|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
61-306 |
1.28e-30 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 125.05 E-value: 1.28e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 61 LDLQGNMLKVIPPAAFQDLPYLTHLDLQHCQveqvaegAFRGLGRLLFLNLASNRLSSLPqEALDGLGSLRRLELERNML 140
Cdd:COG4886 77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQL 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 141 EELrPGTFGALGSLATLNLAHNALVYLPAmAFQGLMRTRWLQLSHNALSVLaPEALAGLPVLRRLSLHHNELQALPgAAL 220
Cdd:COG4886 149 TDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLP-EPL 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 221 SQARSLARLELGHNPLTytgeedglALPGLRELaldhgslqalgprafahcPRLHTLDLRGNQLTTLPPLQVPGQLRRLR 300
Cdd:COG4886 225 ANLTNLETLDLSNNQLT--------DLPELGNL------------------TNLEELDLSNNQLTDLPPLANLTNLKTLD 278
|
....*.
gi 672060401 301 LQGNPL 306
Cdd:COG4886 279 LSNNQL 284
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
418-638 |
1.82e-27 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 115.80 E-value: 1.82e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 418 LDLRRNHFPSVPrAAFPGLRHLVSLHLQHCGIAELePGALAGLDGLVYLYLSNNQLSGLSaAALEGAPNLGYLYLEHNRF 497
Cdd:COG4886 118 LDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQI 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 498 LRIPgAALRALPRLFSLHLQDNAVDRLaPGDLAGARALRGLYLSGNHITQVSpgALGPARELEKLHLDRNQLRQVPTgaL 577
Cdd:COG4886 195 TDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--L 268
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672060401 578 EGLPALKELQLSRNPFRALHDGAFQPVGRSLQQLFLNSSDLEQISPRAFSGLGKGLQGLYL 638
Cdd:COG4886 269 ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
436-593 |
1.93e-16 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 79.06 E-value: 1.93e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 436 LRHLVSLHLQHCGIAELEpgALAGLDGLVYLYLSNNQLSGLSAaaLEGAPNLGYLYLEHNRFLRIPGaaLRALPRLFSLH 515
Cdd:cd21340 1 LKRITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 516 LQDNAV-------------------DRLAPGD---------LAGARALRGLYLSGNHITQVSPgaLGPARELEKLHLDRN 567
Cdd:cd21340 75 LGGNRIsvveglenltnleelhienQRLPPGEkltfdprslAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNN 152
|
170 180
....*....|....*....|....*...
gi 672060401 568 QLRQVP--TGALEGLPALKELQLSRNPF 593
Cdd:cd21340 153 QISDLEelLDLLSSWPSLRELDLTGNPV 180
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
20-545 |
5.65e-15 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 79.12 E-value: 5.65e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 20 WNVAAQRCP-QTCVCDNSRRHVTcqhqnltevpdtipeltqrLDLQG-NMLKVIPPAAFQdLPYLTHLDLQHCQVE-QVA 96
Cdd:PLN00113 51 WNSSADVCLwQGITCNNSSRVVS-------------------IDLSGkNISGKISSAIFR-LPYIQTINLSNNQLSgPIP 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 97 EGAFRGLGRLLFLNLASNRLS-SLPQ------EALD---------------GLGSLRRLELERNMLEELRPGTFGALGSL 154
Cdd:PLN00113 111 DDIFTTSSSLRYLNLSNNNFTgSIPRgsipnlETLDlsnnmlsgeipndigSFSSLKVLDLGGNVLVGKIPNSLTNLTSL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 155 ATLNLAHNALV-YLPAMAfqGLMRT-RWLQLSHNALSVLAPEALAGLPVLRRLSLHHNELQALPGAALSQARSLARLELG 232
Cdd:PLN00113 191 EFLTLASNQLVgQIPREL--GQMKSlKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLY 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 233 HNPLT----------------------YTGE--EDGLALPGLRELALDHGSLQALGPRAFAHCPRLHTLDLRGNQLTTLP 288
Cdd:PLN00113 269 QNKLSgpippsifslqklisldlsdnsLSGEipELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEI 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 289 PLQVPGQ--LRRLRLQGNPLW-----CACHARPLLEWLVRARV------RSDGACRGPRRLR--GETLDTLRPSDL-RCP 352
Cdd:PLN00113 349 PKNLGKHnnLTVLDLSTNNLTgeipeGLCSSGNLFKLILFSNSlegeipKSLGACRSLRRVRlqDNSFSGELPSEFtKLP 428
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 353 GDAAEDEDEDRPAGPRspprslhEEARWATPcppacvcvgetrhsacdgrglqavprgfpnDTQLLDLRRNHF-PSVPRa 431
Cdd:PLN00113 429 LVYFLDISNNNLQGRI-------NSRKWDMP------------------------------SLQMLSLARNKFfGGLPD- 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 432 aFPGLRHLVSLHLQHCGIAELEPGALAGLDGLVYLYLSNNQLSGLSAAALEGAPNLGYLYLEHNRFL-RIPgAALRALPR 510
Cdd:PLN00113 471 -SFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIP-ASFSEMPV 548
|
570 580 590
....*....|....*....|....*....|....*
gi 672060401 511 LFSLHLQDNAVDRLAPGDLAGARALRGLYLSGNHI 545
Cdd:PLN00113 549 LSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
39-216 |
1.18e-13 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 70.59 E-value: 1.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 39 HVTCQHQNLTEVPDTI--PELTQrLDLQGNMLKVIPpaAFQDLPYLTHLDLQHCQVEQVaEGaFRGLGRLLFLNLASNRL 116
Cdd:cd21340 6 HLYLNDKNITKIDNLSlcKNLKV-LYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKI-EN-LENLVNLKKLYLGGNRI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 117 SSLpqEALDGLGSLRRLELERNMLEE-----LRPGTFGALG-SLATLNLAHNALVYLpaMAFQGLMRTRWLQLSHNALSV 190
Cdd:cd21340 81 SVV--EGLENLTNLEELHIENQRLPPgekltFDPRSLAALSnSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISD 156
|
170 180
....*....|....*....|....*...
gi 672060401 191 LAP--EALAGLPVLRRLSLHHNELQALP 216
Cdd:cd21340 157 LEEllDLLSSWPSLRELDLTGNPVCKKP 184
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
437-497 |
7.02e-12 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 61.00 E-value: 7.02e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672060401 437 RHLVSLHLQHCGIAELEPGALAGLDGLVYLYLSNNQLSGLSAAALEGAPNLGYLYLEHNRF 497
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
153-212 |
7.62e-11 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 57.92 E-value: 7.62e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 153 SLATLNLAHNALVYLPAMAFQGLMRTRWLQLSHNALSVLAPEALAGLPVLRRLSLHHNEL 212
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
404-630 |
7.06e-10 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 62.41 E-value: 7.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 404 LQAVPRGFPNDTQLLDLRRNHFPSVPRAAFPGLRHLVSLHLQHCGIAELEPgalaglDGLVYLYLSNNQLSGLSAAALEG 483
Cdd:PRK15370 232 LTSIPATLPDTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLP------EELRYLSVYDNSIRTLPAHLPSG 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 484 apnLGYLYLEHNRFLRIPgAALRalPRLFSLHLQDNAVDRLaPGDLagARALRGLYLSGNHITqVSPGALGPAreLEKLH 563
Cdd:PRK15370 306 ---ITHLNVQSNSLTALP-ETLP--PGLKTLEAGENALTSL-PASL--PPELQVLDVSKNQIT-VLPETLPPT--ITTLD 373
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 564 LDRNQLRQVPtgalEGLP-ALKELQLSRN------------------PFRALHDgaFQPVG-RSLQ--QLFLNSSDLEqi 621
Cdd:PRK15370 374 VSRNALTNLP----ENLPaALQIMQASRNnlvrlpeslphfrgegpqPTRIIVE--YNPFSeRTIQnmQRLMSSVGYQ-- 445
|
....*....
