|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
199-378 |
5.56e-123 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 366.86 E-value: 5.56e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 199 LPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNYIERGIGSACRIVCTQPRRISAISVAERVAAERAESCGN 278
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGKGSSCRIVCTQPRRISAISVAERVAAERAESCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 279 GNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMS 358
Cdd:cd17981 81 GNSTGYQIRLESRKPRKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160
|
170 180
....*....|....*....|
gi 672042532 359 ATLNAEKFSEYFGNCPMIHI 378
Cdd:cd17981 161 ATLNAEKFSDYFNNCPMIHI 180
|
|
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
207-768 |
1.90e-115 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 369.80 E-value: 1.90e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 207 ELVNLINNHQVTVISGETGCGKTTQVTQFILDnyieRGIGSACRIVCTQPRRISAISVAERVAAERAESCGNgnSTGYQI 286
Cdd:COG1643 18 ELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGGRIGMLEPRRLAARAAAERMAEELGEPVGE--TVGYRV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 287 RLQSRLpRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLH-FRSDLKVILMSATLNAEK 365
Cdd:COG1643 92 RFEDKV-SAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPaLRPDLKLLVMSATLDAER 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 366 FSEYFGNCPMIHIPGFTFPVveyllediiEkIRYFPEQKEHRSQfkrgfmqghvnrqekeekeaiykerwpayikelqtr 445
Cdd:COG1643 171 FARLLGDAPVIESSGRTYPV---------E-VRYRPLPADERDL------------------------------------ 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 446 ysastidvlemmdddkvdLNLIAALIRyIVLEEEDGAILVFLPGWDNISTLHDLLMSQVmfkSDRFLIIPLHSLMPTVNQ 525
Cdd:COG1643 205 ------------------EDAVADAVR-EALAEEPGDILVFLPGEREIRRTAEALRGRL---PPDTEILPLYGRLSAAEQ 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 526 TQVFKKTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYH 605
Cdd:COG1643 263 DRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYR 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 606 LYNGLRASLLDDYQLPEILRTPLEELCLQIKILRLGGIAYFlsRLMDPPSDEAVVLSIKHLMELSALDKQEELTPLGVHL 685
Cdd:COG1643 343 LWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDL--PFLDPPPARAIADARALLQELGALDADGRLTPLGRAL 420
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 686 ARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPfviplgkekiadaRRkelaKETRSDHLTVVNAFEGWEEAKRRG 765
Cdd:COG1643 421 ARLPLDPRLARMLLAAAELGCLREAAILAALLSERDP-------------RR----GAAGSDLLARLNLWRRLREQQREF 483
|
...
gi 672042532 766 FRY 768
Cdd:COG1643 484 LSY 486
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
194-753 |
1.72e-82 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 287.73 E-value: 1.72e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 194 RFRKKLPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILdnyiERGIGSACRIVCTQPRRISAISVAERVAAERA 273
Cdd:PRK11131 68 TYPENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICL----ELGRGVKGLIGHTQPRRLAARTVANRIAEELE 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 274 ESCGNgnSTGYQIRLQSRLpRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLK 353
Cdd:PRK11131 144 TELGG--CVGYKVRFNDQV-SDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLK 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 354 VILMSATLNAEKFSEYFGNCPMIHIPGFTFPVveyllediieKIRYFPeqkehrsqfkrgfMQGHVNRQEKEEKEAIYKE 433
Cdd:PRK11131 221 VIITSATIDPERFSRHFNNAPIIEVSGRTYPV----------EVRYRP-------------IVEEADDTERDQLQAIFDA 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 434 rwpayIKELQtrysastidvlemmdddkvdlnliaaliryivlEEEDGAILVFLPGWDNISTLHDLLMSQVMFKSDrflI 513
Cdd:PRK11131 278 -----VDELG---------------------------------REGPGDILIFMSGEREIRDTADALNKLNLRHTE---I 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 514 IPLHSLMPTVNQTQVFKktPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKG 593
Cdd:PRK11131 317 LPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKG 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 594 RAGRVQPGHCYHLYNGL----RASLLDdyqlPEILRTPLEELCLQIKILRLGGIAYFlsRLMDPPSDEAVVLSIKHLMEL 669
Cdd:PRK11131 395 RCGRVSEGICIRLYSEDdflsRPEFTD----PEILRTNLASVILQMTALGLGDIAAF--PFVEAPDKRNIQDGVRLLEEL 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 670 SALDKQE-----ELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKIADARRKELAKEt 744
Cdd:PRK11131 469 GAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDKQQASDEKHRRFADK- 547
|
....*....
gi 672042532 745 RSDHLTVVN 753
Cdd:PRK11131 548 ESDFLAFVN 556
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
443-607 |
3.96e-77 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 246.68 E-value: 3.96e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 443 QTRYSASTIDVL--EMMDDDKVDLNLIAALIRYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKS-DRFLIIPLHSL 519
Cdd:cd18791 4 EVYYLEDILELLgiSSEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLREELLSPDlGKLLVLPLHSS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 520 MPTVNQTQVFKKTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQ 599
Cdd:cd18791 84 LPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTR 163
|
....*...
