|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
961-1276 |
7.15e-149 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 454.73 E-value: 7.15e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 961 AMQNLQNLLQMPYGCGEQNMVLFVPNIYVLEYLNETQQLTEAIKSKAISYLISGYQRQLNYQHSDGSYSTFGDRgmrHSQ 1040
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGES---DKS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1041 GNTWLTAFVLKAFAQAQSYIYIEKTHITNAFNWLSMKQRENGCFQQSGSLLNNAMKGGVDDEVTLSAYITIALLEMPLPV 1120
Cdd:cd02897 78 GSTWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1121 THSVVRNALFCLETAWASISNsqeshVYTKALLAYAFALAGNRaKRSEVLESLNKDAVNEEESVHWQRPKNVEEnvremr 1200
Cdd:cd02897 158 ERPVVEKALSCLEAALDSISD-----PYTLALAAYALTLAGSE-KRPEALKKLDELAISEDGTKHWSRPPPSEE------ 225
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672051179 1201 SFSYKPRAPSAEVEMTAYVLLAYLTsassrptrdLSSSDLTTASKIVKWISKQQNSHGGFSSTQDTVVALQALSKY 1276
Cdd:cd02897 226 GPSYYWQAPSAEVEMTAYALLALLS---------AGGEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
952-1276 |
1.11e-148 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 455.22 E-value: 1.11e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 952 SVLGDILGSAMQ----NLQNLLQMPYGCGEQNMVLFVPNIYVLEYLNETQQLTEAIKSKAISYLISGYQRQLNYQHSDGS 1027
Cdd:pfam07678 2 SVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDGS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1028 YSTFGdrgmrHSQGNTWLTAFVLKAFAQAQSYIYIEKTHITNAFNWLSMKQRENGCFQQSGSLLNNAMKGGVDDEVTLSA 1107
Cdd:pfam07678 82 YSAFG-----HSPGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1108 YITIALLEM-----PLPVTHSVVRNALFCLETAwasiSNSQESHVYTKALLAYAFALAGNRAKRSEVLESLNKDAVNEEE 1182
Cdd:pfam07678 157 YVTIALLEAldingLLQRVHPSIRKALTYLEQA----QLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEGN 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1183 SVHWQRPknveENVREMRSFSYKPRAPSAEVEMTAYVLLAYltsassrptrdLSSSDLTTASKIVKWISKQQNSHGGFSS 1262
Cdd:pfam07678 233 SRYWERD----EKSDPQGVPEYPPQAPSLEVETTAYALLAY-----------LLLGDLTYADPIVKWLTSQRNSHGGFSS 297
|
330
....*....|....
gi 672051179 1263 TQDTVVALQALSKY 1276
Cdd:pfam07678 298 TQDTVVALQALAEY 311
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
127-1395 |
1.06e-37 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 155.24 E-value: 1.06e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 127 VFVQTDKPIYKPGQTVKFRVVSVDISFRPVNETfPV-VYIENPKRNRIFQWQNVDLPGGLHQLSFPLSVEPALGIYKVVV 205
Cdd:COG2373 371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLEL 449
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 206 QKDSGKKI-EHSFEVKEYVLPKFEVQVKMPKTMAFLEEELVVTACGLYTYGKPVPGL-----VTMKVCRKYTQSYSNCH- 278
Cdd:COG2373 450 YVDPKPALgSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGLkvegeVTLRPARTAFPGYPGYRf 529
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 279 GQHSKSICEEFSKQA----DEKGCFRQVVKTKvfQPRQKGYDMKIEVEAKIKEDGtGIELTGTGSCEI--ANTLSKLKFT 352
Cdd:COG2373 530 GDPDEEFEPEELDLGegtlDADGKASLSLPLP--DAPDAPGPLRATVEASVFESG-GRPVTRSATVPVhpADFYVGIRLP 606
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 353 KANTFYRPG-LPFfgQVLLVDEKGQPIPNKNLTVQVNSVRSQFTFTTDEHGLAN-------ILIDTTNFT--------FS 416
Cdd:COG2373 607 LFDGDPEGApATF--EVVAVDPDGKPVAGKGLKVELYREEWRYVWYKSDDGGWRyesqekeEPVAEGTLTtgadgpasLS 684
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 417 FM----G---IRVIYKQNNICfdnwwvdeyhTQADHSAARIFSPSRSYI-QLELVLG--TLACGQTQEIRIhfllnedal 486
Cdd:COG2373 685 LTpvewGryrLEVKDPDGGLA----------TSVRFYAGGNASWGAERPdRLELSLDkeSYKPGETAKLLI--------- 745
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 487 kdakdlTFYYliKARGSIFNSGSHVLPLEQGKVKG---VVSFPirVEPGMAPVAKLIVYTILPNEELIAD-------VQK 556
Cdd:COG2373 746 ------QSPF--AGRALVTVERDGVLETQWVDVKGggtTVEIP--VTEDWAPNAYVSATLVRPGDSTANDmparaygVAP 815
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 557 FDIEKCfANTVNLSF-PSAQSLPASDTHLTVKATPLSLCA----LTAVDQSVLLLKPeaklspqsiynllpqkaeqgayl 631