gi 672060401 622 SPRAFSGLG 630
Cdd:PRK15370 446 GPRVLFAMG 454
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
663-711 |
1.71e-07 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 48.20 E-value: 1.71e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 672060401 663 NPFHCDCQLLPLHRWLTG---LNLRVGATCATPPSVRGQkVKAAASVFEACP 711
Cdd:smart00082 1 NPFICDCELRWLLRWLQAnehLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
638-698 |
1.85e-07 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 55.09 E-value: 1.85e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672060401 638 LQQNQLQSLPAPMW--LSGLELIDLSGNPFHCDCQLLPLHRWLTGLNLRV----GATCATPPSVRGQ 698
Cdd:TIGR00864 2 ISNNKISTIEEGICanLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpeAALCAGPGALAGQ 68
|
|
| LRRNT |
smart00013 |
Leucine rich repeat N-terminal domain; |
383-417 |
7.58e-06 |
|
Leucine rich repeat N-terminal domain;
Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 43.08 E-value: 7.58e-06
10 20 30
....*....|....*....|....*....|....*
gi 672060401 383 PCPPACVCVGetRHSACDGRGLQAVPRGFPNDTQL 417
Cdd:smart00013 1 ACPAPCNCSG--TAVDCSGRGLTEVPLDLPPDTTL 33
|
|
| LRRNT |
pfam01462 |
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ... |
383-412 |
4.67e-04 |
|
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.
Pssm-ID: 396168 [Multi-domain] Cd Length: 28 Bit Score: 37.99 E-value: 4.67e-04
10 20 30
....*....|....*....|....*....|
gi 672060401 383 PCPPACVCVGetRHSACDGRGLQAVPRGFP 412
Cdd:pfam01462 1 ACPVPCHCSA--TVVNCSDRGLTAVPRDLP 28
|
|
| LRRNT |
smart00013 |
Leucine rich repeat N-terminal domain; |
27-59 |
4.83e-04 |
|
Leucine rich repeat N-terminal domain;
Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 38.07 E-value: 4.83e-04
10 20 30
....*....|....*....|....*....|...
gi 672060401 27 CPQTCVCdnSRRHVTCQHQNLTEVPDTIPELTQ 59
Cdd:smart00013 2 CPAPCNC--SGTAVDCSGRGLTEVPLDLPPDTT 32
|
|
| LRRNT |
pfam01462 |
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ... |
27-55 |
1.78e-03 |
|
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.
Pssm-ID: 396168 [Multi-domain] Cd Length: 28 Bit Score: 36.45 E-value: 1.78e-03
10 20
....*....|....*....|....*....
gi 672060401 27 CPQTCVCdnSRRHVTCQHQNLTEVPDTIP 55
Cdd:pfam01462 2 CPVPCHC--SATVVNCSDRGLTAVPRDLP 28
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
61-306 |
1.28e-30 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 125.05 E-value: 1.28e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 61 LDLQGNMLKVIPPAAFQDLPYLTHLDLQHCQveqvaegAFRGLGRLLFLNLASNRLSSLPqEALDGLGSLRRLELERNML 140
Cdd:COG4886 77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQL 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 141 EELrPGTFGALGSLATLNLAHNALVYLPAmAFQGLMRTRWLQLSHNALSVLaPEALAGLPVLRRLSLHHNELQALPgAAL 220
Cdd:COG4886 149 TDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLP-EPL 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 221 SQARSLARLELGHNPLTytgeedglALPGLRELaldhgslqalgprafahcPRLHTLDLRGNQLTTLPPLQVPGQLRRLR 300
Cdd:COG4886 225 ANLTNLETLDLSNNQLT--------DLPELGNL------------------TNLEELDLSNNQLTDLPPLANLTNLKTLD 278
|
....*.
gi 672060401 301 LQGNPL 306
Cdd:COG4886 279 LSNNQL 284
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
418-638 |
1.82e-27 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 115.80 E-value: 1.82e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 418 LDLRRNHFPSVPrAAFPGLRHLVSLHLQHCGIAELePGALAGLDGLVYLYLSNNQLSGLSaAALEGAPNLGYLYLEHNRF 497
Cdd:COG4886 118 LDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQI 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 498 LRIPgAALRALPRLFSLHLQDNAVDRLaPGDLAGARALRGLYLSGNHITQVSpgALGPARELEKLHLDRNQLRQVPTgaL 577
Cdd:COG4886 195 TDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--L 268
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672060401 578 EGLPALKELQLSRNPFRALHDGAFQPVGRSLQQLFLNSSDLEQISPRAFSGLGKGLQGLYL 638
Cdd:COG4886 269 ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
433-665 |
2.04e-26 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 112.72 E-value: 2.04e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 433 FPGLRHLVSLHLQHCGiaelepgALAGLDGLVYLYLSNNQLSGLSAAaLEGAPNLGYLYLEHNRFLRIPgAALRALPRLF 512
Cdd:COG4886 92 LGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLP-EPLGNLTNLK 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 513 SLHLQDNAVDRLaPGDLAGARALRGLYLSGNHITQVsPGALGPARELEKLHLDRNQLRQVPTgALEGLPALKELQLSRNP 592
Cdd:COG4886 163 SLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQ 239
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672060401 593 FRALhdgafqpvgRSLQQLflnssdleqisprafsglgKGLQGLYLQQNQLQSLPAPMWLSGLELIDLSGNPF 665
Cdd:COG4886 240 LTDL---------PELGNL-------------------TNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
38-261 |
5.69e-26 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 111.18 E-value: 5.69e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 38 RHVTCQHQNLTEVPDTIPELT--QRLDLQGNMLKVIPPAaFQDLPYLTHLDLQHCQVEQVAEgAFRGLGRLLFLNLASNR 115
Cdd:COG4886 116 ESLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQ 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 116 LSSLPqEALDGLGSLRRLELERNMLEELrPGTFGALGSLATLNLAHNALVYLPAMAfqGLMRTRWLQLSHNALSVLAPea 195
Cdd:COG4886 194 ITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPELG--NLTNLEELDLSNNQLTDLPP-- 267
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672060401 196 LAGLPVLRRLSLHHNELQALPGAALSQARSLARLELGHNPLTYTGEEDGLALPGLRELALDHGSLQ 261
Cdd:COG4886 268 LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
102-306 |
7.57e-24 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 105.02 E-value: 7.57e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 102 GLGRLLFLNLASNRLSSLPQEALDGLGSLRRLELERNmleelrpGTFGALGSLATLNLAHNALVYLPAmAFQGLMRTRWL 181
Cdd:COG4886 70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKEL 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 182 QLSHNALSVLaPEALAGLPVLRRLSLHHNELQALPgAALSQARSLARLELGHNPLTYTGEEdgLA-LPGLRELALDHGSL 260
Cdd:COG4886 142 DLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPEP--LGnLTNLEELDLSGNQL 217
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 672060401 261 QALgPRAFAHCPRLHTLDLRGNQLTTLPPLQVPGQLRRLRLQGNPL 306
Cdd:COG4886 218 TDL-PEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQL 262
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
399-646 |
2.08e-18 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 88.45 E-value: 2.08e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 399 CDGRGLQAVPRGFPNDTQL--LDLRRNHFPSVPrAAFPGLRHLVSLHLQHCGIAELePGALAGLDGLVYLYLSNNQLSGL 476
Cdd:COG4886 143 LSNNQLTDLPEPLGNLTNLksLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDL 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 477 SAAaLEGAPNLGYLYLEHNRFLRIPgaALRALPRLFSLHLQDNAVDRLAPgdLAGARALRGLYLSGNHITQVSPGALGPA 556
Cdd:COG4886 221 PEP-LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELL 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 557 RELEKLHLDRNQLRQVPT--GALEGLPALKELQLSRNPFRALHDGAFQPVGRSLQQLFLNSSDLEQISPRAFSGLGKGLQ 634
Cdd:COG4886 296 LGLNSLLLLLLLLNLLELliLLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLL 375
|
250
....*....|..
