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Conserved domains on  [gi|578806213|ref|XP_006713262|]
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inositol hexakisphosphate kinase 2 isoform X1 [Homo sapiens]

Protein Classification

inositol polyphosphate kinase family protein( domain architecture ID 10510177)

inositol polyphosphate kinase family protein similar to inositol hexakisphosphate kinase, which converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5) and 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4

CATH:  1.10.510.50
EC:  2.7.-.-
Gene Ontology:  GO:0032958|GO:0016301|GO:0005524
SCOP:  4002804

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
IPK pfam03770
Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol ...
262-477 4.45e-84

Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol polyphosphate kinase.


:

Pssm-ID: 397715  Cd Length: 190  Bit Score: 257.49  E-value: 4.45e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578806213  262 FILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGSGQLMFMNKYHGRKLSV 341
Cdd:pfam03770   1 YILLEDLTAGFKKPCVLDLKMGTRTYGDDASEEKRRRQQKKCRETTSASLGFRICGMKVWNVDTDGYIFRDKYYGRSLSA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578806213  342 QGFKEALFQFFHNGRYLRR--ELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGkerpevvlDSDAEDLEDLSEesa 419
Cdd:pfam03770  81 EEFKEALKRFFSNGKSLRRkkKIIPRFLERLQELRNVLESQESYRFYSSSLLFVYDG--------DPESAEEDPPPK--- 149
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 578806213  420 desagayaykpigassVDVRMIDFAHTTCRLYGeDTVVHEGQDAGYIFGLQSLIDIVT 477
Cdd:pfam03770 150 ----------------VKVKLIDFAHTVPLPDG-PPWPGGGPDEGYLFGLRSLIKILE 190
 
Name Accession Description Interval E-value
IPK pfam03770
Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol ...
262-477 4.45e-84

Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol polyphosphate kinase.


Pssm-ID: 397715  Cd Length: 190  Bit Score: 257.49  E-value: 4.45e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578806213  262 FILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGSGQLMFMNKYHGRKLSV 341
Cdd:pfam03770   1 YILLEDLTAGFKKPCVLDLKMGTRTYGDDASEEKRRRQQKKCRETTSASLGFRICGMKVWNVDTDGYIFRDKYYGRSLSA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578806213  342 QGFKEALFQFFHNGRYLRR--ELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGkerpevvlDSDAEDLEDLSEesa 419
Cdd:pfam03770  81 EEFKEALKRFFSNGKSLRRkkKIIPRFLERLQELRNVLESQESYRFYSSSLLFVYDG--------DPESAEEDPPPK--- 149
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 578806213  420 desagayaykpigassVDVRMIDFAHTTCRLYGeDTVVHEGQDAGYIFGLQSLIDIVT 477
Cdd:pfam03770 150 ----------------VKVKLIDFAHTVPLPDG-PPWPGGGPDEGYLFGLRSLIKILE 190
PLN02667 PLN02667
inositol polyphosphate multikinase
261-485 7.52e-34

inositol polyphosphate multikinase


Pssm-ID: 215359  Cd Length: 286  Bit Score: 129.07  E-value: 7.52e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578806213 261 KFILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGSGQLMFMNKYHGRKLS 340
Cdd:PLN02667  79 GLLVLEDLLAGYTKPCVMDVKMGSRTWYPEASEEYIQKCLKKDRETTTVSLGFRVSGFKVYDHKESEFWKAERKLVKGLD 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578806213 341 VQGFKEALFQFFHNG--------RYLRRELLG---PVLKKLTELKAVLERQESYRFYSSSLLVIYDGkerpEVVLDSDAE 409
Cdd:PLN02667 159 ADGVRLALRKFVSSNspadpnpdCAFASAVYGgshGILAQLLELKSWFEEQTLYHFFSASILIVYEG----EAILKGNPE 234
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578806213 410 DledlseesadesagayaykpigaSSVDVRMIDFAHTTcrlYGEDTVvhegqDAGYIFGLQSLIDIVTEISEESGE 485
Cdd:PLN02667 235 D-----------------------SRVEVKLVDFAHVL---DGNGVI-----DHNFLGGLCSLIKFISEILTSPDE 279
 
Name Accession Description Interval E-value
IPK pfam03770
Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol ...
262-477 4.45e-84

Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol polyphosphate kinase.


Pssm-ID: 397715  Cd Length: 190  Bit Score: 257.49  E-value: 4.45e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578806213  262 FILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGSGQLMFMNKYHGRKLSV 341
Cdd:pfam03770   1 YILLEDLTAGFKKPCVLDLKMGTRTYGDDASEEKRRRQQKKCRETTSASLGFRICGMKVWNVDTDGYIFRDKYYGRSLSA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578806213  342 QGFKEALFQFFHNGRYLRR--ELLGPVLKKLTELKAVLERQESYRFYSSSLLVIYDGkerpevvlDSDAEDLEDLSEesa 419
Cdd:pfam03770  81 EEFKEALKRFFSNGKSLRRkkKIIPRFLERLQELRNVLESQESYRFYSSSLLFVYDG--------DPESAEEDPPPK--- 149
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 578806213  420 desagayaykpigassVDVRMIDFAHTTCRLYGeDTVVHEGQDAGYIFGLQSLIDIVT 477
Cdd:pfam03770 150 ----------------VKVKLIDFAHTVPLPDG-PPWPGGGPDEGYLFGLRSLIKILE 190
PLN02667 PLN02667
inositol polyphosphate multikinase
261-485 7.52e-34

inositol polyphosphate multikinase


Pssm-ID: 215359  Cd Length: 286  Bit Score: 129.07  E-value: 7.52e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578806213 261 KFILLENLTSRYEVPCVLDLKMGTRQHGDDASEEKAANQIRKCQQSTSAVIGVRVCGMQVYQAGSGQLMFMNKYHGRKLS 340
Cdd:PLN02667  79 GLLVLEDLLAGYTKPCVMDVKMGSRTWYPEASEEYIQKCLKKDRETTTVSLGFRVSGFKVYDHKESEFWKAERKLVKGLD 158
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578806213 341 VQGFKEALFQFFHNG--------RYLRRELLG---PVLKKLTELKAVLERQESYRFYSSSLLVIYDGkerpEVVLDSDAE 409
Cdd:PLN02667 159 ADGVRLALRKFVSSNspadpnpdCAFASAVYGgshGILAQLLELKSWFEEQTLYHFFSASILIVYEG----EAILKGNPE 234
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578806213 410 DledlseesadesagayaykpigaSSVDVRMIDFAHTTcrlYGEDTVvhegqDAGYIFGLQSLIDIVTEISEESGE 485
Cdd:PLN02667 235 D-----------------------SRVEVKLVDFAHVL---DGNGVI-----DHNFLGGLCSLIKFISEILTSPDE 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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