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Conserved domains on  [gi|578813570|ref|XP_006715818|]
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kelch-like protein 7 isoform X2 [Homo sapiens]

Protein Classification

BTB_POZ_KLHL7 and BACK domain-containing protein( domain architecture ID 13032989)

protein containing domains BTB_POZ_KLHL7, PHA03098, and BACK

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-126 4.90e-69

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 218.90  E-value: 4.90e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLD 97
Cdd:cd18237   18 QKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARISVNSNNVQSLLD 97

                         90       100
                 ....*....|....*....|....*....
gi 578813570  98 AANQYQIEPVKKMCVDFLKEQVDASNCLG 126
Cdd:cd18237   98 AANQYQIEPVKKMCVDFLKEQLDASNCLG 126
BACK super family cl28903
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 118-228 6.65e-68

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


The actual alignment was detected with superfamily member cd18447:

Pssm-ID: 475122 [Multi-domain]  Cd Length: 98  Bit Score: 214.91  E-value: 6.65e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 118 QVDASNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQ 197
Cdd:cd18447    1 QVDASNCLG-------------ISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQ 67

                         90       100       110
                 ....*....|....*....|....*....|.
gi 578813570 198 VYDAAVRWLKYDEPNRQPFMVDILAKVRFPL 228
Cdd:cd18447   68 VYDAAVRWLKYDEPNRQPYMVDILAKVRFPL 98
PHA03098 super family cl33709
kelch-like protein; Provisional
 20-546 1.62e-53

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 190.36  E-value: 1.62e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  20 TLCD--VILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESksfEVELKDAEpDIIEQLVEFAYTARISVNSNNVQSLLD 97
Cdd:PHA03098   8 KFCDesIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKEN---EINLNIDY-DSFNEVIKYIYTGKINITSNNVKDILS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  98 AANQYQIEPVKKMCVDFLKEQVDASNCLgeaekvdqslpecGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLD 177
Cdd:PHA03098  84 IANYLIIDFLINLCINYIIKIIDDNNCI-------------DIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLS 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 178 VKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLIS-------KNFLSKTVQAEPLIQDNPec 250
Cdd:PHA03098 151 KNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSeegikklKRWKLRIKKKKIVFNKRC-- 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 251 lkmvISGMRYhllspedREELVDGTRPRRKKHD---YRIALFGGSQPQSCRYFNPKDYSWTDIRCPFekRRDAACVFWDN 327
Cdd:PHA03098 229 ----IKIIYS-------KKYNLNKILPRSSTFGsiiYIHITMSIFTYNYITNYSPLSEINTIIDIHY--VYCFGSVVLNN 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 328 VVYILGGSqlfpIKRMDC------YNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSaLYLFECYDTRTESW 401
Cdd:PHA03098 296 VIYFIGGM----NKNNLSvnsvvsYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSIS-LNTVESWKPGESKW 370

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 402 HTKPSMLTQRCSHGMVEANGLIYVCGGSLGNnvsGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGG-- 479
Cdd:PHA03098 371 REEPPLIFPRYNPCVVNVNNLIYVIGGISKN---DELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGis 447

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578813570 480 -QNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 546
Cdd:PHA03098 448 yIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTW 515
 
Name Accession Description Interval E-value
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-126 4.90e-69

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 218.90  E-value: 4.90e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLD 97
Cdd:cd18237   18 QKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARISVNSNNVQSLLD 97

                         90       100
                 ....*....|....*....|....*....
gi 578813570  98 AANQYQIEPVKKMCVDFLKEQVDASNCLG 126
Cdd:cd18237   98 AANQYQIEPVKKMCVDFLKEQLDASNCLG 126
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 118-228 6.65e-68

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 214.91  E-value: 6.65e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 118 QVDASNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQ 197
Cdd:cd18447    1 QVDASNCLG-------------ISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQ 67

                         90       100       110
                 ....*....|....*....|....*....|.
gi 578813570 198 VYDAAVRWLKYDEPNRQPFMVDILAKVRFPL 228
Cdd:cd18447   68 VYDAAVRWLKYDEPNRQPYMVDILAKVRFPL 98
PHA03098 PHA03098
kelch-like protein; Provisional
 20-546 1.62e-53

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 190.36  E-value: 1.62e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  20 TLCD--VILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESksfEVELKDAEpDIIEQLVEFAYTARISVNSNNVQSLLD 97
Cdd:PHA03098   8 KFCDesIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKEN---EINLNIDY-DSFNEVIKYIYTGKINITSNNVKDILS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  98 AANQYQIEPVKKMCVDFLKEQVDASNCLgeaekvdqslpecGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLD 177
Cdd:PHA03098  84 IANYLIIDFLINLCINYIIKIIDDNNCI-------------DIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLS 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 178 VKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLIS-------KNFLSKTVQAEPLIQDNPec 250
Cdd:PHA03098 151 KNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSeegikklKRWKLRIKKKKIVFNKRC-- 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 251 lkmvISGMRYhllspedREELVDGTRPRRKKHD---YRIALFGGSQPQSCRYFNPKDYSWTDIRCPFekRRDAACVFWDN 327
Cdd:PHA03098 229 ----IKIIYS-------KKYNLNKILPRSSTFGsiiYIHITMSIFTYNYITNYSPLSEINTIIDIHY--VYCFGSVVLNN 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 328 VVYILGGSqlfpIKRMDC------YNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSaLYLFECYDTRTESW 401
Cdd:PHA03098 296 VIYFIGGM----NKNNLSvnsvvsYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSIS-LNTVESWKPGESKW 370

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 402 HTKPSMLTQRCSHGMVEANGLIYVCGGSLGNnvsGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGG-- 479
Cdd:PHA03098 371 REEPPLIFPRYNPCVVNVNNLIYVIGGISKN---DELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGis 447

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578813570 480 -QNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 546
Cdd:PHA03098 448 yIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTW 515
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
315-548 1.24e-39

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 146.07  E-value: 1.24e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 315 EKRRDAACVFWDNVVYILGGSQL-FPIKRMDCYNVVKDSWySKLGP-PTPRDSLAACAA-EGKIY-TSGGSEVGNSALYL 390
Cdd:COG3055   11 TPRSEAAAALLDGKVYVAGGLSGgSASNSFEVYDPATNTW-SELAPlPGPPRHHAAAVAqDGKLYvFGGFTGANPSSTPL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 391 --FECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVlnscEVYDPATETWTELCPMIEARKNHGLV 468
Cdd:COG3055   90 ndVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWV----EVYDPATGTWTQLAPLPTPRDHLAAA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 469 FV-KDKIFAVGGQNGLGGLDNveyydiklneWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVgrLGHILEYNTETDKWV 547
Cdd:COG3055  166 VLpDGKILVIGGRNGSGFSNT----------WTTLAPLPTARAGHAAAVLGGKILVFGGESGF--SDEVEAYDPATNTWT 233


                 .
gi 578813570 548 A 548
Cdd:COG3055  234 A 234
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 138-239 2.90e-32

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 119.57  E-value: 2.90e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  138 CGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFM 217
Cdd:pfam07707   2 LGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKHL 81

                          90       100
                  ....*....|....*....|..
gi 578813570  218 VDILAKVRFPLISKNFLSKTVQ 239
Cdd:pfam07707  82 PELLSAVRLPLLSPQYLLNLVE 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 138-234 4.52e-32

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 118.98  E-value: 4.52e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570   138 CGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFM 217
Cdd:smart00875   2 LGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREHL 81

                           90
                   ....*....|....*..
gi 578813570   218 VDILAKVRFPLISKNFL 234
Cdd:smart00875  82 PELLEHVRLPLLSPDYL 98
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 17-118 8.45e-31

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 115.82  E-value: 8.45e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570   17 LKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARIsVNSNNVQSLL 96
Cdd:pfam00651   6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDLL 84

                          90       100
                  ....*....|....*....|..
gi 578813570   97 DAANQYQIEPVKKMCVDFLKEQ 118
Cdd:pfam00651  85 AAADKLQIPSLVDKCEEFLIKS 106
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 23-118 1.50e-26

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 103.54  E-value: 1.50e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570    23 DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQY 102
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*.
gi 578813570   103 QIEPVKKMCVDFLKEQ 118
Cdd:smart00225  81 QIPGLVELCEEFLLKL 96
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 461-506 1.93e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 58.78  E-value: 1.93e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 578813570  461 ARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMP 506
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
422-472 1.63e-10

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 56.41  E-value: 1.63e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 578813570   422 LIYVCGGSLGNNVsgrvLNSCEVYDPATETWTELCPMIEARKNHGLVFVKD 472
Cdd:smart00612   1 KIYVVGGFDGGQR----LKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
 
Name Accession Description Interval E-value
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-126 4.90e-69

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 218.90  E-value: 4.90e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLD 97
Cdd:cd18237   18 QKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARISVNSNNVQSLLD 97

                         90       100
                 ....*....|....*....|....*....
gi 578813570  98 AANQYQIEPVKKMCVDFLKEQVDASNCLG 126
Cdd:cd18237   98 AANQYQIEPVKKMCVDFLKEQLDASNCLG 126
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 118-228 6.65e-68

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 214.91  E-value: 6.65e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 118 QVDASNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQ 197
Cdd:cd18447    1 QVDASNCLG-------------ISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQ 67

                         90       100       110
                 ....*....|....*....|....*....|.
gi 578813570 198 VYDAAVRWLKYDEPNRQPFMVDILAKVRFPL 228
Cdd:cd18447   68 VYDAAVRWLKYDEPNRQPYMVDILAKVRFPL 98
PHA03098 PHA03098
kelch-like protein; Provisional
 20-546 1.62e-53

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 190.36  E-value: 1.62e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  20 TLCD--VILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESksfEVELKDAEpDIIEQLVEFAYTARISVNSNNVQSLLD 97
Cdd:PHA03098   8 KFCDesIIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKEN---EINLNIDY-DSFNEVIKYIYTGKINITSNNVKDILS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  98 AANQYQIEPVKKMCVDFLKEQVDASNCLgeaekvdqslpecGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLD 177
Cdd:PHA03098  84 IANYLIIDFLINLCINYIIKIIDDNNCI-------------DIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLS 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 178 VKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLIS-------KNFLSKTVQAEPLIQDNPec 250
Cdd:PHA03098 151 KNELIKILSDDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSeegikklKRWKLRIKKKKIVFNKRC-- 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 251 lkmvISGMRYhllspedREELVDGTRPRRKKHD---YRIALFGGSQPQSCRYFNPKDYSWTDIRCPFekRRDAACVFWDN 327
Cdd:PHA03098 229 ----IKIIYS-------KKYNLNKILPRSSTFGsiiYIHITMSIFTYNYITNYSPLSEINTIIDIHY--VYCFGSVVLNN 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 328 VVYILGGSqlfpIKRMDC------YNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSaLYLFECYDTRTESW 401
Cdd:PHA03098 296 VIYFIGGM----NKNNLSvnsvvsYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGIYNSIS-LNTVESWKPGESKW 370

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 402 HTKPSMLTQRCSHGMVEANGLIYVCGGSLGNnvsGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGG-- 479
Cdd:PHA03098 371 REEPPLIFPRYNPCVVNVNNLIYVIGGISKN---DELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGis 447

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578813570 480 -QNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKW 546
Cdd:PHA03098 448 yIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTW 515
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
315-548 1.24e-39

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 146.07  E-value: 1.24e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 315 EKRRDAACVFWDNVVYILGGSQL-FPIKRMDCYNVVKDSWySKLGP-PTPRDSLAACAA-EGKIY-TSGGSEVGNSALYL 390
Cdd:COG3055   11 TPRSEAAAALLDGKVYVAGGLSGgSASNSFEVYDPATNTW-SELAPlPGPPRHHAAAVAqDGKLYvFGGFTGANPSSTPL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 391 --FECYDTRTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVlnscEVYDPATETWTELCPMIEARKNHGLV 468
Cdd:COG3055   90 ndVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWV----EVYDPATGTWTQLAPLPTPRDHLAAA 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 469 FV-KDKIFAVGGQNGLGGLDNveyydiklneWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVgrLGHILEYNTETDKWV 547
Cdd:COG3055  166 VLpDGKILVIGGRNGSGFSNT----------WTTLAPLPTARAGHAAAVLGGKILVFGGESGF--SDEVEAYDPATNTWT 233


                 .
gi 578813570 548 A 548
Cdd:COG3055  234 A 234
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-126 1.04e-37

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 135.50  E-value: 1.04e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLD 97
Cdd:cd18238   12 NGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKDIDEEAVELLVDFAYTGKLTLTVDNVQSLLY 91

                         90       100
                 ....*....|....*....|....*....
gi 578813570  98 AANQYQIEPVKKMCVDFLKEQVDASNCLG 126
Cdd:cd18238   92 AASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-118 1.24e-36

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 132.40  E-value: 1.24e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18247   19 LCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSGRIAIDTSNVQSLLVGAS 98

                         90
                 ....*....|....*...
gi 578813570 101 QYQIEPVKKMCVDFLKEQ 118
Cdd:cd18247   99 FLQLQSVKDACCEFLKER 116
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 3-124 1.09e-35

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 129.87  E-value: 1.09e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570   3 GGTDCRTFLTSHINLKK--TLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFA 80
Cdd:cd18242    1 TNSHAKSILNTMNSLRKsnTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFV 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 578813570  81 YTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNC 124
Cdd:cd18242   81 YTETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-126 1.34e-35

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 130.34  E-value: 1.34e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18259   32 LSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYTGKLTINQGNVEALIRTSN 111

                         90       100
                 ....*....|....*....|....*.
gi 578813570 101 QYQIEPVKKMCVDFLKEQVDASNCLG 126
Cdd:cd18259  112 RLQFPTVRKVCSRYLQQQIDATNCLG 137
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-125 3.78e-34

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 125.17  E-value: 3.78e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18234    1 LCDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATAC 80

                         90       100
                 ....*....|....*....|....*
gi 578813570 101 QYQIEPVKKMCVDFLKEQVDASNCL 125
Cdd:cd18234   81 LLQLSEVVEACCGFLMKQLHPSNCL 105
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 122-245 1.48e-33

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 123.50  E-value: 1.48e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 122 SNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDA 201
Cdd:cd18445    4 SNCLG-------------IRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEA 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 578813570 202 AVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQ 245
Cdd:cd18445   71 VMSWVNHDPENRKEHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 138-239 2.90e-32

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 119.57  E-value: 2.90e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  138 CGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFM 217
Cdd:pfam07707   2 LGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKHL 81