gi 672042532 600 PGHCYHLY 607
Cdd:cd18791 164 PGKCYRLY 171
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
199-737 |
6.40e-75 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 260.08 E-value: 6.40e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 199 LPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDnyiERGIGSacRIVCTQPRRISAISVAERVAAERAESCGN 278
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALLD---APGIGG--KIIMLEPRRLAARSAAQRLASQLGEAVGQ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 279 gnSTGYQIRLQSRLPRKQgSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLH-FRSDLKVILM 357
Cdd:TIGR01970 76 --TVGYRVRGENKVSRRT-RLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVQSsLREDLKILAM 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 358 SATLNAEKFSEYFGNCPMIHIPGFTFPVveyllediieKIRYFPEQKEHRsqfkrgfMQGHVNRQekeekeaiykerwpa 437
Cdd:TIGR01970 153 SATLDGERLSSLLPDAPVVESEGRSFPV----------EIRYLPLRGDQR-------LEDAVSRA--------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 438 yikelqtrysastidVLEMmdddkvdlnliaaliryivLEEEDGAILVFLPGWDNISTLHDLLMSQVmfkSDRFLIIPLH 517
Cdd:TIGR01970 201 ---------------VEHA-------------------LASETGSILVFLPGQAEIRRVQEQLAERL---DSDVLICPLY 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 518 SLMPTVNQTQVFKKTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGR 597
Cdd:TIGR01970 244 GELSLAAQDRAIKPDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITRLETVRISQASATQRAGRAGR 323
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 598 VQPGHCYHLYNGLRASLLDDYQLPEILRTPLEELCLQikILRLGGIAYFLSRLMDPPSDEAVVLSIKHLMELSALDKQEE 677
Cdd:TIGR01970 324 LEPGVCYRLWSEEQHQRLPAQDEPEILQADLSGLALE--LAQWGAKDPSDLRWLDAPPSVALAAARQLLQRLGALDAQGR 401
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672042532 678 LTPLGVHLARLPVEPHIGKMILFG------ALFCCLDPVLT-----------IAASLSFKDPFVIPLGKEKIADARR 737
Cdd:TIGR01970 402 LTAHGKAMAALGCHPRLAAMLLSAhstglaALACDLAALLEerglprqggadLMNRLHRLQQGRQGRGQRAQQLAKK 478
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
662-751 |
1.82e-27 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 106.94 E-value: 1.82e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 662 SIKHLMELSALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLG------------- 728
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFldprsaakaarrr 80
|
90 100
....*....|....*....|....
gi 672042532 729 -KEKIADARRKELAKETRSDHLTV 751
Cdd:pfam04408 81 rRAADEKARAKFARLDLEGDHLTL 104
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
202-384 |
3.82e-25 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 103.73 E-value: 3.82e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 202 YGMQKELVN-LINNHQVTVISGETGCGKTTQVTQFILDNYIErgiGSACRIVCTQPRRISAISVAERVAAERAESCGN-- 278
Cdd:smart00487 10 RPYQKEAIEaLLSGLRDVILAAPTGSGKTLAALLPALEALKR---GKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKvv 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 279 GNSTGYQIRLQ-SRLPRKQGSILYCTTGIILQWLQSDS-RLSSVSHIVLDEIHER--NLQSDVLMTVIKDLlhfRSDLKV 354
Cdd:smart00487 87 GLYGGDSKREQlRKLESGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLldGGFGDQLEKLLKLL---PKNVQL 163
|
170 180 190
....*....|....*....|....*....|..
gi 672042532 355 ILMSATL--NAEKFSEYFGNCPMIHIPGFTFP 384
Cdd:smart00487 164 LLLSATPpeEIENLLELFLNDPVFIDVGFTPL 195
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
668-752 |
1.45e-24 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 97.72 E-value: 1.45e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 668 ELSALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFviPLGKEKIADARRKELAKEtRSD 747
Cdd:smart00847 1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFADP-ESD 77
|
....*
gi 672042532 748 HLTVV 752
Cdd:smart00847 78 HLTLL 82
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
205-364 |
9.56e-12 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 63.80 E-value: 9.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 205 QKELVNLINNHQVTVISGETGCGKTTqVTQF-ILDNYIERGIGSacRIVCTQPRRISAISVAERvAAERAESCG------ 277
Cdd:pfam00270 4 QAEAIPAILEGRDVLVQAPTGSGKTL-AFLLpALEALDKLDNGP--QALVLAPTRELAEQIYEE-LKKLGKGLGlkvasl 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 278 -NGNSTGYQIRLQSRLPrkqgsILYCTTGIILQWLQSDSRLSSVSHIVLDEIHE--RNLQSDVLMTVIKdllHFRSDLKV 354
Cdd:pfam00270 80 lGGDSRKEQLEKLKGPD-----ILVGTPGRLLDLLQERKLLKNLKLLVLDEAHRllDMGFGPDLEEILR---RLPKKRQI 151
|
170
....*....|
gi 672042532 355 ILMSATLNAE 364
Cdd:pfam00270 152 LLLSATLPRN 161
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
199-378 |
5.56e-123 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 366.86 E-value: 5.56e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 199 LPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNYIERGIGSACRIVCTQPRRISAISVAERVAAERAESCGN 278
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGKGSSCRIVCTQPRRISAISVAERVAAERAESCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 279 GNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMS 358
Cdd:cd17981 81 GNSTGYQIRLESRKPRKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILMS 160
|
170 180
....*....|....*....|
gi 672042532 359 ATLNAEKFSEYFGNCPMIHI 378
Cdd:cd17981 161 ATLNAEKFSDYFNNCPMIHI 180
|
|
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
207-768 |
1.90e-115 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 369.80 E-value: 1.90e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 207 ELVNLINNHQVTVISGETGCGKTTQVTQFILDnyieRGIGSACRIVCTQPRRISAISVAERVAAERAESCGNgnSTGYQI 286
Cdd:COG1643 18 ELLAALRAHQVVVLAAPPGAGKTTQLPLALLE----LGWGAGGRIGMLEPRRLAARAAAERMAEELGEPVGE--TVGYRV 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 287 RLQSRLpRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLH-FRSDLKVILMSATLNAEK 365
Cdd:COG1643 92 RFEDKV-SAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPaLRPDLKLLVMSATLDAER 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 366 FSEYFGNCPMIHIPGFTFPVveyllediiEkIRYFPEQKEHRSQfkrgfmqghvnrqekeekeaiykerwpayikelqtr 445
Cdd:COG1643 171 FARLLGDAPVIESSGRTYPV---------E-VRYRPLPADERDL------------------------------------ 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 446 ysastidvlemmdddkvdLNLIAALIRyIVLEEEDGAILVFLPGWDNISTLHDLLMSQVmfkSDRFLIIPLHSLMPTVNQ 525
Cdd:COG1643 205 ------------------EDAVADAVR-EALAEEPGDILVFLPGEREIRRTAEALRGRL---PPDTEILPLYGRLSAAEQ 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 526 TQVFKKTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQPGHCYH 605
Cdd:COG1643 263 DRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRAGRAGRLAPGICYR 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 606 LYNGLRASLLDDYQLPEILRTPLEELCLQIKILRLGGIAYFlsRLMDPPSDEAVVLSIKHLMELSALDKQEELTPLGVHL 685
Cdd:COG1643 343 LWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDL--PFLDPPPARAIADARALLQELGALDADGRLTPLGRAL 420
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 686 ARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPfviplgkekiadaRRkelaKETRSDHLTVVNAFEGWEEAKRRG 765
Cdd:COG1643 421 ARLPLDPRLARMLLAAAELGCLREAAILAALLSERDP-------------RR----GAAGSDLLARLNLWRRLREQQREF 483
|
...
gi 672042532 766 FRY 768
Cdd:COG1643 484 LSY 486
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
215-378 |
6.63e-88 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 274.72 E-value: 6.63e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 215 HQVTVISGETGCGKTTQVTQFILDNYIERGigSACRIVCTQPRRISAISVAERVAAERAESCGNgnSTGYQIRLQSRLPR 294
Cdd:cd17917 1 NQVVVIVGETGSGKTTQVPQFLLEDGLAKG--GKGRIVCTQPRRIAAISVAERVAEERGEKLGE--EVGYQIRFESKTSS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 295 KqGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCP 374
Cdd:cd17917 77 K-TRIKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGGAP 155
|
....
gi 672042532 375 MIHI 378
Cdd:cd17917 156 VIHI 159
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
194-753 |
1.72e-82 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 287.73 E-value: 1.72e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 194 RFRKKLPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILdnyiERGIGSACRIVCTQPRRISAISVAERVAAERA 273
Cdd:PRK11131 68 TYPENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICL----ELGRGVKGLIGHTQPRRLAARTVANRIAEELE 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 274 ESCGNgnSTGYQIRLQSRLpRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLK 353
Cdd:PRK11131 144 TELGG--CVGYKVRFNDQV-SDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLK 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 354 VILMSATLNAEKFSEYFGNCPMIHIPGFTFPVveyllediieKIRYFPeqkehrsqfkrgfMQGHVNRQEKEEKEAIYKE 433
Cdd:PRK11131 221 VIITSATIDPERFSRHFNNAPIIEVSGRTYPV----------EVRYRP-------------IVEEADDTERDQLQAIFDA 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 434 rwpayIKELQtrysastidvlemmdddkvdlnliaaliryivlEEEDGAILVFLPGWDNISTLHDLLMSQVMFKSDrflI 513
Cdd:PRK11131 278 -----VDELG---------------------------------REGPGDILIFMSGEREIRDTADALNKLNLRHTE---I 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 514 IPLHSLMPTVNQTQVFKktPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKG 593
Cdd:PRK11131 317 LPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTARISRYSYRTKVQRLPIEPISQASANQRKG 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 594 RAGRVQPGHCYHLYNGL----RASLLDdyqlPEILRTPLEELCLQIKILRLGGIAYFlsRLMDPPSDEAVVLSIKHLMEL 669
Cdd:PRK11131 395 RCGRVSEGICIRLYSEDdflsRPEFTD----PEILRTNLASVILQMTALGLGDIAAF--PFVEAPDKRNIQDGVRLLEEL 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 670 SALDKQE-----ELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLGKEKIADARRKELAKEt 744
Cdd:PRK11131 469 GAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQDPRERPMDKQQASDEKHRRFADK- 547
|
....*....
gi 672042532 745 RSDHLTVVN 753
Cdd:PRK11131 548 ESDFLAFVN 556
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
443-607 |
3.96e-77 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 246.68 E-value: 3.96e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 443 QTRYSASTIDVL--EMMDDDKVDLNLIAALIRYIVLEEEDGAILVFLPGWDNISTLHDLLMSQVMFKS-DRFLIIPLHSL 519
Cdd:cd18791 4 EVYYLEDILELLgiSSEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELLREELLSPDlGKLLVLPLHSS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 520 MPTVNQTQVFKKTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGRVQ 599
Cdd:cd18791 84 LPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTR 163
|
....*...
gi 672042532 600 PGHCYHLY 607
Cdd:cd18791 164 PGKCYRLY 171
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
199-737 |
6.40e-75 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 260.08 E-value: 6.40e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 199 LPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDnyiERGIGSacRIVCTQPRRISAISVAERVAAERAESCGN 278
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALLD---APGIGG--KIIMLEPRRLAARSAAQRLASQLGEAVGQ 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 279 gnSTGYQIRLQSRLPRKQgSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLH-FRSDLKVILM 357
Cdd:TIGR01970 76 --TVGYRVRGENKVSRRT-RLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVQSsLREDLKILAM 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 358 SATLNAEKFSEYFGNCPMIHIPGFTFPVveyllediieKIRYFPEQKEHRsqfkrgfMQGHVNRQekeekeaiykerwpa 437
Cdd:TIGR01970 153 SATLDGERLSSLLPDAPVVESEGRSFPV----------EIRYLPLRGDQR-------LEDAVSRA--------------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 438 yikelqtrysastidVLEMmdddkvdlnliaaliryivLEEEDGAILVFLPGWDNISTLHDLLMSQVmfkSDRFLIIPLH 517
Cdd:TIGR01970 201 ---------------VEHA-------------------LASETGSILVFLPGQAEIRRVQEQLAERL---DSDVLICPLY 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 518 SLMPTVNQTQVFKKTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKGRAGR 597
Cdd:TIGR01970 244 GELSLAAQDRAIKPDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITRLETVRISQASATQRAGRAGR 323
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 598 VQPGHCYHLYNGLRASLLDDYQLPEILRTPLEELCLQikILRLGGIAYFLSRLMDPPSDEAVVLSIKHLMELSALDKQEE 677
Cdd:TIGR01970 324 LEPGVCYRLWSEEQHQRLPAQDEPEILQADLSGLALE--LAQWGAKDPSDLRWLDAPPSVALAAARQLLQRLGALDAQGR 401
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672042532 678 LTPLGVHLARLPVEPHIGKMILFG------ALFCCLDPVLT-----------IAASLSFKDPFVIPLGKEKIADARR 737
Cdd:TIGR01970 402 LTAHGKAMAALGCHPRLAAMLLSAhstglaALACDLAALLEerglprqggadLMNRLHRLQQGRQGRGQRAQQLAKK 478
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
199-378 |
7.30e-72 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 232.81 E-value: 7.30e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 199 LPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNYIERGIGSACRIVCTQPRRISAISVAERVAAERAESCGN 278
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPPLPVANIICTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 279 gnSTGYQIRLQSRlpRKQGS-ILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILM 357
Cdd:cd17985 81 --SVGYQIRLESV--KSSATrLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILM 156
|
170 180
....*....|....*....|.
gi 672042532 358 SATLNAEKFSEYFGNCPMIHI 378
Cdd:cd17985 157 SATLNAELFSDYFNSCPVIHI 177
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
172-378 |
2.20e-70 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 231.26 E-value: 2.20e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 172 LDQQLLEDLQ-KKKTDPRYIEMQRFRKKLPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNYIERGIGSACR 250
Cdd:cd17972 31 ISMDLKNELMyQREQDHNLQQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDFIQNDRAAECN 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 251 IVCTQPRRISAISVAERVAAERAESCgnGNSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDSRlsSVSHIVLDEIHE 330
Cdd:cd17972 111 IVVTQPRRISAVSVAERVAFERGEEV--GKSCGYSVRFESVLPRPHASILFCTVGVLLRKLEAGIR--GISHVIVDEIHE 186
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 672042532 331 RNLQSDVLMTVIKDLLHFRSDLKVILMSATLNAEKFSEYFGNCPMIHI 378
Cdd:cd17972 187 RDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFFNCPVIEV 234
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
199-378 |
1.36e-66 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 218.89 E-value: 1.36e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 199 LPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNYIERGIGSACRIVCTQPRRISAISVAERVAAERAESCGN 278
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRGRGARCNVVITQPRRISAVSVAQRVAHELGPNLRR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 279 gnSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMS 358
Cdd:cd17976 81 --NVGYQVRLESRPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMS 158
|
170 180
....*....|....*....|
gi 672042532 359 ATLNAEKFSEYFGNCPMIHI 378
Cdd:cd17976 159 ATGDNQRLSRYFGGCPVVRV 178
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
199-378 |
2.31e-61 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 204.68 E-value: 2.31e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 199 LPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNYIERGIgsACRIVCTQPRRISAISVAERVAAERAESCGN 278
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYANGI--PCRIFCTQPRRLAAIAVAERVAAERGEKIGQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 279 gnSTGYQIRLQSRLPRKQgSILYCTTGIILQWLQS-DSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILM 357
Cdd:cd17987 79 --TVGYQIRLESRVSPKT-LLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILS 155
|
170 180
....*....|....*....|.
gi 672042532 358 SATLNAEKFSEYFGNCPMIHI 378
Cdd:cd17987 156 SAALDVNLFIRYFGSCPVIYI 176
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
199-378 |
2.68e-61 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 204.76 E-value: 2.68e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 199 LPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNYI-ERGIGSACRIVCTQPRRISAISVAERVAAERAESCG 277
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLlNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 278 NG--NS-TGYQIRLQSRlPRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKV 354
Cdd:cd17975 81 PGgkNSlCGYQIRMESR-TGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHL 159
|
170 180
....*....|....*....|....
gi 672042532 355 ILMSATLNAEKFSEYFGNCPMIHI 378
Cdd:cd17975 160 ILMSATVDCEKFSSYFTHCPILRI 183
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
199-702 |
4.93e-57 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 209.40 E-value: 4.93e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 199 LPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNYIERGigsacRIVCTQPRRISAISVAERVAAERAESCGN 278
Cdd:PRK11664 4 LPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPLQLLQHGGING-----KIIMLEPRRLAARNVAQRLAEQLGEKPGE 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 279 gnSTGYQIRLQSRL-PRKQGSILycTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDV----LMTVIKDLlhfRSDLK 353
Cdd:PRK11664 79 --TVGYRMRAESKVgPNTRLEVV--TEGILTRMIQRDPELSGVGLVILDEFHERSLQADLalalLLDVQQGL---RDDLK 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 354 VILMSATLNAEKFSEYFGNCPMIHIPGFTFPVveyllediieKIRYFPeqkehrsqfkrgfMQGHvnrQEKEEKEAiyke 433
Cdd:PRK11664 152 LLIMSATLDNDRLQQLLPDAPVIVSEGRSFPV----------ERRYQP-------------LPAH---QRFDEAVA---- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 434 rwpayikelqtrysastidvlemmdddkvdlNLIAALiryivLEEEDGAILVFLPGWDNISTLHDLLMSQVmfkSDRFLI 513
Cdd:PRK11664 202 -------------------------------RATAEL-----LRQESGSLLLFLPGVGEIQRVQEQLASRV---ASDVLL 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 514 IPLHSLMPTVNQTQVFKKTPPGVRKIVIATNIAETSITIDDVVYVIDGGKIKETHFDTQNNISTMSAEWVSKANAKQRKG 593
Cdd:PRK11664 243 CPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGLTRLVTQRISQASMTQRAG 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 594 RAGRVQPGHCYHLYNGLRASLLDDYQLPEILRTPLEELCLQikILRLGgiAYFLSRLM--DPPSDEAVVLSIKHLMELSA 671
Cdd:PRK11664 323 RAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLLE--LLQWG--CHDPAQLSwlDQPPAAALAAAKRLLQQLGA 398
|
490 500 510
....*....|....*....|....*....|.
gi 672042532 672 LDKQEELTPLGVHLARLPVEPHIGKMILFGA 702
Cdd:PRK11664 399 LDGQGRLTARGRKMAALGNDPRLAAMLVAAK 429
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
187-378 |
3.66e-52 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 179.92 E-value: 3.66e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 187 PRYIEMQRFRKKLPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNYIERGIGSAcrIVCTQPRRISAISVAE 266
Cdd:cd17973 1 QRYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPHQPKKL--VACTQPRRVAAMSVAQ 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 267 RVAAERAESCGNgnSTGYQIRLQSRLPRKqgSIL-YCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDL 345
Cdd:cd17973 79 RVAEEMDVKLGE--EVGYSIRFEDCSSAK--TILkYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEV 154
|
170 180 190
....*....|....*....|....*....|...
gi 672042532 346 LHFRSDLKVILMSATLNAEKFSEYFGNCPMIHI 378
Cdd:cd17973 155 VRRRPDLKLIVMSATLDAGKFQKYFDNAPLLKV 187
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
199-385 |
5.36e-52 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 179.23 E-value: 5.36e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 199 LPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNYIERGIgsACRIVCTQPRRISAISVAERVAAERAesCGN 278
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHYYKRGK--YCNIVVTQPRRIAAISIARRVSQERE--WTL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 279 GNSTGYQIRLQsRLPRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSD-LKVILM 357
Cdd:cd17988 77 GSLVGYQVGLE-RPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRTNSRhVKIILM 155
|
170 180
....*....|....*....|....*...
gi 672042532 358 SATLNAEKFSEYFGncpMIHIPGFTFPV 385
Cdd:cd17988 156 SATISCKEFADYFT---TPNNPAYVFEV 180
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
196-379 |
6.94e-50 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 173.44 E-value: 6.94e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 196 RKKLPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFIldnyIERGIGSACRIVCTQPRRISAISVAERVAAERAes 275
Cdd:cd17971 3 RESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYL----AEAGYTSRGKIGCTQPRRVAAMSVAKRVAEEFG-- 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 276 CGNGNSTGYQIRLQSRLPRKQgSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVI 355
Cdd:cd17971 77 CCLGQEVGYTIRFEDCTSPET-VIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLI 155
|
170 180
....*....|....*....|....
gi 672042532 356 LMSATLNAEKFSEYFGNCPMIHIP 379
Cdd:cd17971 156 VTSATLDAVKFSQYFYEAPIFTIP 179
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
199-378 |
2.52e-48 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 168.39 E-value: 2.52e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 199 LPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNyierGIGsacRIVCTQPRRISAISVAERVAAERAEScgN 278
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAA----GFR---HIACTQPRRIACISLAKRVAFESLNQ--Y 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 279 GNSTGYQIRLQ-SRLPRKQgsILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILM 357
Cdd:cd17979 72 GSKVAYQIRFErTRTLATK--LLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILM 149
|
170 180
....*....|....*....|.
gi 672042532 358 SATLNAEKFSEYFGNCPMIHI 378
Cdd:cd17979 150 SATINIELFSGYFEGAPVVQV 170
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
199-378 |
1.52e-47 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 166.48 E-value: 1.52e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 199 LPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFIL-DNYIERGIgsacrIVCTQPRRISAISVAERVAAERAESCG 277
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHeDGYTDYGM-----IGCTQPRRVAAMSVAKRVSEEMGVELG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 278 NgnSTGYQIRLQSrLPRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILM 357
Cdd:cd17983 76 E--EVGYAIRFED-CTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVT 152
|
170 180
....*....|....*....|.
gi 672042532 358 SATLNAEKFSEYFGNCPMIHI 378
Cdd:cd17983 153 SATMDADKFADFFGNVPIFTI 173
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
199-378 |
6.57e-47 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 164.60 E-value: 6.57e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 199 LPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNYIERGIGsacRIVCTQPRRISAISVAERVAAERaeSCGN 278
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGG---KIGCTQPRRVAAMSVAARVAEEM--GVKL 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 279 GNSTGYQIRLQSRLPRKqgSIL-YCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILM 357
Cdd:cd17974 76 GNEVGYSIRFEDCTSEK--TVLkYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLIS 153
|
170 180
....*....|....*....|.
gi 672042532 358 SATLNAEKFSEYFGNCPMIHI 378
Cdd:cd17974 154 SATMDAEKFSAFFDDAPIFRI 174
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
199-378 |
6.87e-45 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 159.06 E-value: 6.87e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 199 LPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNYIERG--IGsacrivCTQPRRISAISVAERVAAERaeSC 276
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFARGgmIG------ITQPRRVAAVSVAKRVAEEM--GV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 277 GNGNSTGYQIRLQSRLPRkQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFR-----SD 351
Cdd:cd17978 73 ELGQLVGYSVRFDDVTSE-ETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqklSP 151
|
170 180
....*....|....*....|....*..
gi 672042532 352 LKVILMSATLNAEKFSEYFGNCPMIHI 378
Cdd:cd17978 152 LKVIIMSATLDADLFSEYFNGAPVLYI 178
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
199-370 |
1.67e-43 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 155.70 E-value: 1.67e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 199 LPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILdnyiERGIGSACR-IVCTQPRRISAISVAERVAAERAESCG 277
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLA----EAGWTAGGRvVGCTQPRRVAAVTVAGRVAEEMGAVLG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 278 NgnSTGYQIRLQSRLPRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILM 357
Cdd:cd17980 77 H--EVGYCIRFDDCTDPQATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVA 154
|
170
....*....|...
gi 672042532 358 SATLNAEKFSEYF 370
Cdd:cd17980 155 SATLDAEKFRDFF 167
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
199-378 |
5.94e-42 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 150.68 E-value: 5.94e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 199 LPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILdnyiERGIGSACRIVCTQPRRISAISVAERVAAERAESCGN 278
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICL----ELGRGIRGLIGHTQPRRLAARSVAERIAEELKTELGG 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 279 gnSTGYQIRLQSRLPRKQgSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILMS 358
Cdd:cd17989 77 --AVGYKVRFTDQTSDET-CVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITS 153
|
170 180
....*....|....*....|
gi 672042532 359 ATLNAEKFSEYFGNCPMIHI 378
Cdd:cd17989 154 ATIDAERFSRHFNNAPIIEV 173
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
199-378 |
2.23e-39 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 143.84 E-value: 2.23e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 199 LPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILdnyiERGIGSACRIVCTQPRRISAISVAERVAAERaeSCGN 278
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLY----EAGFSQHGMIGVTQPRRVAAISVAQRVAEEM--KCTL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 279 GNSTGYQIRLQSrLPRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRS-----DLK 353
Cdd:cd17984 75 GSKVGYQVRFDD-CSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLFQEKSpnrkeHLK 153
|
170 180
....*....|....*....|....*
gi 672042532 354 VILMSATLNAEKFSEYFGNCPMIHI 378
Cdd:cd17984 154 VVVMSATLELAKLSAFFGNCPVFDI 178
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
199-368 |
3.76e-39 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 143.65 E-value: 3.76e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 199 LPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILD-NYIERGIGSACRIVCTQPRRISAISVAERVAAERAEScg 277
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEaGFGSPESDNPGMIGITQPRRVAAVSMAKRVAEELNVF-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 278 nGNSTGYQIRLQSRLpRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSD------ 351
Cdd:cd17982 79 -GKEVSYQIRYDSTV-SENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdq 156
|
170 180
....*....|....*....|.
gi 672042532 352 ----LKVILMSATLNAEKFSE 368
Cdd:cd17982 157 tvkpLKLVIMSATLRVEDFTE 177
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
199-376 |
9.62e-33 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 124.75 E-value: 9.62e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 199 LPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQFILDNYIERGigsaCRIVCTQPRRISAISVAERVAAERAESCGN 278
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAG----GKIIVLEPRRVAARAAARRLATLLGEAPGE 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 279 gnSTGYQIRLQSRLPRKQgSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLH-FRSDLKVILM 357
Cdd:cd17990 77 --TVGYRVRGESRVGRRT-RVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQlLRDDLRLLAM 153
|
170
....*....|....*....
gi 672042532 358 SATLNAEKFSEYFGNCPMI 376
Cdd:cd17990 154 SATLDGDGLAALLPEAPVV 172
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
662-751 |
1.82e-27 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 106.94 E-value: 1.82e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 662 SIKHLMELSALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFVIPLG------------- 728
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFldprsaakaarrr 80
|
90 100
....*....|....*....|....
gi 672042532 729 -KEKIADARRKELAKETRSDHLTV 751
Cdd:pfam04408 81 rRAADEKARAKFARLDLEGDHLTL 104
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
202-384 |
3.82e-25 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 103.73 E-value: 3.82e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 202 YGMQKELVN-LINNHQVTVISGETGCGKTTQVTQFILDNYIErgiGSACRIVCTQPRRISAISVAERVAAERAESCGN-- 278
Cdd:smart00487 10 RPYQKEAIEaLLSGLRDVILAAPTGSGKTLAALLPALEALKR---GKGGRVLVLVPTRELAEQWAEELKKLGPSLGLKvv 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 279 GNSTGYQIRLQ-SRLPRKQGSILYCTTGIILQWLQSDS-RLSSVSHIVLDEIHER--NLQSDVLMTVIKDLlhfRSDLKV 354
Cdd:smart00487 87 GLYGGDSKREQlRKLESGKTDILVTTPGRLLDLLENDKlSLSNVDLVILDEAHRLldGGFGDQLEKLLKLL---PKNVQL 163
|
170 180 190
....*....|....*....|....*....|..
gi 672042532 355 ILMSATL--NAEKFSEYFGNCPMIHIPGFTFP 384
Cdd:smart00487 164 LLLSATPpeEIENLLELFLNDPVFIDVGFTPL 195
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
199-378 |
1.45e-24 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 101.06 E-value: 1.45e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 199 LPSYGMQKELVNLINNHQVTVISGETGCGKTTQVTQ----FILDNYIERGIgsacrIVCTQPRRISAISVAERVAAERae 274
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQwcaeYCLSAHYQHGV-----VVCTQVHKQTAVWLALRVADEM-- 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 275 SCGNGNSTGYQIRLQSRLprKQGSIL-YCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLK 353
Cdd:cd17977 74 DVNIGHEVGYVIPFENCC--TNETILrYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELK 151
|
170 180
....*....|....*....|....*
gi 672042532 354 VILMSATLNAEKFSEYFGNCPMIHI 378
Cdd:cd17977 152 LVIITCPHLSSKLLSYYGNVPLIEV 176
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
668-752 |
1.45e-24 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 97.72 E-value: 1.45e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 668 ELSALDKQEELTPLGVHLARLPVEPHIGKMILFGALFCCLDPVLTIAASLSFKDPFviPLGKEKIADARRKELAKEtRSD 747
Cdd:smart00847 1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFADP-ESD 77
|
....*
gi 672042532 748 HLTVV 752
Cdd:smart00847 78 HLTLL 82
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
199-378 |
3.25e-21 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 91.50 E-value: 3.25e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 199 LPSYGMQKE-LVNLINNHQVTVISGETGCGKTTQVTQFILDNYIERGIgSACRIVCTQPRRISAISVAERVAAERAESCG 277
Cdd:cd17986 1 LPIWAAKFTfLEQLESPSGIVLVSGEPGSGKSTQVPQWCAEFALSRGF-QKGQVTVTQPHPLAARSLALRVADEMDLNLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 278 NgnSTGYQIRlQSRLPRKQGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFRSDLKVILM 357
Cdd:cd17986 80 H--EVGYSIP-QEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVV 156
|
170 180
....*....|....*....|.