gi 672060401 635 GLYLQQNQLQSL 646
Cdd:COG4886 376 EATLLTLALLLL 387
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
436-593 |
1.93e-16 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 79.06 E-value: 1.93e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 436 LRHLVSLHLQHCGIAELEpgALAGLDGLVYLYLSNNQLSGLSAaaLEGAPNLGYLYLEHNRFLRIPGaaLRALPRLFSLH 515
Cdd:cd21340 1 LKRITHLYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 516 LQDNAV-------------------DRLAPGD---------LAGARALRGLYLSGNHITQVSPgaLGPARELEKLHLDRN 567
Cdd:cd21340 75 LGGNRIsvveglenltnleelhienQRLPPGEkltfdprslAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNN 152
|
170 180
....*....|....*....|....*...
gi 672060401 568 QLRQVP--TGALEGLPALKELQLSRNPF 593
Cdd:cd21340 153 QISDLEelLDLLSSWPSLRELDLTGNPV 180
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
103-502 |
3.56e-15 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 78.44 E-value: 3.56e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 103 LGRLLFLNLASNRLSSLPQEALDGLGSLRRLELERNMLEELRPGTFGALGSLATLNLAHNAlvylpamAFQGLMRTRWLQ 182
Cdd:COG4886 47 LLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLD 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 183 LSHNALSVLaPEALAGLPVLRRLSLHHNELQALPgAALSQARSLARLELGHNPLTYTGEEDGlALPGLRELALDHGSLQA 262
Cdd:COG4886 120 LSGNQLTDL-PEELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQITD 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 263 LgPRAFAHCPRLHTLDLRGNQLTTLP-PLqvpGQLRRLrlqgnplwcacharpllewlvrarvrsdgacrgprrlrgetl 341
Cdd:COG4886 197 L-PEPLGNLTNLEELDLSGNQLTDLPePL---ANLTNL------------------------------------------ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 342 dtlrpsdlrcpgdaaedededrpagprspprslheearwatpcppacvcvgetrhsacdgrglqavprgfpndtQLLDLR 421
Cdd:COG4886 231 --------------------------------------------------------------------------ETLDLS 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 422 RNHFPSVPraAFPGLRHLVSLHLQHCGIAELEPgaLAGLDGLVYLYLSNNQLSGLSAAALEGAPNLGYLYLEHNRFLRIP 501
Cdd:COG4886 237 NNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLE 312
|
.
gi 672060401 502 G 502
Cdd:COG4886 313 L 313
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
20-545 |
5.65e-15 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 79.12 E-value: 5.65e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 20 WNVAAQRCP-QTCVCDNSRRHVTcqhqnltevpdtipeltqrLDLQG-NMLKVIPPAAFQdLPYLTHLDLQHCQVE-QVA 96
Cdd:PLN00113 51 WNSSADVCLwQGITCNNSSRVVS-------------------IDLSGkNISGKISSAIFR-LPYIQTINLSNNQLSgPIP 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 97 EGAFRGLGRLLFLNLASNRLS-SLPQ------EALD---------------GLGSLRRLELERNMLEELRPGTFGALGSL 154
Cdd:PLN00113 111 DDIFTTSSSLRYLNLSNNNFTgSIPRgsipnlETLDlsnnmlsgeipndigSFSSLKVLDLGGNVLVGKIPNSLTNLTSL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 155 ATLNLAHNALV-YLPAMAfqGLMRT-RWLQLSHNALSVLAPEALAGLPVLRRLSLHHNELQALPGAALSQARSLARLELG 232
Cdd:PLN00113 191 EFLTLASNQLVgQIPREL--GQMKSlKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLY 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 233 HNPLT----------------------YTGE--EDGLALPGLRELALDHGSLQALGPRAFAHCPRLHTLDLRGNQLTTLP 288
Cdd:PLN00113 269 QNKLSgpippsifslqklisldlsdnsLSGEipELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEI 348
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 289 PLQVPGQ--LRRLRLQGNPLW-----CACHARPLLEWLVRARV------RSDGACRGPRRLR--GETLDTLRPSDL-RCP 352
Cdd:PLN00113 349 PKNLGKHnnLTVLDLSTNNLTgeipeGLCSSGNLFKLILFSNSlegeipKSLGACRSLRRVRlqDNSFSGELPSEFtKLP 428
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 353 GDAAEDEDEDRPAGPRspprslhEEARWATPcppacvcvgetrhsacdgrglqavprgfpnDTQLLDLRRNHF-PSVPRa 431
Cdd:PLN00113 429 LVYFLDISNNNLQGRI-------NSRKWDMP------------------------------SLQMLSLARNKFfGGLPD- 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 432 aFPGLRHLVSLHLQHCGIAELEPGALAGLDGLVYLYLSNNQLSGLSAAALEGAPNLGYLYLEHNRFL-RIPgAALRALPR 510
Cdd:PLN00113 471 -SFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSgQIP-ASFSEMPV 548
|
570 580 590
....*....|....*....|....*....|....*
gi 672060401 511 LFSLHLQDNAVDRLAPGDLAGARALRGLYLSGNHI 545
Cdd:PLN00113 549 LSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
466-684 |
5.67e-15 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 74.44 E-value: 5.67e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 466 LYLSNNQLSGLSAaaLEGAPNLGYLYLEHNRFLRIPGaaLRALPRLFSLHLQDNAVDRLapGDLAGARALRGLYLSGNHI 545
Cdd:cd21340 7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 546 TQVSpgalgpareleklhldrnqlrqvptgALEGLPALKELQLSRnpfralhdgafqpvgrslQQLFLNSSdLEqISPRA 625
Cdd:cd21340 81 SVVE--------------------------GLENLTNLEELHIEN------------------QRLPPGEK-LT-FDPRS 114
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672060401 626 FSGLGKGLQGLYLQQNQLQSLpAPMW-LSGLELIDLSGNP---FHCDCQLLPLHRWLTGLNLR 684
Cdd:cd21340 115 LAALSNSLRVLNISGNNIDSL-EPLApLRNLEQLDASNNQisdLEELLDLLSSWPSLRELDLT 176
|
|
| LRR |
COG4886 |
Leucine-rich repeat (LRR) protein [Transcription]; |
