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Conserved domains on  [gi|578817826|ref|XP_006717322|]
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transducin-like enhancer protein 1 isoform X8 [Homo sapiens]

Protein Classification

WD40 domain-containing protein( domain architecture ID 10511324)

WD40 domain-containing protein similar to Drosophila melanogaster protein groucho and Homo sapiens transducin-like enhancer proteins; also contains a Groucho/TLE N-terminal Q-rich domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 18-77 1.12e-46

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


:

Pssm-ID: 461094  Cd Length: 117  Bit Score: 161.44  E-value: 1.12e-46
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826   18 FKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHK 77
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHK 60
WD40 COG2319
WD40 repeat [General function prediction only];
471-756 2.12e-43

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.00  E-value: 2.12e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 471 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDISHPGNKSPVSqldclNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAa 549
Cdd:COG2319   77 HTAAVLSVAFSPDGRLLASASAdGTVRLWDLATGLLLRTLT-----GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA- 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 550 pTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 629
Cdd:COG2319  151 -TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 630 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSLKFAYCGKWFVSTGKD 707
Cdd:COG2319  230 LWDLATGKLLRTlTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGElLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 578817826 708 NLLNAWRTPYGASIFQSK-ESSSVLSCDISVDDKYIVTGSGDKKATVYEV 756
Cdd:COG2319  310 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
 
Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 18-77 1.12e-46

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


Pssm-ID: 461094  Cd Length: 117  Bit Score: 161.44  E-value: 1.12e-46
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826   18 FKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHK 77
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHK 60
WD40 COG2319
WD40 repeat [General function prediction only];
471-756 2.12e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.00  E-value: 2.12e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 471 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDISHPGNKSPVSqldclNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAa 549
Cdd:COG2319   77 HTAAVLSVAFSPDGRLLASASAdGTVRLWDLATGLLLRTLT-----GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA- 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 550 pTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 629
Cdd:COG2319  151 -TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 630 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSLKFAYCGKWFVSTGKD 707
Cdd:COG2319  230 LWDLATGKLLRTlTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGElLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 578817826 708 NLLNAWRTPYGASIFQSK-ESSSVLSCDISVDDKYIVTGSGDKKATVYEV 756
Cdd:COG2319  310 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 471-755 1.19e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.47  E-value: 1.19e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 471 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDIShpgNKSPVSQLdCLNRDNyIRSCKLLPDGCTLIVGGEASTLSIWDLaa 549
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGdGTIKVWDLE---TGELLRTL-KGHTGP-VRDVAASADGTYLASGSSDKTIRLWDL-- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 550 PTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 629
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 630 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSLKFAYCGKWFVSTGKD 707
Cdd:cd00200  161 LWDLRTGKCVATlTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKcLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 578817826 708 NLLNAWRTPYGASIFQ-SKESSSVLSCDISVDDKYIVTGSGDKKATVYE 755
Cdd:cd00200  241 GTIRVWDLRTGECVQTlSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 593-632 4.71e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 4.71e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 578817826   593 NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 632
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 583-754 8.60e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.40  E-value: 8.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 583 DGNIAVWDLHNQTLVRQFQGHTDGASCIDISN-DGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGY-CPTGEWL 660
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFpSESGRSL 633

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 661 AVGMESSNVEVLHVNKPdkyQLHL-----HESCVLSLKFAYCGKwFVSTGKDNLLNAWRTPYGASIFQSKESSSVLS--- 732
Cdd:PLN00181 634 AFGSADHKVYYYDLRNP---KLPLctmigHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLSMSISGINETPLHSFMGhtn 709

                        170       180
                 ....*....|....*....|....*.
gi 578817826 733 ----CDISVDDKYIVTGSGDKKATVY 754
Cdd:PLN00181 710 vknfVGLSVSDGYIATGSETNEVFVY 735
WD40 pfam00400
WD domain, G-beta repeat;
595-632 6.30e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 6.30e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 578817826  595 TLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 632
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 18-77 1.12e-46

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


Pssm-ID: 461094  Cd Length: 117  Bit Score: 161.44  E-value: 1.12e-46
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826   18 FKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHK 77
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHK 60
WD40 COG2319
WD40 repeat [General function prediction only];
471-756 2.12e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.00  E-value: 2.12e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 471 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDISHPGNKSPVSqldclNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAa 549
Cdd:COG2319   77 HTAAVLSVAFSPDGRLLASASAdGTVRLWDLATGLLLRTLT-----GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA- 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 550 pTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 629
Cdd:COG2319  151 -TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 630 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSLKFAYCGKWFVSTGKD 707
Cdd:COG2319  230 LWDLATGKLLRTlTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGElLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 578817826 708 NLLNAWRTPYGASIFQSK-ESSSVLSCDISVDDKYIVTGSGDKKATVYEV 756
Cdd:COG2319  310 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
471-756 3.91e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.54  E-value: 3.91e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 471 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDIShpgNKSPVSQLDclNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAa 549
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSAdGTVRLWDLA---TGKLLRTLT--GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA- 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 550 pTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 629
Cdd:COG2319  193 -TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 630 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDK-YQLHLHESCVLSLKFAYCGKWFVSTGKD 707
Cdd:COG2319  272 LWDLATGELLRTlTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLASGSDD 351

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 578817826 708 NLLNAWRTPYGASIFQSKE-SSSVLSCDISVDDKYIVTGSGDKKATVYEV 756
Cdd:COG2319  352 GTVRLWDLATGELLRTLTGhTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 471-755 1.19e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.47  E-value: 1.19e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 471 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDIShpgNKSPVSQLdCLNRDNyIRSCKLLPDGCTLIVGGEASTLSIWDLaa 549
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGdGTIKVWDLE---TGELLRTL-KGHTGP-VRDVAASADGTYLASGSSDKTIRLWDL-- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 550 PTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 629
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 630 SWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSLKFAYCGKWFVSTGKD 707
Cdd:cd00200  161 LWDLRTGKCVATlTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKcLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 578817826 708 NLLNAWRTPYGASIFQ-SKESSSVLSCDISVDDKYIVTGSGDKKATVYE 755
Cdd:cd00200  241 GTIRVWDLRTGECVQTlSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
464-716 1.55e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.05  E-value: 1.55e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 464 RQINTLN-HGEVVCAVTISNPTRHVYTGGK-GCVKVWDIShpgNKSPVSQLDclNRDNYIRSCKLLPDGCTLIVGGEAST 541
Cdd:COG2319  153 KLLRTLTgHSGAVTSVAFSPDGKLLASGSDdGTVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKLLASGSADGT 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 542 LSIWDLAapTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWT 621
Cdd:COG2319  228 VRLWDLA--TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 622 GGLDNTVRSWDLREGRQLQQHD-FTSQIFSLGYCPTGEWLAVGMESSNVEVLHVN-KPDKYQLHLHESCVLSLKFAYCGK 699
Cdd:COG2319  306 GSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAtGELLRTLTGHTGAVTSVAFSPDGR 385

                        250
                 ....*....|....*..
gi 578817826 700 WFVSTGKDNLLNAWRTP 716
Cdd:COG2319  386 TLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
521-756 6.04e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.10  E-value: 6.04e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 521 IRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPacYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQF 600
Cdd:COG2319   39 VASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV--LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 601 QGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDK 679
Cdd:COG2319  117 TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTlTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKL 196

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578817826 680 YQ-LHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSK-ESSSVLSCDISVDDKYIVTGSGDKKATVYEV 756
Cdd:COG2319  197 LRtLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 565-756 1.03e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.81  E-value: 1.03e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 565 CYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ-HD 643
Cdd:cd00200   12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTlTG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 644 FTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPD-KYQLHLHESCVLSLKFAyCGKWFVSTGK-DNLLNAWRTPYGASI 721
Cdd:cd00200   92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKcLTTLRGHTDWVNSVAFS-PDGTFVASSSqDGTIKLWDLRTGKCV 170

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 578817826 722 --FQSkESSSVLSCDISVDDKYIVTGSGDKKATVYEV 756
Cdd:cd00200  171 atLTG-HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 596-756 1.01e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.09  E-value: 1.01e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 596 LVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREG---RQLQQHdfTSQIFSLGYCPTGEWLAVGMESSNVEVL 672
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGellRTLKGH--TGPVRDVAASADGTYLASGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 673 HVNKPDK-YQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASI--FQSKEsSSVLSCDISVDDKYIVTGSGDK 749
Cdd:cd00200   79 DLETGECvRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLttLRGHT-DWVNSVAFSPDGTFVASSSQDG 157


                 ....*..
gi 578817826 750 KATVYEV 756
Cdd:cd00200  158 TIKLWDL 164
WD40 COG2319
WD40 repeat [General function prediction only];
539-756 4.15e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.36  E-value: 4.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 539 ASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTK 618
Cdd:COG2319   13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 619 LWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDK-YQLHLHESCVLSLKFAY 696
Cdd:COG2319   93 LASASADGTVRLWDLATGLLLRTlTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLlRTLTGHSGAVTSVAFSP 172

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578817826 697 CGKWFVSTGKDNLLNAWRTPYGASIFQ-SKESSSVLSCDISVDDKYIVTGSGDKKATVYEV 756
Cdd:COG2319  173 DGKLLASGSDDGTVRLWDLATGKLLRTlTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL 233
WD40 COG2319
WD40 repeat [General function prediction only];
464-593 6.52e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.01  E-value: 6.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 464 RQINTLN-HGEVVCAVTISNPTRHVYTGGKGC-VKVWDIShpgNKSPVSQLDclNRDNYIRSCKLLPDGCTLIVGGEAST 541
Cdd:COG2319  279 ELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKTLASGSDDGT 353

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 578817826 542 LSIWDLAapTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHN 593
Cdd:COG2319  354 VRLWDLA--TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 593-632 4.71e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 4.71e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 578817826   593 NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 632
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 583-754 8.60e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.40  E-value: 8.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 583 DGNIAVWDLHNQTLVRQFQGHTDGASCIDISN-DGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGY-CPTGEWL 660
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFpSESGRSL 633

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826 661 AVGMESSNVEVLHVNKPdkyQLHL-----HESCVLSLKFAYCGKwFVSTGKDNLLNAWRTPYGASIFQSKESSSVLS--- 732
Cdd:PLN00181 634 AFGSADHKVYYYDLRNP---KLPLctmigHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLSMSISGINETPLHSFMGhtn 709

                        170       180
                 ....*....|....*....|....*.
gi 578817826 733 ----CDISVDDKYIVTGSGDKKATVY 754
Cdd:PLN00181 710 vknfVGLSVSDGYIATGSETNEVFVY 735
WD40 pfam00400
WD domain, G-beta repeat;
595-632 6.30e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 6.30e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 578817826  595 TLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 632
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 556-637 1.01e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 41.98  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817826  556 AELTSSAPACYALAISPDSKVCFSCcsdGNiavWD-------LHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTV 628
Cdd:pfam20426  75 AENVELGAQCFATLQTPSENFLISC---GN---WEnsfqvisLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTV 148


                  ....*....
gi 578817826  629 RSWDLREGR 637
Cdd:pfam20426 149 MVWEVLRGR 157
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 551-590 1.11e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.11e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 578817826   551 TPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWD 590
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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