                          90       100
                  ....*....|....*....|..
gi 578813570  218 VDILAKVRFPLISKNFLSKTVQ 239
Cdd:pfam07707  82 PELLSAVRLPLLSPQYLLNLVE 103
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
300-493 3.10e-32

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 125.27  E-value: 3.10e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 300 FNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQL-FPIKRMDCYNVVKDSWySKLGP-PTPRDSL-AACAAEGKIY 376
Cdd:COG3055   95 YDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDgGNVAWVEVYDPATGTW-TQLAPlPTPRDHLaAAVLPDGKIL 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 377 TSGGSEVGNSalylfecydtrTESWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGnnvsgrVLNSCEVYDPATETWTELC 456
Cdd:COG3055  174 VIGGRNGSGF-----------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESG------FSDEVEAYDPATNTWTALG 236

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 578813570 457 PMIEARKNHGLVFVKDKIFAVGGQNGLGGLDN----VEYYD 493
Cdd:COG3055  237 ELPTPRHGHAAVLTDGKVYVIGGETKPGVRTPlvtsAEVYD 277
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-121 3.41e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 120.23  E-value: 3.41e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLD 97
Cdd:cd18235   18 QNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYTAEIQVTEENVQVLLP 97

                         90       100
                 ....*....|....*....|....
gi 578813570  98 AANQYQIEPVKKMCVDFLKEQVDA 121
Cdd:cd18235   98 AANLLQLTDVRDACCDFLQSQLHP 121
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 138-234 4.52e-32

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 118.98  E-value: 4.52e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570   138 CGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFM 217
Cdd:smart00875   2 LGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREHL 81

                           90
                   ....*....|....*..
gi 578813570   218 VDILAKVRFPLISKNFL 234
Cdd:smart00875  82 PELLEHVRLPLLSPDYL 98
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-126 9.74e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 119.09  E-value: 9.74e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  19 KTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDA 98
Cdd:cd18249   21 RELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYTSQITVEEGNVQTLLPA 100

                         90       100
                 ....*....|....*....|....*...
gi 578813570  99 ANQYQIEPVKKMCVDFLKEQVDASNCLG 126
Cdd:cd18249  101 ACLLQLAEIQEVCCEFLKRQLDPSNCLG 128
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 139-238 1.61e-31

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 117.79  E-value: 1.61e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 139 GISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMV 218
Cdd:cd18457    8 GIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRENREEYLP 87

                         90       100
                 ....*....|....*....|
gi 578813570 219 DILAKVRFPLISKNFLSKTV 238
Cdd:cd18457   88 ELLSKVRLPLLRPQFLTDRV 107
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
300-526 4.74e-31

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 122.19  E-value: 4.74e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 300 FNPKDYSWTDI-RCPFEKRRDAACVFWDNVVYILGG-----SQLFPIKRMDCYNVVKDSWySKLGP-PTPRDSLAACAAE 372
Cdd:COG3055   43 YDPATNTWSELaPLPGPPRHHAAAVAQDGKLYVFGGftganPSSTPLNDVYVYDPATNTW-TKLAPmPTPRGGATALLLD 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 373 GKIYTSGGSEvGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEA-NGLIYVCGGSLGNNvsgrvlnscevydpATET 451
Cdd:COG3055  122 GKIYVVGGWD-DGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDGKILVIGGRNGSG--------------FSNT 186

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578813570 452 WTELCPMIEARKNHGLVFVKDKIFAVGGQNGLggLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAG 526
Cdd:COG3055  187 WTTLAPLPTARAGHAAAVLGGKILVFGGESGF--SDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGG 259
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-121 7.90e-31

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 116.48  E-value: 7.90e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18257   18 LCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQCIDETALQAIVEYAYTGTVFISQATVESLLPAAN 97

                         90       100
                 ....*....|....*....|.
gi 578813570 101 QYQIEPVKKMCVDFLKEQVDA 121
Cdd:cd18257   98 LLQIKLVLKECCDFLESQLDP 118
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 17-118 8.45e-31

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 115.82  E-value: 8.45e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570   17 LKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARIsVNSNNVQSLL 96
Cdd:pfam00651   6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGKL-ISEENVDDLL 84

                          90       100
                  ....*....|....*....|..
gi 578813570   97 DAANQYQIEPVKKMCVDFLKEQ 118
Cdd:pfam00651  85 AAADKLQIPSLVDKCEEFLIKS 106
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-126 1.42e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 115.96  E-value: 1.42e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  22 CDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQ 101
Cdd:cd18256   21 CDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGVVEVTVSNVQELLVAADM 100

                         90       100
                 ....*....|....*....|....*
gi 578813570 102 YQIEPVKKMCVDFLKEQVDASNCLG 126
Cdd:cd18256  101 LQLTEVVEICCEFLKGQLHPSNCIG 125
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-102 3.59e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 113.03  E-value: 3.59e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80


                 ..
gi 578813570 101 QY 102
Cdd:cd18186   81 KL 82
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 139-261 6.06e-30

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 114.39  E-value: 6.06e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 139 GISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMV 218
Cdd:cd18513    8 GIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKEARLEHMA 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 578813570 219 DILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYH 261
Cdd:cd18513   88 KLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMKYH 130
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 120-268 1.55e-29

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 113.26  E-value: 1.55e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 120 DASNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVY 199
Cdd:cd18452    2 DPSNCLG-------------IRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVF 68

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578813570 200 DAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYHlLSPEDR 268
Cdd:cd18452   69 EAVLNWVKHDKEEREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRCSLECRDLVDEAKKFH-LRPELR 136
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-124 3.89e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 111.65  E-value: 3.89e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570   5 TDCRTFltSHINLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTAR 84
Cdd:cd18240    3 MACNVF--NELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPGVSPEMMELIIEYAYTRT 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 578813570  85 ISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNC 124
Cdd:cd18240   81 VPITAENVEELLPAADQFNIMGIVKACCDFLEDQLCPENC 120
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-120 5.51e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 111.32  E-value: 5.51e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  17 LKKTLCDVILMV----QERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNV 92
Cdd:cd18248   17 LSQQLCDVTLKVkyqdPKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEGVHPCVMSRLIEFAYTASISVGEKCV 96

                         90       100
                 ....*....|....*....|....*...
gi 578813570  93 QSLLDAANQYQIEPVKKMCVDFLKEQVD 120
Cdd:cd18248   97 LHVLPGAVMYQMDSVVKACCDFLEQQLD 124
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-126 1.27e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 110.43  E-value: 1.27e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  19 KTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDA 98
Cdd:cd18306   16 RQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTSRLEVPADLVKSVYSA 95

                         90       100
                 ....*....|....*....|....*...
gi 578813570  99 ANQYQIEPVKKMCVDFLKEQVDASNCLG 126
Cdd:cd18306   96 AKKLKMDRVKKACGDFLLEKLTPQNCIG 123
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-124 2.58e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 109.41  E-value: 2.58e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLD 97
Cdd:cd18255   15 KGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIELKGVSAKGLKHILDFAYTSELTLDLDCIQDVLG 94

                         90       100
                 ....*....|....*....|....*..
gi 578813570  98 AANQYQIEPVKKMCVDFLKEQVDASNC 124
Cdd:cd18255   95 AAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-124 3.65e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 109.09  E-value: 3.65e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  23 DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQY 102
Cdd:cd18250   23 DVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHGVSAEILGLLLDFSYTGRVTVTQDNVEALLRAADLF 102

                         90       100
                 ....*....|....*....|..
gi 578813570 103 QIEPVKKMCVDFLKEQVDASNC 124
Cdd:cd18250  103 QFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-119 2.27e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 106.73  E-value: 2.27e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLD 97
Cdd:cd18339   18 KQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLP 97

                         90       100
                 ....*....|....*....|..
gi 578813570  98 AANQYQIEPVKKMCVDFLKEQV 119
Cdd:cd18339   98 AASLLQLMDVRQNCCDFLQSQL 119
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
400-548 3.08e-27

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 111.40  E-value: 3.08e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 400 SWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGnnvsGRVLNSCEVYDPATETWTELCPMIEARKNH-GLVFVKDKIFAVG 478
Cdd:COG3055    2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSG----GSASNSFEVYDPATNTWSELAPLPGPPRHHaAAVAQDGKLYVFG 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578813570 479 G----QNGLGGLDNVEYYDIKLNEWKMVSPMPWKGVTVKCAAVGSIVYVLAGFQGVGRLGHILEYNTETDKWVA 548
Cdd:COG3055   78 GftgaNPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQ 151
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-126 5.84e-27

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 105.90  E-value: 5.84e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLD 97
Cdd:cd18336   16 HKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYTGVLELKEDTIESLLA 95

                         90       100
                 ....*....|....*....|....*....
gi 578813570  98 AANQYQIEPVKKMCVDFLKEQVDASNCLG 126
Cdd:cd18336   96 AACLLQLSQVIDVCCNFLMKQLHPSNCLG 124
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 139-261 1.47e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 104.73  E-value: 1.47e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 139 GISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMV 218
Cdd:cd18512    8 GIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKEVRQEHMA 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 578813570 219 DILAKVRFPLISKNFLSKTVQAEPLIQDNPECLKMVISGMRYH 261
Cdd:cd18512   88 HLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMKYH 130
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 23-118 1.50e-26

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 103.54  E-value: 1.50e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570    23 DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQY 102
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*.
gi 578813570   103 QIEPVKKMCVDFLKEQ 118
Cdd:smart00225  81 QIPGLVELCEEFLLKL 96
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-124 1.98e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 104.15  E-value: 1.98e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  14 HINLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQ 93
Cdd:cd18253   11 EFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTGKVKITTENVQ 90

                         90       100       110
                 ....*....|....*....|....*....|.
gi 578813570  94 SLLDAANQYQIEPVKKMCVDFLKEQVDASNC 124
Cdd:cd18253   91 YLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-126 4.03e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 104.30  E-value: 4.03e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  11 LTSHINL---KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDA-EPDIIEQLVEFAYTARIS 86
Cdd:cd18267   27 VLTHLNLlrqQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFHDSiHPEVLELLLDYAYSSRVI 106

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 578813570  87 VNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLG 126
Cdd:cd18267  107 INEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLG 146
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-120 7.27e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 103.19  E-value: 7.27e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18246   39 LCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHDIDPQALEQLVQYAYTAEIVVGEGNVQTLLPAAS 118

                         90       100
                 ....*....|....*....|
gi 578813570 101 QYQIEPVKKMCVDFLKEQVD 120
Cdd:cd18246  119 LLQLNGVRDACCKFLLSQLD 138
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-125 2.44e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 101.45  E-value: 2.44e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  23 DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQY 102
Cdd:cd18340   29 DCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSEIEITEQNVQDIFAAANMF 108

                         90       100
                 ....*....|....*....|...
gi 578813570 103 QIEPVKKMCVDFLKEQVDASNCL 125
Cdd:cd18340  109 QIPSIFTVCVSFLQKRLCLSNCL 131
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-125 1.28e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 99.40  E-value: 1.28e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  23 DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQY 102
Cdd:cd18269   29 DCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYTSEIDLNDQNVQDIFALASRF 108

                         90       100
                 ....*....|....*....|...
gi 578813570 103 QIEPVKKMCVDFLKEQVDASNCL 125
Cdd:cd18269  109 QIPSIFTVCVSYLQKRLSLSNCL 131
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-126 2.84e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 98.16  E-value: 2.84e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  13 SHINLKKTLC---DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDA-EPDIIEQLVEFAYTARISVN 88
Cdd:cd18254   11 THLNTLRKQCmftDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDSlHPEVLELLLDFAYSSRIIIN 90

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 578813570  89 SNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLG 126
Cdd:cd18254   91 EENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 128
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 118-221 4.54e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 96.21  E-value: 4.54e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 118 QVDASNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQ 197
Cdd:cd18458    1 QLDPSNCIG-------------IANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESE 67

                         90       100
                 ....*....|....*....|....
gi 578813570 198 VYDAAVRWLKYDEPNRQPFMVDIL 221
Cdd:cd18458   68 VYNAVIRWVKYDEENRRQYLEALL 91
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-126 6.05e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 97.59  E-value: 6.05e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  19 KTLCDVILMV--------QERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSN 90
Cdd:cd18273   24 RLLTDVTIEVngpgsgpgSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSESMALIIDYCYTGRVTLSEA 103

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 578813570  91 NVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLG 126
Cdd:cd18273  104 NVQRLYAAANMLQLEYVREACASFLARRLDLSNCVG 139
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-119 1.12e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 96.29  E-value: 1.12e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18338   21 LCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEENVQVLLPAAG 100

                         90
                 ....*....|....*....
gi 578813570 101 QYQIEPVKKMCVDFLKEQV 119
Cdd:cd18338  101 LLQLQDVKKTCCEFLESQL 119
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-126 1.26e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 96.67  E-value: 1.26e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  19 KTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDA 98
Cdd:cd18337   21 KQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKMEGVEPNALWALVQYAYTGRLELKEDNIECLLST 100

                         90       100
                 ....*....|....*....|....*...
gi 578813570  99 ANQYQIEPVKKMCVDFLKEQVDASNCLG 126
Cdd:cd18337  101 ACLLQLSQVVEACCKFLMKQLHPSNCLG 128
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-126 3.68e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 94.89  E-value: 3.68e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  36 HRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFL 115
Cdd:cd18252   37 HKAALAACSSYFKVMFTADMKEKSNNVIKLSGIDHDILEALVNYVYTSQICITERNVQSLLEAADLLQFISVKKACEQFL 116

                         90
                 ....*....|.
gi 578813570 116 KEQVDASNCLG 126
Cdd:cd18252  117 VRHLDIDNCLG 127
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-126 7.11e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 94.34  E-value: 7.11e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLD 97
Cdd:cd18335   16 QQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIENLLA 95

                         90       100
                 ....*....|....*....|....*....
gi 578813570  98 AANQYQIEPVKKMCVDFLKEQVDASNCLG 126
Cdd:cd18335   96 AACLLQLSQVVEVCCHFLMKLLHPSNCLG 124
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-126 9.91e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 93.70  E-value: 9.91e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18268   23 LTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTGEILITRDNVLPLMEAAS 102

                         90       100
                 ....*....|....*....|....*.
gi 578813570 101 QYQIEPVKKMCVDFLKEQVDASNCLG 126
Cdd:cd18268  103 MLQYPKLFEACSLYLQDQLTPENCLS 128
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 122-227 8.51e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 90.06  E-value: 8.51e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 122 SNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDA 201
Cdd:cd18448    5 SNCLG-------------VRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEA 71

