NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|578835606|ref|XP_006723715|]
View 

protein sel-1 homolog 2 isoform X9 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11434433)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

Gene Ontology:  GO:0005515
PubMed:  10517866|30708253

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
282-468 9.29e-50

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 172.03  E-value: 9.29e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835606 282 WDIYQYYKFLAERGDVQIQVSLGQLHLIGRkGLDQDYYKALHYFLKAAKAGSANAMAFIGKMYLEGNAaVPQNNATAFKY 361
Cdd:COG0790   48 AAAAAAAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLG-VPQDYAKALEW 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835606 362 FSMAASKGNAIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEKGWPDAQFQLGFMYYSGSGIWKDYKLAFKYFYLASQSG 441
Cdd:COG0790  126 YEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQG 205

                        170       180
                 ....*....|....*....|....*..
gi 578835606 442 QPLAIYYLAKMYATGTGVVRSCRTAVE 468
Cdd:COG0790  206 DADAQYNLGRLYLNGEGVEKDLEKALR 232
TPR COG0790
TPR repeat [General function prediction only];
124-247 2.58e-18

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 84.59  E-value: 2.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835606 124 QKQKEEAYLLFAKAADMGNLKAMEKMADALLFGNFGVQNITAAIQLYESLAKEGSCKAQNALGFLSSYGIGMEYDQAKAL 203
Cdd:COG0790  116 PQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKAL 195

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 578835606 204 IYYTFGSAGGNMMSQMILGYRYLSGINVLQNCEVALSYYKKVAD 247
Cdd:COG0790  196 EWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAE 239
Mplasa_alph_rch super family cl37461
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 18-128 1.17e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


The actual alignment was detected with superfamily member TIGR04523:

Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 45.01  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835606   18 IKTIKAEEHNKRQKERNVTTQVS-----VNEIKQYLSHILEQRTSSNV--------INKRENLLEKKKNQRKIRIKGIQN 84
Cdd:TIGR04523 309 NKELKSELKNQEKKLEEIQNQISqnnkiISQLNEQISQLKKELTNSESensekqreLEEKQNEIEKLKKENQSYKQEIKN 388

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 578835606   85 kdiLKRNKNHLQKQAEKNftDEGDQLFKMGIKVLQQSKSQKQKE 128
Cdd:TIGR04523 389 ---LESQINDLESKIQNQ--EKLNQQKDEQIKKLQQEKELLEKE 427
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
282-468 9.29e-50

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 172.03  E-value: 9.29e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835606 282 WDIYQYYKFLAERGDVQIQVSLGQLHLIGRkGLDQDYYKALHYFLKAAKAGSANAMAFIGKMYLEGNAaVPQNNATAFKY 361
Cdd:COG0790   48 AAAAAAAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLG-VPQDYAKALEW 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835606 362 FSMAASKGNAIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEKGWPDAQFQLGFMYYSGSGIWKDYKLAFKYFYLASQSG 441
Cdd:COG0790  126 YEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQG 205

                        170       180
                 ....*....|....*....|....*..
gi 578835606 442 QPLAIYYLAKMYATGTGVVRSCRTAVE 468
Cdd:COG0790  206 DADAQYNLGRLYLNGEGVEKDLEKALR 232
TPR COG0790
TPR repeat [General function prediction only];
124-247 2.58e-18

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 84.59  E-value: 2.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835606 124 QKQKEEAYLLFAKAADMGNLKAMEKMADALLFGNFGVQNITAAIQLYESLAKEGSCKAQNALGFLSSYGIGMEYDQAKAL 203
Cdd:COG0790  116 PQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKAL 195

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 578835606 204 IYYTFGSAGGNMMSQMILGYRYLSGINVLQNCEVALSYYKKVAD 247
Cdd:COG0790  196 EWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAE 239
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 407-441 5.99e-07

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 46.01  E-value: 5.99e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 578835606   407 PDAQFQLGFMYYSGSGIWKDYKLAFKYFYLASQSG 441
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 371-405 1.94e-06

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 44.43  E-value: 1.94e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 578835606  371 AIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEKG 405
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 18-128 1.17e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 45.01  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835606   18 IKTIKAEEHNKRQKERNVTTQVS-----VNEIKQYLSHILEQRTSSNV--------INKRENLLEKKKNQRKIRIKGIQN 84
Cdd:TIGR04523 309 NKELKSELKNQEKKLEEIQNQISqnnkiISQLNEQISQLKKELTNSESensekqreLEEKQNEIEKLKKENQSYKQEIKN 388

