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Conserved domains on  [gi|586540942|ref|XP_006905620|]
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cystatin-A [Pteropus alecto]

Protein Classification

CY domain-containing protein( domain architecture ID 10440427)

CY domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 4-89 1.24e-24

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


:

Pssm-ID: 425431  Cd Length: 92  Bit Score: 88.55  E-value: 1.24e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586540942   4 GGLTEAKPATPEIQEIANEVKPQLEEKT-NETYEEFEVVEYKTQVVAGTNYYLKVRVGHNNYI-HLKIFEALP-QQHQPL 80
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPlLDEKWL 80


                 ....*....
gi 586540942  81 TLTGYQTDK 89
Cdd:pfam00031 81 GLCSAQVYK 89
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 4-89 1.24e-24

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 88.55  E-value: 1.24e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586540942   4 GGLTEAKPATPEIQEIANEVKPQLEEKT-NETYEEFEVVEYKTQVVAGTNYYLKVRVGHNNYI-HLKIFEALP-QQHQPL 80
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPlLDEKWL 80


                 ....*....
gi 586540942  81 TLTGYQTDK 89
Cdd:pfam00031 81 GLCSAQVYK 89
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 1-67 1.07e-19

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 76.70  E-value: 1.07e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 586540942     1 MMPGGLTEAKPATPEIQEIANEVKPQLEEKTNETYE--EFEVVEYKTQVVAGTNYYLKVRVGHNNYIHL 67
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYElrVIKVVSAKSQVVAGTNYYLKVEVGETNCKKL 69
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 4-63 3.17e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 59.80  E-value: 3.17e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 586540942   4 GGLTEAKPATPEIQEIANEVKPQLEEKTNETY-EEFEVVEYKTQVVAGTNYYLKVRVGHNN 63
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYlEFFKVLSAKSQVVAGTNYYITVEAGDTN 61
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
 4-89 1.24e-24

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 88.55  E-value: 1.24e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586540942   4 GGLTEAKPATPEIQEIANEVKPQLEEKT-NETYEEFEVVEYKTQVVAGTNYYLKVRVGHNNYI-HLKIFEALP-QQHQPL 80
Cdd:pfam00031  1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPlLDEKWL 80


                 ....*....
gi 586540942  81 TLTGYQTDK 89
Cdd:pfam00031 81 GLCSAQVYK 89
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 1-67 1.07e-19

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 76.70  E-value: 1.07e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 586540942     1 MMPGGLTEAKPATPEIQEIANEVKPQLEEKTNETYE--EFEVVEYKTQVVAGTNYYLKVRVGHNNYIHL 67
Cdd:smart00043   1 LCLGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYElrVIKVVSAKSQVVAGTNYYLKVEVGETNCKKL 69
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 4-63 3.17e-13

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 59.80  E-value: 3.17e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 586540942   4 GGLTEAKPATPEIQEIANEVKPQLEEKTNETY-EEFEVVEYKTQVVAGTNYYLKVRVGHNN 63
Cdd:cd00042    1 GGPSDIPANDPEVQELADFAVAEYNKKSNDKYlEFFKVLSAKSQVVAGTNYYITVEAGDTN 61
SQAPI pfam16845
Aspartic acid proteinase inhibitor; SQAPI, aspartic acid inhibitor first isolated from squash, ...
 14-59 2.23e-03

Aspartic acid proteinase inhibitor; SQAPI, aspartic acid inhibitor first isolated from squash, inhibits a wide range of aspartic proteinases. This particular family of PAAPIs (proteinaceous aspartic acid inhibitors) seems to have evolved quite recently from an ancestral cystatin. Structurally it consists of a four-stranded anti-parallel beta-sheet gripping an alpha-helix in much the same manner that a hand grips a tennis racket. The unstructured N-terminus and the loop connecting beta-strands 1 and 2 are important for pepsin inhibition, but the loop connecting strands 3 and 4 is not.


Pssm-ID: 407092  Cd Length: 83  Bit Score: 33.94  E-value: 2.23e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 586540942  14 PEIQEIANEVKPQLEEKTNETYEEFEVVEYKTQVVAGTNYYLKVRV 59
Cdd:pfam16845  7 PHVVEIAKFAVSEHNKQSKANLVFVKVVKGETQVVSGTNYRLVIAA 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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