                         90       100
                 ....*....|....*....|....*.
gi 578813570 202 AVRWLKYDEPNRQPFMVDILAKVRFP 227
Cdd:cd18448   72 VMKWVKHDPQHRKRHLDDLLSQVRLP 97
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 118-235 2.81e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 88.93  E-value: 2.81e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 118 QVDASNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQ 197
Cdd:cd18444    1 QLHPSNCLG-------------IRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEET 67

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 578813570 198 VYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLS 235
Cdd:cd18444   68 IFHALLLWVKHDLPERKKHLAKLLALIRLPLLTPQFLA 105
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 120-209 2.94e-21

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 87.85  E-value: 2.94e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 120 DASNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVY 199
Cdd:cd18508    1 DATNCLG-------------IHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVY 67

                         90
                 ....*....|
gi 578813570 200 DAAVRWLKYD 209
Cdd:cd18508   68 EAAVAWLKHD 77
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-126 6.03e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 88.68  E-value: 6.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  20 TLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAA 99
Cdd:cd18265   22 TFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESVLEAS 101

                         90       100
                 ....*....|....*....|....*..
gi 578813570 100 NQYQIEPVKKMCVDFLKEQVDASNCLG 126
Cdd:cd18265  102 DLLQVSKLREACVRFLEGQLHPCNCLG 128
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-126 7.28e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 88.37  E-value: 7.28e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  17 LKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLL 96
Cdd:cd18236   20 LENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVLITKQNVQRVL 99

                         90       100       110
                 ....*....|....*....|....*....|
gi 578813570  97 DAANQYQIEPVKKMCVDFLKEQVDASNCLG 126
Cdd:cd18236  100 EAASLFQFLRMVDACASFLTEALHPENCVG 129
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-124 1.26e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 87.94  E-value: 1.26e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  14 HINLKKTLCDVILMVQE--RKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNN 91
Cdd:cd18239   16 QLRGEGLLCDVTLVPGDgdETFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLHGVSKIGLKNIIDFIYTAKLSLNMDN 95

                         90       100       110
                 ....*....|....*....|....*....|...
gi 578813570  92 VQSLLDAANQYQIEPVKKMCVDFLKEQVDASNC 124
Cdd:cd18239   96 LQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 120-234 2.65e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 85.93  E-value: 2.65e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 120 DASNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVY 199
Cdd:cd18468    1 TPSNCLG-------------IWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVF 67

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 578813570 200 DAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFL 234
Cdd:cd18468   68 ETAIKWLKKDPKNRKQHIAELLAVVRLPFIHPSYL 102
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-125 3.97e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 86.44  E-value: 3.97e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLD 97
Cdd:cd18341   24 ENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYSAEIDLNDGNVQDIFA 103

                         90       100
                 ....*....|....*....|....*...
gi 578813570  98 AANQYQIEPVKKMCVDFLKEQVDASNCL 125
Cdd:cd18341  104 LASRFQIPSVFTVCVTYLQKRLSPANCL 131
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 118-230 4.04e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 85.56  E-value: 4.04e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 118 QVDASNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQ 197
Cdd:cd18459    1 QLDPSNCLG-------------IRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQ 67

                         90       100       110
                 ....*....|....*....|....*....|...
gi 578813570 198 VYDAAVRWLKYDEPNRQPFMVDILAKVRFPLIS 230
Cdd:cd18459   68 VFNAVMAWVKYNIQERRPHLPQVLQHVRLPLLS 100
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-125 5.71e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 86.04  E-value: 5.71e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLD 97
Cdd:cd18271   21 QNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKAEITDDNVEMFFQ 100

                         90       100
                 ....*....|....*....|....*...
gi 578813570  98 AANQYQIEPVKKMCVDFLKEQVDASNCL 125
Cdd:cd18271  101 MSSFLQVSLLSKACSDFLIKSIDLTNCL 128
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 139-226 8.74e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 84.29  E-value: 8.74e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 139 GISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMV 218
Cdd:cd18455    7 GIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEERKVHLK 86


                 ....*...
gi 578813570 219 DILAKVRF 226
Cdd:cd18455   87 DLMSSCWR 94
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 23-111 1.17e-19

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 83.93  E-value: 1.17e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  23 DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQY 102
Cdd:cd18314    8 DVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLASKY 87


                 ....*....
gi 578813570 103 QIEPVKKMC 111
Cdd:cd18314   88 QVPDLEKLC 96
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-115 1.24e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 84.60  E-value: 1.24e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18326   25 LCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSAEALTALLDFAYTATLTVSTSNVGDILSAAR 104

                         90
                 ....*....|....*
gi 578813570 101 QYQIEPVKKMCVDFL 115
Cdd:cd18326  105 LLEIPAVSHVCADLL 119
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-116 1.55e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 84.31  E-value: 1.55e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTN--MLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDA 98
Cdd:cd18245   14 LCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNppKDDGSTYKIELEGISVEVMEEILDYIYTGQIKLSEDNIQDIVQA 93

                         90
                 ....*....|....*...
gi 578813570  99 ANQYQIEPVKKMCVDFLK 116
Cdd:cd18245   94 ADLLLMTDLKDLCCEFLE 111
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-126 2.05e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 84.47  E-value: 2.05e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18276   21 LTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHDITAESVSIILNYMYSSDLHLTNSNVQGVATAAF 100

                         90       100
                 ....*....|....*....|....*.
gi 578813570 101 QYQIEPVKKMCVDFLKEQVDASNCLG 126
Cdd:cd18276  101 FLQMEDIFSVCQKYMMDHMDASNCLG 126
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-116 2.35e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 83.76  E-value: 2.35e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18198   25 LCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAVVDQQNVYEIDFVSPEALTALLEFAYTATLTVSTANVGDILSAAR 104

                         90
                 ....*....|....*.
gi 578813570 101 QYQIEPVKKMCVDFLK 116
Cdd:cd18198  105 LLEIPCVSHVCAEILD 120
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-125 3.66e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 83.90  E-value: 3.66e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLD 97
Cdd:cd18270   23 QQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAINDSTVEQLYE 102

                         90       100
                 ....*....|....*....|....*...
gi 578813570  98 AANQYQIEPVKKMCVDFLKEQVDASNCL 125
Cdd:cd18270  103 TACFLQVEDVLQRCREYLIKKINAENCV 130
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-114 1.11e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 81.95  E-value: 1.11e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTT-NMLESKSFEVELKDAEP--DIIEQLVEFAYTARISVNSNNVQSLLD 97
Cdd:cd18292   17 LSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNdWWSESKQSEIELVEDPEcaAVFEKFLRYLYTGQISVNLETALPLLM 96

                         90
                 ....*....|....*..
gi 578813570  98 AANQYQIEPVKKMCVDF 114
Cdd:cd18292   97 LADKYNVTDLKQLCVDF 113
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-126 1.23e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 82.34  E-value: 1.23e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERK-IPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAA 99
Cdd:cd18274   22 LTDIVVEVDHGKtFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYTSRVTLTEANVQALFTAA 101

                         90       100
                 ....*....|....*....|....*..
gi 578813570 100 NQYQIEPVKKMCVDFLKEQVDASNCLG 126
Cdd:cd18274  102 SIFQIPSLQDQCAQFMISRLDPQNSIG 128
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-125 1.32e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 82.25  E-value: 1.32e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18266   25 FCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGLKAVIDFLYSSELPLDGGNIDYVLETAH 104

                         90       100
                 ....*....|....*....|....*
gi 578813570 101 QYQIEPVKKMCVDFLKEQVDASNCL 125
Cdd:cd18266  105 LLQIWKVVDFCCEYLENEVSEENYL 129
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-126 1.35e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 81.94  E-value: 1.35e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  19 KTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKS---FEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSL 95
Cdd:cd18258   15 KEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGgekLELTMSNINADVLELLLEFVYTGSLIIDSANAKTL 94

                         90       100       110
                 ....*....|....*....|....*....|.
gi 578813570  96 LDAANQYQIEPVKKMCVDFLKEQVDASNCLG 126
Cdd:cd18258   95 LEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-115 2.03e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 81.47  E-value: 2.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18328   25 LCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQPYVYEIDFVTPEALSAILEFAYTSTLTITTSNVKHILNAAQ 104

                         90
                 ....*....|....*
gi 578813570 101 QYQIEPVKKMCVDFL 115
Cdd:cd18328  105 MLEIQCIINVCLEIM 119
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-115 3.71e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 80.37  E-value: 3.71e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  19 KTLCDVILMV-QERK-IPAHRVVLAAASHFFNLMFTTNML-ESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSL 95
Cdd:cd18294   12 PEFSDVKFLVgPERQeIFAHKCILAARCEVFRAMFLTGPQkESTQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNHTVIEV 91

                         90       100
                 ....*....|....*....|
gi 578813570  96 LDAANQYQIEPVKKMCVDFL 115
Cdd:cd18294   92 LAAAVEYGLDELRKLCERFI 111
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-123 5.17e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 80.17  E-value: 5.17e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  13 SHINLKKTLCDVILMV----QERKIPAHRVVLAAASHFFNLMFTTNMlESKSFEVELKDAEPDIIEQLVEFAYTARISVN 88
Cdd:cd18281   14 AFLFNNETLSDVHFIVgkgdNEQRIPAHKFVLSIGSAVFDAMFNGGM-ATTSAEIELPDVEPAAFLALLRFLYSDEVQIG 92

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 578813570  89 SNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASN 123
Cdd:cd18281   93 PETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-124 7.10e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 80.29  E-value: 7.10e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  22 CDVILMVQE---RKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKD------AEPDIIEQLVEFAYTARISVNSNNV 92
Cdd:cd18241   24 CDITLAFGGaggREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKwssepgPDPDTVEAVIQYMYTGRIRVSTGNV 103

                         90       100       110
                 ....*....|....*....|....*....|..
gi 578813570  93 QSLLDAANQYQIEPVKKMCVDFLKEQVDASNC 124
Cdd:cd18241  104 HEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-125 2.29e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 78.85  E-value: 2.29e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18261   28 LCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLHGVTSLGLKQALDFAYTGQILLEPGVIQDVLAAGS 107

                         90       100
                 ....*....|....*....|....*
gi 578813570 101 QYQIEPVKKMCVDFLKEQVDASNCL 125
Cdd:cd18261  108 HLQLLELLSLCSHYLIQELNSFNYL 132
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 22-125 3.15e-17

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 77.93  E-value: 3.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  22 CDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQ 101
Cdd:cd18263   14 CDVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLPTIPAKDLRLLISFAYSGILHLSWENLFEATCTALQ 93

                         90       100
                 ....*....|....*....|....
gi 578813570 102 YQIEPVKKMCVDFLKEQVDASNCL 125
Cdd:cd18263   94 LQISGALALCLDFLQREISPARCL 117
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 119-230 5.86e-17

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 76.36  E-value: 5.86e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 119 VDASNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQV 198
Cdd:cd18466    1 IDPANCIG-------------IFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQV 67

                         90       100       110
                 ....*....|....*....|....*....|..
gi 578813570 199 YDAAVRWLKYDEPNRQPFMVDILAKVRFPLIS 230
Cdd:cd18466   68 FTAAMEWILKDVGKRKKHVVEVLEPVRFPLLP 99
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 21-104 6.18e-17

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 75.66  E-value: 6.18e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFtTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALL-KETPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAE 79


                 ....
gi 578813570 101 QYQI 104
Cdd:cd18315   80 LLQI 83
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 119-230 6.93e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 76.14  E-value: 6.93e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 119 VDASNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQV 198
Cdd:cd18467    1 LDPGNCIG-------------ISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETV 67

                         90       100       110
                 ....*....|....*....|....*....|..
gi 578813570 199 YDAAVRWLKYDEPNRQPFMVDILAKVRFPLIS 230
Cdd:cd18467   68 FYALESWIKYDVQERQKYLAQLLHCVRLPLLS 99
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-115 1.79e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 75.74  E-value: 1.79e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  10 FLTSHIN---LKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARIS 86
Cdd:cd18287    8 FLSEDIGalfLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEAFKALLKYIYTGRLT 87

                         90       100       110
                 ....*....|....*....|....*....|..
gi 578813570  87 VNS---NNVQSLLDAANQYQIEPVKKMCVDFL 115
Cdd:cd18287   88 LTDlkeDVLLDVLGLAHQYGFEELEAAISDYL 119
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-123 1.91e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 75.64  E-value: 1.91e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570   6 DCRtfLTSHI-NL--KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYT 82
Cdd:cd18279    2 ECR--LAEDLgNLweNSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYT 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 578813570  83 ARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASN 123
Cdd:cd18279   80 GKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-123 2.03e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 75.63  E-value: 2.03e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  20 TLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAA 99
Cdd:cd18251   22 ILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCKILDFIYTSELELSLDNVQETLTAA 101

                         90       100
                 ....*....|....*....|....
gi 578813570 100 NQYQIEPVKKMCVDFLKEQVDASN 123
Cdd:cd18251  102 CQLQIPEVIGFCCDFLMSWVDNEN 125
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-124 2.39e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 75.99  E-value: 2.39e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  17 LKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLL 96
Cdd:cd18264   24 AEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLEDTL 103

                         90       100
                 ....*....|....*....|....*...
gi 578813570  97 DAANQYQIEPVKKMCVDFLKEQVDASNC 124
Cdd:cd18264  104 EAASYLQVTEAIGLCSQYLINNLAPENC 131
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-119 3.13e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 75.28  E-value: 3.13e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTnmlESKSFEVELKDAEPDIIE----------QLVEFAYTARISVNSN 90
Cdd:cd18228   19 FCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVG---QASPRLVLVSPAGKCVLDlhhvtvtgfaPLLEYAYTSTLSINTE 95

                         90       100
                 ....*....|....*....|....*....
gi 578813570  91 NVQSLLDAANQYQIEPVKKMCVDFLKEQV 119
Cdd:cd18228   96 NIIDVLAAASYMQMFNVANTCSEFMKSSI 124
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 119-233 1.11e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 72.73  E-value: 1.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 119 VDASNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQV 198
Cdd:cd18456    1 LDPSNCLG-------------IRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEV 67

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 578813570 199 YDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNF 233
Cdd:cd18456   68 YRAVLSWVKHDVDGRRQHVPRLMKCVRLPLLSRDF 102
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 18-111 1.33e-15

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 72.66  E-value: 1.33e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNN-VQSLL 96
Cdd:cd18300    6 KGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPILEDGdCVGLI 85