Cdd:COG2373 816 LPVDPP-ARRLKVELtAPEKLRPGETLTVTVKVKGAAGKAaevtLAAVDEGILNLTG----------------------- 871
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 632 gplpYKggencikaedithngivyTPkqdlndnDAYSVF---QSIGLKIftntrvhkprycpmYQAYPPLpyVGGAGYRS 708
Cdd:COG2373 872 ----YK------------------TP-------DPLDFFygkRALGVET--------------RDLYGRL--IGAFGGAA 906
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 709 SNIRTSSMMMMGASEVAqevevrETVRKYFPETWIWD-MVPLDLSGDGELPVKVPDTITEWKASAFCLSGT-TGLGLSST 786
Cdd:COG2373 907 GALRSGGDGALGRGGNP------KPPRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRVMAVAWSDDrFGSAEATV 980
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 787 ISHKvfqPFFLELTLPYSVVRGEAFILKATVLNYMPHCIRIHVSLEMSPDFlaVPVGSHEDSHCICGNERKTVSWAVTPK 866
Cdd:COG2373 981 TVRK---PLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGL--TLEGEATQTVTLAAGGRATVRFPLKAP 1055
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 867 SLGEVNFTATAEAlqspelcGNKVAEVpalvQKDTVVKPvivePEGIEKEQTYNTLlcpqdaELQENWTL--DLPANVVE 944
Cdd:COG2373 1056 DAGDAKVTVTATG-------GGESDAR----EVELPVRP----ANPLVTRATSGVL------APGESWTLplDLPGGLRP 1114
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 945 GSARATQSVLGDILGSAMQNLQNLLQMPYGCGEQNMVLFVPNIYVLEyLNETQQLTEAIKSKAISYLISGYQRQLNYQHS 1024
Cdd:COG2373 1115 GTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIARLLSMQNS 1193
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1025 DGSYSTFGdrgmRHSQGNTWLTAFVLKAF--AQAQSYIyIEKTHITNAFNWLSMKQRENGcfqqsgsllnnAMKGGVDDE 1102
Cdd:COG2373 1194 DGGFGLWP----GGSESDPWLTAYATDFLleAREAGYA-VPDDALDRALDYLRNYLRNPW-----------EIEYDDAYR 1257
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1103 VTLSAYITIALLEMPLPVTHSVvrNALFCLETAWASisnsqeshVYTKALLAYAFALAGNRAKRSEVLESLNKDAVNEEE 1182
Cdd:COG2373 1258 LAVRAYALYVLARAGKADLGDL--RYLYDRRKDALS--------PLAKAQLAAALALLGDKARAEELLAAALARLRETGA 1327
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1183 SVHWqrpknveenvremrSFSYkprapSAEVEMTAYVLLAYLTSASSRPTRDlsssdlttasKIVKWISKQQNShGGFSS 1262
Cdd:COG2373 1328 RDYW--------------YGDY-----GSPLRDQALALALLAELGPDAPLAP----------KLARWLAKALKS-GRWLS 1377
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1263 TQDTVVALQALSKYGAAtfTKSNKEVSVTIESSGTvsgTLHVNNGNRLLLQEVRLADLPGNYIT-KVSGSGCVYLQTSLK 1341
Cdd:COG2373 1378 TQETAWALLALAAYARA--AGASPDFTATLTLDGK---TLPLTGRGPLARVTLPAAELLAGPLTiTNTGDGPLYYTLTLS 1452
|
1290 1300 1310 1320 1330 1340
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672051179 1342 Y--NILPEAEGEAPFTLKVNTLPLNFDKAEHHR-----KFQIHINVSYIGERPNsNMVIVD 1395
Cdd:COG2373 1453 GypAEGPPPAASNGLEIERRYYDLDGKPIDPASlkqgdLVVVRLTVTAPSGRVE-NVAVVD 1512
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
741-831 |
2.29e-36 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 132.71 E-value: 2.29e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 741 TWIWDMVPLDLSGDGELPVKVPDTITEWKASAFCLSGTTGLGLSSTISHKVFQPFFLELTLPYSVVRGEAFILKATVLNY 820
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 672051179 821 MPHCIRIHVSL 831
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1387-1477 |
4.49e-36 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 131.92 E-value: 4.49e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1387 PNSNMVIVDVKMVSGFIPVKPSVKKLQDQSNIQRTEVNT-NHVLIYIEKLTNQTMGFSFAVEQDIPVKNLKPAPVKVYDY 1465
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVETVDdGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 672051179 1466 YETDEFAIEEYS 1477
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| A2M_2 |
cd02897 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy ... |
961-1276 |
7.15e-149 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production contributing to fetal survival. It has been suggested that thioester bond cleavage promotes the binding of PZ and alpha (2)-M to the CD91 receptor clearing them from circulation.
Pssm-ID: 239227 Cd Length: 292 Bit Score: 454.73 E-value: 7.15e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 961 AMQNLQNLLQMPYGCGEQNMVLFVPNIYVLEYLNETQQLTEAIKSKAISYLISGYQRQLNYQHSDGSYSTFGDRgmrHSQ 1040
Cdd:cd02897 1 ALQNLDNLLRMPYGCGEQNMVNFAPNIYVLDYLKATGQLTPEIESKALGFLRTGYQRQLTYKHSDGSYSAFGES---DKS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1041 GNTWLTAFVLKAFAQAQSYIYIEKTHITNAFNWLSMKQRENGCFQQSGSLLNNAMKGGVDDEVTLSAYITIALLEMPLPV 1120
Cdd:cd02897 78 GSTWLTAFVLKSFAQARPFIYIDENVLQQALTWLSSHQKSNGCFREVGRVFHKAMQGGVDDEVALTAYVLIALLEAGLPS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1121 THSVVRNALFCLETAWASISNsqeshVYTKALLAYAFALAGNRaKRSEVLESLNKDAVNEEESVHWQRPKNVEEnvremr 1200
Cdd:cd02897 158 ERPVVEKALSCLEAALDSISD-----PYTLALAAYALTLAGSE-KRPEALKKLDELAISEDGTKHWSRPPPSEE------ 225
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672051179 1201 SFSYKPRAPSAEVEMTAYVLLAYLTsassrptrdLSSSDLTTASKIVKWISKQQNSHGGFSSTQDTVVALQALSKY 1276
Cdd:cd02897 226 GPSYYWQAPSAEVEMTAYALLALLS---------AGGEDLAEALPIVKWLAKQRNSLGGFSSTQDTVVALQALAKY 292
|
|
| TED_complement |
pfam07678 |
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement ... |
952-1276 |
1.11e-148 |
|
A-macroglobulin TED domain; This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved.
Pssm-ID: 462227 [Multi-domain] Cd Length: 311 Bit Score: 455.22 E-value: 1.11e-148
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 952 SVLGDILGSAMQ----NLQNLLQMPYGCGEQNMVLFVPNIYVLEYLNETQQLTEAIKSKAISYLISGYQRQLNYQHSDGS 1027
Cdd:pfam07678 2 SVVGDIMGPAIQvvpeNLSSLLRLPYGCGEQNMVLFAPNVYVLRYLDKTNQLTKLIKSKAIDYLEQGYQRQLSYKHPDGS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1028 YSTFGdrgmrHSQGNTWLTAFVLKAFAQAQSYIYIEKTHITNAFNWLSMKQRENGCFQQSGSLLNNAMKGGVDDEVTLSA 1107
Cdd:pfam07678 82 YSAFG-----HSPGSTWLTAFVLKVFAQARKFIFIDPEEICQSLRWLLSQQKPDGSFREPGPLLHRAMKGGVDGEVSLTA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1108 YITIALLEM-----PLPVTHSVVRNALFCLETAwasiSNSQESHVYTKALLAYAFALAGNRAKRSEVLESLNKDAVNEEE 1182
Cdd:pfam07678 157 YVTIALLEAldingLLQRVHPSIRKALTYLEQA----QLAGLTSPYTLAILAYALALAGSPETREELLKSLDAMAREEGN 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1183 SVHWQRPknveENVREMRSFSYKPRAPSAEVEMTAYVLLAYltsassrptrdLSSSDLTTASKIVKWISKQQNSHGGFSS 1262
Cdd:pfam07678 233 SRYWERD----EKSDPQGVPEYPPQAPSLEVETTAYALLAY-----------LLLGDLTYADPIVKWLTSQRNSHGGFSS 297
|
330
....*....|....
gi 672051179 1263 TQDTVVALQALSKY 1276
Cdd:pfam07678 298 TQDTVVALQALAEY 311
|
|
| A2M_like |
cd02891 |
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier ... |
961-1276 |
7.06e-103 |
|
Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of proteases. This group contains another broadly specific proteinase inhibitor: pregnancy zone protein (PZP). PZP is a trace protein in the plasma of non-pregnant females and males which is elevated in pregnancy. Alpha (2)-M and PZ bind to placental protein-14 and may modulate its activity in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system. This group also contains C3, C4 and C5 of vertebrate complement. The vertebrate complement is an effector of both the acquired and innate immune systems The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239221 [Multi-domain] Cd Length: 282 Bit Score: 329.73 E-value: 7.06e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 961 AMQNLQNLLQMPYGCGEQNMVLFVPNIYVLEYLNETQQLTEAIKSKAISYLISGYQRQLNYQHSDGSYSTFGDRgmrhSQ 1040
Cdd:cd02891 1 SLGNLDYLLRYPYGCGEQTMSRAAPNLYVLKYLDATGQLTPEIREKALEYIRKGYQRLLTYQRSDGSFSAWGNS----DS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1041 GNTWLTAFVLKAFAQAQSYIYIEKTHITNAFNWLSMKQRENGCFQQSGSLLNNAMKGGVDDEVTLSAYITIALLEMPLPV 1120
Cdd:cd02891 77 GSTWLTAYVVKFLSQARKYIDVDENVLARALGWLVPQQKEDGSFRELGPVIHREMKGGVDDSVSLTAYVLIALAEAGKAC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1121 tHSVVRNALFCLETAWASISNsqeshVYTKALLAYAFALAGNRAKRSEVLESLNKDAVNEEESVHWQRPknveenvremr 1200
Cdd:cd02891 157 -DASIEKALAYLETQLDGLLD-----PYALAILAYALALAGDSTRADEALKKLLEAAREKGGTAHWSLS----------- 219
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672051179 1201 sfSYKPRAPSAEVEMTAYVLLAYltsassrptrdLSSSDLTTASKIVKWISKQQNSHGGFSSTQDTVVALQALSKY 1276
Cdd:cd02891 220 --WPGDYGSSLRVEATAYALLAL-----------LKLGDLEEAGPIAKWLAQQRNSGGGFLSTQDTVVALQALAAY 282
|
|
| complement_C3_C4_C5 |
cd02896 |
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, ... |
964-1276 |
3.50e-73 |
|
Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the classical, alternative and lectin pathways of the complement system is the proteolytic activation of C3. C4 plays a key role in propagating the classical and lectin pathways. C5 participates in the classical and alternative pathways. The thioester bond located within the structure of C3 and C4 is central to the function of complement. C5 does not contain an active thioester bond.
Pssm-ID: 239226 [Multi-domain] Cd Length: 297 Bit Score: 246.42 E-value: 3.50e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 964 NLQNLLQMPYGCGEQNMVLFVPNIYVLEYLNETQQ---LTEAIKSKAISYLISGYQRQLNYQHSDGSYSTFGDRGmrhsq 1040
Cdd:cd02896 4 GLEKLIRLPTGCGEQTMIKLAPTVYALRYLDTTNQwekLGPERRDEALKYIRQGYQRQLSYRKPDGSYAAWKNRP----- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1041 GNTWLTAFVLKAFAQAQSYIYIEKTHITNAFNWLSMKQRENGCFQQSGSLLNNAMKGGV---DDEVTLSAYITIALLEmP 1117
Cdd:cd02896 79 SSTWLTAFVVKVFSLARKYIPVDQNVICGSVNWLISNQKPDGSFQEPSPVIHREMTGGVegsEGDVSLTAFVLIALQE-A 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1118 LPVTHSVVRNALFCLETAWASISNSQES--HVYTKALLAYAFALAGNRAKrSEVLESLNKDAVNEEESVHWQRPKNveen 1195
Cdd:cd02896 158 RSICPPEVQNLDQSIRKAISYLENQLPNlqRPYALAITAYALALADSPLS-HAANRKLLSLAKRDGNGWYWWTIDS---- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1196 vremrSFSYKPRAPSAEVEMTAYVLLAYltsassrptrdLSSSDLTTASKIVKWISKQQNSHGGFSSTQDTVVALQALSK 1275
Cdd:cd02896 233 -----PYWPVPGPSAITVETTAYALLAL-----------LKLGDIEYANPIARWLTEQRNYGGGFGSTQDTVVALQALAE 296
|
.
gi 672051179 1276 Y 1276
Cdd:cd02896 297 Y 297
|
|
| ISOPREN_C2_like |
cd00688 |
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two ... |
961-1276 |
3.76e-60 |
|
This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate complement. Class II terpene cyclases include squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY), these integral membrane proteins catalyze a cationic cyclization cascade converting linear triterpenes to fused ring compounds. The protein prenyltransferases include protein farnesyltransferase (FTase) and geranylgeranyltransferase types I and II (GGTase-I and GGTase-II) which catalyze the carboxyl-terminal lipidation of Ras, Rab, and several other cellular signal transduction proteins, facilitating membrane associations and specific protein-protein interactions. Alpha (2)-M is a major carrier protein in serum and involved in the immobilization and entrapment of proteases. PZP is a pregnancy associated protein. Alpha (2)-M and PZP are known to bind to and, may modulate, the activity of placental protein-14 in T-cell growth and cytokine production thereby protecting the allogeneic fetus from attack by the maternal immune system.
Pssm-ID: 238362 [Multi-domain] Cd Length: 300 Bit Score: 208.94 E-value: 3.76e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 961 AMQNLQNLLQMPYG--------CGEQNMVLFVPNIYVLEYLNETQqlteaIKSKAISYLISGYQRQLNYQHSDGSYSTFG 1032
Cdd:cd00688 1 IEKHLKYLLRYPYGdghwyqslCGEQTWSTAWPLLALLLLLAATG-----IRDKADENIEKGIQRLLSYQLSDGGFSGWG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1033 drgmRHSQGNTWLTAFVLKAFAQAQSYIYIEKTHITNAFNWLSMKQRENGCFQQSGSLLNNAMkgGVDDEVTLSAYITIA 1112
Cdd:cd00688 76 ----GNDYPSLWLTAYALKALLLAGDYIAVDRIDLARALNWLLSLQNEDGGFREDGPGNHRIG--GDESDVRLTAYALIA 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1113 LLEMPLPVTHSVVRNALFCLETAWA---SISNSQESHVYTKALLAYAFALAG--NRAKRSEVLESLNKDAVNEEESVHWQ 1187
Cdd:cd00688 150 LALLGKLDPDPLIEKALDYLLSCQNydgGFGPGGESHGYGTACAAAALALLGdlDSPDAKKALRWLLSRQRPDGGWGEGR 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1188 RPKNveenvremrsfsykPRAPSAEVEMTAYVLLAYltsassrptrdLSSSDLTTASKIVKWISKQQNSHGGFSS----- 1262
Cdd:cd00688 230 DRTN--------------KLSDSCYTEWAAYALLAL-----------GKLGDLEDAEKLVKWLLSQQNEDGGFSSkpgks 284
|
330
....*....|....*.
gi 672051179 1263 --TQDTVVALQALSKY 1276
Cdd:cd00688 285 ydTQHTVFALLALSLY 300
|
|
| YfaS |
COG2373 |
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function ... |
127-1395 |
1.06e-37 |
|
Uncharacterized conserved protein YfaS, alpha-2-macroglobulin family [General function prediction only];
Pssm-ID: 441940 [Multi-domain] Cd Length: 1605 Bit Score: 155.24 E-value: 1.06e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 127 VFVQTDKPIYKPGQTVKFRVVSVDISFRPVNETfPV-VYIENPKRNRIFQWQNVDLPGGLHQLSFPLSVEPALGIYKVVV 205
Cdd:COG2373 371 AFLFTDRGIYRPGETVHLKALLRDADGKAPAGL-PLtLELTDPDGKEVRRQTLTLNEFGGYSFSFPLPEDAPTGTWRLEL 449
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 206 QKDSGKKI-EHSFEVKEYVLPKFEVQVKMPKTMAFLEEELVVTACGLYTYGKPVPGL-----VTMKVCRKYTQSYSNCH- 278
Cdd:COG2373 450 YVDPKPALgSKSFRVEEFKPPRFKVDLTLDKEPLKPGDPVTVTVDARYLFGAPAAGLkvegeVTLRPARTAFPGYPGYRf 529
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 279 GQHSKSICEEFSKQA----DEKGCFRQVVKTKvfQPRQKGYDMKIEVEAKIKEDGtGIELTGTGSCEI--ANTLSKLKFT 352
Cdd:COG2373 530 GDPDEEFEPEELDLGegtlDADGKASLSLPLP--DAPDAPGPLRATVEASVFESG-GRPVTRSATVPVhpADFYVGIRLP 606
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 353 KANTFYRPG-LPFfgQVLLVDEKGQPIPNKNLTVQVNSVRSQFTFTTDEHGLAN-------ILIDTTNFT--------FS 416
Cdd:COG2373 607 LFDGDPEGApATF--EVVAVDPDGKPVAGKGLKVELYREEWRYVWYKSDDGGWRyesqekeEPVAEGTLTtgadgpasLS 684
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 417 FM----G---IRVIYKQNNICfdnwwvdeyhTQADHSAARIFSPSRSYI-QLELVLG--TLACGQTQEIRIhfllnedal 486
Cdd:COG2373 685 LTpvewGryrLEVKDPDGGLA----------TSVRFYAGGNASWGAERPdRLELSLDkeSYKPGETAKLLI--------- 745
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 487 kdakdlTFYYliKARGSIFNSGSHVLPLEQGKVKG---VVSFPirVEPGMAPVAKLIVYTILPNEELIAD-------VQK 556
Cdd:COG2373 746 ------QSPF--AGRALVTVERDGVLETQWVDVKGggtTVEIP--VTEDWAPNAYVSATLVRPGDSTANDmparaygVAP 815
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 557 FDIEKCfANTVNLSF-PSAQSLPASDTHLTVKATPLSLCA----LTAVDQSVLLLKPeaklspqsiynllpqkaeqgayl 631
Cdd:COG2373 816 LPVDPP-ARRLKVELtAPEKLRPGETLTVTVKVKGAAGKAaevtLAAVDEGILNLTG----------------------- 871
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 632 gplpYKggencikaedithngivyTPkqdlndnDAYSVF---QSIGLKIftntrvhkprycpmYQAYPPLpyVGGAGYRS 708
Cdd:COG2373 872 ----YK------------------TP-------DPLDFFygkRALGVET--------------RDLYGRL--IGAFGGAA 906
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 709 SNIRTSSMMMMGASEVAqevevrETVRKYFPETWIWD-MVPLDLSGDGELPVKVPDTITEWKASAFCLSGT-TGLGLSST 786
Cdd:COG2373 907 GALRSGGDGALGRGGNP------KPPRKRFKPVALFSgPVKTDADGKATVSFDLPDFNGTLRVMAVAWSDDrFGSAEATV 980
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 787 ISHKvfqPFFLELTLPYSVVRGEAFILKATVLNYMPHCIRIHVSLEMSPDFlaVPVGSHEDSHCICGNERKTVSWAVTPK 866
Cdd:COG2373 981 TVRK---PLVVRPSLPRFLAPGDRFELPVDVFNLTGKAGTVTVTLEASGGL--TLEGEATQTVTLAAGGRATVRFPLKAP 1055
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 867 SLGEVNFTATAEAlqspelcGNKVAEVpalvQKDTVVKPvivePEGIEKEQTYNTLlcpqdaELQENWTL--DLPANVVE 944
Cdd:COG2373 1056 DAGDAKVTVTATG-------GGESDAR----EVELPVRP----ANPLVTRATSGVL------APGESWTLplDLPGGLRP 1114
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 945 GSARATQSVLGDILGSAMQNLQNLLQMPYGCGEQNMVLFVPNIYVLEyLNETQQLTEAIKSKAISYLISGYQRQLNYQHS 1024
Cdd:COG2373 1115 GTGSLTLSLSSSPPLDLAGLLRYLLRYPYGCTEQTTSRALPLLYLSD-LAEALGLKGDKDAELRARIQAAIARLLSMQNS 1193