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 578835606   85 kdiLKRNKNHLQKQAEKNftDEGDQLFKMGIKVLQQSKSQKQKE 128
Cdd:TIGR04523 389 ---LESQINDLESKIQNQ--EKLNQQKDEQIKKLQQEKELLEKE 427
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 216-247 3.02e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 35.61  E-value: 3.02e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 578835606   216 MSQMILGYRYLSGINVLQNCEVALSYYKKVAD 247
Cdd:smart00671   2 EAQYNLGQMYEYGLGVPKDLEKALEYYKKAAE 33
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
282-468 9.29e-50

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 172.03  E-value: 9.29e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835606 282 WDIYQYYKFLAERGDVQIQVSLGQLHLIGRkGLDQDYYKALHYFLKAAKAGSANAMAFIGKMYLEGNAaVPQNNATAFKY 361
Cdd:COG0790   48 AAAAAAAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLG-VPQDYAKALEW 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835606 362 FSMAASKGNAIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEKGWPDAQFQLGFMYYSGSGIWKDYKLAFKYFYLASQSG 441
Cdd:COG0790  126 YEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQG 205

                        170       180
                 ....*....|....*....|....*..
gi 578835606 442 QPLAIYYLAKMYATGTGVVRSCRTAVE 468
Cdd:COG0790  206 DADAQYNLGRLYLNGEGVEKDLEKALR 232
TPR COG0790
TPR repeat [General function prediction only];
165-437 8.14e-42

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 150.85  E-value: 8.14e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835606 165 AAIQLYESLAKEGSCKAQNALGFLSSYGIGMEYDQAKALIYYTFGSAGGNMMSQMILGYRYLSGINVLQNCEVALSYYKK 244
Cdd:COG0790   13 AAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEK 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835606 245 vadyiadtfeksegvpvekvrlterpenlssnseildwdiyqyykfLAERGDVQIQVSLGQLHLIGRkGLDQDYYKALHY 324
Cdd:COG0790   93 ----------------------------------------------AAEQGDAEAQYNLGLMYEEGL-GVPQDYAKALEW 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835606 325 FLKAAKAGSANAMAFIGKMYLEGNAaVPQNNATAFKYFSMAASKGNAIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEK 404
Cdd:COG0790  126 YEKAAEQGDADAQYNLGLLYLNGEG-VPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALEWYRKAAEQ 204

                        250       260       270
                 ....*....|....*....|....*....|...
gi 578835606 405 GWPDAQFQLGFMYYSGSGIWKDYKLAFKYFYLA 437
Cdd:COG0790  205 GDADAQYNLGRLYLNGEGVEKDLEKALRWLRKA 237
TPR COG0790
TPR repeat [General function prediction only];
126-404 2.65e-34

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 130.05  E-value: 2.65e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835606 126 QKEEAYLLFAKAADMGNLKAMEKMADALLFGnfGVQNITAAIQLYESLAKEGSCKAQNALGFLSSYGIGMEYDQAKALIY 205
Cdd:COG0790   12 AAAAAALAAAAAAAGAAAAAAAAAAAAAALA--AAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEW 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835606 206 YTFGSAGGNMMSQMILGYRYLSGINVLQNCEVALSYYKKVAdyiadtfeksegvpvekvrlterpenlssnseildwdiy 285
Cdd:COG0790   90 FEKAAEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAA--------------------------------------- 130

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835606 286 qyykflaERGDVQIQVSLGQLHLIGRkGLDQDYYKALHYFLKAAKAGSANAMAFIGKMYLEGNAaVPQNNATAFKYFSMA 365
Cdd:COG0790  131 -------EQGDADAQYNLGLLYLNGE-GVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRG-VPKDPAKALEWYRKA 201

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 578835606 366 ASKGNAIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEK 404
Cdd:COG0790  202 AEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
326-507 7.20e-28

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 111.94  E-value: 7.20e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835606 326 LKAAKAGSANAMAFIGKMYLEGNAAVPQNNATAFKYFSMAASKGNAIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEKG 405
Cdd:COG0790   18 LAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEKAAEQG 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835606 406 WPDAQFQLGFMYYSGSGIWKDYKLAFKYFYLASQSGQPLAIYYLAKMYATGTGVVRSCRTAVEkrltFLKK--------- 476
Cdd:COG0790   98 DAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAE----WYRKaaeqgdada 173

                        170       180       190
                 ....*....|....*....|....*....|.
gi 578835606 477 RRCIQWRFSYGIELPfKDIHLARRLYDMAAQ 507
Cdd:COG0790  174 QYNLGVLYENGRGVP-KDPAKALEWYRKAAE 203
TPR COG0790
TPR repeat [General function prediction only];
124-247 2.58e-18