                         90
                 ....*....|....*
gi 578813570  97 DAANQYQIEPVKKMC 111
Cdd:cd18300   86 VLANRLCLPRLVALC 100
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-125 1.39e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 73.78  E-value: 1.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  23 DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQY 102
Cdd:cd18272   34 DVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRVEELQETYEVADMY 113

                         90       100
                 ....*....|....*....|...
gi 578813570 103 QIEPVKKMCVDFLKEQVDASNCL 125
Cdd:cd18272  114 QLTALFEECSRFLARTVQVRNCL 136
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 147-229 1.42e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 72.50  E-value: 1.42e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 147 LDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRF 226
Cdd:cd18517   16 LDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKENRVKSLGEIFDCIRF 95


                 ...
gi 578813570 227 PLI 229
Cdd:cd18517   96 RLM 98
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 120-230 1.55e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 72.45  E-value: 1.55e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 120 DASNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVY 199
Cdd:cd18485    2 DASNCLG-------------IYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESIL 68

                         90       100       110
                 ....*....|....*....|....*....|.
gi 578813570 200 DAAVRWLKYDEPNRQPFMVDILAKVRFPLIS 230
Cdd:cd18485   69 DLVLRWVNHNRKSRVQHLVELLKQVRLELVS 99
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 139-239 1.76e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 72.50  E-value: 1.76e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 139 GISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMV 218
Cdd:cd18446    8 GILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKESERLPLLP 87

                         90       100
                 ....*....|....*....|.
gi 578813570 219 DILAKVRFPLISKNFLSKTVQ 239
Cdd:cd18446   88 RVLENVRLPLLDPWYFVETVE 108
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 117-233 2.06e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 72.10  E-value: 2.06e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 117 EQVDASNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAED 196
Cdd:cd18469    1 QQIDATNCLG-------------ICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQ 67

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 578813570 197 QVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNF 233
Cdd:cd18469   68 SRLEAVLRWVGHDPQARAAHLPELLSLVHLSLLTDQY 104
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 118-235 2.56e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 72.02  E-value: 2.56e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 118 QVDASNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQ 197
Cdd:cd18511    1 QLHPSNCLG-------------IRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEET 67

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 578813570 198 VYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLS 235
Cdd:cd18511   68 ILNALLSWVRHDVEQRRKDLSKLLAYIRLPLLAPQFLA 105
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-123 3.32e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 72.34  E-value: 3.32e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  23 DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQY 102
Cdd:cd18343   23 DCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPNLDKMADNLLAAADKY 102

                         90       100
                 ....*....|....*....|.
gi 578813570 103 QIEPVKKMCVDFLKEQVDASN 123
Cdd:cd18343  103 ALERLKVMCEEALCNNLSVEN 123
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-115 5.23e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 71.42  E-value: 5.23e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  23 DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQY 102
Cdd:cd18345   20 DVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGKAPNLDKMADDLLAAADKY 99

                         90
                 ....*....|...
gi 578813570 103 QIEPVKKMCVDFL 115
Cdd:cd18345  100 ALERLKVMCEEAL 112
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-123 6.04e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 71.63  E-value: 6.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  29 QERKIPAHRVVLAAASHFFNLMFTTNMlESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVK 108
Cdd:cd18346   40 GAQRIPAHRFVLAAGSAVFDAMFNGGM-ATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALE 118

                         90
                 ....*....|....*
gi 578813570 109 KMCVDFLKEQVDASN 123
Cdd:cd18346  119 AHCVEFLTKHLRADN 133
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 119-231 6.73e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 70.60  E-value: 6.73e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 119 VDASNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQV 198
Cdd:cd18460    1 LDVSNCLE-------------MQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETA 67

                         90       100       110
                 ....*....|....*....|....*....|...
gi 578813570 199 YDAAVRWLKYDEPNRQPFMVDILAKVRFPLISK 231
Cdd:cd18460   68 YQIALRWVKADPKHRQHFWPELLQHVRLPFVRR 100
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-118 7.53e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 71.11  E-value: 7.53e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDV-ILMVQERKI-PAHRVVLAAASHFFNLMFTTNMlESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDA 98
Cdd:cd18231   14 LCDVdIVLVRQRSTfPAHKGVLAAYSQFFHSLFTQNK-QLQRVELSLEALTSQGLQQILNFIYTSKLLVNSCNVQDVLNA 92

                         90       100
                 ....*....|....*....|
gi 578813570  99 ANQYQIEPVKKMCVDFLKEQ 118
Cdd:cd18231   93 AAVLQMNDIAASCQELIDSR 112
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-116 1.00e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 71.03  E-value: 1.00e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEV-------ELKDAEPDIIEQLVEFAYTARISVNSNNVQ 93
Cdd:cd18327   25 LCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGAgggqdvcELDFVGPEALGALLEFAYTATLTISSSNMR 104

                         90       100
                 ....*....|....*....|...
gi 578813570  94 SLLDAANQYQIEPVKKMCVDFLK 116
Cdd:cd18327  105 EVLRAARLLEIPCVADACADILQ 127
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 20-111 1.94e-14

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 69.81  E-value: 1.94e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  20 TLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAA 99
Cdd:cd18352   12 TLSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAA 91

                         90
                 ....*....|..
gi 578813570 100 NQYQIEPVKKMC 111
Cdd:cd18352   92 DQYLLEGLKRLC 103
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-123 1.97e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 70.10  E-value: 1.97e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  19 KTLCDVILMVQE----RKIPAHRVVLAAASHFFNLMFTTNMlESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQS 94
Cdd:cd18347   20 EVLSDVHFLVGKglgsQRIPAHRFVLAVGSAVFDAMFNGGM-ATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMT 98

                         90       100
                 ....*....|....*....|....*....
gi 578813570  95 LLDAANQYQIEPVKKMCVDFLKEQVDASN 123
Cdd:cd18347   99 TLYTAKKYAVPALEAHCVEFLKKNLRADN 127
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-123 2.10e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 69.61  E-value: 2.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  19 KTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARIS---VNSNNVQSL 95
Cdd:cd18297   10 PEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPDIRYDIFQLMMQYLYTGGVEsldVAQDDALEL 89

                         90       100
                 ....*....|....*....|....*...
gi 578813570  96 LDAANQYQIEPVKKMCVDFLKEQVDASN 123
Cdd:cd18297   90 LRAASFFQLDGLKRHCEILLSQQIDLDN 117
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 147-229 2.85e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 68.71  E-value: 2.85e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 147 LDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRF 226
Cdd:cd18477   16 LDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKENRQKALPTVFESIRF 95


                 ...
gi 578813570 227 PLI 229
Cdd:cd18477   96 RLL 98
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-114 3.50e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 68.29  E-value: 3.50e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  22 CDVILMVQERKIPAHRVVLAAASHFFNLMFTTNML---ESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDA 98
Cdd:cd18307    2 CDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMkatDELSITIDCDYLSPETVEQLLDYFYTGKIVISEKNVEDLLKG 81

                         90
                 ....*....|....*.
gi 578813570  99 ANQYQIEPVKKMCVDF 114
Cdd:cd18307   82 AKYFNIPRLKDHCVDF 97
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 143-225 4.52e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 68.16  E-value: 4.52e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 143 LAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILA 222
Cdd:cd18479   12 FADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLS 91


                 ...
gi 578813570 223 KVR 225
Cdd:cd18479   92 QIR 94
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-124 5.69e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 69.21  E-value: 5.69e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18244   30 LLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHLKGLTATGFSHVLQFMYYGTIELSMLTVHEILQAAM 109

                         90       100
                 ....*....|....*....|....
gi 578813570 101 QYQIEPVKKMCVDFLKEQVDASNC 124
Cdd:cd18244  110 YVQLTEVVKFCCSFLLAKICLDNC 133
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 118-235 1.06e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 67.25  E-value: 1.06e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 118 QVDASNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQ 197
Cdd:cd18510    1 QLHPSNCLG-------------IRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEET 67

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 578813570 198 VYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLS 235
Cdd:cd18510   68 IFQALMMWVRHDLQNRQKDLGMLLSYIRLPLLPPQLLA 105
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-123 1.17e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 67.82  E-value: 1.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  23 DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQY 102
Cdd:cd18342   24 DCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKY 103

                         90       100
                 ....*....|....*....|.
gi 578813570 103 QIEPVKKMCVDFLKEQVDASN 123
Cdd:cd18342  104 ALERLKVMCEDALCSNLSVEN 124
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 139-227 1.18e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 66.81  E-value: 1.18e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 139 GISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMV 218
Cdd:cd18483    8 GVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQSKREMHLP 87

                         90
                 ....*....|
gi 578813570 219 DILAK-VRFP 227
Cdd:cd18483   88 EIFAKcIRMP 97
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 122-229 1.45e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 66.70  E-value: 1.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 122 SNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDA 201
Cdd:cd18516    4 SNCLA-------------IFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEA 70

                         90       100
                 ....*....|....*....|....*...
gi 578813570 202 AVRWLKYDEPNRQPFMVDILAKVRFPLI 229
Cdd:cd18516   71 VMKWVGKDQEERTKALPVLLESIRFRLM 98
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 122-235 1.47e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 66.97  E-value: 1.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 122 SNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDA 201
Cdd:cd18509    5 SNCLG-------------IRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHA 71

                         90       100       110
                 ....*....|....*....|....*....|....
gi 578813570 202 AVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLS 235
Cdd:cd18509   72 LMMWVKYDMQRRCSDLSMLLAYIRLPLLPPQLLA 105
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-125 1.54e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 67.15  E-value: 1.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  13 SHINLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKsfeVELKDAEPDIIEQLVEFAYTARISVNSNNV 92
Cdd:cd18260   10 NRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDPSLQR---VELNDISPLGLATVITYAYTGKLTLSLYTI 86

                         90       100       110
                 ....*....|....*....|....*....|...
gi 578813570  93 QSLLDAANQYQIEPVKKMCVDFLKEQVDASNCL 125
Cdd:cd18260   87 GSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-117 4.36e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 65.49  E-value: 4.36e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  31 RKIPAHRVVLAAASHFFNLMFTTNMLESKSfEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKM 110
Cdd:cd18282   21 QRIPAHKYVLATGSSVFYAMFYGGLAENKN-EIEIPDVEPAAFLNLLRYLYCDEIDLEPDTVLATLYAAKKYLVPHLARA 99


                 ....*..
gi 578813570 111 CVDFLKE 117
Cdd:cd18282  100 CVQFLET 106
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-116 5.57e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 65.68  E-value: 5.57e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKS-FEVELKDAEPdiIEQLVEFAYTARISVNSNNVQSLLDAA 99
Cdd:cd18233   18 LCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKNDvFHLDIKNVGG--IGQILDFMYTSHLDLNQDNVQVMLDIA 95

                         90
                 ....*....|....*..
gi 578813570 100 NQYQIEPVKKMCVDFLK 116
Cdd:cd18233   96 QCLQVQNVLNMCYTFLK 112
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-116 2.01e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 64.29  E-value: 2.01e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  13 SHIN---LKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVeLKDaePDIIEQLVEFAYTARISVNS 89
Cdd:cd18222   14 SHLNqlrMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLNEMSTVSISV-IKN--PTVFEQLLSFCYTGRICLQL 90

                         90       100
                 ....*....|....*....|....*..
gi 578813570  90 NNVQSLLDAANQYQIEPVKKMCVDFLK 116
Cdd:cd18222   91 ADIISYLTAASFLQMQHIIDKCTQILE 117
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-117 2.72e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 64.22  E-value: 2.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLE-SKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAA 99
Cdd:cd18207   27 FCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDgGTPRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAA 106

                         90
                 ....*....|....*...
gi 578813570 100 NQYQIEPVKKMCVDFLKE 117
Cdd:cd18207  107 KFLLMRSVIDICQEVIKQ 124
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 140-229 4.28e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 62.62  E-value: 4.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 140 ISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDePNRQPFMVD 219
Cdd:cd18465    9 IGQMATTFSLASLKESVDAFTFRHFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHD-PSRRASASH 87

                         90
                 ....*....|
gi 578813570 220 ILAKVRFPLI 229
Cdd:cd18465   88 VLCHIRFPLM 97
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-116 4.49e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 62.69  E-value: 4.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMV----QERKIPAHRVVLAAASHFFNLMFTTNMLESKSfEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLL 96
Cdd:cd18349    8 MADVHFIVgppgASQRVPAHKYVLAVGSSVFYAMFYGDLAEVKS-EIHIPDVEPAAFLILLKYMYSDEIDLEADTVLATL 86

                         90       100
                 ....*....|....*....|
gi 578813570  97 DAANQYQIEPVKKMCVDFLK 116
Cdd:cd18349   87 YAAKKYIVPALAKACVNFLE 106
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 143-230 1.71e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 60.66  E-value: 1.71e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 143 LAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEpNRQPFMVDILA 222
Cdd:cd18470   12 IAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFDQ-KRVKYAADLLS 90


                 ....*...
gi 578813570 223 KVRFPLIS 230
Cdd:cd18470   91 NIRFGTIS 98
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 461-506 1.93e-11

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 58.78  E-value: 1.93e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 578813570  461 ARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMP 506
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-111 2.08e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 61.19  E-value: 2.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  22 CDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARI------------SVNS 89
Cdd:cd18280   15 ADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYKDELpddvepagsdssSLDT 94

                         90       100
                 ....*....|....*....|..
gi 578813570  90 NNVQSLLDAANQYQIEPVKKMC 111
Cdd:cd18280   95 TMAQHLLAAADRYALERLRLLC 116
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-115 2.69e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 60.43  E-value: 2.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  13 SHINLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNmleskSFEVELKDAEPDIIEQLVEFAYTARISVNSNNV 92
Cdd:cd18205   10 NQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFHRN-----SQHYTLDFLSPKTFQQILEYAYTATLQAKVEDL 84

                         90       100
                 ....*....|....*....|...
gi 578813570  93 QSLLDAANQYQIEPVKKMCVDFL 115
Cdd:cd18205   85 DDLLYAAEILEIEYLEEQCLKIL 107
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 17-116 4.97e-11

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 59.53  E-value: 4.97e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  17 LKKTLC-DVILMVQER-KIPAHRVVLAAASHFFNLMFTTnMLesksfEVEL-KDAEPDIIEQLVEFAYTARISVNSNNVQ 93
Cdd:cd18299    7 LHSPSCaDVVFILQGGvRIFAHRIVLAAASSVFADLFLM-MT-----VVTLdSDITPEAFRRVLEFLYTGVLDENEDDLK 80

                         90       100
                 ....*....|....*....|...
gi 578813570  94 SLLDAANQYQIEPVKKMCVDFLK 116
Cdd:cd18299   81 ELKDAAELLELFDLVMMCTNVLN 103
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-116 5.91e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 60.04  E-value: 5.91e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  13 SHINLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVeLKDaePDIIEQLVEFAYTARISVNSNNV 92
Cdd:cd18220   17 NELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISV-IKN--PNVFEQLLSFCYTGRMSLQLKDV 93

                         90       100
                 ....*....|....*....|....
gi 578813570  93 QSLLDAANQYQIEPVKKMCVDFLK 116
Cdd:cd18220   94 VSFLTAASFLQMQCVIDKCTQILE 117
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-111 6.70e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 59.67  E-value: 6.70e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  17 LKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFeVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLL 96
Cdd:cd18204   14 LEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKLEVDSSSV-IEIDFLRSDIFEEVLNYMYTAKISVKKEDVNLMM 92

                         90
                 ....*....|....*
gi 578813570  97 DAANQYQIEPVKKMC 111
Cdd:cd18204   93 SSGQILGIRFLDKLC 107
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 119-213 8.81e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 58.10  E-value: 8.81e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 119 VDASNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQV 198
Cdd:cd18480    1 LDLSNCLQ-------------LLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAV 67

                         90
                 ....*....|....*
gi 578813570 199 YDAAVRWLKYDEPNR 213
Cdd:cd18480   68 LKAVLRWTKHDLEAR 82
PHA02790 PHA02790
Kelch-like protein; Provisional
 73-509 1.03e-10

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 64.29  E-value: 1.03e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  73 IEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCLgeaekvdqslpECGISVLAECLDcpEL 152
Cdd:PHA02790  74 LTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFIIYTCINFILRDFRKEYCV-----------ECYMMGIEYGLS--NL 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 153 KATADDFIHQHFTEVyKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKydepNRQPFMVDILAKVRfPLISKN 232
Cdd:PHA02790 141 LCHTKDFIAKHFLEL-EDDIIDNFDYLSMKLILESDELNVPDEDYVVDFVIKWYM----KRRNRLGNLLLLIK-NVIRSN 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 233 FLS-KTVQAEPLIQDnpeCLKMvisgmrYHLlspedreelvdGTRPrRKKHDYRIALFGGSQPQSCRYFNPkdyswtdir 311
Cdd:PHA02790 215 YLSpRGINNVKWILD---CTKI------FHC-----------DKQP-RKSYKYPFIEYPMNMDQIIDIFHM--------- 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 312 cpfekrrdAACVFWDNVVYILGGSQLFPIKRMD-CYNVVKDSWYSKLGPPTPRDSLAACAAEGKIYTSGGSEVGNSALYL 390
Cdd:PHA02790 265 --------CTSTHVGEVVYLIGGWMNNEIHNNAiAVNYISNNWIPIPPMNSPRLYASGVPANNKLYVVGGLPNPTSVERW 336

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 391 FECyDTrteSWHTKPSMLTQRCSHGMVEANGLIYVCGGSLGNNVSGRVL------------------NSC---------- 442
Cdd:PHA02790 337 FHG-DA---AWVNMPSLLKPRCNPAVASINNVIYVIGGHSETDTTTEYLlpnhdqwqfgpstyyphyKSCalvfgrrlfl 412

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578813570 443 -----EVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMvspmpWKG 509
Cdd:PHA02790 413 vgrnaEFYCESSNTWTLIDDPIYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSWNI-----WDG 479
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 119-228 1.07e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 58.59  E-value: 1.07e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 119 VDASNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQV 198
Cdd:cd18462    1 LDIDNCLG-------------MHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVL 67

                         90       100       110
                 ....*....|....*....|....*....|
gi 578813570 199 YDAAVRWLKYDEPNRQPFMVDILAKVRFPL 228
Cdd:cd18462   68 IEAVVKWVAHDVEKRIECAYDLLSSIKLDL 97
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-114 1.30e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 59.28  E-value: 1.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  17 LKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTnmleSKSFEVELKDA-EPDIIEQLVEFAYTARISVNSNNVQSL 95
Cdd:cd18290   23 LQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELPAAvQPQSFQQILSFCYTGRLSMNVGDQFLL 98

                         90
                 ....*....|....*....
gi 578813570  96 LDAANQYQIEPVKKMCVDF 114
Cdd:cd18290   99 MYTAGFLQIQEIMEKGTEF 117
Kelch smart00612
Kelch domain;
422-472 1.63e-10

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 56.41  E-value: 1.63e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 578813570   422 LIYVCGGSLGNNVsgrvLNSCEVYDPATETWTELCPMIEARKNHGLVFVKD 472
Cdd:smart00612   1 KIYVVGGFDGGQR----LKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-123 1.74e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 58.81  E-value: 1.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  23 DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARI-SVNSNNVQ-SLLDAAN 100
Cdd:cd18344   25 DCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTGKApHLHSHSMAcDVLAAAD 104

                         90       100
                 ....*....|....*....|...
gi 578813570 101 QYQIEPVKKMCVDFLKEQVDASN 123
Cdd:cd18344  105 KYGLEGLKVLCEDALCRNLSVEN 127
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 119-206 1.82e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 57.01  E-value: 1.82e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 119 VDASNCLgeaekvdQSLPecgisvLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQV 198
Cdd:cd18472    1 LSPANCL-------ELWA------FADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAV 67


                 ....*...
gi 578813570 199 YDAAVRWL 206
Cdd:cd18472   68 FEAAVRWL 75
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-115 2.23e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 58.15  E-value: 2.23e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFT----TNMLESKSFEVELKDAEPdiieqLVEFAYTARISVNSNNVQ 93
Cdd:cd18277   24 KDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVgqadAELNITLPEEVTVKGFEP-----LIQFAYTAKLILSKDNVD 98

                         90       100
                 ....*....|....*....|..
gi 578813570  94 SLLDAANQYQIEPVKKMCVDFL 115
Cdd:cd18277   99 EVCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-113 2.84e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 57.88  E-value: 2.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  22 CDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMlESKSFEV--ELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAA 99
Cdd:cd18293   16 CDVLLQAEGESVPAHCCVLSACSPYLTERLSSEP-PPAGQKVvlELQGLKAHTLLKLVDFLYTSELEVSSEEAQDVLAAA 94

                         90
                 ....*....|....
gi 578813570 100 NQYQIEPVKKMCVD 113
Cdd:cd18293   95 RRLQISELESLCLE 108
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-95 2.86e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 57.58  E-value: 2.86e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  17 LKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFeVELKDAEPDIIEQLVEFAYTARISVNSNN---VQ 93
Cdd:cd18209   14 LKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKENESQSV-FQLDFCEPDAFENVLNYIYSSSLFVEKSSlaaVQ 92


                 ..
gi 578813570  94 SL 95
Cdd:cd18209   93 EL 94
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-114 2.88e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 57.88  E-value: 2.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVeLKDAEPDIIEQLVEFAYTARISVNSNNVQSLLD 97
Cdd:cd18212   20 KDFLCDITLIVENVQFRAHKALLAASSEYFSMMFADEGEVGQSIYM-LEGMVAETFGALLEFIYTGCLQVGEKSLEQILA 98

                         90
                 ....*....|....*..
gi 578813570  98 AANQYQIEPVKKMCVDF 114
Cdd:cd18212   99 TAQFLKVNDLVKAYSDY 115
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 120-185 2.97e-10

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 55.74  E-value: 2.97e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578813570 120 DASNClgeaekvdqslpeCGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLL 185
Cdd:cd14733    1 DPENC-------------LGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELL 53
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-123 3.20e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 58.13  E-value: 3.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNmlesksfEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLD 97
Cdd:cd18243   29 KQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFSIN-------NLVLQGCSSIGLRLVLEYLYTANVTLSLDTVEEVLS 101

                         90       100
                 ....*....|....*....|....*.
gi 578813570  98 AANQYQIEPVKKMCVDFLKEQVDASN 123
Cdd:cd18243  102 VSKILHIPQVTKLCVQFLNDQISVQN 127
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 23-120 4.51e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 57.31  E-value: 4.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  23 DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSF-----EVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLD 97
Cdd:cd18296   19 DVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENngsipVVTLHDVSPEVFAIVLYYIYTDDTDLPPENAYDVLY 98

                         90       100
                 ....*....|....*....|...
gi 578813570  98 AANQYQIEPVKKMCVDFLKEQVD 120
Cdd:cd18296   99 VADMYLLPGLKRLCGTVLAQSLD 121
PHA02713 PHA02713
hypothetical protein; Provisional
 21-477 4.81e-10

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 62.33  E-value: 4.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQE-RKIPAHRVVLAAASHFFNLMFTTNML-ESKSFEVELKDAEPDIIEQLVEFAYTARISvnSNNVQSLLDA 98
Cdd:PHA02713  25 LCDVIITIGDgEEIKAHKTILAAGSKYFRTLFTTPMIiRDLVTRVNLQMFDKDAVKNIVQYLYNRHIS--SMNVIDVLKC 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  99 ANQYQIEPVKKMCVDFLKEQVDASNCLgeaekvdqslpeCGISVLAECLDCPELKATaDDFIHQHFTEVYKTDEFLQLDV 178
Cdd:PHA02713 103 ADYLLIDDLVTDCESYIKDYTNHDTCI------------YMYHRLYEMSHIPIVKYI-KRMLMSNIPTLITTDAFKKTVF 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 179 KRVTHLLN-QDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVdILAKVRFPLISKnflsktvQAEPLIQDNpECLKMVISG 257
Cdd:PHA02713 170 EILFDIIStNDNVYLYREGYKVTILLKWLEYNYITEEQLLC-ILSCIDIQNLDK-------KSRLLLYSN-KTINMYPSC 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 258 MRYHLLSPEDREELvdgtrPRRKKHDYRIALFGGSQPQSCRYfNPKDYSWTDIRCPFEKRRDAACVFWDNVVYILGGSQL 337
Cdd:PHA02713 241 IQFLLDNKQNRNII-----PRQLCLVCHDTKYNVCNPCILVY-NINTMEYSVISTIPNHIINYASAIVDNEIIIAGGYNF 314

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 338 FPIKRMDCYNV-VKDSWYSKLGPPTP-RDSLAACAAEGKIYTSGGSEvGNSALYLFECYDTRTESWHTKPSMLTQRCSHG 415
Cdd:PHA02713 315 NNPSLNKVYKInIENKIHVELPPMIKnRCRFSLAVIDDTIYAIGGQN-GTNVERTIECYTMGDDKWKMLPDMPIALSSYG 393

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578813570 416 MVEANGLIYVCGGSLG--NNVSGRVLNSCEV------------YDPATETWTELCPMIEARKNHGLVFVKDKIFAV 477
Cdd:PHA02713 394 MCVLDQYIYIIGGRTEhiDYTSVHHMNSIDMeedthssnkvirYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVV 469
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-115 5.35e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 56.32  E-value: 5.35e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSF----EVELKDAEPdiieqLVEFAYTARISVNSNNVQSLL 96
Cdd:cd18955    1 LCDVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQTDGDLVItlpeEVTVKGFEP-----LLQFAYTAKLLLSKENVLEVC 75

                         90
                 ....*....|....*....
gi 578813570  97 DAANQYQIEPVKKMCVDFL 115
Cdd:cd18955   76 RCAEFLGVHNIEKACFDFL 94
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 149-209 5.77e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 55.70  E-value: 5.77e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578813570 149 CPELKATADDFIHQHFTEV-YKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYD 209
Cdd:cd18450   18 CPELERKAYRYILRNFEEVaKDSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 134-227 9.87e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 55.51  E-value: 9.87e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 134 SLPEC-GISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYdEPN 212
Cdd:cd18449    2 SLENCvEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRH-EDD 80

                         90
                 ....*....|....*
gi 578813570 213 RQPFMVDILAKVRFP 227
Cdd:cd18449   81 RMQFAAKLMENIRFP 95
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 118-208 1.00e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 55.09  E-value: 1.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 118 QVDASNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQ 197
Cdd:cd18463    1 QLDPCNCLG-------------IQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEE 67

                         90
                 ....*....|.
gi 578813570 198 VYDAAVRWLKY 208
Cdd:cd18463   68 VFEAVMRWVYH 78
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-114 1.10e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 56.09  E-value: 1.10e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFttnmLESKSFeVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18206   22 LCDCTFVVDGVDFKAHKAVLAACSEYFRMLF----VDQKDV-VHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVAT 96

                         90
                 ....*....|....
gi 578813570 101 QYQIEPVKKMCVDF 114
Cdd:cd18206   97 FLQMQDIVTACHAL 110
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-117 1.15e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 55.72  E-value: 1.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  23 DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQY 102
Cdd:cd18298   14 DLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNEDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPPEDAIGLLDLANSY 93

                         90
                 ....*....|....*
gi 578813570 103 QIEPVKKMCVDFLKE 117
Cdd:cd18298   94 CEERLKKLCEDIIKQ 108
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 24-102 1.16e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 54.98  E-value: 1.16e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578813570  24 VILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQY 102
Cdd:cd01165    1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-123 1.78e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 55.56  E-value: 1.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISV-NSNNVQSLLDAA 99
Cdd:cd18223   18 LCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQEIWISSHVLELPDLKAEVFAEILNFIYSSKVVVkRQETVTDLVAAG 97

                         90       100
                 ....*....|....*....|....
gi 578813570 100 nqyqiepvKKMCVDFLKEQVDASN 123
Cdd:cd18223   98 --------KKLGITFLENLTDQNF 113
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 120-229 2.02e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 54.75  E-value: 2.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 120 DASNCLGEAEkvdqslpecgisvLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLtVRAEDQVY 199
Cdd:cd18476    2 TPSNCLSMIR-------------LSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVF 67

                         90       100       110
                 ....*....|....*....|....*....|
gi 578813570 200 DAAVRWLKYDEPNRQPFMVDILAKVRFPLI 229
Cdd:cd18476   68 ETLMVWIRHDPKARKGYIHDLFKKVRLQYV 97
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 9-117 2.63e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 55.23  E-value: 2.63e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570   9 TFLTSHINLKKT---LCDVILMVQERKIPAHRVVLAAASHFF-NLMFTTNMLESKSFEVelkdaEPDIIEQLVEFAYTAR 84
Cdd:cd18216    5 TQLLLQLNNQRTkgfLCDVIIVVENSLFRAHKNVLAASSGYFkSLVLHDNLIHLDQDMV-----SPTVFQQILDFIYTGK 79

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 578813570  85 ISVNS---NNVQSLLDAANQYQIEPVKKMCVDFLKE 117
Cdd:cd18216   80 LLDSLfeePNLSEVLAAANYLQLPDLAALCRSKLKR 115
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 163-229 2.90e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 54.43  E-value: 2.90e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578813570 163 HFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLI 229
Cdd:cd18464   31 NFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPRRHEVLPELLRSVRLALL 97
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-115 3.56e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 54.83  E-value: 3.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  22 CDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLE-----SKSFEVelkdAEPDIIEQLVEFAYTARISVNSNNVQSLL 96
Cdd:cd18329   22 CDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKEtgqptVATFDV----FSPDTFTIILDFVYSGKLSLTSQNVIEVM 97

                         90
                 ....*....|....*....
gi 578813570  97 DAANQYQIEPVKKMCVDFL 115
Cdd:cd18329   98 SAASYLQMTDVISVCKTFI 116
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-111 3.58e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 54.76  E-value: 3.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFttnmlESKSFEVELKDAE---PDIIEQLVEFAYTARISVNSNNVQSLLD 97
Cdd:cd18217   18 LCDCTIVIGQFQFKAHRNVLAAFSEYFGAQY-----KDTEDNIVFLDQSqvsADGFQKLLEFIYTGNLNLDSWNVAEIHQ 92

                         90
                 ....*....|....
gi 578813570  98 AANQYQIEPVKKMC 111
Cdd:cd18217   93 AASYLGMEEVVAKC 106
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-123 3.88e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 55.02  E-value: 3.88e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  31 RKIPAHRVVLAAASHFFNLMFTTNMLESKSfEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQYQIEPVKKM 110
Cdd:cd18348   35 QRLPGHKYVLAVGSSVFHAMFYGELAEDKD-EIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLARA 113

                         90
                 ....*....|...
gi 578813570 111 CVDFLKEQVDASN 123
Cdd:cd18348  114 CVNFLETSLSAKN 126
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 122-229 4.11e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 54.21  E-value: 4.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 122 SNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDA 201
Cdd:cd18515    3 TNCLG-------------MLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEA 69

                         90       100
                 ....*....|....*....|....*...
gi 578813570 202 AVRWLKYDEPNRQPFMVDILAKVRFPLI 229
Cdd:cd18515   70 AINWVNYDLKKRHCYLSELLQTVRLALL 97
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 411-458 4.57e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 52.23  E-value: 4.57e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 578813570  411 RCSHGMVEANGLIYVCGGSLGNnvsgRVLNSCEVYDPATETWTELCPM 458
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGN----QSLNSVEVYDPETNTWSKLPSM 45
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-119 5.60e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 54.47  E-value: 5.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIP----AHRVVLAAASHFFNLMF-TTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSL 95
Cdd:cd18211   25 LCDVTVQVEHQGSKeefsAHKAVLAASSKYFKEVFlNEKISDGKNTNVMLNEIYTADFASFLEFVYTAKVEVEEDRVQRM 104

                         90       100
                 ....*....|....*....|....
gi 578813570  96 LDAANQYQIEPVKKMCVDfLKEQV 119
Cdd:cd18211  105 LEIAEKLKCLDLSETCFQ-LKKQM 127
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-116 6.96e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 53.79  E-value: 6.96e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  11 LTSHINLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTnmlESKSFEVELKDAEPDIIEQLVEFAYTARISVNSN 90
Cdd:cd18218    8 LAARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTN---PNPGQWCLGEGISPSTFKQLLDFVYGESVEVQPG 84

                         90       100
                 ....*....|....*....|....*.
gi 578813570  91 NVQSLLDAANQYQIEPVKKMCVDFLK 116
Cdd:cd18218   85 ELRPLLEAARALEVESLEEACWRALG 110
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 2-111 8.06e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 54.07  E-value: 8.06e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570   2 LGGTDCRTFLTSHIN---LKKTLCDVILMVQERKIPAHRVVLA-AASHFFNLMFTTNMLESKSFEVELkdAEPDIIEQLV 77
Cdd:cd18224    4 LHSSDHPNNLLKELNkcrLSETMCDVTIVVGNRSFAAHKAVLAcAAGYFQKLFLSTELDVARTYVVDF--ITPANFEKVL 81

                         90       100       110
                 ....*....|....*....|....*....|....
gi 578813570  78 EFAYTARISVNSNNVQSLLDAANQYQIEPVKKMC 111
Cdd:cd18224   82 SFIYTSELFTDLINVGVIYEVAEKLGMEDLLKAC 115
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-114 8.12e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 53.61  E-value: 8.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  20 TLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMleskSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAA 99
Cdd:cd18232   17 QYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGT----SGSVVLPESFAEVFGLLLDFFYTGELALTRENRDRVLLAA 92

                         90
                 ....*....|....*
gi 578813570 100 NQYQIEPVKKMCVDF 114
Cdd:cd18232   93 KELRVPEAVELCQRF 107
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-115 1.41e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 53.41  E-value: 1.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTT----NMLESKSFEVELKDAEPdiieqLVEFAYTARISVNSNNVQ 93
Cdd:cd18278   28 QDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGqtenDLVVSLPEEVTARGFGP-----LLQFAYTAKLLLSRENIQ 102

                         90       100
                 ....*....|....*....|..
gi 578813570  94 SLLDAANQYQIEPVKKMCVDFL 115
Cdd:cd18278  103 EVIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-122 1.45e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 53.14  E-value: 1.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMF-TTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAA 99
Cdd:cd18230   21 LCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYcQVQKTSDQATVTHLDIVTAQGFKAIIDFMYSAHLALTSKNVIEVMSAA 100

                         90       100
                 ....*....|....*....|...
gi 578813570 100 NQYQIEPVKKMCVDFLKEQVDAS 122
Cdd:cd18230  101 SYLQMTDIVQACHNFIKAALDIS 123
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-124 1.59e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 53.10  E-value: 1.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNlmfttNMLESKSFEVELKDAEPDIIEQLVEFAYT--ARISVNSNNVQSL 95
Cdd:cd18303   15 KELYSDITIKLADKSIPAHKFVLAARSEKWS-----NENLASTNELDLSDISYEVVLALLRWLYTdeLDLTLDDEFLLEL 89

                         90       100
                 ....*....|....*....|....*....
gi 578813570  96 LDAANQYQIEPVKKMCVDFLKEQVDASNC 124
Cdd:cd18303   90 MKAAKRFQLTDLVERCERALMSSVNVDNC 118
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-116 2.10e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 52.63  E-value: 2.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFfnlmFTTNMLESKSFEVELKDA-EPDIIEQLVEFAYTARISVNSNNVQSLLDAA 99
Cdd:cd18227   25 LCDISVVVQGHLFRAHKAVLAASSPY----FCDQVLLKNSRRIVLPDVmNPRVFENILLSCYTGRLVLPAPEIVSYLTAA 100

                         90
                 ....*....|....*..
gi 578813570 100 NQYQIEPVKKMCVDFLK 116
Cdd:cd18227  101 SFLQMWHVVDKCTELLE 117
Kelch_6 pfam13964
Kelch motif;
411-462 2.35e-08

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 50.41  E-value: 2.35e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 578813570  411 RCSHGMVEANGLIYVCGGslgNNVSGRVLNSCEVYDPATETWTELCPMIEAR 462
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGG---YTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch smart00612
Kelch domain;
473-506 2.57e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 50.25  E-value: 2.57e-08
                           10        20        30
                   ....*....|....*....|....*....|....
gi 578813570   473 KIFAVGGQNGLGGLDNVEYYDIKLNEWKMVSPMP 506
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMP 34
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 119-210 2.57e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 51.35  E-value: 2.57e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 119 VDASNClgeaekvdqslpeCGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQV 198
Cdd:cd18474    1 IGANNC-------------LALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVV 67

                         90
                 ....*....|..
gi 578813570 199 YDAAVRWLKYDE 210
Cdd:cd18474   68 LEAALRWVDADP 79
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-114 2.74e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 52.18  E-value: 2.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  17 LKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLL 96
Cdd:cd18215   15 SRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSVINLDPEIEPEGFRILLDFMYTSRLNLREGNIMAVM 94

                         90
                 ....*....|....*...
gi 578813570  97 DAANQYQIEPVKKMCVDF 114
Cdd:cd18215   95 ATAMYLQMEHVVDTCRKF 112
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-116 2.81e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 52.17  E-value: 2.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  15 INLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQS 94
Cdd:cd18332   13 LRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGVSVLTLPSGLEARGFQLLLDFMYTSRLPLTPRTVPA 92

                         90       100
                 ....*....|....*....|..
gi 578813570  95 LLDAANQYQIEPVKKMCVDFLK 116
Cdd:cd18332   93 VLAAATYLQMEHVVETCRRFIQ 114
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 122-229 2.97e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 51.77  E-value: 2.97e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 122 SNCLGeaekvdqslpecgISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDA 201
Cdd:cd18514    4 SNCLG-------------MMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNA 70

                         90       100
                 ....*....|....*....|....*...
gi 578813570 202 AVRWLKYDEPNRQPFMVDILAKVRFPLI 229
Cdd:cd18514   71 VLQWVKYDLEKRKDYLPELLRNVRLALL 98
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 23-109 4.95e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 51.49  E-value: 4.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  23 DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISV-NSNNVQSLLDAANQ 101
Cdd:cd18286   19 DITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTGVSHAAVSFVLLFIYGGVLDLpDDVNLGELLSLADM 98


                 ....*...
gi 578813570 102 YQIEPVKK 109
Cdd:cd18286   99 YGLDGLKD 106
BACK_NS1BP_IVNS1ABP cd18502
BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); ...
 136-224 7.24e-08

BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP); NS1-BP, also called NS1-binding protein, or Aryl hydrocarbon receptor-associated protein 3, or IVNS1ABP, is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control.


Pssm-ID: 350577  Cd Length: 99  Bit Score: 50.31  E-value: 7.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 136 PECGISV--LAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQ-DTLTVRAEDQVYDAAVRWLKYDEPN 212
Cdd:cd18502    3 PENCIGIrsFAGRMNDSELLQKVDSYIQENIEEVAESKEFLKLPRLQIEVILESnQELESINERKLCQLVLEWVQRSIEE 82

                         90
                 ....*....|..
gi 578813570 213 RQPFMVDILAKV 224
Cdd:cd18502   83 GGLDLDDLTEKV 94
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-115 9.13e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 50.63  E-value: 9.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18331   24 LTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSVINLDPEINPEGFNILLDFMYTSRLNLREGNIMAVMATAM 103

                         90
                 ....*....|....*
gi 578813570 101 QYQIEPVKKMCVDFL 115
Cdd:cd18331  104 YLQMEHVVDTCRKFI 118
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-116 1.00e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 50.74  E-value: 1.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  18 KKTLCDVILMVQERKIPAHRVVLAAASHFF-NLMFTTNMLESKSFEVelkdaEPDIIEQLVEFAYTARI----SVNSNNV 92
Cdd:cd18334   18 KGFLCDVIIVVENALFRAHKNILAASSMYFkSLVLHDNLINLDTDMV-----NPTVFRQILDFIYTGKLltsdQPGEQNF 92

                         90       100
                 ....*....|....*....|....
gi 578813570  93 QSLLDAANQYQIEPVKKMCVDFLK 116
Cdd:cd18334   93 NALLTAASYLQLHDLAALCRKKLK 116
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 143-229 1.02e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 49.90  E-value: 1.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 143 LAECLDCPELKATADDFIHQHFTEVYKT--DEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDepNRQPFMVDI 220
Cdd:cd18471   12 LADLFNLTLLEEAVVDFLVKHLSELLKShpEEVLALPYRLLREVLKSDRLTSLSEEQIWQLAVRWLEHN--CRYQYMDEL 89


                 ....*....
gi 578813570 221 LAKVRFPLI 229
Cdd:cd18471   90 LQYVRFGLM 98
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 23-105 1.05e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 50.71  E-value: 1.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  23 DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQY 102
Cdd:cd18295   21 DVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYTGRLEIHVDDVEDCKRLAKQC 100


                 ...
gi 578813570 103 QIE 105
Cdd:cd18295  101 RLE 103
Kelch smart00612
Kelch domain;
374-421 1.31e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 47.94  E-value: 1.31e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 578813570   374 KIYTSGGSEvGNSALYLFECYDTRTESWHTKPSMLTQRCSHGMVEANG 421
Cdd:smart00612   1 KIYVVGGFD-GGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-115 1.57e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 50.43  E-value: 1.57e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  17 LKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTT-------NMLESKSfevELKDAEPdiIEQLVEFAYTARISVNS 89
Cdd:cd18196   17 LHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTVaegdqtmNMIQLDS---EVVTAEA--FAALIDMMYTSTLMLGE 91

                         90       100
                 ....*....|....*....|....*.
gi 578813570  90 NNVQSLLDAANQYQIEPVKKMCVDFL 115
Cdd:cd18196   92 SNVMDVLLAASHLHLNSVVKACKHYL 117
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 21-111 2.13e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 49.67  E-value: 2.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERK-IPAHRVVLAAASHFFNLMFTTNMLES---KSFEVELKDaepDIIEQLVEFAYTARISV--NSNNVQS 94
Cdd:cd18302    5 LYDVTIVSEDGKeFPCHKCVLVARLEYFHSMLSSSWIEAsscSALTMPIPS---DILEIILDYLYTDEASAvkESQNVEF 81

                         90       100
                 ....*....|....*....|
gi 578813570  95 L---LDAANQYQIEPVKKMC 111
Cdd:cd18302   82 LcnvLVIADQLLITRLKEIC 101
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-111 2.38e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 49.47  E-value: 2.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  17 LKKTLCDVILMVQERKIPAHRVVLAAASHFFNlmftTNMLESKSfEVELKDAEP-DIIEQLVEFAYTARISVNSNNVQSL 95
Cdd:cd18229   14 LGGHFCDVTVRIHDASLRAHRCVLAAGSPFFH----DKLLLGHS-EIEVPPVVPaQTVRQLVEFMYSGSLVVAQSEALQI 88

                         90
                 ....*....|....*.
gi 578813570  96 LDAANQYQIEPVKKMC 111
Cdd:cd18229   89 LTAASILQIKTVIDEC 104
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 143-208 2.45e-07