gi 672042532 358 SATLNAEKFSEYFGNCPMIHI 378
Cdd:cd17986 157 TSPALEPKLRAFWGNPPVVHV 177
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
204-601 |
3.04e-16 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 83.10 E-value: 3.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 204 MQKELVNLINNHQVTVISGETGCGKTTQVTQFIL----------------DNYIERgigsacRIVCTQPRrisaISVAER 267
Cdd:PHA02653 168 VQLKIFEAWISRKPVVLTGGTGVGKTSQVPKLLLwfnylfggfdnldkidPNFIER------PIVLSLPR----VALVRL 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 268 VAAERAESCGNGNSTGYQIRLQ---------SRLPRKQGsILYCTTGIILqwlqsdSRLSSVSHIVLDEIHERNLQSDVL 338
Cdd:PHA02653 238 HSITLLKSLGFDEIDGSPISLKygsipdeliNTNPKPYG-LVFSTHKLTL------NKLFDYGTVIIDEVHEHDQIGDII 310
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 339 MTVI-KDLLHFRSdlkVILMSATL--NAEKFSEYFGNCPMIHIPGFT-FPVVEylledIIEKIRYFPEQKEhrsqfkrgf 414
Cdd:PHA02653 311 IAVArKHIDKIRS---LFLMTATLedDRDRIKEFFPNPAFVHIPGGTlFPISE-----VYVKNKYNPKNKR--------- 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 415 mqghvnRQEKEEKEAIYKErwpayIKELQTRYSASTIdvlemmdddkVDLNLIAALIRYI-VLEEEdgailvfLPGWDni 493
Cdd:PHA02653 374 ------AYIEEEKKNIVTA-----LKKYTPPKGSSGI----------VFVASVSQCEEYKkYLEKR-------LPIYD-- 423
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 494 stlhdllmsqvmfksdrFLIIplHSLMPTVNQ--TQVFKKTPPgvrKIVIATNIAETSITIDDVVYVIDGGKIKETHFDT 571
Cdd:PHA02653 424 -----------------FYII--HGKVPNIDEilEKVYSSKNP---SIIISTPYLESSVTIRNATHVYDTGRVYVPEPFG 481
|
410 420 430
....*....|....*....|....*....|
gi 672042532 572 QNNIstmsaeWVSKANAKQRKGRAGRVQPG 601
Cdd:PHA02653 482 GKEM------FISKSMRTQRKGRVGRVSPG 505
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
218-360 |
2.62e-14 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 70.90 E-value: 2.62e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 218 TVISGETGCGKTTQVTQFILDNYIERGigsaCRIVCTQPRRISAISVAERVAAERAE--SCGnGNSTGYQIRLQSRLPRK 295
Cdd:cd00046 4 VLITAPTGSGKTLAALLAALLLLLKKG----KKVLVLVPTKALALQTAERLRELFGPgiRVA-VLVGGSSAEEREKNKLG 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672042532 296 QGSILYCTTGIILQWLQSD--SRLSSVSHIVLDEIHERNLQSDV-LMTVIKDLLHFRSDLKVILMSAT 360
Cdd:cd00046 79 DADIIIATPDMLLNLLLREdrLFLKDLKLIIVDEAHALLIDSRGaLILDLAVRKAGLKNAQVILLSAT 146
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
469-598 |
3.56e-14 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 69.16 E-value: 3.56e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 469 ALIRYIVLEEEDGAILVFLPGWDnistlhdLLMSQVMFKSDRFLIIPLHSLMPTVNQTQVFKKTPPGVRKIVIATNIAET 548
Cdd:pfam00271 4 EALLELLKKERGGKVLIFSQTKK-------TLEAELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAER 76
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 672042532 549 SITIDDVVYVIdggkiketHFDTQNNISTMsaewvskanaKQRKGRAGRV 598
Cdd:pfam00271 77 GLDLPDVDLVI--------NYDLPWNPASY----------IQRIGRAGRA 108
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
505-597 |
2.55e-13 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 65.70 E-value: 2.55e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 505 MFKSDRFLIIPLHSLMPTVNQTQVFKKTPPGVRKIVIATNIAETSITIDDVVYVIdggkiketHFDTqnnistmsaeWVS 584
Cdd:smart00490 6 LLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVI--------IYDL----------PWS 67
|
90
....*....|...
gi 672042532 585 KANAKQRKGRAGR 597
Cdd:smart00490 68 PASYIQRIGRAGR 80
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
205-364 |
9.56e-12 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 63.80 E-value: 9.56e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 205 QKELVNLINNHQVTVISGETGCGKTTqVTQF-ILDNYIERGIGSacRIVCTQPRRISAISVAERvAAERAESCG------ 277
Cdd:pfam00270 4 QAEAIPAILEGRDVLVQAPTGSGKTL-AFLLpALEALDKLDNGP--QALVLAPTRELAEQIYEE-LKKLGKGLGlkvasl 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 278 -NGNSTGYQIRLQSRLPrkqgsILYCTTGIILQWLQSDSRLSSVSHIVLDEIHE--RNLQSDVLMTVIKdllHFRSDLKV 354
Cdd:pfam00270 80 lGGDSRKEQLEKLKGPD-----ILVGTPGRLLDLLQERKLLKNLKLLVLDEAHRllDMGFGPDLEEILR---RLPKKRQI 151
|
170
....*....|
gi 672042532 355 ILMSATLNAE 364
Cdd:pfam00270 152 LLLSATLPRN 161
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
205-379 |
1.49e-07 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 52.26 E-value: 1.49e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 205 QKELVNLINNHQV-TVISGETGCGKTTQVTQFILDNYIERGigsaCRIVCTQPRRisaiSVAERVAAERAESCGN----- 278
Cdd:cd17921 6 QREALRALYLSGDsVLVSAPTSSGKTLIAELAILRALATSG----GKAVYIAPTR----ALVNQKEADLRERFGPlgknv 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 279 GNSTGYQIRLQSRLPRKQgsILYCTTGIILQWLQ--SDSRLSSVSHIVLDEIHERNLQS--DVLMTVIKDLLHFRSDLKV 354
Cdd:cd17921 78 GLLTGDPSVNKLLLAEAD--ILVATPEKLDLLLRngGERLIQDVRLVVVDEAHLIGDGErgVVLELLLSRLLRINKNARF 155
|
170 180
....*....|....*....|....*.
gi 672042532 355 ILMSATL-NAEKFSEYFGNCPMIHIP 379
Cdd:cd17921 156 VGLSATLpNAEDLAEWLGVEDLIRFD 181
|
|
| DEXHc_viral_Ns3 |
cd17931 |
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ... |
216-360 |
1.71e-04 |
|
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350689 [Multi-domain] Cd Length: 151 Bit Score: 42.54 E-value: 1.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 216 QVTVISGETGCGKTTQVtqfiLDNYIERGIGSACRIVCTQPRRISAISVAERVaaeraescgNGNSTGYQIRLQSRLPRK 295
Cdd:cd17931 2 QLTVLDLHPGAGKTTRV----LPQIIREAIKKRLRTLVLAPTRVVAAEMYEAL---------RGLPIRYRTGAVKEEHGG 68
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672042532 296 QGSILYCTTGIILQWLQSDSRLSSVSHIVLDEIHERNLQSDVLMTVIKDLLHFrSDLKVILMSAT 360
Cdd:cd17931 69 NEIVDYMCHGTFTCRLLSPKRVPNYNLIIMDEAHFTDPASIAARGYIHTRVEM-GEAAVIFMTAT 132
|
|
| DEXSc_RecD-like |
cd17933 |
DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1. ... |
205-245 |
3.38e-04 |
|
DEXS-box helicase domain of RecD and similar proteins; RecD is a member of the RecBCD (EC 3.1.11.5, Exonuclease V) complex. It is the alpha chain of the complex and functions as a 3'-5' helicase. The RecBCD enzyme is both a helicase that unwinds, or separates the strands of DNA, and a nuclease that makes single-stranded nicks in DNA. RecD is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350691 [Multi-domain] Cd Length: 155 Bit Score: 41.77 E-value: 3.38e-04
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 672042532 205 QKELVNLINNHQVTVISGETGCGKTTqVTQFILDNYIERGI 245
Cdd:cd17933 2 QKAAVRLVLRNRVSVLTGGAGTGKTT-TLKALLAALEAEGK 41
|
|
| Cas3 |
COG1203 |
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; ... |
158-557 |
7.47e-04 |
|
CRISPR-Cas type I system-associated endonuclease/helicase Cas3 [Defense mechanisms]; CRISPR-Cas type I system-associated endonuclease/helicase Cas3 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 440816 [Multi-domain] Cd Length: 535 Bit Score: 42.76 E-value: 7.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 158 DSEYLLQQNEPNLGLDQQLLEDLQKKKTDPRYiEMQRFRKKLpsygMQKELVNLINNHQVTVISGETGCGKTTQVTQFIL 237
Cdd:COG1203 95 DSANFDMARQALDHLLAERLERLLPKKSKPRT-PINPLQNEA----LELALEAAEEEPGLFILTAPTGGGKTEAALLFAL 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 238 DNYIERGigsACRIVCTQP------------RRISAISVAE---RVAAERAESCGNGNSTGYQIRLQSRL---PrkqgsI 299
Cdd:COG1203 170 RLAAKHG---GRRIIYALPftsiinqtydrlRDLFGEDVLLhhsLADLDLLEEEEEYESEARWLKLLKELwdaP-----V 241
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 300 LYCTtgiILQWLqsDSRLSSVSH------------IVLDEIH--ERNLQSdVLMTVIKDLLHFRSdlKVILMSATLnaek 365
Cdd:COG1203 242 VVTT---IDQLF--ESLFSNRKGqerrlhnlansvIILDEVQayPPYMLA-LLLRLLEWLKNLGG--SVILMTATL---- 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 366 fseyfgncPMIHIPGFtFPVVEYLLEDIIEKIRYFPEQKEHRSQFKRGFMQghvnrqekeekeaiykerWPAYIKELQTR 445
Cdd:COG1203 310 --------PPLLREEL-LEAYELIPDEPEELPEYFRAFVRKRVELKEGPLS------------------DEELAELILEA 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 446 YSASTiDVLemmdddkVDLNLIAALIR-YIVLEEEDGAILVFLpgwdnistLHdllmSQVMFKsDRFLIIplhslmptvn 524
Cdd:COG1203 363 LHKGK-SVL-------VIVNTVKDAQElYEALKEKLPDEEVYL--------LH----SRFCPA-DRSEIE---------- 411
|
410 420 430
....*....|....*....|....*....|....
gi 672042532 525 qTQVFKKTPPGVRKIVIATNIAETSITID-DVVY 557
Cdd:COG1203 412 -KEIKERLERGKPCILVSTQVVEAGVDIDfDVVI 444
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
192-327 |
2.56e-03 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 40.43 E-value: 2.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 192 MQRFRKKLPSyGMQKELVNLINNHQVTVISGETGCGKTTQ----VTQFILDNYI--ERGIGSACRIVCTQPRRISAI--S 263
Cdd:cd17948 5 LQRQGITKPT-TVQKQGIPSILRGRNTLCAAETGSGKTLTyllpIIQRLLRYKLlaEGPFNAPRGLVITPSRELAEQigS 83
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672042532 264 VAERVAAE---RAESCGNGNSTGyQIRLqsrLPRKQGSILYCTTGIILQWLQSD-SRLSSVSHIVLDE 327
Cdd:cd17948 84 VAQSLTEGlglKVKVITGGRTKR-QIRN---PHFEEVDILVATPGALSKLLTSRiYSLEQLRHLVLDE 147
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
296-362 |
4.14e-03 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 39.10 E-value: 4.14e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672042532 296 QGSILYCTTGIILQWLQsdSRLSSVSHI---VLDE----IHERNLQSDVLMtvIKDLLhfRSDLKVILMSATLN 362
Cdd:cd17963 111 TAQIVIGTPGTVLDWLK--KRQLDLKKIkilVLDEadvmLDTQGHGDQSIR--IKRML--PRNCQILLFSATFP 178
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
538-597 |
9.16e-03 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 35.76 E-value: 9.16e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 672042532 538 KIVIATNIAETSITIDDVVYVIdggkiketHFDtqnnistmsaEWVSKANAKQRKGRAGR 597
Cdd:cd18785 24 EILVATNVLGEGIDVPSLDTVI--------FFD----------PPSSAASYIQRVGRAGR 65
|
|
| |