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 84.59  E-value: 2.58e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835606 124 QKQKEEAYLLFAKAADMGNLKAMEKMADALLFGNFGVQNITAAIQLYESLAKEGSCKAQNALGFLSSYGIGMEYDQAKAL 203
Cdd:COG0790  116 PQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKAL 195

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 578835606 204 IYYTFGSAGGNMMSQMILGYRYLSGINVLQNCEVALSYYKKVAD 247
Cdd:COG0790  196 EWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWLRKAAE 239
TPR COG0790
TPR repeat [General function prediction only];
345-468 1.46e-14

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 73.42  E-value: 1.46e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835606 345 LEGNAAVPQNNATAFKYFSMAASKGNAIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEKGWPDAQFQLGFMYYSGSGIW 424
Cdd:COG0790    1 LALAAAAAAAAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVP 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 578835606 425 KDYKLAFKYFYLASQSGQPLAIYYLAKMYATGTGVVRSCRTAVE 468
Cdd:COG0790   81 KDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLGVPQDYAKALE 124
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 407-441 5.99e-07

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 46.01  E-value: 5.99e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 578835606   407 PDAQFQLGFMYYSGSGIWKDYKLAFKYFYLASQSG 441
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 371-405 9.13e-07

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 45.63  E-value: 9.13e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 578835606   371 AIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEKG 405
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 371-405 1.94e-06

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 44.43  E-value: 1.94e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 578835606  371 AIGLHGLGLLYFHGKGVPLNYAEALKYFQKAAEKG 405
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 407-441 5.94e-05

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 40.20  E-value: 5.94e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 578835606  407 PDAQFQLGFMYYSGSGIWKDYKLAFKYFYLASQSG 441
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 18-128 1.17e-04

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 45.01  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835606   18 IKTIKAEEHNKRQKERNVTTQVS-----VNEIKQYLSHILEQRTSSNV--------INKRENLLEKKKNQRKIRIKGIQN 84
Cdd:TIGR04523 309 NKELKSELKNQEKKLEEIQNQISqnnkiISQLNEQISQLKKELTNSESensekqreLEEKQNEIEKLKKENQSYKQEIKN 388

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 578835606   85 kdiLKRNKNHLQKQAEKNftDEGDQLFKMGIKVLQQSKSQKQKE 128
Cdd:TIGR04523 389 ---LESQINDLESKIQNQ--EKLNQQKDEQIKKLQQEKELLEKE 427
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 334-370 8.65e-04

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 37.15  E-value: 8.65e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 578835606   334 ANAMAFIGKMYLEGNAaVPQNNATAFKYFSMAASKGN 370
Cdd:smart00671   1 AEAQYNLGQMYEYGLG-VPKDLEKALEYYKKAAELGN 36
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 216-247 3.02e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 35.61  E-value: 3.02e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 578835606   216 MSQMILGYRYLSGINVLQNCEVALSYYKKVAD 247
Cdd:smart00671   2 EAQYNLGQMYEYGLGVPKDLEKALEYYKKAAE 33
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 334-369 3.59e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 35.19  E-value: 3.59e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 578835606  334 ANAMAFIGKMYLEGnAAVPQNNATAFKYFSMAASKG 369
Cdd:pfam08238   1 AEAQYRLGYLYLYG-LGVPKDPEKALEWYEKAAELG 35
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
317-454 5.88e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 38.83  E-value: 5.88e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578835606 317 DYYKALHYFLKAAK--AGSANAMAFIGKMYLEGNaavpqNNATAFKYFSMAASK--GNAIGLHGLGLLYFHGKgvplNYA 392
Cdd:COG0457   23 RYEEAIEDYEKALEldPDDAEALYNLGLAYLRLG-----RYEEALADYEQALELdpDDAEALNNLGLALQALG----RYE 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578835606 393 EALKYFQKAAEK--GWPDAQFQLGFMYYSgsgiWKDYKLAFKYF--YLASQSGQPLAIYYLAKMYA 454
Cdd:COG0457   94 EALEDYDKALELdpDDAEALYNLGLALLE----LGRYDEAIEAYerALELDPDDADALYNLGIALE 155
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 300-333 7.47e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 34.46  E-value: 7.47e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 578835606   300 QVSLGQLHLIGrKGLDQDYYKALHYFLKAAKAGS 333
Cdd:smart00671   4 QYNLGQMYEYG-LGVPKDLEKALEYYKKAAELGN 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH