.14e-29

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 116.98  E-value: 6.14e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722  1250 SQAFNVIVMVLICFQAIAMMIDTDVQSLQ-MSIALYWINSIFVMLYTMECILKLIAFRCF--YFTIAWNIFDFMVVIFSI 1326
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKkrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722  1327 TGLCLPMTVGsylvpPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYV- 1405
Cdd:pfam00520   81 ISLVLSSVGS-----LSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKl 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722  1406 -KKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKwsdcdpdkinpgtqvrgdcgNPSVGIFYFVSYILISW 1484
Cdd:pfam00520  156 kTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK--------------------GEFWAYIYFVSFIILGG 215
                          250
                   ....*....|...
gi 578804722  1485 LIIVNMYIVVVME 1497
Cdd:pfam00520  216 FLLLNLFIAVIID 228
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
743-927 1.23e-26

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


:

Pssm-ID: 428983  Cd Length: 195  Bit Score: 108.97  E-value: 1.23e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   743 NEAKNLQLAVARIKKGINYV-------LLKILCKTQNVPKDTMDHVNEVYVKED--ISDHTlselsntqDFLKDKEKSSG 813
Cdd:pfam06512    2 GEMNNLQIALARIQRGIRFVkstlrdfCCRLCLEPQLPEKKPLDESKDARSKLTnqIANHT--------KKAPGGGGKYE 73
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   814 TEKNateneSQSLIPSPSVSETVPIASGESDIENLDNKEIQS-KSGDGGSKEKIKQ----SSSSECSTVDIAISEEEEMf 888
Cdd:pfam06512   74 LDEG-----HMDFITNPNLTVCVPIAEGESDLENEEDDDESSqSSDEEKSKQQEQLedddSSSSEGSTVDLQDPEEELE- 147
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 578804722   889 YGGERSKHLK-------NGC-RRGSSLgQISGASKKGKIWQNIRKTC 927
Cdd:pfam06512  148 KIPEEAEELKepedcftEGCvRRFPCC-AVDTTKGPWKIWWNLRKTC 193
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1194-1246 7.14e-22

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


:

Pssm-ID: 240441  Cd Length: 54  Bit Score: 89.93  E-value: 7.14e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 578804722 1194 DNFNKHKIKLGGS-NIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFD 1246
Cdd:cd13433     1 DNFNQLKKKYGGGlDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
933-1198 2.16e-46

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 167.06  E-value: 2.16e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   933 NNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILlEYADMIFTYIFILEMLLKWMAYGF-KAYFSNGWYRLDFVVVIVF 1011
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVL-EILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722  1012 CLSLIGKTREE---LKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECI 1088
Cdd:pfam00520   80 LISLVLSSVGSlsgLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722  1089 DPtsgerfpssevmnksrcesllfnesmlwENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSvavniqphfEVNIY 1168
Cdd:pfam00520  160 NP----------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDG---------KGEFW 202
                          250       260       270
                   ....*....|....*....|....*....|
gi 578804722  1169 MYCYFINFIIFGVFLPLSMLITVIIDNFNK 1198
Cdd:pfam00520  203 AYIYFVSFIILGGFLLLNLFIAVIIDNFQE 232
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
504-717 1.50e-44

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 161.67  E-value: 1.50e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   504 APFTDLFLIICIILNVCFLTLEHYPMSKQ-TNTLLNIGNLVFIGIFTAEMIFKIIAMHP-YGYFQVGWNIFDSMIVFHGL 581
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   582 IELCLA---NVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYeefvc 658
Cdd:pfam00520   81 ISLVLSsvgSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   659 HIDKDCQLPRWHMHDFFHSFLNVFRILCGE-WVETLWDCMEVAGQSWCIPFYLMVILIGN 717
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
117-403 1.95e-34

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 132.78  E-value: 1.95e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   117 HPFFQLFILISVLIDCVFMSL-------TNLPKWRPVLENTLLGIYTFEILVKLFARGVWagsFSFLGDPWNWLDFSVTV 189
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALetyfqpeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   190 FEVII----RYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKH 265
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   266 kcfrwpqenenetlhnrtgnpyyiretenfyylegeryallcgnrtdagqcpegyvcvkaGINPDQGFTNFDSFGWALFA 345
Cdd:pfam00520  158 ------------------------------------------------------------WENPDNGRTNFDNFPNAFLW 177
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 578804722   346 LFRLMAQD-YPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQR 403
Cdd:pfam00520  178 LFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1250-1497 6.14e-29

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 116.98  E-value: 6.14e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722  1250 SQAFNVIVMVLICFQAIAMMIDTDVQSLQ-MSIALYWINSIFVMLYTMECILKLIAFRCF--YFTIAWNIFDFMVVIFSI 1326
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKkrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722  1327 TGLCLPMTVGsylvpPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYV- 1405
Cdd:pfam00520   81 ISLVLSSVGS-----LSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKl 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722  1406 -KKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKwsdcdpdkinpgtqvrgdcgNPSVGIFYFVSYILISW 1484
Cdd:pfam00520  156 kTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK--------------------GEFWAYIYFVSFIILGG 215
                          250
                   ....*....|...
gi 578804722  1485 LIIVNMYIVVVME 1497
Cdd:pfam00520  216 FLLLNLFIAVIID 228
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
743-927 1.23e-26

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 428983  Cd Length: 195  Bit Score: 108.97  E-value: 1.23e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   743 NEAKNLQLAVARIKKGINYV-------LLKILCKTQNVPKDTMDHVNEVYVKED--ISDHTlselsntqDFLKDKEKSSG 813
Cdd:pfam06512    2 GEMNNLQIALARIQRGIRFVkstlrdfCCRLCLEPQLPEKKPLDESKDARSKLTnqIANHT--------KKAPGGGGKYE 73
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   814 TEKNateneSQSLIPSPSVSETVPIASGESDIENLDNKEIQS-KSGDGGSKEKIKQ----SSSSECSTVDIAISEEEEMf 888
Cdd:pfam06512   74 LDEG-----HMDFITNPNLTVCVPIAEGESDLENEEDDDESSqSSDEEKSKQQEQLedddSSSSEGSTVDLQDPEEELE- 147
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 578804722   889 YGGERSKHLK-------NGC-RRGSSLgQISGASKKGKIWQNIRKTC 927
Cdd:pfam06512  148 KIPEEAEELKepedcftEGCvRRFPCC-AVDTTKGPWKIWWNLRKTC 193
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1194-1246 7.14e-22

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 89.93  E-value: 7.14e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 578804722 1194 DNFNKHKIKLGGS-NIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFD 1246
Cdd:cd13433     1 DNFNQLKKKYGGGlDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
933-1198 2.16e-46

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 167.06  E-value: 2.16e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   933 NNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILlEYADMIFTYIFILEMLLKWMAYGF-KAYFSNGWYRLDFVVVIVF 1011
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEPLTTVL-EILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPS 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722  1012 CLSLIGKTREE---LKPLISMKFLRPLRVLSQFERMKVVVRALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECI 1088
Cdd:pfam00520   80 LISLVLSSVGSlsgLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722  1089 DPtsgerfpssevmnksrcesllfnesmlwENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSvavniqphfEVNIY 1168
Cdd:pfam00520  160 NP----------------------------DNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDG---------KGEFW 202
                          250       260       270
                   ....*....|....*....|....*....|
gi 578804722  1169 MYCYFINFIIFGVFLPLSMLITVIIDNFNK 1198
Cdd:pfam00520  203 AYIYFVSFIILGGFLLLNLFIAVIIDNFQE 232
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
504-717 1.50e-44

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 161.67  E-value: 1.50e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   504 APFTDLFLIICIILNVCFLTLEHYPMSKQ-TNTLLNIGNLVFIGIFTAEMIFKIIAMHP-YGYFQVGWNIFDSMIVFHGL 581
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   582 IELCLA---NVAGMALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYeefvc 658
Cdd:pfam00520   81 ISLVLSsvgSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL----- 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   659 HIDKDCQLPRWHMHDFFHSFLNVFRILCGE-WVETLWDCMEVAGQSWCIPFYLMVILIGN 717
Cdd:pfam00520  156 KTWENPDNGRTNFDNFPNAFLWLFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGG 215
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
117-403 1.95e-34