38-256 |
1.70e-14 |
|
Leucine-rich repeat (LRR) protein [Transcription];
Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 76.13 E-value: 1.70e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 38 RHVTCQHQNLTEVPDTIPELT--QRLDLQGNMLKVIPpAAFQDLPYLTHLDLQHCQVEQVAEgAFRGLGRLLFLNLASNR 115
Cdd:COG4886 162 KSLDLSNNQLTDLPEELGNLTnlKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQ 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 116 LSSLPQeaLDGLGSLRRLELERNMLEELRPgtFGALGSLATLNLAHNALVYLPAMAFQGLMRTRWLQLSHNALSVLAPEA 195
Cdd:COG4886 240 LTDLPE--LGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672060401 196 LAGLPVLRRLSLHHNELQALPGAALSQARSLARLELGHNPLTYTGEEDGLALPGLRELALD 256
Cdd:COG4886 316 LLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLE 376
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
39-216 |
1.18e-13 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 70.59 E-value: 1.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 39 HVTCQHQNLTEVPDTI--PELTQrLDLQGNMLKVIPpaAFQDLPYLTHLDLQHCQVEQVaEGaFRGLGRLLFLNLASNRL 116
Cdd:cd21340 6 HLYLNDKNITKIDNLSlcKNLKV-LYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKI-EN-LENLVNLKKLYLGGNRI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 117 SSLpqEALDGLGSLRRLELERNMLEE-----LRPGTFGALG-SLATLNLAHNALVYLpaMAFQGLMRTRWLQLSHNALSV 190
Cdd:cd21340 81 SVV--EGLENLTNLEELHIENQRLPPgekltFDPRSLAALSnSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISD 156
|
170 180
....*....|....*....|....*...
gi 672060401 191 LAP--EALAGLPVLRRLSLHHNELQALP 216
Cdd:cd21340 157 LEEllDLLSSWPSLRELDLTGNPVCKKP 184
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
437-497 |
7.02e-12 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 61.00 E-value: 7.02e-12
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672060401 437 RHLVSLHLQHCGIAELEPGALAGLDGLVYLYLSNNQLSGLSAAALEGAPNLGYLYLEHNRF 497
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
23-306 |
1.21e-11 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 68.18 E-value: 1.21e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 23 AAQRCpQTCVCDNSRRhVTCQHQNLTEVPDTIPELTQRLDLQGNMLKVIPPaafqdlpylthlDLQhcqveqvaegafrg 102
Cdd:PRK15370 168 AVQRM-RDCLKNNKTE-LRLKILGLTTIPACIPEQITTLILDNNELKSLPE------------NLQ-------------- 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 103 lGRLLFLNLASNRLSSLPQEALDglgSLRRLELERNMLEELrPGTFGAlgSLATLNLAHNALVYLPAMAFQGLmrtRWLQ 182
Cdd:PRK15370 220 -GNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITEL-PERLPS--ALQSLDLFHNKISCLPENLPEEL---RYLS 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 183 LSHNALSVLaPEALAGlpVLRRLSLHHNELQALPgAALSQarSLARLELGHNPLTYTGEEdglALPGLRELALDHGSLQA 262
Cdd:PRK15370 290 VYDNSIRTL-PAHLPS--GITHLNVQSNSLTALP-ETLPP--GLKTLEAGENALTSLPAS---LPPELQVLDVSKNQITV 360
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 672060401 263 LgPRAFAhcPRLHTLDLRGNQLTTLPPlQVPGQLRRLRLQGNPL 306
Cdd:PRK15370 361 L-PETLP--PTITTLDVSRNALTNLPE-NLPAALQIMQASRNNL 400
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
153-212 |
7.62e-11 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 57.92 E-value: 7.62e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 153 SLATLNLAHNALVYLPAMAFQGLMRTRWLQLSHNALSVLAPEALAGLPVLRRLSLHHNEL 212
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
109-164 |
1.57e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 57.15 E-value: 1.57e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 672060401 109 LNLASNRLSSLPQEALDGLGSLRRLELERNMLEELRPGTFGALGSLATLNLAHNAL 164
Cdd:pfam13855 6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
80-140 |
2.74e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 56.38 E-value: 2.74e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672060401 80 PYLTHLDLQHCQVEQVAEGAFRGLGRLLFLNLASNRLSSLPQEALDGLGSLRRLELERNML 140
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
129-188 |
3.86e-10 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 55.99 E-value: 3.86e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 129 SLRRLELERNMLEELRPGTFGALGSLATLNLAHNALVYLPAMAFQGLMRTRWLQLSHNAL 188
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
404-630 |
7.06e-10 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 62.41 E-value: 7.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 404 LQAVPRGFPNDTQLLDLRRNHFPSVPRAAFPGLRHLVSLHLQHCGIAELEPgalaglDGLVYLYLSNNQLSGLSAAALEG 483
Cdd:PRK15370 232 LTSIPATLPDTIQEMELSINRITELPERLPSALQSLDLFHNKISCLPENLP------EELRYLSVYDNSIRTLPAHLPSG 305
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 484 apnLGYLYLEHNRFLRIPgAALRalPRLFSLHLQDNAVDRLaPGDLagARALRGLYLSGNHITqVSPGALGPAreLEKLH 563
Cdd:PRK15370 306 ---ITHLNVQSNSLTALP-ETLP--PGLKTLEAGENALTSL-PASL--PPELQVLDVSKNQIT-VLPETLPPT--ITTLD 373
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 564 LDRNQLRQVPtgalEGLP-ALKELQLSRN------------------PFRALHDgaFQPVG-RSLQ--QLFLNSSDLEqi 621
Cdd:PRK15370 374 VSRNALTNLP----ENLPaALQIMQASRNnlvrlpeslphfrgegpqPTRIIVE--YNPFSeRTIQnmQRLMSSVGYQ-- 445
|
....*....