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 48.50  E-value: 2.45e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578813570 143 LAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKY 208
Cdd:cd18503   12 LATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 21-119 2.72e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 49.08  E-value: 2.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSN-NVQSLLDAA 99
Cdd:cd18360   10 LADVVFKIQGTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTDSCCPASIlQAMALLICA 89

                         90       100
                 ....*....|....*....|
gi 578813570 100 NQYQIEPVKKMCVDFLKEQV 119
Cdd:cd18360   90 EMYQVSRLQHICELYIITQL 109
BACK_KLHL36 cd18475
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...
 143-231 3.01e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350550  Cd Length: 100  Bit Score: 48.68  E-value: 3.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 143 LAECLDCPELKATADDFIHQHFTEVYKTDEFLQ-LDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKyDEPNRQPFMVDIL 221
Cdd:cd18475   12 LASIYSLERLDSFIDSFILQNFGTLSFTPDFLQnVSMQKLCQYLSSNQVQHECEHDLLQAALQWLT-QSPERENEAYQVL 90

                         90
                 ....*....|
gi 578813570 222 AKVRFPLISK 231
Cdd:cd18475   91 SNIHFPLIPK 100
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 21-99 3.17e-07

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 48.74  E-value: 3.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHffnlMFTTNMLESKSFEVELK-DAEPDIIEQLVEFAYTARISVNSNNVQSLLDAA 99
Cdd:cd18262   18 LLDETVSVGGRSYGVHSVILAAVSS----LFRERLLGSNGPLPPLSlEVTPVGWEAVLTFAYTGVLGRNPATVGDILVAA 93
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-145 3.56e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 50.04  E-value: 3.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLmFTTNMLESKSFeVELKDaepDIIEQ-----LVEFAYTARISVNSNNVQSL 95
Cdd:cd18324   23 LCDCTVLVGDAQFRAHRAVLASCSMYFHL-FYKDQLDKRDI-VHLNS---DIVTApafalLLEFMYEGKLQFKDLPIEDV 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 578813570  96 LDAANQYQIEPVKKMCVDFLKEQVDASnclGEAEKVDQSLPECGISVLAE 145
Cdd:cd18324   98 LAAASYLHMYDIVKVCKKKLKEKATTE---ADSTKKEEDASSCSDKVESF 144
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-122 4.10e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 49.05  E-value: 4.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18194   23 LCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRLDKRDLVRLNSDIVTAPAFGLLLDFMYEGRLALRDLPVEDVLAAAS 102

                         90       100
                 ....*....|....*....|..
gi 578813570 101 QYQIEPVKKMCVDFLKEQVDAS 122
Cdd:cd18194  103 YLHMYDIVKVCKGRLQEKALAE 124
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 143-229 4.51e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 48.22  E-value: 4.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 143 LAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW---LKYDEPNRQPFMV- 218
Cdd:cd18461   12 LADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLYhytPEQVEKDQVSLQEp 91

                         90
                 ....*....|..
gi 578813570 219 -DILAKVRFPLI 229
Cdd:cd18461   92 pKLLEAVRFPLM 103
PHA02713 PHA02713
hypothetical protein; Provisional
 423-526 5.19e-07

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 52.32  E-value: 5.19e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 423 IYVCGGSLGNNVSgrvLNSCEVYDPATETWTELCPMIEARKNHGLVFVKDKIFAVGGQNGLGGLDNVEYYDIKLNEWKMV 502
Cdd:PHA02713 306 IIIAGGYNFNNPS---LNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKML 382

                         90       100
                 ....*....|....*....|....
gi 578813570 503 SPMPWKGVTVKCAAVGSIVYVLAG 526
Cdd:PHA02713 383 PDMPIALSSYGMCVLDQYIYIIGG 406
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 7-89 5.38e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 48.74  E-value: 5.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570   7 CRTFLtSHIN---LKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNM-------------LESKSFEVELKDAEP 70
Cdd:cd18195    2 AGALL-LQLNeqrLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPLplgaaavaaapgaTQSPERVLELPGVKA 80

                         90
                 ....*....|....*....
gi 578813570  71 DIIEQLVEFAYTARISVNS 89
Cdd:cd18195   81 GVFSDVLNFIYSSRVALPG 99
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-117 6.28e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 48.31  E-value: 6.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  17 LKKTLCDVILMVQERKIPAHRVVLAAASHFFN---LMFTTNMLESKSFevelkdAEPDIIEQLVEFAYTARISVNSNNVQ 93
Cdd:cd18200   14 LEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHdklLLNDTNCLVLPSV------IEAAAFENLLQLIYSGRLTLCMDALP 87

                         90       100
                 ....*....|....*....|....
gi 578813570  94 SLLDAANQYQIEPVKKMCVDFLKE 117
Cdd:cd18200   88 SHLLVASGLQMWQVVDRCSELLKE 111
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-118 6.39e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 48.66  E-value: 6.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSfEVELKDaepDIIE-----QLVEFAYTARISVNSNNVQSL 95
Cdd:cd18956   23 LCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGGRD-TVRLNG---DIVTapafgRLLDFMYEGRLDLRSLPVEDV 98

                         90       100
                 ....*....|....*....|...
gi 578813570  96 LDAANQYQIEPVKKMCVDFLKEQ 118
Cdd:cd18956   99 LAAASYLHMYDIVKVCKGRLREK 121
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-111 6.59e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 48.69  E-value: 6.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  11 LTSHINLKKTLCDVILMVQERKIPAHRVVLAAASHFFN-LMFTTNMLESKSFE-VELKDAEPDIIEQLVEFAY---TARI 85
Cdd:cd18350   14 LDPHFLNNKEMSDVTFLVEGKLFYAHKVLLVTASNRFKsLLTNKSEQESQGSKtIEISDIKYHIFQMLMQYLYyggTESM 93

                         90       100
                 ....*....|....*....|....*.
gi 578813570  86 SVNSNNVQSLLDAANQYQIEPVKKMC 111
Cdd:cd18350   94 EIPIADVLELLSAASLFQLDALQRHC 119
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-115 6.69e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 48.19  E-value: 6.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  22 CDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLES-----KSFEVelkdAEPDIIEQLVEFAYTARISVNSNNVQSLL 96
Cdd:cd18199   19 CDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTgrpstASFDV----FSSDAFSIILDFVYSGKLSLTSQNVIEVM 94

                         90
                 ....*....|....*....
gi 578813570  97 DAANQYQIEPVKKMCVDFL 115
Cdd:cd18199   95 SAASYLQMTDVINVCKTFI 113
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-124 6.95e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 48.49  E-value: 6.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  22 CDVILMVQERKIPAHRVVLAAASHFFNLMFTTNmleSKS-FEVElKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18289   30 CDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGN---SKSaFELP-ATVPPACFQQILSFCYTGKLTMAASEQLVVMYTAG 105

                         90       100
                 ....*....|....*....|....
gi 578813570 101 QYQIEPVKKMCVDfLKEQVDASNC 124
Cdd:cd18289  106 FLQIQHIVERGTD-LMFKVSSPHC 128
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-118 6.95e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 48.49  E-value: 6.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLmFTTNMLESKsfevELKDAEPDIIEQ-----LVEFAYTARISVNSNNVQSL 95
Cdd:cd18325   23 LCDCTVLVGEAQFRAHRAVLASCSMYFHL-FYRDQLDKR----DIVHLNSDIVTApafslLLEFMYEGKLEFSSLPVEDV 97

                         90       100
                 ....*....|....*....|...
gi 578813570  96 LDAANQYQIEPVKKMCVDFLKEQ 118
Cdd:cd18325   98 LAAASYLHMYDIVKVCKGKLKDK 120
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-125 7.89e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 47.87  E-value: 7.89e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  23 DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVElkdaepdIIEQLVEFAYTARISVNSNNVQSLLDAANQY 102
Cdd:cd18275    6 DLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDILKVKGLSYA-------TLRLLVDYVYSGRMAVSKDNVVEVVAGARFL 78

                         90       100
                 ....*....|....*....|...
gi 578813570 103 QIEPVKKMCVDFLKEQVDASNCL 125
Cdd:cd18275   79 QMPCAAQCAVDAVRAQLCLGNCY 101
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-125 9.25e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 48.44  E-value: 9.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  11 LTSHINLKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFeVELKDAEPDIIEQLVEFAY---TARISV 87
Cdd:cd18351   14 LDPHFLNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNKPSAENTC-IEISYVKYHIFQLVMQYLYcggTESLLI 92

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 578813570  88 NSNNVQSLLDAANQYQIEPVKKMCVDFLKEQVDASNCL 125
Cdd:cd18351   93 KNNEIMELLSAAKFFQLEALQRHCEIICAKSINTENCV 130
Kelch_4 pfam13418
Galactose oxidase, central domain;
461-506 9.38e-07

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 45.68  E-value: 9.38e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 578813570  461 ARKNHGLVFV-KDKIFAVGGQNGLGG-LDNVEYYDIKLNEWKMVSPMP 506
Cdd:pfam13418   1 PRAYHTSTSIpDDTIYLFGGEGEDGTlLSDLWVFDLSTNEWTRLGSLP 48
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 23-82 1.86e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 46.51  E-value: 1.86e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578813570  23 DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSF----EVELKDAEPDIIEQLVEFAYT 82
Cdd:cd18301   20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTSEDAvgcdVVHIEKVPPEIFEQLLQFIYT 83
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 139-226 2.17e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 46.34  E-value: 2.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 139 GISVLAECLDCPELKATADDFIHQHFTE-VYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFM 217
Cdd:cd18482    8 GILKFADAFDNRELKSKALAFIARNFQQlLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANLKERAASA 87


                 ....*....
gi 578813570 218 VDILAKVRF 226
Cdd:cd18482   88 AEVLKCVRW 96
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-99 2.51e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 46.72  E-value: 2.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  20 TLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNmleSKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAA 99
Cdd:cd18226   21 SFCDLVITVEGKEFSAHKVVVAVGSSYFHACLSKN---PNTDAVTLDHVSYSVFQHLLEFLYTSEFFVYENEIPLVLEAA 97
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-116 3.06e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 46.43  E-value: 3.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  11 LTSHINLKKT---LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVelkdAEPDIIEQLVEFAYTARIS- 86
Cdd:cd18333    8 LLLQLNTQRTkgfLCDVIIVVQNALFRAHKNILAASSVYLKSLVVHDNLINLDHEM----VSPGIFRLILDYIYTGRLSe 83

                         90       100       110
                 ....*....|....*....|....*....|...
gi 578813570  87 ---VNSNNVQSLLDAANQYQIEPVKKMCVDFLK 116
Cdd:cd18333   84 gdpGSEQNLGAVLAAASYLQIPDLVALCKKKLK 116
PLN02193 PLN02193
nitrile-specifier protein
 411-547 3.25e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 49.95  E-value: 3.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 411 RCSHGMVEANGLIYVCGGSLGNNVSgrVLNSCEVYDPATETWTeLCPMIEARKNHG-----LVFVKDKIFAVGGQNGLGG 485
Cdd:PLN02193 166 RCSHGIAQVGNKIYSFGGEFTPNQP--IDKHLYVFDLETRTWS-ISPATGDVPHLSclgvrMVSIGSTLYVFGGRDASRQ 242

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578813570 486 LDNVEYYDIKLNEWKMVSPMPwKGVTVKC----AAVGSIVYVLAGFQGVGRLGHILEYNTETDKWV 547
Cdd:PLN02193 243 YNGFYSFDTTTNEWKLLTPVE-EGPTPRSfhsmAADEENVYVFGGVSATARLKTLDSYNIVDKKWF 307
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 23-102 3.44e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 45.20  E-value: 3.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  23 DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDI--IEQLVEFAYTARIS-VNSNNVQSLLDAA 99
Cdd:cd18190    1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEENGISIeaMRAVIDFSVTGRLDlFSVENVHEVLELA 80


                 ...
gi 578813570 100 NQY 102
Cdd:cd18190   81 SKF 83
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-126 6.17e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 45.66  E-value: 6.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  10 FLTSHINLKKT---LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNmlESKSFEVELKDAEPDIIEQLVEFAYTA--- 83
Cdd:cd18213    7 VLLQQLNMQREfgfLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQ--SSECIKIQPTDIQPDIFSYLLHIMYTGkgp 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 578813570  84 RISVNSNNVQSLLDAANQYQIEPVK-KMCVDFLKEQVDASNCLG 126
Cdd:cd18213   85 KQSVDHSRLEEGIRFLHANYLSRIAtEMNQDFSPETMQSSNLYG 128
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 22-63 6.54e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 45.84  E-value: 6.54e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 578813570  22 CDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEV 63
Cdd:cd18309   21 CDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDNTVNI 62
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-101 6.92e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 45.21  E-value: 6.92e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  22 CDVILMVQERKIPAHRVVLAAASHFFNLMFTTnmlesKSFEVELKDAEPDIIEQLVEFAYTARI-SVNSNNVQSLLDAAN 100
Cdd:cd18219   22 CDVTVIVEDRKFRAHKNILSASSTYFHQLFSV-----AGQVVELNFIRADIFAEILNYIYSSKIvRVRSDLLEELIKSGQ 96


                 .
gi 578813570 101 Q 101
Cdd:cd18219   97 L 97
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 362-407 8.03e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.98  E-value: 8.03e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 578813570  362 PRDSLAACAAEGKIYTSGGSeVGNSALYLFECYDTRTESWHTKPSM 407
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGF-DGNQSLNSVEVYDPETNTWSKLPSM 45
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-111 9.06e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 45.20  E-value: 9.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNlMFTTNMLESKsfEVELKDAE---PDIIEQLVEFAYTARISVNSNNVQSLLD 97
Cdd:cd18323   23 LCDCTVLVGSTQFLAHRAVLASCSPFFH-MFYKEQLDKR--DLVCINNEivtAPAFSLLLEFMYEGRLSFNDTPVEDVLA 99

                         90
                 ....*....|....
gi 578813570  98 AANQYQIEPVKKMC 111
Cdd:cd18323  100 AASYLHMNDIVKVC 113
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-110 1.12e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 44.61  E-value: 1.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  23 DVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKsfeVELKDAEPDIIEQLVEFAYTARISVNS-NNVQSLLDAANQ 101
Cdd:cd18221   20 DITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQEPL---VEIEGVSNMAFRHLIEFTYTAKLMVQGeEEANDVWKAAEY 96

                         90
                 ....*....|
gi 578813570 102 YQI-EPVKKM 110
Cdd:cd18221   97 LQMqEAIKAL 106
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-111 1.27e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 44.87  E-value: 1.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNmlESKSFEVELKDAePDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18203   25 FCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLN--PSSELQVSLMHS-SRVVADLLLSCYTGALEFSVRDIVNYLTAAS 101