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 132.78  E-value: 1.95e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   117 HPFFQLFILISVLIDCVFMSL-------TNLPKWRPVLENTLLGIYTFEILVKLFARGVWagsFSFLGDPWNWLDFSVTV 189
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALetyfqpeEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFK---KRYFRSPWNILDFVVVL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   190 FEVII----RYSPLDFIPTLQTARTLRILKIIPLNQGLKSLVGVLIHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKH 265
Cdd:pfam00520   78 PSLISlvlsSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKT 157
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   266 kcfrwpqenenetlhnrtgnpyyiretenfyylegeryallcgnrtdagqcpegyvcvkaGINPDQGFTNFDSFGWALFA 345
Cdd:pfam00520  158 ------------------------------------------------------------WENPDNGRTNFDNFPNAFLW 177
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 578804722   346 LFRLMAQD-YPEVLYHQILYASGKVYMIFFVVVSFLFSFYMASLFLGILAMAYEEEKQR 403
Cdd:pfam00520  178 LFQTMTTEgWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1250-1497 6.14e-29

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 116.98  E-value: 6.14e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722  1250 SQAFNVIVMVLICFQAIAMMIDTDVQSLQ-MSIALYWINSIFVMLYTMECILKLIAFRCF--YFTIAWNIFDFMVVIFSI 1326
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKkrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722  1327 TGLCLPMTVGsylvpPSLVQLILLSRIIHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYV- 1405
Cdd:pfam00520   81 ISLVLSSVGS-----LSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKl 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722  1406 -KKEAGINDVSNFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKwsdcdpdkinpgtqvrgdcgNPSVGIFYFVSYILISW 1484
Cdd:pfam00520  156 kTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGK--------------------GEFWAYIYFVSFIILGG 215
                          250
                   ....*....|...
gi 578804722  1485 LIIVNMYIVVVME 1497
Cdd:pfam00520  216 FLLLNLFIAVIID 228
Na_trans_assoc pfam06512
Sodium ion transport-associated; Members of this family contain a region found exclusively in ...
743-927 1.23e-26

Sodium ion transport-associated; Members of this family contain a region found exclusively in eukaryotic sodium channels or their subunits, many of which are voltage-gated. Members very often also contain between one and four copies of pfam00520 and, less often, one copy of pfam00612.


Pssm-ID: 428983  Cd Length: 195  Bit Score: 108.97  E-value: 1.23e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   743 NEAKNLQLAVARIKKGINYV-------LLKILCKTQNVPKDTMDHVNEVYVKED--ISDHTlselsntqDFLKDKEKSSG 813
Cdd:pfam06512    2 GEMNNLQIALARIQRGIRFVkstlrdfCCRLCLEPQLPEKKPLDESKDARSKLTnqIANHT--------KKAPGGGGKYE 73
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   814 TEKNateneSQSLIPSPSVSETVPIASGESDIENLDNKEIQS-KSGDGGSKEKIKQ----SSSSECSTVDIAISEEEEMf 888
Cdd:pfam06512   74 LDEG-----HMDFITNPNLTVCVPIAEGESDLENEEDDDESSqSSDEEKSKQQEQLedddSSSSEGSTVDLQDPEEELE- 147
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 578804722   889 YGGERSKHLK-------NGC-RRGSSLgQISGASKKGKIWQNIRKTC 927
Cdd:pfam06512  148 KIPEEAEELKepedcftEGCvRRFPCC-AVDTTKGPWKIWWNLRKTC 193
Na_channel_gate cd13433
Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of ...
1194-1246 7.14e-22

Inactivation gate of the voltage-gated sodium channel alpha subunits; This region is part of the intracellular linker between domains III and IV of the alpha subunits of voltage-gated sodium channels. It is responsible for fast inactivation of the channel and essential for proper physiological function.


Pssm-ID: 240441  Cd Length: 54  Bit Score: 89.93  E-value: 7.14e-22
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 578804722 1194 DNFNKHKIKLGGS-NIFITVKQRKQYRRLKKLMYEDSQRPVPRPLNKLQGFIFD 1246
Cdd:cd13433     1 DNFNQLKKKYGGGlDIFLTESQKKYYNAMKKLGSKKPQKPIPRPKNKFQGFIFD 54
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 ...
592-715 3.99e-03

Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 proteins.


Pssm-ID: 400395  Cd Length: 424  Bit Score: 41.56  E-value: 3.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804722   592 MALLRLFRMLRIFKLGKYWPTFQILMWSLSNSWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFvchidkdcqlprwhm 671
Cdd:pfam08016  299 LAFLVFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFGTQAPNF--------------- 363
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 578804722   672 HDFFHSFLNVFRILCGEWVET-LWDCMEVAGQSWCIPFYLMVILI 715
Cdd:pfam08016  364 SNFVKSILTLFRTILGDFGYNeIFSGNRVLGPLLFLTFVFLVIFI 408
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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