gi 672060401 622 SPRAFSGLG 630
Cdd:PRK15370 446 GPRVLFAMG 454
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
59-116 |
1.94e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 54.07 E-value: 1.94e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 672060401 59 QRLDLQGNMLKVIPPAAFQDLPYLTHLDLQHCQVEQVAEGAFRGLGRLLFLNLASNRL 116
Cdd:pfam13855 4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
179-236 |
4.92e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 52.91 E-value: 4.92e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 672060401 179 RWLQLSHNALSVLAPEALAGLPVLRRLSLHHNELQALPGAALSQARSLARLELGHNPL 236
Cdd:pfam13855 4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
557-618 |
6.86e-09 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 52.53 E-value: 6.86e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672060401 557 RELEKLHLDRNQLRQVPTGALEGLPALKELQLSRNPFRALHDGAFQPVgRSLQQLFLNSSDL 618
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
485-545 |
1.06e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 51.76 E-value: 1.06e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672060401 485 PNLGYLYLEHNRFLRIPGAALRALPRLFSLHLQDNAVDRLAPGDLAGARALRGLYLSGNHI 545
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
468-663 |
1.11e-08 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 58.71 E-value: 1.11e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 468 LSNNQLSG-LSAAALEGAPNLGYLYLEHNRFL-RIPGAALralPRLFSLHLQDNAVDRLAPGDLAGARALRGLYLSGNHI 545
Cdd:PLN00113 100 LSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSI---PNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVL 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 546 TQVSPGALGPARELEKLHLDRNQLR-QVPTgALEGLPALKELQLSRNpfrALHDGAFQPVGR--SLQQLFLNSSDLEQIS 622
Cdd:PLN00113 177 VGKIPNSLTNLTSLEFLTLASNQLVgQIPR-ELGQMKSLKWIYLGYN---NLSGEIPYEIGGltSLNHLDLVYNNLTGPI 252
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 672060401 623 PRAFSGLgKGLQGLYLQQNQLQ-SLPAPMW-LSGLELIDLSGN 663
Cdd:PLN00113 253 PSSLGNL-KNLQYLFLYQNKLSgPIPPSIFsLQKLISLDLSDN 294
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
248-306 |
2.40e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 50.99 E-value: 2.40e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672060401 248 PGLRELALDHGSLQALGPRAFAHCPRLHTLDLRGNQLTTLPP--LQVPGQLRRLRLQGNPL 306
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
82-306 |
3.02e-08 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 54.79 E-value: 3.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 82 LTHLDLQHCQVEQVaeGAFRGLGRLLFLNLASNRLSSLpqEALDGLGSLRRLELERNMLEELRpgtfgalgslatlNLah 161
Cdd:cd21340 4 ITHLYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIE-------------NL-- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 162 NALVYLpamafqglmrtRWLQLSHNALSVLapEALAGLPVLRRLSLHHNELQA------LPGAALSQARSLARLELGHNP 235
Cdd:cd21340 65 ENLVNL-----------KKLYLGGNRISVV--EGLENLTNLEELHIENQRLPPgekltfDPRSLAALSNSLRVLNISGNN 131
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672060401 236 LTytgeedglalpglrelaldhgSLQALgprafAHCPRLHTLDLRGNQLTTLPPLQVP----GQLRRLRLQGNPL 306
Cdd:cd21340 132 ID---------------------SLEPL-----APLRNLEQLDASNNQISDLEELLDLlsswPSLRELDLTGNPV 180
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
533-593 |
3.19e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 50.60 E-value: 3.19e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672060401 533 RALRGLYLSGNHITQVSPGALGPARELEKLHLDRNQLRQVPTGALEGLPALKELQLSRNPF 593
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
418-473 |
3.25e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 50.60 E-value: 3.25e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 672060401 418 LDLRRNHFPSVPRAAFPGLRHLVSLHLQHCGIAELEPGALAGLDGLVYLYLSNNQL 473
Cdd:pfam13855 6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
462-519 |
6.27e-08 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 49.83 E-value: 6.27e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 672060401 462 GLVYLYLSNNQLSGLSAAALEGAPNLGYLYLEHNRFLRIPGAALRALPRLFSLHLQDN 519
Cdd:pfam13855 2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
44-210 |
1.52e-07 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 55.09 E-value: 1.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 44 HQNLTEVPDTIPELTQRLDLQGNMLKVIPpaafQDLPY-LTHLDLQHCQVEQVAEGAFRGLGrllFLNLASNRLSSLPqE 122
Cdd:PRK15370 271 HNKISCLPENLPEELRYLSVYDNSIRTLP----AHLPSgITHLNVQSNSLTALPETLPPGLK---TLEAGENALTSLP-A 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 123 ALDglGSLRRLELERN---MLEELRPGTfgalgsLATLNLAHNALVYLPAMAFQGLmrtRWLQLSHNALSVLaPEALAGL 199
Cdd:PRK15370 343 SLP--PELQVLDVSKNqitVLPETLPPT------ITTLDVSRNALTNLPENLPAAL---QIMQASRNNLVRL-PESLPHF 410
|
170
....*....|....*
gi 672060401 200 ----PVLRRLSLHHN 210
Cdd:PRK15370 411 rgegPQPTRIIVEYN 425
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
418-665 |
1.56e-07 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 54.85 E-value: 1.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 418 LDLRRNHFPSVPRAAFPGLRHLVSLHLQHCGIAELEPGALAGLDGLVYLYLSNNQLSGLSAAALEGAPNLGYLYLEHNRF 497
Cdd:PLN00113 241 LDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNF 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 498 L-RIPGAaLRALPRLFSLHLQDNAVDRLAPGDLAGARALRGLYLSGNHITQVSPGALGPARELEKLHLDRNQLR-QVPTg 575
Cdd:PLN00113 321 TgKIPVA-LTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEgEIPK- 398
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 576 ALEGLPALKELQLSRNPFRALHDGAFQpvgrSLQQL-FLNSSD---LEQISPRAFSglGKGLQGLYLQQNQ-LQSLPAPM 650
Cdd:PLN00113 399 SLGACRSLRRVRLQDNSFSGELPSEFT----KLPLVyFLDISNnnlQGRINSRKWD--MPSLQMLSLARNKfFGGLPDSF 472
|
250
....*....|....*
gi 672060401 651 WLSGLELIDLSGNPF 665
Cdd:PLN00113 473 GSKRLENLDLSRNQF 487
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
581-643 |
1.65e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 48.67 E-value: 1.65e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672060401 581 PALKELQLSRNPFRALHDGAFQPVgRSLQQLFLNSSDLEQISPRAFSGLGKgLQGLYLQQNQL 643
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGL-SNLKVLDLSNNLLTTLSPGAFSGLPS-LRYLDLSGNRL 61
|
|
| LRRCT |
smart00082 |
Leucine rich repeat C-terminal domain; |
663-711 |
1.71e-07 |
|
Leucine rich repeat C-terminal domain;
Pssm-ID: 214507 [Multi-domain] Cd Length: 51 Bit Score: 48.20 E-value: 1.71e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 672060401 663 NPFHCDCQLLPLHRWLTG---LNLRVGATCATPPSVRGQkVKAAASVFEACP 711
Cdd:smart00082 1 NPFICDCELRWLLRWLQAnehLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
|
|
| PCC |
TIGR00864 |
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ... |
638-698 |
1.85e-07 |
|
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.