                         90
                 ....*....|.
gi 578813570 101 QYQIEPVKKMC 111
Cdd:cd18203  102 YLQMEHVVEKC 112
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 138-206 1.63e-05

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 42.95  E-value: 1.63e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578813570 138 CGISVLAECldCpelkataDDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWL 206
Cdd:cd18493   15 CGHKELAEA--C-------LEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
PLN02153 PLN02153
epithiospecifier protein
 411-547 2.56e-05

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 46.52  E-value: 2.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 411 RCSHGMVEANGLIYVCGGSLGNNVSgrVLNSCEVYDPATETWTELCPMIEARKNHGL----VFVKDKIFAVGGQNGLGGL 486
Cdd:PLN02153  23 RCSHGIAVVGDKLYSFGGELKPNEH--IDKDLYVFDFNTHTWSIAPANGDVPRISCLgvrmVAVGTKLYIFGGRDEKREF 100

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578813570 487 DNVEYYDIKLNEWKMVSPM-----PWKGVTVKCAAVGSIVYVLAGFQGVG------RLGHILEYNTETDKWV 547
Cdd:PLN02153 101 SDFYSYDTVKNEWTFLTKLdeeggPEARTFHSMASDENHVYVFGGVSKGGlmktpeRFRTIEAYNIADGKWV 172
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 22-110 3.02e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 43.34  E-value: 3.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  22 CDVIL-MVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVElKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18311   15 CDLTLqFRDNEQLKVHRLVLSACTDYFNVLEQTCEIVDDTLIMP-NELQADAVVPVINFMYTGQLEFEEKSYGKLLRTAK 93

                         90
                 ....*....|
gi 578813570 101 QYQIEPVKKM 110
Cdd:cd18311   94 ELNMTVLLKL 103
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-120 3.61e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 43.41  E-value: 3.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLM--FTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSL 95
Cdd:cd18201   18 KGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLycFTNKESCDQTTVTHLDVVAVQGFSVILDFMYSGNLVLTSQNAIEV 97

                         90       100
                 ....*....|....*....|....*
gi 578813570  96 LDAANQYQIEPVKKMCVDFLKEQVD 120
Cdd:cd18201   98 MSVASYLQMTEVVQSCRNFIKDALN 122
BACK_BTBD1 cd18522
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 1 (BTBD1); ...
 144-230 3.66e-05

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein specifically expressed in skeletal muscle. It interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. It may serve as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350597  Cd Length: 107  Bit Score: 43.13  E-value: 3.66e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 144 AECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRaEDQVYDAAVRW---------LKYDEPNRQ 214
Cdd:cd18522   13 ARLFDEPQLASLCLDTIDKSTMDAISAEGFTDIDLDTLCAVLERDTLSIR-ESRLFGAVVRWaeaecqrqqLPVTSENKQ 91

                         90
                 ....*....|....*.
gi 578813570 215 PFMVDILAKVRFPLIS 230
Cdd:cd18522   92 KVLGKALSLIRFPLMT 107
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 411-458 6.88e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 40.40  E-value: 6.88e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 578813570  411 RCSHGMVEANGLIYVCGGSLGNNVSgrVLNSCEVYDPATETWTELCPM 458
Cdd:pfam07646   2 RYPHASSVPGGKLYVVGGSDGLGDL--SSSDVLVYDPETNVWTEVPRL 47
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-115 7.46e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 42.14  E-value: 7.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNlmfTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18210   21 LCDISIHVQGRVFRAHRAVLAASSPYFH---DQVLLKNMSSISLPGVMDPGAFESVLASAYTGKLTMLADEIVNYLTVGS 97

                         90
                 ....*....|....*
gi 578813570 101 QYQIEPVKKMCVDFL 115
Cdd:cd18210   98 VLQMWHIVDKCTELL 112
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-111 8.30e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 42.15  E-value: 8.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  17 LKKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTN-MLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSL 95
Cdd:cd18202   15 LNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKgAVSSHEAVVDLSGFCKSSFLPLLEFAYTSELTFDFCSMAEV 94

                         90
                 ....*....|....*.
gi 578813570  96 LDAANQYQIEPVKKMC 111
Cdd:cd18202   95 AMLARHLFMNEVLEIC 110
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-111 9.23e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 42.22  E-value: 9.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLES-KSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAA 99
Cdd:cd18330   18 FCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSgRHSTASLDIVTSEAFSIILDFLYSGKLDLCSENVIEVMSAA 97

                         90
                 ....*....|..
gi 578813570 100 NQYQIEPVKKMC 111
Cdd:cd18330   98 SYLQMTDVVNFC 109
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-117 1.05e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 42.12  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  22 CDVILMVQERKIPAHRVVLAAAShffnLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAANQ 101
Cdd:cd18225   24 CDCTIFIGTFHFRAHKLVLAASS----LLFKSLLDSTDTISIDASVVSPEEFALLLEMVYTGKLPPGKHNFTKIISVADS 99

                         90
                 ....*....|....*.
gi 578813570 102 YQIEPVKKMCVDFLKE 117
Cdd:cd18225  100 LQMFDVAVSCKNLLTS 115
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 150-230 1.18e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 41.44  E-value: 1.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 150 PELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVrAEDQVYDAAVRWLKYdEPNRQPFMVDILAKVRFPLI 229
Cdd:cd14822   19 DDLCQTCCQFMDRNAQEVLSSEGFLTLSKSALKELLSRDSFCA-PEVDIFNAVRRWCEH-NPDSKEDAKEILEAVRLPLM 96


                 .
gi 578813570 230 S 230
Cdd:cd14822   97 S 97
BACK_BTBD2 cd18523
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); ...
 144-229 1.52e-04

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme in cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.


Pssm-ID: 350598  Cd Length: 106  Bit Score: 41.12  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 144 AECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRaEDQVYDAAVRW---------LKYDEPNRQ 214
Cdd:cd18523   13 ARLFDEPQLASLCLENIDKNTSDAINAEGFTDIDLDTLVAVLERDTLGIR-EVRLFNAVVRWaeaecqrqqLQVTPENKR 91

                         90
                 ....*....|....*
gi 578813570 215 PFMVDILAKVRFPLI 229
Cdd:cd18523   92 KVLGKALSLIRFPLM 106
PLN02153 PLN02153
epithiospecifier protein
 360-499 1.73e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 43.82  E-value: 1.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 360 PTPRDSLAACAAEGKIYTSGGSEVGNSA----LYLFecyDTRTESWHTKP--------SMLTQRcshgMVEANGLIYVCG 427
Cdd:PLN02153  20 PGPRCSHGIAVVGDKLYSFGGELKPNEHidkdLYVF---DFNTHTWSIAPangdvpriSCLGVR----MVAVGTKLYIFG 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 428 GSLGNnvsgRVLNSCEVYDPATETWTELCPM-----IEARKNHGLVFVKDKIFAVGGQNGlGGLDN-------VEYYDIK 495
Cdd:PLN02153  93 GRDEK----REFSDFYSYDTVKNEWTFLTKLdeeggPEARTFHSMASDENHVYVFGGVSK-GGLMKtperfrtIEAYNIA 167


                 ....
gi 578813570 496 LNEW 499
Cdd:PLN02153 168 DGKW 171
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-117 2.77e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 40.82  E-value: 2.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFN--LMFTTNMLESKSFeVELKDaepdiIEQLVEFAYTARISVNSNNVQSLLDA 98
Cdd:cd18208   25 FCDVTVRIHGSMLRAHRCVLAAGSPFFQdkLLLGYSDIEIPSV-VSVQS-----VQKLIDFMYSGVLRVSQSEALQILTA 98

                         90
                 ....*....|....*....
gi 578813570  99 ANQYQIEPVKKMCVDFLKE 117
Cdd:cd18208   99 ASILQIKTVIDECTRIVSQ 117
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-104 2.94e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 40.57  E-value: 2.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18192   21 LCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSNMKISAECFDLILQFMYLGKIMTAPSDFEQLKVAMN 100


                 ....
gi 578813570 101 QYQI 104
Cdd:cd18192  101 YLQL 104
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-116 3.25e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 40.70  E-value: 3.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  10 FLTSHINLKKTL-----CDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTAR 84
Cdd:cd18353    4 FLTVAESLKKEFdspetSDLKFRVDGKYIHVHKAVLKIRCEHFRTMFQSHWNEDMKEVIEIDQFSYPVYRAFLEYLYTDS 83

                         90       100       110
                 ....*....|....*....|....*....|..
gi 578813570  85 ISVNSNNVQSLLDAANQYQIEPVKKMCVDFLK 116
Cdd:cd18353   84 VDLPPEDAIGLLDLATSYCENRLKKLCQHIIK 115
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 134-216 3.37e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 39.94  E-value: 3.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570 134 SLPEC-GISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPN 212
Cdd:cd18451    2 NLSNCvAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAEE 81


                 ....
gi 578813570 213 RQPF 216
Cdd:cd18451   82 RERY 85
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-86 5.90e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 39.98  E-value: 5.90e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNmlESKSFEVELKDAEPDIIEQLVEFAYTARIS 86
Cdd:cd18193   21 LCDCTVAIGDVYFKAHKSVLASFSNYFKMLFVHQ--TSECVRLKPTDIQPDIFSYLLHLMYTGKMA 84
Kelch_6 pfam13964
Kelch motif;
362-411 6.84e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 37.70  E-value: 6.84e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 578813570  362 PRDSLAACAAEGKIYTSGGSEVGNSALYLFECYDTRTESWHTKPSMLTQR 411
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch_3 pfam13415
Galactose oxidase, central domain;
420-470 9.26e-04

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 37.27  E-value: 9.26e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 578813570  420 NGLIYVCGGSLGNNvsGRVLNSCEVYDPATETWTELCPMIEARKNHGLVFV 470
Cdd:pfam13415   1 GDKLYIFGGLGFDG--QTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
BTB_POZ_RCBTB2_CHC1L cd18354
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 10-119 9.93e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349663 [Multi-domain]  Cd Length: 117  Bit Score: 39.15  E-value: 9.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  10 FLTSHINLKKTL-----CDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESksfeVELKDAEPDIIEQLVEFAYTAR 84
Cdd:cd18354    4 HLTVAESLKREFdnpdtADLKFLVDGKYIYVHKVLLKIRCEHFRSLLNENEEEI----IEMSQFSYPVYRAFLEYLYTDS 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 578813570  85 ISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQV 119
Cdd:cd18354   80 ISLSPEDAIGLLDLATFYRENRLKKLCQQTIKQGI 114
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-117 1.15e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 38.80  E-value: 1.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  23 DVILMVQERKIPAHRVVLAAaSHFFNLMFTTNMLESKSFEVELKDAEPDI-IEQL-VEFA--YTARISVNSNNVQSLLDA 98
Cdd:cd18305   17 DITICALGREWKLHKIYLCQ-SGYFASMFSGSWKESKETVINLEIPDDNItVEALnVVFGslYRDEIEIKPSRVVSILAA 95

                         90
                 ....*....|....*....
gi 578813570  99 ANQYQIEPVKKMCVDFLKE 117
Cdd:cd18305   96 ATLLQLDGLIQQCSEVMKE 114
Kelch_6 pfam13964
Kelch motif;
461-506 1.50e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.93  E-value: 1.50e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 578813570  461 ARKNHGLVFVKDKIFAVGGQ-NGLGGLDNVEYYDIKLNEWKMVSPMP 506
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELPPLP 47
Kelch_4 pfam13418
Galactose oxidase, central domain;
411-455 1.68e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.44  E-value: 1.68e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 578813570  411 RCSHGMVE-ANGLIYVCGGSlgnNVSGRVLNSCEVYDPATETWTEL 455
Cdd:pfam13418   2 RAYHTSTSiPDDTIYLFGGE---GEDGTLLSDLWVFDLSTNEWTRL 44
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 18-102 3.05e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 38.02  E-value: 3.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSN-NVQSLL 96
Cdd:cd18358   17 KGTFSDVTFKLDDGTINAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQLSPTADlDPLELI 96


                 ....*.
gi 578813570  97 DAANQY 102
Cdd:cd18358   97 ALANRF 102
BACK_KLHL14 cd18453
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...
 168-240 3.13e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.


Pssm-ID: 350528  Cd Length: 102  Bit Score: 37.30  E-value: 3.13e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578813570 168 YKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQPFMVDILAKVRFPLISKNFLSKTVQA 240
Cdd:cd18453   28 YLVEDVLLLNFEEMRAMLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQS 100
BTB2_POZ_RHOBTB2 cd18359
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 18-90 3.50e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 2 (RhoBTB2); RhoBTB2, also called Deleted in breast cancer 2 gene protein (DBC2) or p83, is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB2 functions as a tumor suppressor that regulates the expression of the methyltransferase METTL7A. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349668 [Multi-domain]  Cd Length: 124  Bit Score: 37.68  E-value: 3.50e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578813570  18 KKTLCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNMLESKSFEVELKDAEPDIIEQLVEFAYTARISVNSN 90
Cdd:cd18359   17 KGTFSDVTFMLDDGTISAHKPLLISSCDWMAAMFGGPFVESSTTEVVFPYTSRSSMRAVLEYLYTGQFSSSPD 89
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-115 4.48e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 37.16  E-value: 4.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  21 LCDVILMVQERKIPAHRVVLAAASHFFNLMFTTNmlESKSFEVE-LKDAEpdIIEQLVEFAYTARISVNSNNVQSLLDAA 99
Cdd:cd18197   25 FCDVSIYINDTEFHGHKVILAACSTFMRDQFLLN--QSKQVRITiLQSAE--VGRKLLLSCYTGALEVKKKELLKYLTAA 100

                         90
                 ....*....|....*.
gi 578813570 100 NQYQIEPVKKMCVDFL 115
Cdd:cd18197  101 SYLQMVHIVEKCTEAL 116
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-115 7.80e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 36.73  E-value: 7.80e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813570  22 CDVILMVQERKIPAHRVVLAAASHFFNLMFTTNmlESKSFEVE-LKDAEpdIIEQLVEFAYTARISVNSNNVQSLLDAAN 100
Cdd:cd18214   26 CDVTVHIDDLEVPGHKVVFAAGSPFLRDQFLLN--DSREVQISiLQNSE--VGRQLLLSCYTGVLEFPEMELVNYLTAAS 101

                         90
                 ....*....|....*
gi 578813570 101 QYQIEPVKKMCVDFL 115
Cdd:cd18214  102 FLQMSHIVERCTQAL 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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