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1025 DGSYSTFGdrgmRHSQGNTWLTAFVLKAF--AQAQSYIyIEKTHITNAFNWLSMKQRENGcfqqsgsllnnAMKGGVDDE 1102
Cdd:COG2373 1194 DGGFGLWP----GGSESDPWLTAYATDFLleAREAGYA-VPDDALDRALDYLRNYLRNPW-----------EIEYDDAYR 1257
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1103 VTLSAYITIALLEMPLPVTHSVvrNALFCLETAWASisnsqeshVYTKALLAYAFALAGNRAKRSEVLESLNKDAVNEEE 1182
Cdd:COG2373 1258 LAVRAYALYVLARAGKADLGDL--RYLYDRRKDALS--------PLAKAQLAAALALLGDKARAEELLAAALARLRETGA 1327
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1183 SVHWqrpknveenvremrSFSYkprapSAEVEMTAYVLLAYLTSASSRPTRDlsssdlttasKIVKWISKQQNShGGFSS 1262
Cdd:COG2373 1328 RDYW--------------YGDY-----GSPLRDQALALALLAELGPDAPLAP----------KLARWLAKALKS-GRWLS 1377
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1263 TQDTVVALQALSKYGAAtfTKSNKEVSVTIESSGTvsgTLHVNNGNRLLLQEVRLADLPGNYIT-KVSGSGCVYLQTSLK 1341
Cdd:COG2373 1378 TQETAWALLALAAYARA--AGASPDFTATLTLDGK---TLPLTGRGPLARVTLPAAELLAGPLTiTNTGDGPLYYTLTLS 1452
|
1290 1300 1310 1320 1330 1340
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672051179 1342 Y--NILPEAEGEAPFTLKVNTLPLNFDKAEHHR-----KFQIHINVSYIGERPNsNMVIVD 1395
Cdd:COG2373 1453 GypAEGPPPAASNGLEIERRYYDLDGKPIDPASlkqgdLVVVRLTVTAPSGRVE-NVAVVD 1512
|
|
| A2M |
pfam00207 |
Alpha-2-macroglobulin family; This family includes the C-terminal region of the ... |
741-831 |
2.29e-36 |
|
Alpha-2-macroglobulin family; This family includes the C-terminal region of the alpha-2-macroglobulin family.
Pssm-ID: 459711 [Multi-domain] Cd Length: 91 Bit Score: 132.71 E-value: 2.29e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 741 TWIWDMVPLDLSGDGELPVKVPDTITEWKASAFCLSGTTGLGLSSTISHKVFQPFFLELTLPYSVVRGEAFILKATVLNY 820
Cdd:pfam00207 1 TWLWDPVLVTDNGKASLSFTLPDSITTWRATAFALSPDTGLGVAEPPELVVFKPFFVDLNLPYSVRRGEQFELKATVFNY 80
|
90
....*....|.
gi 672051179 821 MPHCIRIHVSL 831
Cdd:pfam00207 81 LDKCLKVRVRL 91
|
|
| A2M_recep |
pfam07677 |
A-macroglobulin receptor binding domain; This family includes the receptor binding domain ... |
1387-1477 |
4.49e-36 |
|
A-macroglobulin receptor binding domain; This family includes the receptor binding domain region of the alpha-2-macroglobulin family.
Pssm-ID: 462226 Cd Length: 92 Bit Score: 131.92 E-value: 4.49e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 1387 PNSNMVIVDVKMVSGFIPVKPSVKKLQDQSNIQRTEVNT-NHVLIYIEKLTNQTMGFSFAVEQDIPVKNLKPAPVKVYDY 1465
Cdd:pfam07677 1 ESSNMAILEVGLPSGFVPDEEDLKKLGVDPLIKRVETVDdGKVILYLDKLSGEPLCFSFRAEQTFPVANLKPAPVKVYDY 80
|
90
....*....|..
gi 672051179 1466 YETDEFAIEEYS 1477
Cdd:pfam07677 81 YEPERRATTFYS 92
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
458-606 |
3.30e-30 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 117.07 E-value: 3.30e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 458 IQLELVLGTLACGQTQEIRIHFLLNEDALKDakdlTFYYLIKARGSIFNSGSHvlpleqgkvKGVVSFPIRVEPGMAPVA 537
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKSPFDGTVERD----GFTYLVLSKGQIVVVGRG---------GVTTSFSLPVTAEMAPSA 67
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672051179 538 KLIVYTI---LPNEELIADVQKFDIEKCFANTVNLSFPSAQSLPASDTHLTVKATPLSLCALTAVDQSVLLL 606
Cdd:pfam07703 68 RVVAYYVrvdLSKPEVVADSVWVDVDDTCENKLKVTLSAEKYRPGSTVELKVKADPGAYVALAAVDKGVLLL 139
|
|
| MG4 |
pfam17789 |
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins. |
349-443 |
5.15e-29 |
|
Macroglobulin domain MG4; This domain is MG4 found in complement C3 and C5 proteins.
Pssm-ID: 465507 Cd Length: 95 Bit Score: 111.96 E-value: 5.15e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 349 LKFTKANTFYRPGLPFFGQVLLVDEKGQPIPNKNLTVQVNSVRSQFTFTTDEHGLANILIDTTNFTFSFmGIRVIYKQNN 428
Cdd:pfam17789 1 ITFEKTPKYFKPGLPFSGQVLVVDPDGSPAPNVPVFIEAGNTEFNQNLTTDEDGTAQFSINTPGNAASL-SITVKTKDPD 79
|
90
....*....|....*
gi 672051179 429 ICFDNWWVDEYHTQA 443
Cdd:pfam17789 80 LCPEHQALAEMYAEA 94
|
|
| MG2 |
pfam01835 |
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. ... |
127-219 |
2.88e-27 |
|
MG2 domain; This is the MG2 (macroglobulin) domain of alpha-2-macroglobulin in eukaryotes. Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain is termed macroglobulin-like (MG) domain 2 and in Salmonella enterica ser A2Ms, this is domain 4.
Pssm-ID: 426464 [Multi-domain] Cd Length: 95 Bit Score: 107.02 E-value: 2.88e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 127 VFVQTDKPIYKPGQTVKFRVVSVDISFRPVNETFPVVYIENPKRNRIFQWQNVDLPGGLHQLSFPLSVEPALGIYKVVVQ 206
Cdd:pfam01835 2 AFVYTDRGIYRPGETVHFKGLLRDQDLRPLAGLPVTLTVTDPDGNEVRRLPLTTDEFGGFSGSFPLPETAPTGTYTVVLR 81
|
90
....*....|....
gi 672051179 207 K-DSGKKIEHSFEV 219
Cdd:pfam01835 82 DgAGGSLGSGSFRV 95
|
|
| MG3 |
pfam17791 |
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement ... |
221-309 |
5.12e-23 |
|
Macroglobulin domain MG3; This entry corresponds to the MG3 domain found in complement components C3, C4 and C5.
Pssm-ID: 465509 Cd Length: 83 Bit Score: 94.26 E-value: 5.12e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 221 EYVLPKFEVQVKMPKTMAFLEEELVVTACGLYTYGKPVPGLVTMKVCRKYTqsysnchgqhSKSIC-EEFSKQADEKGCF 299
Cdd:pfam17791 1 EYVLPKFEVKVEVPKFISVKDEEFQVTICAKYTYGKPVKGKAYVTLCLKDD----------SKRKCfESFSKELDKDGCG 70
|
90
....*....|
gi 672051179 300 RQVVKTKVFQ 309
Cdd:pfam17791 71 SASLSTEEFQ 80
|
|
| A2M_BRD |
pfam07703 |
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins ... |
127-237 |
8.20e-03 |
|
Alpha-2-macroglobulin bait region domain; Alpha-2-macroglobulins (A2Ms) are plasma proteins that trap and inhibit a broad range of proteases and are major components of the eukaryotic innate immune system. However, A2M-like proteins were identified in pathogenically invasive bacteria and species that colonize higher eukaryotes. This domain is found in eukaryotic and bacterial proteins. In human A2Ms, this domain encompasses macroglobulin-like domain MG5 and 6 including bait region. In Salmonella enterica ser A2Ms, this domain encompasses MG7 and MG8 including the bait region. The Bait region is cleaved by proteases, followed by a large conformational change that blocks the target protease within a cage-like complex. This model of protease entrapment is recognized as the Venus flytrap mechanism.
Pssm-ID: 462235 [Multi-domain] Cd Length: 139 Bit Score: 38.48 E-value: 8.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672051179 127 VFVQTDKPIYKPGQTVKFRVVSvdisfrpvneTFPVVYIENPKRNRIFQWQNVDLPGGL-HQLSFPLSVEPAL------- 198
Cdd:pfam07703 1 LHLSTDKTEYKPGETATVTVKS----------PFDGTVERDGFTYLVLSKGQIVVVGRGgVTTSFSLPVTAEMapsarvv 70
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 672051179 199 ---------------GIYKVVVQKDSGKKIEHSFEVKEYvLP--KFEVQVKMPKTM 237
Cdd:pfam07703 71 ayyvrvdlskpevvaDSVWVDVDDTCENKLKVTLSAEKY-RPgsTVELKVKADPGA 125
|
|
| |