Pssm-ID: 188093 [Multi-domain] Cd Length: 2740 Bit Score: 55.09 E-value: 1.85e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672060401 638 LQQNQLQSLPAPMW--LSGLELIDLSGNPFHCDCQLLPLHRWLTGLNLRV----GATCATPPSVRGQ 698
Cdd:TIGR00864 2 ISNNKISTIEEGICanLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpeAALCAGPGALAGQ 68
|
|
| PRK15370 |
PRK15370 |
type III secretion system effector E3 ubiquitin transferase SlrP; |
46-237 |
1.90e-07 |
|
type III secretion system effector E3 ubiquitin transferase SlrP;
Pssm-ID: 185268 [Multi-domain] Cd Length: 754 Bit Score: 54.70 E-value: 1.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 46 NLTEVPDTIPELTQRLDLQGNMLKVIPpaafQDLP-YLTHLDLQHCQVEQVAEGAFRGlgrLLFLNLASNRLSSLPQEAL 124
Cdd:PRK15370 252 RITELPERLPSALQSLDLFHNKISCLP----ENLPeELRYLSVYDNSIRTLPAHLPSG---ITHLNVQSNSLTALPETLP 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 125 DGlgsLRRLELERNMLEELrPGTFGAlgSLATLNLAHNALVYLPAMAFQGLMRtrwLQLSHNALSVLaPEALAGlpVLRR 204
Cdd:PRK15370 325 PG---LKTLEAGENALTSL-PASLPP--ELQVLDVSKNQITVLPETLPPTITT---LDVSRNALTNL-PENLPA--ALQI 392
|
170 180 190
....*....|....*....|....*....|....*.
gi 672060401 205 LSLHHNELQALPGAA---LSQARSLARLELGHNPLT 237
Cdd:PRK15370 393 MQASRNNLVRLPESLphfRGEGPQPTRIIVEYNPFS 428
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
381-617 |
2.75e-07 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 53.13 E-value: 2.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 381 ATPCPPACVCVGETRHSACDGRGLQAVPRGFPNDTQL--LDLRRNHFPSVPRAAFPGLRHLVSLHLQHCGIAELEPGALA 458
Cdd:cd00116 47 LRPQPSLKELCLSLNETGRIPRGLQSLLQGLTKGCGLqeLDLSDNALGPDGCGVLESLLRSSSLQELKLNNNGLGDRGLR 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 459 GLDG--------LVYLYLSNNQLSGLSAAALEGA----PNLGYLYLEHNRfLRIPGA-----ALRALPRLFSLHLQDNAV 521
Cdd:cd00116 127 LLAKglkdlppaLEKLVLGRNRLEGASCEALAKAlranRDLKELNLANNG-IGDAGIralaeGLKANCNLEVLDLNNNGL 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 522 DRLAPGDLAGA----RALRGLYLSGNHITQV-----SPGALGPARELEKLHLDRNQLRQVPTGAL-EGLPA---LKELQL 588
Cdd:cd00116 206 TDEGASALAETlaslKSLEVLNLGDNNLTDAgaaalASALLSPNISLLTLSLSCNDITDDGAKDLaEVLAEkesLLELDL 285
|
250 260 270
....*....|....*....|....*....|.
gi 672060401 589 SRNPFRALHDGAFQPVGRSL--QQLFLNSSD 617
Cdd:cd00116 286 RGNKFGEEGAQLLAESLLEPgnELESLWVKD 316
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
509-569 |
4.54e-07 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 47.13 E-value: 4.54e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672060401 509 PRLFSLHLQDNAVDRLAPGDLAGARALRGLYLSGNHITQVSPGALGPARELEKLHLDRNQL 569
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| PPP1R42 |
cd21340 |
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
418-549 |
7.07e-07 |
|
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.
Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 50.55 E-value: 7.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 418 LDLRRNHFPSVPraAFPGLRHLVSLHLQHCGIAELEpgalaGLDGLVYL---YLSNNQLSGLSAaaLEGAPNLGYLYLEH 494
Cdd:cd21340 29 LYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIE-----NLENLVNLkklYLGGNRISVVEG--LENLTNLEELHIEN 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 495 NR----------------------FLRIPG------AALRALPRLFSLHLQDNAVDRLAP--GDLAGARALRGLYLSGNH 544
Cdd:cd21340 100 QRlppgekltfdprslaalsnslrVLNISGnnidslEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNP 179
|
....*
gi 672060401 545 ITQVS 549
Cdd:cd21340 180 VCKKP 184
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
55-286 |
7.74e-07 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 51.59 E-value: 7.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 55 PELTQRLDLQGNMLKVIPPA------AFQDLPYLTHLDLQHCQVEQVAEGAFRGLGRLLFL---NLASNRLSSLPQEAL- 124
Cdd:cd00116 50 QPSLKELCLSLNETGRIPRGlqsllqGLTKGCGLQELDLSDNALGPDGCGVLESLLRSSSLqelKLNNNGLGDRGLRLLa 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 125 DGLGS----LRRLELERNMLE----ELRPGTFGALGSLATLNLAHNalvylpamafqglmrtrwlQLSHNALSVLApEAL 196
Cdd:cd00116 130 KGLKDlppaLEKLVLGRNRLEgascEALAKALRANRDLKELNLANN-------------------GIGDAGIRALA-EGL 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 197 AGLPVLRRLSLHHNEL-----QALpGAALSQARSLARLELGHNPLTYTG-----EEDGLALPGLRELALDHGSLQALGPR 266
Cdd:cd00116 190 KANCNLEVLDLNNNGLtdegaSAL-AETLASLKSLEVLNLGDNNLTDAGaaalaSALLSPNISLLTLSLSCNDITDDGAK 268
|
250 260
....*....|....*....|....
gi 672060401 267 AFAHC----PRLHTLDLRGNQLTT 286
Cdd:cd00116 269 DLAEVlaekESLLELDLRGNKFGE 292
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
224-284 |
2.81e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 45.21 E-value: 2.81e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672060401 224 RSLARLELGHNPLTYTGEEDGLALPGLRELALDHGSLQALGPRAFAHCPRLHTLDLRGNQL 284
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
|
|
| LRR_RI |
cd00116 |
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ... |
452-628 |
2.86e-06 |
|
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).
Pssm-ID: 238064 [Multi-domain] Cd Length: 319 Bit Score: 50.05 E-value: 2.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 452 LEPGALAGLDGLVYLYLSNNQLSGLSAAALEGA---PNLGYLYLEHNRF----LRIPGAALRAL-PRLFSLHLQDNAVDR 523
Cdd:cd00116 72 SLLQGLTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLgdrgLRLLAKGLKDLpPALEKLVLGRNRLEG 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 524 LAPGDLAGA----RALRGLYLSGNHITQVSPGALGPA----RELEKLHLDRNQLRQVPTGALEG----LPALKELQLSRN 591
Cdd:cd00116 152 ASCEALAKAlranRDLKELNLANNGIGDAGIRALAEGlkanCNLEVLDLNNNGLTDEGASALAEtlasLKSLEVLNLGDN 231
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 672060401 592 PFR-----ALHDgAFQPVGRSLQQLFLNSSDLEQISPRAFSG 628
Cdd:cd00116 232 NLTdagaaALAS-ALLSPNISLLTLSLSCNDITDDGAKDLAE 272
|
|
| LRR_8 |
pfam13855 |
Leucine rich repeat; |
606-665 |
6.35e-06 |
|
Leucine rich repeat;
Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 44.05 E-value: 6.35e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672060401 606 RSLQQLFLNSSDLEQISPRAFSGLgKGLQGLYLQQNQLQSLPAPMW--LSGLELIDLSGNPF 665
Cdd:pfam13855 1 PNLRSLDLSNNRLTSLDDGAFKGL-SNLKVLDLSNNLLTTLSPGAFsgLPSLRYLDLSGNRL 61
|
|
| LRRNT |
smart00013 |
Leucine rich repeat N-terminal domain; |
383-417 |
7.58e-06 |
|
Leucine rich repeat N-terminal domain;
Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 43.08 E-value: 7.58e-06
10 20 30
....*....|....*....|....*....|....*
gi 672060401 383 PCPPACVCVGetRHSACDGRGLQAVPRGFPNDTQL 417
Cdd:smart00013 1 ACPAPCNCSG--TAVDCSGRGLTEVPLDLPPDTTL 33
|
|
| PksD |
COG3321 |
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites ... |
116-601 |
1.26e-05 |
|
Acyl transferase domain in polyketide synthase (PKS) enzymes [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 442550 [Multi-domain] Cd Length: 1386 Bit Score: 48.72 E-value: 1.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 116 LSSLPQEALDG------LGSLRRLELERNMLeelrpgtFGALGSLAT--LNLAHNAL--------VYLPAMAFQglmRTR 179
Cdd:COG3321 803 LTGLVRQCLAAagdavvLPSLRRGEDELAQL-------LTALAQLWVagVPVDWSALypgrgrrrVPLPTYPFQ---RED 872
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 180 WLQLSHNALSVLAPEALAGLPVLRRLSLHHNELQALPGAALSQARSLARLELGHNPLTYTGEEDGLALPGLRELALDHGS 259
Cdd:COG3321 873 AAAALLAAALAAALAAAAALGALLLAALAAALAAALLALAAAAAAALALAAAALAALLALVALAAAAAALLALAAAAAAA 952
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 260 LQALGPRAFAHCPRLHTLDLRGNQLTTLPPLQVPGQLRRLRLQGNPLWCACHARPLLEWLVRARVRSDGACRGPRRLRGE 339
Cdd:COG3321 953 AAALAAAEAGALLLLAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAALALLAAAALLLAAAAAAAALLALAALLAAAA 1032
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 340 TLDTLRpsdlrcPGDAAEDEDEDRPAGPRSPPRSLHEEARWATPCPPACVCVGETRHSACDGRGLQAVPRGFPNDTQLLD 419
Cdd:COG3321 1033 AALAAA------AAAAAAAAALAALAAAAAAAAALALALAALLLLAALAELALAAAALALAAALAAAALALALAALAAAL 1106
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 420 LRRNHFPSVPRAAFPGLRHLVSLHLQHCGIAELEPGALAGLDGLVYLYLSNNQLSGLSAAALEGAPNLGYLYLEHNRFLR 499
Cdd:COG3321 1107 LLLALLAALALAAAAAALLALAALLAAAAAAAALAAAAAAAAALALAAAAAALAAALAAALLAAAALLLALALALAAALA 1186
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 500 IPGAALRALPRLFSLHLQDNAVDRLAPGDLAGARALRGLYLSGNHITQVSPGALGPARELEKLHLDRNQLRQVPTGALEG 579
Cdd:COG3321 1187 AALAGLAALLLAALLAALLAALLALALAALAAAAAALLAAAAAAAALALLALAAAAAAVAALAAAAAALLAALAALALLA 1266
|
490 500
....*....|....*....|..
gi 672060401 580 LPALKELQLSRNPFRALHDGAF 601
Cdd:COG3321 1267 AAAGLAALAAAAAAAAAALALA 1288
|
|
| PLN00113 |
PLN00113 |
leucine-rich repeat receptor-like protein kinase; Provisional |
407-593 |
3.82e-05 |
|
leucine-rich repeat receptor-like protein kinase; Provisional
Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 47.15 E-value: 3.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 407 VPRGFPNDTQLLDLRRNHFPSVPRAAFPGLRHLVSLHLQHCGIAELEPGALAGLDGLVYLYLSNNQLSGLSAAALEGAPN 486
Cdd:PLN00113 134 IPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKS 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 487 LGYLYLEHNRFL-------------------------RIPgAALRALPRLFSLHLQDNAVDRLAPGDLAGARALRGLYLS 541
Cdd:PLN00113 214 LKWIYLGYNNLSgeipyeiggltslnhldlvynnltgPIP-SSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLS 292
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 672060401 542 GNHITQVSPGALGPARELEKLHLDRNQLRQVPTGALEGLPALKELQLSRNPF 593
Cdd:PLN00113 293 DNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKF 344
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
35-313 |
5.68e-05 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 46.32 E-value: 5.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 35 NSRRHVTCQHQNL--TEVPDTIPELTQRLDLQGNM-LKVIPPAAFQDLPYLTHLDLQHCQVEQVAEGAFRGLG-RLLFLN 110
Cdd:COG5238 107 ETATAVATPPPDLrrIMAKTLEDSLILYLALPRRInLIQVLKDPLGGNAVHLLGLAARLGLLAAISMAKALQNnSVETVY 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 111 LASNRLSS----LPQEALDGLGSLRRLELERN-MLEELRPGTFGALG---SLATLNLAHNALVYLPAMAFQGLMRT---- 178
Cdd:COG5238 187 LGCNQIGDegieELAEALTQNTTVTTLWLKRNpIGDEGAEILAEALKgnkSLTTLDLSNNQIGDEGVIALAEALKNnttv 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 179 RWLQLSHNALSV-----LApEALAGLPVLRRLSLHHNELQAlPGA-----ALSQARSLARLELGHNPLTYTGEEdGLA-- 246
Cdd:COG5238 267 ETLYLSGNQIGAegaiaLA-KALQGNTTLTSLDLSVNRIGD-EGAialaeGLQGNKTLHTLNLAYNGIGAQGAI-ALAka 343
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672060401 247 ---LPGLRELALDHGSLQALGPRAFAH----CPRLHTLDLRGNQLT-----TLPPLQVPGQLRRLRLQGNPLWCACHAR 313
Cdd:COG5238 344 lqeNTTLHSLDLSDNQIGDEGAIALAKylegNTTLRELNLGKNNIGkqgaeALIDALQTNRLHTLILDGNLIGAEAQQR 422
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
456-584 |
2.39e-04 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 44.40 E-value: 2.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 456 ALAGLDGLVYLYLSNNQLSGLSAAA----LEGAPNLGYLYLEHNRfLRIPGA-----ALRALPRLFSLHLQDNAVdrlap 526
Cdd:COG5238 287 ALQGNTTLTSLDLSVNRIGDEGAIAlaegLQGNKTLHTLNLAYNG-IGAQGAialakALQENTTLHSLDLSDNQI----- 360
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672060401 527 GD---------LAGARALRGLYLSGNHITQVSPGALGPARELEKLH---LDRNQLRQVPTGAL-EGLPALK 584
Cdd:COG5238 361 GDegaialakyLEGNTTLRELNLGKNNIGKQGAEALIDALQTNRLHtliLDGNLIGAEAQQRLeQLLERIK 431
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
466-635 |
2.70e-04 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 44.01 E-value: 2.70e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 466 LYLSNNQLS--GLS--AAALEGAPNLGYLYLEHNRF----LRIPGAALRALPRLFSLHLQDNAVDrlAPGDLAGARALR- 536
Cdd:COG5238 185 VYLGCNQIGdeGIEelAEALTQNTTVTTLWLKRNPIgdegAEILAEALKGNKSLTTLDLSNNQIG--DEGVIALAEALKn 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 537 -----GLYLSGNHITqvSPGALGPARELEK------LHLDRNQLRQvpTGA------LEGLPALKELQLSRNPFRAlhDG 599
Cdd:COG5238 263 nttveTLYLSGNQIG--AEGAIALAKALQGnttltsLDLSVNRIGD--EGAialaegLQGNKTLHTLNLAYNGIGA--QG 336
|
170 180 190
....*....|....*....|....*....|....*....
gi 672060401 600 AfQPVGRSLQQLF-LNSSDLE--QISPRAFSGLGKGLQG 635
Cdd:COG5238 337 A-IALAKALQENTtLHSLDLSdnQIGDEGAIALAKYLEG 374
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
124-252 |
3.83e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 43.65 E-value: 3.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 124 LDGLGslrrleLERNMLEELRPGTFGALGSLATLNLAHNALVYLPAMAFQGLMRTRWLQLSHNALSVLAPEALAGLPVLR 203
Cdd:PLN03150 420 IDGLG------LDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLR 493
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 672060401 204 RLSLHHNELQA-LPGAALSQARSLARLELGHNPltytgeedGL-ALPGLRE 252
Cdd:PLN03150 494 ILNLNGNSLSGrVPAALGGRLLHRASFNFTDNA--------GLcGIPGLRA 536
|
|
| RNA1 |
COG5238 |
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
122-300 |
3.85e-04 |
|
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];
Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 43.63 E-value: 3.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 122 EALDGLGSLRRLELERN---------MLEELRPGTfgalgSLATLNLAHN-----ALVYLpAMAFQGLMRTRWLQLSHNA 187
Cdd:COG5238 230 EALKGNKSLTTLDLSNNqigdegviaLAEALKNNT-----TVETLYLSGNqigaeGAIAL-AKALQGNTTLTSLDLSVNR 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 188 LS-----VLApEALAGLPVLRRLSLHHNELQALPGAALSQA----RSLARLELGHNPLTYTGEEdGLA-----LPGLREL 253
Cdd:COG5238 304 IGdegaiALA-EGLQGNKTLHTLNLAYNGIGAQGAIALAKAlqenTTLHSLDLSDNQIGDEGAI-ALAkylegNTTLREL 381
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 672060401 254 ALDHGSLQALGPRAFA---HCPRLHTLDLRGNQLTTLPPLQVPGQLRRLR 300
Cdd:COG5238 382 NLGKNNIGKQGAEALIdalQTNRLHTLILDGNLIGAEAQQRLEQLLERIK 431
|
|
| LRRNT |
pfam01462 |
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ... |
383-412 |
4.67e-04 |
|
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.
Pssm-ID: 396168 [Multi-domain] Cd Length: 28 Bit Score: 37.99 E-value: 4.67e-04
10 20 30
....*....|....*....|....*....|
gi 672060401 383 PCPPACVCVGetRHSACDGRGLQAVPRGFP 412
Cdd:pfam01462 1 ACPVPCHCSA--TVVNCSDRGLTAVPRDLP 28
|
|
| LRRNT |
smart00013 |
Leucine rich repeat N-terminal domain; |
27-59 |
4.83e-04 |
|
Leucine rich repeat N-terminal domain;
Pssm-ID: 214470 [Multi-domain] Cd Length: 33 Bit Score: 38.07 E-value: 4.83e-04
10 20 30
....*....|....*....|....*....|...
gi 672060401 27 CPQTCVCdnSRRHVTCQHQNLTEVPDTIPELTQ 59
Cdd:smart00013 2 CPAPCNC--SGTAVDCSGRGLTEVPLDLPPDTT 32
|
|
| LRRNT |
pfam01462 |
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ... |
27-55 |
1.78e-03 |
|
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.
Pssm-ID: 396168 [Multi-domain] Cd Length: 28 Bit Score: 36.45 E-value: 1.78e-03
10 20
....*....|....*....|....*....
gi 672060401 27 CPQTCVCdnSRRHVTCQHQNLTEVPDTIP 55
Cdd:pfam01462 2 CPVPCHC--SATVVNCSDRGLTAVPRDLP 28
|
|
| PLN03150 |
PLN03150 |
hypothetical protein; Provisional |
50-163 |
1.81e-03 |
|
hypothetical protein; Provisional
Pssm-ID: 178695 [Multi-domain] Cd Length: 623 Bit Score: 41.73 E-value: 1.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672060401 50 VPDTIPELT--QRLDLQGNMLKVIPPAAFQDLPYLTHLDLQHcqveqvaegafrglgrllflnlasNRLSSLPQEALDGL 127
Cdd:PLN03150 434 IPNDISKLRhlQSINLSGNSIRGNIPPSLGSITSLEVLDLSY------------------------NSFNGSIPESLGQL 489
|
90 100 110
....*....|....*....|....*....|....*..
gi 672060401 128 GSLRRLELERNMLEELRPGTFGA-LGSLATLNLAHNA 163
Cdd:PLN03150 490 TSLRILNLNGNSLSGRVPAALGGrLLHRASFNFTDNA 526
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
272-306 |
4.35e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 35.68 E-value: 4.35e-03
10 20 30
....*....|....*....|....*....|....*
gi 672060401 272 PRLHTLDLRGNQLTTLPPLQVPGQLRRLRLQGNPL 306
Cdd:pfam12799 1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK 35
|
|
| LRR_4 |
pfam12799 |
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
463-499 |
5.30e-03 |
|
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.
Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 35.30 E-value: 5.30e-03
10 20 30
....*....|....*....|....*....|....*..
gi 672060401 463 LVYLYLSNNQLSGLSaaALEGAPNLGYLYLEHNRFLR 499
Cdd:pfam12799 3 LEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKIT 37
|
|
| |
